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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:idebenone
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Accession:CHEBI:31687 term browser browse the term
Definition:A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.
Synonyms:related_synonym: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione;   6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone;   6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinone;   BRN 2001459;   CV 2619;   Formula=C19H30O5;   InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3;   InChIKey=JGPMMRGNQUBGND-UHFFFAOYSA-N;   SMILES=COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O;   idebenona;   idebenonum
 xref: CAS:58186-27-9;   Drug_Central:1416;   KEGG:D01750;   LINCS:LSM-5505
 xref_mesh: MESH:C036619
 xref: PMID:11207459;   PMID:15374364;   PMID:18045357;   PMID:18710357;   PMID:19283347;   PMID:19283350;   PMID:20955109;   PMID:22269948;   PMID:23859348;   PMID:2669658;   PMID:7981485;   PMID:7988944;   Patent:DE2519730;   Patent:US4271083;   Reaxys:2001459;   Wikipedia:Idebenone


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idebenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn2 cellular communication network factor 2 multiple interactions EXP idebenone inhibits the reaction [Streptozocin results in increased expression of CCN2 protein] CTD PMID:28648635 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP idebenone inhibits the reaction [Streptozocin results in increased expression of MMP9 protein]
idebenone results in decreased expression of MMP9 protein
CTD PMID:28648635 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
EXP idebenone inhibits the reaction [Streptozocin results in increased expression of PPARA protein]
idebenone results in decreased expression of PPARA protein
CTD PMID:28648635 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO idebenone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      chemical role 19339
        antioxidant 14254
          idebenone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      ketone 16216
                                        cyclic ketone 13930
                                          quinone 8386
                                            benzoquinones 722
                                              1,4-benzoquinones 718
                                                idebenone 4
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