Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexestrol
go back to main search page
Accession:CHEBI:31669 term browser browse the term
Definition:A stilbenoid that has formula C18H22O2.
Synonyms:related_synonym: Exestrol;   Formula=C18H22O2;   InChI=1S/C18H22O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,17-20H,3-4H2,1-2H3;   InChIKey=PBBGSZCBWVPOOL-UHFFFAOYSA-N;   SMILES=C=1C=C(C=CC1O)C(CC)C(CC)C2=CC=C(C=C2)O;   cycloestrol;   dihydrodiethylstilbestrol;   erythrohexestrol;   hexanoestrol;   hexestrofen;   hexoestrol;   hormoestrol;   mesohexestrol
 xref: CAS:5635-50-7;   Drug_Central:1368;   KEGG:C13101;   KEGG:D01641;   LINCS:LSM-4300
 xref_mesh: MESH:D006589


show annotations for term's descendants           Sort by:
 
hexestrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression ISO Hexestrol results in increased expression of ABHD2 mRNA CTD PMID:26865669 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Afp alpha-fetoprotein affects binding EXP Hexestrol binds to AFP protein CTD PMID:23013281 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 decreases activity EXP Hexestrol results in decreased activity of AKR1B8 protein CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Hexestrol results in decreased activity of AKR1C4 protein CTD PMID:12604236 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Hexestrol results in decreased activity of AKR1C2 protein CTD PMID:8573067 PMID:12604236 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Hexestrol results in decreased activity of AKR1C3 protein CTD PMID:12604236 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Alad aminolevulinate dehydratase decreases expression ISO Hexestrol results in decreased expression of ALAD mRNA CTD PMID:26865669 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Ar androgen receptor multiple interactions ISO Hexestrol inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] CTD PMID:29162470 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin increases expression ISO Hexestrol results in increased expression of AREG mRNA CTD PMID:26865669 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Ca12 carbonic anhydrase 12 increases expression ISO Hexestrol results in increased expression of CA12 mRNA CTD PMID:26865669 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Hexestrol results in increased expression of CCND1 mRNA CTD PMID:26865669 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 decreases expression ISO Hexestrol results in decreased expression of CCNG2 mRNA CTD PMID:26865669 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Hexestrol results in increased expression of CD44 mRNA CTD PMID:26865669 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Clmn calmin decreases expression ISO Hexestrol results in decreased expression of CLMN mRNA CTD PMID:26865669 NCBI chr 6:128,473,592...128,567,267
Ensembl chr 6:128,473,570...128,567,198
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO Hexestrol results in increased expression of CXCL12 mRNA CTD PMID:26865669 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases expression ISO Hexestrol results in decreased expression of DYRK2 mRNA CTD PMID:26865669 NCBI chr 7:61,785,423...61,816,775
Ensembl chr 7:61,786,309...61,798,729
JBrowse link
G Egr3 early growth response 3 increases expression ISO Hexestrol results in increased expression of EGR3 mRNA CTD PMID:26865669 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Epha4 Eph receptor A4 decreases expression ISO Hexestrol results in decreased expression of EPHA4 mRNA CTD PMID:26865669 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
ISO Hexestrol binds to ESR1 protein
Hexestrol binds to and affects the activity of ESR1 protein; Hexestrol binds to and results in increased activity of ESR1 protein; Hexestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Hexestrol promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Hexestrol promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Hexestrol promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]
CTD PMID:9048584 PMID:18976723 PMID:19233257 PMID:20074635 PMID:20362049 PMID:20435135 PMID:23383871 PMID:26865669 PMID:29162470 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP Hexestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein] CTD PMID:9048584 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F7 coagulation factor VII decreases expression EXP Hexestrol results in decreased expression of F7 protein CTD PMID:2821645 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G Fhl2 four and a half LIM domains 2 increases expression ISO Hexestrol results in increased expression of FHL2 mRNA CTD PMID:26865669 NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093
JBrowse link
G Foxc1 forkhead box C1 increases expression ISO Hexestrol results in increased expression of FOXC1 mRNA CTD PMID:26865669 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Hexestrol results in decreased expression of ID3 mRNA CTD PMID:26865669 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Jak2 Janus kinase 2 increases expression ISO Hexestrol results in increased expression of JAK2 mRNA CTD PMID:26865669 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Kynu kynureninase decreases expression ISO Hexestrol results in decreased expression of KYNU mRNA CTD PMID:26865669 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO Hexestrol results in increased expression of MYB mRNA CTD PMID:26865669 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression ISO Hexestrol results in increased expression of MYBL1 mRNA CTD PMID:26865669 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Hexestrol promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form] CTD PMID:23383871 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 increases expression ISO Hexestrol results in increased expression of NMRK1 mRNA CTD PMID:26865669 NCBI chr 1:234,721,992...234,749,452
