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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indolin-2-one
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Accession:CHEBI:31697 term browser browse the term
Definition:An indolinone carrying an oxo group at position 2.
Synonyms:related_synonym: 1,3-dihydro-(2H)-indol-2-One;   1,3-dihydroindol-2-one;   2-indolinone;   2-oxindole;   Formula=C8H7NO;   InChI=1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-4H,5H2,(H,9,10);   InChIKey=JYGFTBXVXVMTGB-UHFFFAOYSA-N;   SMILES=O=C1Cc2ccccc2N1;   oxindole
 xref: Beilstein:114692;   CAS:59-48-3;   Gmelin:637057;   KEGG:C12312
 xref_mesh: MESH:C022960
 xref: PMID:24433962;   PMID:24500796;   Reaxys:114692


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indolin-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 multiple interactions ISO 2-oxindole analog results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:10403840 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases activity
multiple interactions
ISO 2-oxindole results in decreased activity of CDK4 protein
2-oxindole analog results in decreased activity of [CCND1 protein binds to CDK4 protein]
CTD PMID:10403840, PMID:15724842 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 2-oxindole results in increased expression of HMOX1 protein CTD PMID:22245129 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO 2-oxindole results in decreased ubiquitination of and results in decreased degradation of NFE2L2 protein; 2-oxindole results in increased activity of and results in increased expression of and results in increased stability of NFE2L2 protein CTD PMID:22245129 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 2-oxindole results in increased expression of NQO1 mRNA CTD PMID:22245129 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          nitrogen atom 18539
            nitrogen molecular entity 18539
              amide 17387
                cyclic amide 8026
                  lactam 8026
                    gamma-lactam 6265
                      indolin-2-one 5
                        3-hydroxy-3-(thiazol-2-yl)indolin-2-one 0
                        oxindolyl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                lactam 8026
                                                  gamma-lactam 6265
                                                    indolin-2-one 5
                                                      3-hydroxy-3-(thiazol-2-yl)indolin-2-one 0
                                                      oxindolyl group + 0
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