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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indigo carmine
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Accession:CHEBI:31695 term browser browse the term
Definition:An organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. It is an indicator at pH 11.5-14, changing from blue to yellow.
Synonyms:exact_synonym: disodium (2E)-3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)-2,3-dihydro-1H-indole-5-sulfonate
 related_synonym: Acid blue 74;   C.I. 73015;   C.I. 75781;   C.I. Acid Blue 74;   C.I. Food Blue 1;   C.I. Food Blue 1, disodium salt;   C.I. Natural Blue 2;   Disodium 3,3'-dioxo-(delta2,2'-biindoline)-5,5'-disulfonate;   Disodium 5,5'-disulfoindigo;   Disodium 5,5'-indigotin disulfonate;   Disodium indigo-5,5-disulfonate;   E 132;   FD and C Blue No. 2;   FD&C Blue No. 2;   Formula=C16H8N2Na2O8S2;   Formula=C16H8N2O8S2.2Na;   InChI=1S/C16H10N2O8S2.2Na/c19-15-9-5-7(27(21,22)23)1-3-11(9)17-13(15)14-16(20)10-6-8(28(24,25)26)2-4-12(10)18-14;;/h1-6,17-18H,(H,21,22,23)(H,24,25,26);;/q;2*+1/p-2/b14-13+;;;   InChIKey=KHLVKKOJDHCJMG-QDBORUFSSA-L;   Indigocarmine;   Indigotin-5,5'-disulfonic acid disodium salt;   Indigotindisulfonate sodium;   Natural blue 2;   SMILES=C=1(C=CC2=C(C1)C(\\C(=C\\3/NC=4C=CC(=CC4C3=O)S([O-])(=O)=O)\\N2)=O)S([O-])(=O)=O.[Na+].[Na+];   Sodium 5,5'-indigotindisulfonate;   Sodium indigo-5,5'-bisulfonate
 xref: CAS:860-22-0;   HMDB:HMDB0059912;   KEGG:D01563
 xref_mesh: MESH:D007203
 xref: PMID:24865501;   PMID:24922336;   PMID:25305623;   PMID:25361489;   PMID:25650249;   PMID:25849647;   PMID:25887729;   PMID:26058926;   PMID:26076807;   PMID:26216072;   PMID:26404013;   Reaxys:905434;   Wikipedia:Indigo_carmine


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indigo carmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding		 ISO Indigo Carmine binds to and results in increased activity of AHR protein
Indigo Carmine binds to AHR protein		 CTD PMID:11425848 PMID:15001395 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP [ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of CHRNA4 protein CTD PMID:23429044 NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP [ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of CHRNB2 protein CTD PMID:23429044 NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions		 ISO
EXP		 Indigo Carmine results in increased activity of CYP1A1 protein
Indigo Carmine results in increased expression of CYP1A1 mRNA
Indigo Carmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:15001395 PMID:15882963 PMID:18493746 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP [ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in decreased expression of GRIN2A protein; [ponceau 4R co-treated with Allura Red AC Dye co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Tartrazine co-treated with Amaranth Dye co-treated with brilliant blue co-treated with Indigo Carmine] results in increased expression of GRIN2A protein CTD PMID:23429044 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        dye 3006
          histological dye 259
            indigo carmine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      chalcogen 19580
                        oxygen atom 19551
                          oxygen molecular entity 19551
                            oxide 12885
                              oxoanion 10472
                                chalcogen oxoanion 695
                                  sulfur oxoanion 693
                                    sulfonate 112
                                      organosulfonate oxoanion 112
                                        indigo carmine(2-) 5
                                          indigo carmine 5
paths to the root