Ensembl chr 1:234,721,974...234,749,447
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Hexestrol binds to and results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity
ISO Hexestrol binds to and results in increased activity of NR1I3 protein alternative form
Hexestrol results in increased activity of NR1I3 protein
CTD PMID:20869355 PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO Hexestrol promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form] CTD PMID:23383871 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Olfm1 olfactomedin 1 increases expression ISO Hexestrol results in increased expression of OLFM1 mRNA CTD PMID:26865669 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO Hexestrol results in increased expression of PDZK1 mRNA CTD PMID:26865669 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323
JBrowse link
G Pgr progesterone receptor increases expression ISO Hexestrol results in increased expression of PGR mRNA CTD PMID:26865669 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 decreases expression ISO Hexestrol results in decreased expression of PIK3R3 mRNA CTD PMID:26865669 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO Hexestrol results in increased expression of PLAUR mRNA CTD PMID:26865669 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Plekhf2 pleckstrin homology and FYVE domain containing 2 decreases expression ISO Hexestrol results in decreased expression of PLEKHF2 mRNA CTD PMID:26865669 NCBI chr 5:24,240,241...24,255,922
Ensembl chr 5:24,240,242...24,255,606
JBrowse link
G Prss23 serine protease 23 increases expression ISO Hexestrol results in increased expression of PRSS23 mRNA CTD PMID:26865669 NCBI chr 1:153,732,528...153,742,111
Ensembl chr 1:153,732,532...153,752,541
JBrowse link
G Ptges prostaglandin E synthase increases expression ISO Hexestrol results in increased expression of PTGES mRNA CTD PMID:26865669 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Rapgefl1 Rap guanine nucleotide exchange factor like 1 increases expression ISO Hexestrol results in increased expression of RAPGEFL1 mRNA CTD PMID:26865669 NCBI chr10:86,749,220...86,765,677
Ensembl chr10:86,763,117...86,765,675
JBrowse link
G Rbbp8 RB binding protein 8, endonuclease increases expression ISO Hexestrol results in increased expression of RBBP8 mRNA CTD PMID:26865669 NCBI chr18:3,134,630...3,227,702
Ensembl chr18:3,162,543...3,227,688
JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 increases expression ISO Hexestrol results in increased expression of RCL1 mRNA CTD PMID:26865669 NCBI chr 1:247,228,012...247,272,369
Ensembl chr 1:247,228,061...247,305,693
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Hexestrol results in increased expression of SGK1 mRNA CTD PMID:26865669 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 increases expression ISO Hexestrol results in increased expression of SGK3 mRNA CTD PMID:26865669 NCBI chr 5:9,046,889...9,094,740
Ensembl chr 5:9,048,614...9,094,616
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 increases expression ISO Hexestrol results in increased expression of SIAH2 mRNA CTD PMID:26865669 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900
JBrowse link
G Smox spermine oxidase increases expression ISO Hexestrol results in increased expression of SMOX mRNA CTD PMID:26865669 NCBI chr 3:124,068,796...124,103,726
Ensembl chr 3:124,068,865...124,102,240
JBrowse link
G Ssbp2 single-stranded DNA binding protein 2 decreases expression ISO Hexestrol results in decreased expression of SSBP2 mRNA CTD PMID:26865669 NCBI chr 2:20,416,795...20,707,838
Ensembl chr 2:20,431,243...20,702,515
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Hexestrol results in decreased activity of SULT1E1 protein CTD PMID:16914110 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Svil supervillin increases expression ISO Hexestrol results in increased expression of SVIL mRNA CTD PMID:26865669 NCBI chr17:55,230,298...55,425,967
Ensembl chr17:55,230,298...55,346,279
JBrowse link
G Tfap2a transcription factor AP-2 alpha decreases expression ISO Hexestrol results in decreased expression of TFAP2A mRNA CTD PMID:26865669 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tfap2c transcription factor AP-2 gamma increases expression ISO Hexestrol results in increased expression of TFAP2C mRNA CTD PMID:26865669 NCBI chr 3:170,550,314...170,558,197
Ensembl chr 3:170,550,314...170,558,194
JBrowse link
G Tfpi tissue factor pathway inhibitor decreases expression ISO Hexestrol results in decreased expression of TFPI mRNA CTD PMID:26865669 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Wwc1 WW and C2 domain containing 1 increases expression ISO Hexestrol results in increased expression of WWC1 mRNA CTD PMID:26865669 NCBI chr10:20,662,996...20,818,500
Ensembl chr10:20,663,541...20,818,128
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      atom 19881
        nonmetal atom 19760
          carbon atom 19668
            organic molecular entity 19668
              olefinic compound 14849
                stilbenoid 5643
                  hexestrol 55
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                organic aromatic compound 19233
                                  stilbenoid 5643
                                    hexestrol 55
paths to the root