|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
brazilin results in increased expression of BAX protein |
CTD |
PMID:28063998 |
|
NCBI chr 1:105,076,472...105,081,906
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
brazilin results in decreased expression of BCL2 protein |
CTD |
PMID:28063998 |
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Becn1 |
beclin 1 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [brazilin results in increased expression of BECN1 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein] brazilin results in increased expression of BECN1 mRNA; brazilin results in increased expression of BECN1 protein |
CTD |
PMID:28063998 |
|
NCBI chr10:86,731,649...86,747,002
|
|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
brazilin results in increased activity of CASP3 protein Acetylcysteine promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; BECN1 inhibits the reaction [brazilin results in increased activity of CASP3 protein] |
CTD |
PMID:28063998 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases expression |
ISO |
bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; BECN1 inhibits the reaction [brazilin results in increased expression of PARP1 protein modified form] |
CTD |
PMID:28063998 |
|
NCBI chr13:94,839,484...94,871,295
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 mRNA]; RELA protein promotes the reaction [brazilin results in increased expression of BECN1 protein] |
CTD |
PMID:28063998 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Sqstm1 |
sequestosome 1 |
decreases expression multiple interactions |
ISO |
brazilin results in decreased expression of SQSTM1 protein Acetylcysteine inhibits the reaction [brazilin results in decreased expression of SQSTM1 protein]; RELA protein promotes the reaction [brazilin results in decreased expression of SQSTM1 protein] |
CTD |
PMID:28063998 |
|
NCBI chr10:35,026,598...35,037,750
|
|