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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:teprenone
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Accession:CHEBI:31649 term browser browse the term
Definition:A terpene ketone in which a (9E,13E)-geranylgernayl group is bonded to one of the alpha-methyls of acetone (it is a mixture of 5E- and 5Z-geoisomers in a 3:2 ratio).
Synonyms:exact_synonym: (9E,13E)-6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one
 related_synonym: Formula=C23H38O;   Geranylgeranylacetone;   InChI=1S/C23H38O/c1-19(2)11-7-12-20(3)13-8-14-21(4)15-9-16-22(5)17-10-18-23(6)24/h11,13,15,17H,7-10,12,14,16,18H2,1-6H3/b20-13+,21-15+,22-17?;   InChIKey=HUCXKZBETONXFO-AJDZVAQLSA-N;   SMILES=CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CCC(C)=CCCC(C)=O;   Selbex;   teprenona;   teprenonum
 xref: CAS:6809-52-5;   Drug_Central:2596;   KEGG:C13297;   KEGG:D01827
 xref_mesh: MESH:C031049
 xref: PMID:21645219;   PMID:22004457;   PMID:22548767;   PMID:23229517;   PMID:23289389;   PMID:23684147;   PMID:23792203;   PMID:23942364;   PMID:24008351;   PMID:24098472;   PMID:24531083;   PMID:24573719;   PMID:24582814;   PMID:24631258;   PMID:24633659;   PMID:24695789;   PMID:24737026;   Reaxys:8717724


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teprenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlg1 discs large MAGUK scaffold protein 1 increases expression
multiple interactions
ISO geranylgeranylacetone results in increased expression of DLG1 mRNA; geranylgeranylacetone results in increased expression of DLG1 protein
geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]; Niacinamide inhibits the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]; resveratrol promotes the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]
CTD PMID:21232033 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Edn1 endothelin 1 decreases expression EXP geranylgeranylacetone results in decreased expression of EDN1 protein CTD PMID:16324314 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
increases expression
affects response to substance
ISO geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]
geranylgeranylacetone results in increased expression of HSF1 protein
HSF1 protein affects the susceptibility to geranylgeranylacetone
CTD PMID:17189318 PMID:21232033 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO geranylgeranylacetone promotes the reaction [Ethanol results in increased expression of HSPA1A protein] CTD PMID:17189318 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA; [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein CTD PMID:15340226 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 increases expression ISO geranylgeranylacetone results in increased expression of KCNA5 protein CTD PMID:21232033 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link

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Path 1
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  CHEBI ontology 19817
    role 19767
      biological role 19767
        biochemical role 19315
          Hsp70 inducer 9
            teprenone 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    main group molecular entity 19705
                      s-block molecular entity 19458
                        hydrogen molecular entity 19451
                          hydrides 18730
                            organic hydride 18292
                              organic fundamental parent 18292
                                hydrocarbon 18024
                                  hydrocarbyl group 4618
                                    prenyl groups 6
                                      polyprenyl group 6
                                        geranylgeranyl group 6
                                          teprenone 6
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