CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: iohexol
Accession: CHEBI:31709
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Definition: A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.
Synonyms: exact_synonym: 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
related_synonym: Formula=C19H26I3N3O9; InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34); InChIKey=NTHXOOBQLCIOLC-UHFFFAOYSA-N; N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide; SMILES=CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I; iohexolum
xref: Beilstein:2406632; CAS:66108-95-0; Drug_Central:1461; KEGG:D01817; LINCS:LSM-5095
xref_mesh: MESH:D007472
xref: PMID:15206581; PMID:19359533; PMID:23847035; PMID:24516530; PMID:24752695; Reaxys:2406632; Wikipedia:Iohexol
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Agt
angiotensinogen
increases expression multiple interactions
EXP
Iohexol results in increased expression of AGT protein telmisartan inhibits the reaction [Iohexol results in increased expression of AGT protein]
CTD
PMID:19452295
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
Iohexol results in increased expression of BAK1 mRNA
CTD
PMID:29705293
NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Iohexol results in increased expression of BAX mRNA
CTD
PMID:29705293
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bbc3
Bcl-2 binding component 3
increases expression
ISO
Iohexol results in increased expression of BBC3 mRNA
CTD
PMID:29705293
NCBI chr 1:78,261,491...78,267,802
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Casp3
caspase 3
multiple interactions increases activity
EXP
Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]; Telmisartan inhibits the reaction [Iohexol results in increased activity of CASP3 protein]
CTD
PMID:19452295 PMID:26562095
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp9
caspase 9
increases expression
ISO
Iohexol results in increased expression of CASP9 mRNA; Iohexol results in increased expression of CASP9 protein
CTD
PMID:29705293
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Eng
endoglin
decreases expression
ISO
Iohexol results in decreased expression of ENG protein
CTD
PMID:29705293
NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
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Fabp3
fatty acid binding protein 3
increases expression
ISO
Iohexol results in increased expression of FABP3 mRNA
CTD
PMID:29705293
NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
EXP
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of GCLM mRNA
CTD
PMID:29860548
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
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Hmgb1
high mobility group box 1
multiple interactions
EXP
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMGB1 protein
CTD
PMID:29860548
NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
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Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO EXP
Iohexol results in increased expression of HMOX1 mRNA [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMOX1 mRNA
CTD
PMID:29705293 PMID:29860548
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Ifi44
interferon-induced protein 44
decreases expression
ISO
Iohexol results in decreased expression of IFI44 mRNA
CTD
PMID:29705293
NCBI chr 2:256,897,765...256,915,591
Ensembl chr 2:256,897,772...256,915,569
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Ifih1
interferon induced with helicase C domain 1
decreases expression
ISO
Iohexol results in decreased expression of IFIH1 mRNA
CTD
PMID:29705293
NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
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Il1b
interleukin 1 beta
multiple interactions
EXP
Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]
CTD
PMID:26562095
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Map3k1
mitogen-activated protein kinase kinase kinase 1
increases expression
ISO
Iohexol results in increased expression of MAP3K1 mRNA
CTD
PMID:29705293
NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
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Mapk14
mitogen activated protein kinase 14
increases expression
ISO
Iohexol results in increased expression of MAPK14 mRNA
CTD
PMID:29705293
NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of NLRP3 protein
CTD
PMID:29860548
NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of NQO1 mRNA
CTD
PMID:29860548
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Oas3
2'-5'-oligoadenylate synthetase 3
decreases expression
ISO
Iohexol results in decreased expression of OAS3 mRNA
CTD
PMID:29705293
NCBI chr12:41,313,081...41,368,217
Ensembl chr12:41,316,764...41,336,562
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
Iohexol results in increased expression of PPARG mRNA
CTD
PMID:29705293
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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Rela
RELA proto-oncogene, NF-kB subunit
increases expression
ISO
Iohexol results in increased expression of RELA mRNA
CTD
PMID:29705293
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Rsad2
radical S-adenosyl methionine domain containing 2
decreases expression
ISO
Iohexol results in decreased expression of RSAD2 mRNA
CTD
PMID:29705293
NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
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S100a4
S100 calcium-binding protein A4
increases expression
ISO
Iohexol results in increased expression of S100A4 mRNA
CTD
PMID:29705293
NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
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Sox9
SRY-box transcription factor 9
increases expression
ISO
Iohexol results in increased expression of SOX9 mRNA
CTD
PMID:29705293
NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
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Sqstm1
sequestosome 1
multiple interactions
EXP
Iohexol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein]
CTD
PMID:29860548
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]
CTD
PMID:26562095
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Thy1
Thy-1 cell surface antigen
decreases expression
ISO
Iohexol results in decreased expression of THY1 protein
CTD
PMID:29705293
NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
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Tnf
tumor necrosis factor
multiple interactions
EXP
Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]; Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]; Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]
CTD
PMID:26562095
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tp53
tumor protein p53
increases expression
ISO
Iohexol results in increased expression of TP53 mRNA
CTD
PMID:29705293
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Tubb3
tubulin, beta 3 class III
increases expression
ISO
Iohexol results in increased expression of TUBB3 mRNA
CTD
PMID:29705293
NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
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Usp18
ubiquitin specific peptidase 18
decreases expression
ISO
Iohexol results in decreased expression of USP18 mRNA
CTD
PMID:29705293
NCBI chr 4:153,812,312...153,834,374
Ensembl chr 4:153,805,993...153,834,430
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