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Accession:CHEBI:31687 term browser browse the term
Definition:A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.
Synonyms:related_synonym: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione;   6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone;   6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinone;   BRN 2001459;   CV 2619;   Formula=C19H30O5;   InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3;   InChIKey=JGPMMRGNQUBGND-UHFFFAOYSA-N;   SMILES=COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O;   idebenona;   idebenonum
 xref: CAS:58186-27-9 "ChemIDplus";   Drug_Central:1416 "DrugCentral";   KEGG:D01750;   LINCS:LSM-5505
 xref_mesh: MESH:C036619
 xref: PMID:11207459 "Europe PMC";   PMID:15374364 "Europe PMC";   PMID:18045357 "Europe PMC";   PMID:18710357 "Europe PMC";   PMID:19283347 "Europe PMC";   PMID:19283350 "Europe PMC";   PMID:20955109 "Europe PMC";   PMID:22269948 "Europe PMC";   PMID:23859348 "Europe PMC";   PMID:2669658 "Europe PMC";   PMID:7981485 "Europe PMC";   PMID:7988944 "Europe PMC";   Patent:DE2519730;   Patent:US4271083;   Reaxys:2001459 "Reaxys";   Wikipedia:Idebenone

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idebenone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      chemical role 19218
        antioxidant 14147
          idebenone 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      carbon group element atom 19528
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18422
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18303
                                    carbonyl compound 18303
                                      ketone 15927
                                        cyclic ketone 13368
                                          quinone 8237
                                            benzoquinones 590
                                              1,4-benzoquinones 586
                                                idebenone 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.