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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:idebenone
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Accession:CHEBI:31687 term browser browse the term
Definition:A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.
Synonyms:related_synonym: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione;   6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone;   6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinone;   CV-2619;   Formula=C19H30O5;   InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3;   InChIKey=JGPMMRGNQUBGND-UHFFFAOYSA-N;   Raxone;   SMILES=COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O;   idebenona;   idebenonum
 xref: CAS:58186-27-9;   Chemspider:3558;   DrugBank:DB09081;   Drug_Central:1416;   KEGG:D01750;   LINCS:LSM-5505
 xref_mesh: MESH:C036619
 xref: PMID:11207459;   PMID:15374364;   PMID:18045357;   PMID:18710357;   PMID:19283347;   PMID:19283350;   PMID:20955109;   PMID:22269948;   PMID:23859348;   PMID:2669658;   PMID:30726629;   PMID:32111141;   PMID:33247801;   PMID:33254077;   PMID:33628024;   PMID:7981485;   PMID:7988944;   Patent:DE2519730;   Patent:US4271083;   Reaxys:2001459;   Wikipedia:Idebenone



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idebenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn2 cellular communication network factor 2 multiple interactions EXP idebenone inhibits the reaction [Streptozocin results in increased expression of CCN2 protein] CTD PMID:28648635 PMID:34175429 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP idebenone inhibits the reaction [Streptozocin results in increased expression of MMP9 protein]
idebenone results in decreased expression of MMP9 protein
CTD PMID:28648635 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP idebenone inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA] CTD PMID:31969611 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
EXP idebenone inhibits the reaction [Streptozocin results in increased expression of PPARA protein]
idebenone results in decreased expression of PPARA protein
CTD PMID:28648635 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO idebenone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP idebenone inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] CTD PMID:34175429 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    role 19990
      chemical role 19519
        antioxidant 14503
          idebenone 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    p-block element atom 19938
                      carbon group element atom 19861
                        carbon atom 19852
                          organic molecular entity 19852
                            organic group 18932
                              organic divalent group 18916
                                organodiyl group 18916
                                  carbonyl group 18865
                                    carbonyl compound 18865
                                      ketone 17087
                                        cyclic ketone 15642
                                          quinone 8483
                                            benzoquinones 740
                                              1,4-benzoquinones 736
                                                idebenone 6
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