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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iodixanol
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Accession:CHEBI:31705 term browser browse the term
Definition:A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.
Synonyms:exact_synonym: 5,5'-[(2-hydroxypropane-1,3-diyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide]
 related_synonym: 5,5'-((2-hydroxytrimethylene)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide);   Formula=C35H44I6N6O15;   InChI=1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62);   InChIKey=NBQNWMBBSKPBAY-UHFFFAOYSA-N;   SMILES=CC(=O)N(CC(O)CN(C(C)=O)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I;   iodixanolum
 xref: Beilstein:7245697;   CAS:92339-11-2;   DrugBank:DB01249;   Drug_Central:3302;   KEGG:D01474;   LINCS:LSM-4960
 xref_mesh: MESH:C044834
 xref: Wikipedia:Iodixanol


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iodixanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation ISO iodixanol results in increased phosphorylation of AKT1 protein CTD PMID:34774977 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP iodixanol results in increased expression of CCL2 protein CTD PMID:34774977 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression EXP iodixanol results in increased expression of CCL3 protein CTD PMID:34774977 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP iodixanol results in increased expression of CCL7 protein CTD PMID:34774977 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP iodixanol results in increased expression of CXCL10 protein CTD PMID:34774977 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Edn1 endothelin 1 increases expression ISO iodixanol results in increased expression of EDN1 protein CTD PMID:21354280 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in decreased expression of GCLM mRNA CTD PMID:29860548 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression ISO iodixanol results in increased expression of HAVCR1 mRNA CTD PMID:19104440 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405 		JBrowse link
G Hexb hexosaminidase B multiple interactions
increases secretion		 ISO trigonelline inhibits the reaction [iodixanol results in increased secretion of HEXB protein] CTD PMID:34774977 NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMGB1 protein CTD PMID:29860548 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO iodixanol results in increased expression of HMOX1 mRNA
[Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMOX1 mRNA		 CTD PMID:19104440 PMID:29860548 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases expression ISO iodixanol results in decreased expression of NOS2 protein CTD PMID:21354280 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions ISO [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PINK1 protein CTD PMID:29860548 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases phosphorylation		 ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [iodixanol results in increased phosphorylation of PLCG1 protein]; trigonelline inhibits the reaction [iodixanol results in increased phosphorylation of PLCG1 protein] CTD PMID:34774977 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PRKN protein CTD PMID:29860548 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO iodixanol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein] CTD PMID:29860548 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP iodixanol results in increased expression of VEGFA protein CTD PMID:34774977 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        pharmaceutical 21187
          diagnostic agent 773
            diagnostic imaging agent 569
              radioopaque medium 177
                iodixanol 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      p-block molecular entity 22104
                        carbon group molecular entity 21904
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organohalogen compound 19990
                                organoiodine compound 2415
                                  iodixanol 17
paths to the root