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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Gimeracil
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Accession:CHEBI:31652 term browser browse the term
Synonyms:related_synonym: 5-Chloro-2,4-dihydroxypyridine;   5-Chloro-4-hydroxy-2-pyridone;   Formula=C5H4ClNO2;   InChI=1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9);   InChIKey=ZPLQIPFOCGIIHV-UHFFFAOYSA-N;   SMILES=OC=1C(Cl)=CNC(C1)=O;   Ts-1 (TN);   gimestat
 xref: CAS:103766-25-2;   Drug_Central:1293;   KEGG:D01846
 xref_mesh: MESH:C104201


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Gimeracil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (Indian blood group) multiple interactions EXP [gimeracil co-treated with Fluorouracil] results in decreased expression of CD44 CTD PMID:12364819 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions
decreases activity
ISO DPYD results in increased susceptibility to [Fluorouracil co-treated with gimeracil]; gimeracil affects the reaction [DPYD protein results in increased susceptibility to Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in decreased susceptibility to Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in increased degradation of Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in increased metabolism of Fluorouracil]
gimeracil results in decreased activity of DPYD protein
CTD PMID:12044515 PMID:15949589 PMID:15993511 PMID:17699726 PMID:19093184 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          carbon atom 19588
            organic molecular entity 19588
              Gimeracil 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            Gimeracil 2
paths to the root