CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hydrocortisone succinate
Accession: CHEBI:31677
browse the term
Definition: A derivative of succinic acid in which one of the carboxy groups is esterified by the C-21 hydroxy group of cortisol (hydrocortisone).
Synonyms: related_synonym: 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(hydrogensuccinate); 11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione 21-succinate; Cortisol succinate; Formula=C25H34O8; InChI=1S/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22+,23-,24-,25-/m0/s1; InChIKey=VWQWXZAWFPZJDA-CGVGKPPMSA-N; SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)COC(=O)CCC(O)=O
alt_id: CHEBI:199284
xref: Drug_Central:4456; KEGG:C12888; KEGG:D01442; LINCS:LSM-5816; LIPID_MAPS_instance:LMST02030126
xref_mesh: MESH:C007133
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
[hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2
CTD
PMID:18347083
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
G
Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
multiple interactions
ISO
[hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4
CTD
PMID:18347083
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
G
F2
coagulation factor II
affects expression
ISO
hydrocortisone hemisuccinate affects the expression of F2 protein
CTD
PMID:12542493
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
G
Il18
interleukin 18
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of IL18 protein
CTD
PMID:20421217
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
G
Il1b
interleukin 1 beta
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of IL1B protein
CTD
PMID:20421217
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il6
interleukin 6
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of IL6 protein
CTD
PMID:20421217
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Tnf
tumor necrosis factor
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of TNF protein
CTD
PMID:20421217
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all