CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: iohexol
Accession: CHEBI:31709
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Definition: A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.
Synonyms: exact_synonym: 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
related_synonym: Formula=C19H26I3N3O9; InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34); InChIKey=NTHXOOBQLCIOLC-UHFFFAOYSA-N; N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide; SMILES=CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I; iohexolum
xref: Beilstein:2406632; CAS:66108-95-0; Drug_Central:1461; KEGG:D01817; LINCS:LSM-5095
xref_mesh: MESH:D007472
xref: PMID:15206581; PMID:19359533; PMID:23847035; PMID:24516530; PMID:24752695; Reaxys:2406632; Wikipedia:Iohexol
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Agt
angiotensinogen
increases expression multiple interactions
EXP
Iohexol results in increased expression of AGT protein telmisartan inhibits the reaction [Iohexol results in increased expression of AGT protein]
CTD
PMID:19452295
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
Iohexol results in increased expression of BAK1 mRNA
CTD
PMID:29705293
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Iohexol results in increased expression of BAX mRNA
CTD
PMID:29705293
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bbc3
Bcl-2 binding component 3
increases expression
ISO
Iohexol results in increased expression of BBC3 mRNA
CTD
PMID:29705293
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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Casp3
caspase 3
multiple interactions increases activity
EXP
Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]; Telmisartan inhibits the reaction [Iohexol results in increased activity of CASP3 protein]
CTD
PMID:19452295 PMID:26562095
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases expression
ISO
Iohexol results in increased expression of CASP9 mRNA; Iohexol results in increased expression of CASP9 protein
CTD
PMID:29705293
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Eng
endoglin
decreases expression
ISO
Iohexol results in decreased expression of ENG protein
CTD
PMID:29705293
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
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Fabp3
fatty acid binding protein 3
increases expression
ISO
Iohexol results in increased expression of FABP3 mRNA
CTD
PMID:29705293
NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
EXP
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of GCLM mRNA
CTD
PMID:29860548
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Hmgb1
high mobility group box 1
multiple interactions
EXP
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMGB1 protein
CTD
PMID:29860548
NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
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Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO EXP
Iohexol results in increased expression of HMOX1 mRNA [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMOX1 mRNA
CTD
PMID:29705293 PMID:29860548
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Ifi44
interferon-induced protein 44
decreases expression
ISO
Iohexol results in decreased expression of IFI44 mRNA
CTD
PMID:29705293
NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
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Ifih1
interferon induced with helicase C domain 1
decreases expression
ISO
Iohexol results in decreased expression of IFIH1 mRNA
CTD
PMID:29705293
NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
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Il1b
interleukin 1 beta
multiple interactions
EXP
Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]
CTD
PMID:26562095
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Map3k1
mitogen-activated protein kinase kinase kinase 1
increases expression
ISO
Iohexol results in increased expression of MAP3K1 mRNA
CTD
PMID:29705293
NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
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Mapk14
mitogen activated protein kinase 14
increases expression
ISO
Iohexol results in increased expression of MAPK14 mRNA
CTD
PMID:29705293
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of NLRP3 protein
CTD
PMID:29860548
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
[Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in decreased expression of NQO1 mRNA
CTD
PMID:29860548
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Oas3
2'-5'-oligoadenylate synthetase 3
decreases expression
ISO
Iohexol results in decreased expression of OAS3 mRNA
CTD
PMID:29705293
NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
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Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
Iohexol results in increased expression of PPARG mRNA
CTD
PMID:29705293
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Rela
RELA proto-oncogene, NF-kB subunit
increases expression
ISO
Iohexol results in increased expression of RELA mRNA
CTD
PMID:29705293
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rsad2
radical S-adenosyl methionine domain containing 2
decreases expression
ISO
Iohexol results in decreased expression of RSAD2 mRNA
CTD
PMID:29705293
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
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S100a4
S100 calcium-binding protein A4
increases expression
ISO
Iohexol results in increased expression of S100A4 mRNA
CTD
PMID:29705293
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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Sox9
SRY-box transcription factor 9
increases expression
ISO
Iohexol results in increased expression of SOX9 mRNA
CTD
PMID:29705293
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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Sqstm1
sequestosome 1
multiple interactions
EXP
Iohexol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein]
CTD
PMID:29860548
NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
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Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]]; Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]
CTD
PMID:26562095
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Thy1
Thy-1 cell surface antigen
decreases expression
ISO
Iohexol results in decreased expression of THY1 protein
CTD
PMID:29705293
NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
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Tnf
tumor necrosis factor
multiple interactions
EXP
Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]; Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]; Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]
CTD
PMID:26562095
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
increases expression
ISO
Iohexol results in increased expression of TP53 mRNA
CTD
PMID:29705293
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tubb3
tubulin, beta 3 class III
increases expression
ISO
Iohexol results in increased expression of TUBB3 mRNA
CTD
PMID:29705293
NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
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Usp18
ubiquitin specific peptidase 18
decreases expression
ISO
Iohexol results in decreased expression of USP18 mRNA
CTD
PMID:29705293
NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
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