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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iohexol
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Accession:CHEBI:31709 term browser browse the term
Definition:A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.
Synonyms:exact_synonym: 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
 related_synonym: Formula=C19H26I3N3O9;   InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34);   InChIKey=NTHXOOBQLCIOLC-UHFFFAOYSA-N;   N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide;   SMILES=CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I;   iohexolum
 xref: Beilstein:2406632;   CAS:66108-95-0;   Drug_Central:1461;   KEGG:D01817;   LINCS:LSM-5095
 xref_mesh: MESH:D007472
 xref: PMID:15206581;   PMID:19359533;   PMID:23847035;   PMID:24516530;   PMID:24752695;   Reaxys:2406632;   Wikipedia:Iohexol


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iohexol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression
multiple interactions		 EXP Iohexol results in increased expression of AGT protein
telmisartan inhibits the reaction [Iohexol results in increased expression of AGT protein]		 CTD PMID:19452295 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Iohexol results in increased expression of BAK1 mRNA CTD PMID:29705293 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 Iohexol results in increased expression of BAX mRNA; Iohexol results in increased expression of BAX protein
Amlodipine inhibits the reaction [Iohexol results in increased expression of BAX protein]; cilnidipine inhibits the reaction [Iohexol results in increased expression of BAX protein]; Nifedipine inhibits the reaction [Iohexol results in increased expression of BAX protein]		 CTD PMID:29705293 PMID:36207783 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Iohexol results in increased expression of BBC3 mRNA CTD PMID:29705293 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 Iohexol results in decreased expression of BCL2 protein
Amlodipine inhibits the reaction [Iohexol results in decreased expression of BCL2 protein]; cilnidipine inhibits the reaction [Iohexol results in decreased expression of BCL2 protein]; Nifedipine inhibits the reaction [Iohexol results in decreased expression of BCL2 protein]		 CTD PMID:36207783 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma multiple interactions ISO CAMK2G protein inhibits the reaction [Iohexol results in increased expression of PPIF protein]; CAMK2G protein promotes the reaction [Iohexol results in increased cleavage of CASP3 protein]; cilnidipine inhibits the reaction [CAMK2G protein promotes the reaction [Iohexol results in increased cleavage of CASP3 protein]] CTD PMID:36207783 NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 EXP
ISO		 Amlodipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]]; cilnidipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein]; Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]; Nifedipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein]; Telmisartan inhibits the reaction [Iohexol results in increased activity of CASP3 protein]
Amlodipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein]; CAMK2G protein promotes the reaction [Iohexol results in increased cleavage of CASP3 protein]; cilnidipine inhibits the reaction [CAMK2G protein promotes the reaction [Iohexol results in increased cleavage of CASP3 protein]]; cilnidipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein]; Nifedipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein]		 CTD PMID:19452295 PMID:26562095 PMID:36207783 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases expression ISO Iohexol results in increased expression of CASP9 mRNA; Iohexol results in increased expression of CASP9 protein CTD PMID:29705293 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Iohexol results in increased expression of CCL2 protein CTD PMID:34774977 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Eng endoglin decreases expression ISO Iohexol results in decreased expression of ENG protein CTD PMID:29705293 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Iohexol results in increased expression of FABP3 mRNA CTD PMID:29705293 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of GCLM mRNA CTD PMID:29860548 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression
multiple interactions		 EXP Iohexol results in increased expression of HAVCR1 protein
Amlodipine inhibits the reaction [Iohexol results in increased expression of HAVCR1 protein]; cilnidipine inhibits the reaction [Iohexol results in increased expression of HAVCR1 protein]; Nifedipine inhibits the reaction [Iohexol results in increased expression of HAVCR1 protein]		 CTD PMID:36207783 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hexb hexosaminidase subunit beta increases secretion ISO Iohexol results in increased secretion of HEXB protein CTD PMID:34774977 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMGB1 protein CTD PMID:29860548 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Iohexol results in increased expression of HMOX1 mRNA
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMOX1 mRNA		 CTD PMID:29705293 PMID:29860548 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Iohexol results in decreased expression of IFI44 mRNA CTD PMID:29705293 NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Iohexol results in decreased expression of IFIH1 mRNA CTD PMID:29705293 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA] CTD PMID:26562095 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions
increases expression		 EXP Amlodipine inhibits the reaction [Iohexol results in increased expression of LCN2 protein]; cilnidipine inhibits the reaction [Iohexol results in increased expression of LCN2 protein]; Nifedipine inhibits the reaction [Iohexol results in increased expression of LCN2 protein] CTD PMID:36207783 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Iohexol results in increased expression of MAP3K1 mRNA CTD PMID:29705293 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Iohexol results in decreased phosphorylation of MAPK1 protein CTD PMID:34774977 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression ISO Iohexol results in increased expression of MAPK14 mRNA CTD PMID:29705293 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Iohexol results in decreased phosphorylation of MAPK3 protein CTD PMID:34774977 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of NLRP3 protein CTD PMID:29860548 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of NQO1 mRNA CTD PMID:29860548 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO Iohexol results in decreased expression of OAS3 mRNA CTD PMID:29705293 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Iohexol results in increased expression of PPARG mRNA CTD PMID:29705293 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions
increases expression		 EXP
ISO		 Amlodipine inhibits the reaction [Iohexol results in increased expression of PPIF protein]; cilnidipine inhibits the reaction [Iohexol results in increased expression of PPIF protein]; Nifedipine inhibits the reaction [Iohexol results in increased expression of PPIF protein]
Amlodipine inhibits the reaction [Iohexol results in increased expression of PPIF protein]; CAMK2G protein inhibits the reaction [Iohexol results in increased expression of PPIF protein]; cilnidipine inhibits the reaction [Iohexol results in increased expression of PPIF protein]; Nifedipine inhibits the reaction [Iohexol results in increased expression of PPIF protein]		 CTD PMID:36207783 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Iohexol results in increased expression of RELA mRNA CTD PMID:29705293 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Iohexol results in decreased expression of RSAD2 mRNA CTD PMID:29705293 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO Iohexol results in increased expression of S100A4 mRNA CTD PMID:29705293 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO Iohexol results in increased expression of SOX9 mRNA CTD PMID:29705293 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Iohexol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein] CTD PMID:29860548 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA] CTD PMID:26562095 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression ISO Iohexol results in decreased expression of THY1 protein CTD PMID:29705293 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]; Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]; Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]
Iohexol results in increased expression of TNF protein		 CTD PMID:26562095 PMID:34774977 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Iohexol results in increased expression of TP53 mRNA CTD PMID:29705293 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tubb3 tubulin, beta 3 class III increases expression ISO Iohexol results in increased expression of TUBB3 mRNA CTD PMID:29705293 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression ISO Iohexol results in decreased expression of USP18 mRNA CTD PMID:29705293 NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        xenobiotic 18731
          iohexol 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      carboacyl group 17675
                                        univalent carboacyl group 17675
                                          carbamoyl group 17524
                                            carboxamide 17547
                                              dicarboxylic acid amide 3155
                                                dicarboxylic acid diamide 2702
                                                  benzenedicarboxamide 69
                                                    iohexol 40
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