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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iohexol
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Accession:CHEBI:31709 term browser browse the term
Definition:A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.
Synonyms:exact_synonym: 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
 related_synonym: Formula=C19H26I3N3O9;   InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34);   InChIKey=NTHXOOBQLCIOLC-UHFFFAOYSA-N;   N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide;   SMILES=CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I;   iohexolum
 xref: Beilstein:2406632;   CAS:66108-95-0;   Drug_Central:1461;   KEGG:D01817;   LINCS:LSM-5095
 xref_mesh: MESH:D007472
 xref: PMID:15206581;   PMID:19359533;   PMID:23847035;   PMID:24516530;   PMID:24752695;   Reaxys:2406632;   Wikipedia:Iohexol

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iohexol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression
multiple interactions		 EXP Iohexol results in increased expression of AGT protein
telmisartan inhibits the reaction [Iohexol results in increased expression of AGT protein]		 CTD PMID:19452295 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Iohexol results in increased expression of BAK1 mRNA CTD PMID:29705293 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Iohexol results in increased expression of BAX mRNA CTD PMID:29705293 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Iohexol results in increased expression of BBC3 mRNA CTD PMID:29705293 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]; Telmisartan inhibits the reaction [Iohexol results in increased activity of CASP3 protein] CTD PMID:19452295 PMID:26562095 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 increases expression ISO Iohexol results in increased expression of CASP9 mRNA; Iohexol results in increased expression of CASP9 protein CTD PMID:29705293 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Eng endoglin decreases expression ISO Iohexol results in decreased expression of ENG protein CTD PMID:29705293 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Iohexol results in increased expression of FABP3 mRNA CTD PMID:29705293 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of GCLM mRNA CTD PMID:29860548 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMGB1 protein CTD PMID:29860548 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Iohexol results in increased expression of HMOX1 mRNA
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMOX1 mRNA		 CTD PMID:29705293 PMID:29860548 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Iohexol results in decreased expression of IFI44 mRNA CTD PMID:29705293 NCBI chr 2:256,897,765...256,915,591
Ensembl chr 2:256,897,772...256,915,569 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Iohexol results in decreased expression of IFIH1 mRNA CTD PMID:29705293 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA] CTD PMID:26562095 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Iohexol results in increased expression of MAP3K1 mRNA CTD PMID:29705293 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression ISO Iohexol results in increased expression of MAPK14 mRNA CTD PMID:29705293 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of NLRP3 protein CTD PMID:29860548 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of NQO1 mRNA CTD PMID:29860548 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO Iohexol results in decreased expression of OAS3 mRNA CTD PMID:29705293 NCBI chr12:41,313,081...41,368,217
Ensembl chr12:41,316,764...41,336,562 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Iohexol results in increased expression of PPARG mRNA CTD PMID:29705293 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Iohexol results in increased expression of RELA mRNA CTD PMID:29705293 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Iohexol results in decreased expression of RSAD2 mRNA CTD PMID:29705293 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148 		JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO Iohexol results in increased expression of S100A4 mRNA CTD PMID:29705293 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604 		JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO Iohexol results in increased expression of SOX9 mRNA CTD PMID:29705293 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Iohexol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein] CTD PMID:29860548 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA] CTD PMID:26562095 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression ISO Iohexol results in decreased expression of THY1 protein CTD PMID:29705293 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]; Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]; Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein] CTD PMID:26562095 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Iohexol results in increased expression of TP53 mRNA CTD PMID:29705293 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tubb3 tubulin, beta 3 class III increases expression ISO Iohexol results in increased expression of TUBB3 mRNA CTD PMID:29705293 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression ISO Iohexol results in decreased expression of USP18 mRNA CTD PMID:29705293 NCBI chr 4:153,812,312...153,834,374
Ensembl chr 4:153,805,993...153,834,430 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        xenobiotic 18387
          iohexol 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        carboacyl group 17410
                                          univalent carboacyl group 17410
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                dicarboxylic acid amide 3119
                                                  dicarboxylic acid diamide 2667
                                                    benzenedicarboxamide 50
                                                      iohexol 31
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