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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Gimeracil
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Accession:CHEBI:31652 term browser browse the term
Synonyms:related_synonym: 5-Chloro-2,4-dihydroxypyridine;   5-Chloro-4-hydroxy-2-pyridone;   Formula=C5H4ClNO2;   InChI=1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9);   InChIKey=ZPLQIPFOCGIIHV-UHFFFAOYSA-N;   SMILES=OC=1C(Cl)=CNC(C1)=O;   Ts-1 (TN);   gimestat
 xref: CAS:103766-25-2;   Drug_Central:1293;   KEGG:D01846
 xref_mesh: MESH:C104201



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Gimeracil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (Indian blood group) multiple interactions EXP [gimeracil co-treated with Fluorouracil] results in decreased expression of CD44 CTD PMID:12364819 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions
decreases activity
ISO DPYD results in increased susceptibility to [Fluorouracil co-treated with gimeracil]; gimeracil affects the reaction [DPYD protein results in increased susceptibility to Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in decreased susceptibility to Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in increased degradation of Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in increased metabolism of Fluorouracil]
gimeracil results in decreased activity of DPYD protein
CTD PMID:12044515 PMID:15949589 PMID:15993511 PMID:17699726 PMID:19093184 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      atom 20058
        nonmetal atom 19979
          carbon atom 19909
            organic molecular entity 19909
              Gimeracil 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            Gimeracil 2
paths to the root