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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iohexol
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Accession:CHEBI:31709 term browser browse the term
Definition:A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.
Synonyms:exact_synonym: 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
 related_synonym: Formula=C19H26I3N3O9;   InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34);   InChIKey=NTHXOOBQLCIOLC-UHFFFAOYSA-N;   N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide;   SMILES=CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I;   iohexolum
 xref: Beilstein:2406632;   CAS:66108-95-0;   Drug_Central:1461;   KEGG:D01817;   LINCS:LSM-5095
 xref_mesh: MESH:D007472
 xref: PMID:15206581;   PMID:19359533;   PMID:23847035;   PMID:24516530;   PMID:24752695;   Reaxys:2406632;   Wikipedia:Iohexol


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iohexol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression
multiple interactions		 EXP Iohexol results in increased expression of AGT protein
telmisartan inhibits the reaction [Iohexol results in increased expression of AGT protein]		 CTD PMID:19452295 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Iohexol results in increased expression of BAK1 mRNA CTD PMID:29705293 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Iohexol results in increased expression of BAX mRNA CTD PMID:29705293 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Iohexol results in increased expression of BBC3 mRNA CTD PMID:29705293 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]; Telmisartan inhibits the reaction [Iohexol results in increased activity of CASP3 protein] CTD PMID:19452295 PMID:26562095 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases expression ISO Iohexol results in increased expression of CASP9 mRNA; Iohexol results in increased expression of CASP9 protein CTD PMID:29705293 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Eng endoglin decreases expression ISO Iohexol results in decreased expression of ENG protein CTD PMID:29705293 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Iohexol results in increased expression of FABP3 mRNA CTD PMID:29705293 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of GCLM mRNA CTD PMID:29860548 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMGB1 protein CTD PMID:29860548 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Iohexol results in increased expression of HMOX1 mRNA
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMOX1 mRNA		 CTD PMID:29705293 PMID:29860548 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Iohexol results in decreased expression of IFI44 mRNA CTD PMID:29705293 NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Iohexol results in decreased expression of IFIH1 mRNA CTD PMID:29705293 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA] CTD PMID:26562095 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Iohexol results in increased expression of MAP3K1 mRNA CTD PMID:29705293 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression ISO Iohexol results in increased expression of MAPK14 mRNA CTD PMID:29705293 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of NLRP3 protein CTD PMID:29860548 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of NQO1 mRNA CTD PMID:29860548 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO Iohexol results in decreased expression of OAS3 mRNA CTD PMID:29705293 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Iohexol results in increased expression of PPARG mRNA CTD PMID:29705293 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Iohexol results in increased expression of RELA mRNA CTD PMID:29705293 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Iohexol results in decreased expression of RSAD2 mRNA CTD PMID:29705293 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699 		JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO Iohexol results in increased expression of S100A4 mRNA CTD PMID:29705293 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO Iohexol results in increased expression of SOX9 mRNA CTD PMID:29705293 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Iohexol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein] CTD PMID:29860548 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA] CTD PMID:26562095 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression ISO Iohexol results in decreased expression of THY1 protein CTD PMID:29705293 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]; Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]; Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein] CTD PMID:26562095 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Iohexol results in increased expression of TP53 mRNA CTD PMID:29705293 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tubb3 tubulin, beta 3 class III increases expression ISO Iohexol results in increased expression of TUBB3 mRNA CTD PMID:29705293 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression ISO Iohexol results in decreased expression of USP18 mRNA CTD PMID:29705293 NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        xenobiotic 18671
          iohexol 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic group 18965
                              organic divalent group 18951
                                organodiyl group 18951
                                  carbonyl group 18903
                                    carbonyl compound 18903
                                      carboxylic acid 18601
                                        carboacyl group 17713
                                          univalent carboacyl group 17713
                                            carbamoyl group 17552
                                              carboxamide 17552
                                                dicarboxylic acid amide 3147
                                                  dicarboxylic acid diamide 2695
                                                    benzenedicarboxamide 61
                                                      iohexol 31
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