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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:iodixanol
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Accession:CHEBI:31705 term browser browse the term
Definition:A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.
Synonyms:exact_synonym: 5,5'-[(2-hydroxypropane-1,3-diyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide]
 related_synonym: 5,5'-((2-hydroxytrimethylene)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide);   Formula=C35H44I6N6O15;   InChI=1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62);   InChIKey=NBQNWMBBSKPBAY-UHFFFAOYSA-N;   SMILES=CC(=O)N(CC(O)CN(C(C)=O)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I;   iodixanolum
 xref: Beilstein:7245697;   CAS:92339-11-2;   DrugBank:DB01249;   Drug_Central:3302;   KEGG:D01474;   LINCS:LSM-4960
 xref_mesh: MESH:C044834
 xref: Wikipedia:Iodixanol



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iodixanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 increases expression EXP iodixanol results in increased expression of EDN1 protein CTD PMID:21354280 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in decreased expression of GCLM mRNA CTD PMID:29860548 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP iodixanol results in increased expression of HAVCR1 mRNA CTD PMID:19104440 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMGB1 protein CTD PMID:29860548 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP iodixanol results in increased expression of HMOX1 mRNA
[Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMOX1 mRNA
CTD PMID:19104440 PMID:29860548 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP iodixanol results in decreased expression of NOS2 protein CTD PMID:21354280 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PINK1 protein CTD PMID:29860548 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PRKN protein CTD PMID:29860548 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP iodixanol inhibits the reaction [[Drinking Water deficiency co-treated with Furosemide] results in increased expression of SQSTM1 protein] CTD PMID:29860548 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20026
      application 19773
        pharmaceutical 19647
          diagnostic agent 734
            diagnostic imaging agent 544
              radioopaque medium 171
                iodixanol 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19974
                    p-block element atom 19974
                      p-block molecular entity 19974
                        carbon group molecular entity 19903
                          organic molecular entity 19896
                            heteroorganic entity 19607
                              organohalogen compound 18336
                                organoiodine compound 1825
                                  iodixanol 9
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