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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gadodiamide hydrate
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Accession:CHEBI:31642 term browser browse the term
Definition:The hydrate of gadodiamide.
Synonyms:exact_synonym: [N,N-bis(2-{[(carboxy-kappaO)methyl][2-(methylamino)-2-(oxo-kappaO)ethyl]amino-kappaN}ethyl)glycinato(3-)-kappa(2)N,O]gadolinium--water (1/1)
 related_synonym: Formula=C16H28GdN5O9;   Gadodiamide;   InChI=1S/C16H29N5O8.Gd.H2O/c1-17-12(22)7-20(10-15(26)27)5-3-19(9-14(24)25)4-6-21(11-16(28)29)8-13(23)18-2;;/h3-11H2,1-2H3,(H,17,22)(H,18,23)(H,24,25)(H,26,27)(H,28,29);;1H2/q;+3;/p-3;   InChIKey=XPCLDSMKWNNKOM-UHFFFAOYSA-K;   Omniscan;   SMILES=[H]O[H].CNC1=[O][Gd+3]234567[O-]C(=O)C[N]2(CC[N]3(CC(=O)[O-]4)C1)CC[N]5(CC(=O)[O-]6)CC(NC)=[O]7;   gadodiamida;   gadodiamidum;   gadolinium 5,8-bis(carboxylatomethyl)-11-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,8,11-tetraazatridecan-13-oate hydrate;   gadolinium [bis(2-{(carboxylatomethyl)[2-(methylamino)-2-oxoethyl]amino}ethyl)amino]acetate--water (1/1)
 xref: CAS:122795-43-1;   DrugBank:DB00225;   Gmelin:898533;   KEGG:C13106;   KEGG:D01645
 xref_mesh: MESH:C064925


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gadodiamide hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO gadodiamide results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]
CTD PMID:19561517 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO gadodiamide results in increased expression of ALDH1A1 mRNA CTD PMID:20959327 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Ankrd22 ankyrin repeat domain 22 increases expression ISO gadodiamide results in increased expression of ANKRD22 mRNA CTD PMID:20959327 NCBI chr 1:252,430,750...252,461,346
Ensembl chr 1:252,429,677...252,461,461
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO gadodiamide results in increased expression of ATM mRNA CTD PMID:20959327 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 increases expression ISO gadodiamide results in increased expression of ATP8B1 mRNA CTD PMID:20959327 NCBI chr18:60,013,388...60,152,920
Ensembl chr18:60,013,382...60,095,354
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
increases secretion
ISO
EXP
gadodiamide results in increased expression of CCL2 mRNA
gadodiamide results in increased expression of CCL2 mRNA; gadodiamide results in increased expression of CCL2 protein
gadodiamide results in increased secretion of CCL2 protein
CTD PMID:20938346 PMID:20959327 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression EXP gadodiamide results in increased expression of CCL4 protein CTD PMID:20938346 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP gadodiamide results in increased expression of CCL7 protein CTD PMID:20938346 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
increases secretion
ISO
EXP
gadodiamide results in increased expression of CXCL10 mRNA
gadodiamide results in increased expression of CXCL10 protein
gadodiamide results in increased secretion of CXCL10 protein
CTD PMID:20938346 PMID:20959327 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases secretion
increases expression
ISO gadodiamide results in increased secretion of CXCL11 protein
gadodiamide results in increased expression of CXCL11 mRNA
CTD PMID:20959327 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO gadodiamide results in increased expression of CXCL12 mRNA CTD PMID:20959327 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO gadodiamide results in increased expression of CXCL9 mRNA CTD PMID:20959327 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression ISO gadodiamide results in increased expression of IDO1 mRNA CTD PMID:20959327 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO gadodiamide results in increased expression of IFI44L mRNA CTD PMID:20959327 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression ISO gadodiamide results in increased expression of IFIT3 mRNA CTD PMID:20959327 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Ifng interferon gamma increases expression ISO gadodiamide results in increased expression of IFNG mRNA; gadodiamide results in increased expression of IFNG protein CTD PMID:19404939 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il13 interleukin 13 increases expression ISO gadodiamide results in increased expression of IL13 mRNA; gadodiamide results in increased expression of IL13 protein CTD PMID:19404939 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP gadodiamide results in increased expression of IL1A protein CTD PMID:20938346 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il4 interleukin 4 increases expression
affects expression
ISO gadodiamide results in increased expression of IL4 protein
gadodiamide affects the expression of IL4 mRNA
CTD PMID:19404939 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4i1 interleukin 4 induced 1 increases expression ISO gadodiamide results in increased expression of IL4I1 mRNA CTD PMID:20959327 NCBI chr 1:100,811,727...100,836,901
Ensembl chr 1:100,830,064...100,836,677
JBrowse link
G Il6 interleukin 6 affects expression
increases expression
ISO gadodiamide affects the expression of IL6 protein
gadodiamide results in increased expression of IL6 mRNA
CTD PMID:19404939 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kitlg KIT ligand increases expression EXP gadodiamide results in increased expression of KITLG protein CTD PMID:20938346 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein] CTD PMID:19561517 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein] CTD PMID:19561517 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]
gadodiamide results in increased expression of MMP1 mRNA; gadodiamide results in increased expression of MMP1 protein
CTD PMID:19561517 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO gadodiamide results in increased expression of NOS2 protein CTD PMID:20959327 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nxpe3 neurexophilin and PC-esterase domain family, member 3 increases expression ISO gadodiamide results in increased expression of NXPE3 mRNA CTD PMID:20959327 NCBI chr11:47,188,332...47,238,372
Ensembl chr11:47,188,495...47,238,372
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases localization ISO gadodiamide results in increased localization of RELA protein CTD PMID:20959327 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RGD1306063 similar to HT021 increases expression ISO gadodiamide results in increased expression of C3ORF14 mRNA CTD PMID:20959327 NCBI chr15:12,869,217...12,889,144
Ensembl chr15:12,872,408...12,889,108
JBrowse link
G Rhoq ras homolog family member Q increases expression ISO gadodiamide results in increased expression of RHOQ mRNA CTD PMID:20959327 NCBI chr 6:10,533,151...10,568,582
Ensembl chr 6:10,533,151...10,568,581
JBrowse link
G Rit1 Ras-like without CAAX 1 increases expression ISO gadodiamide results in increased expression of RIT1 mRNA CTD PMID:20959327 NCBI chr 2:188,087,486...188,099,444
Ensembl chr 2:188,087,486...188,099,444
JBrowse link
G Rnf125 ring finger protein 125 increases expression ISO gadodiamide results in increased expression of RNF125 mRNA CTD PMID:20959327 NCBI chr18:15,193,226...15,225,454
Ensembl chr18:15,192,962...15,225,427
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 increases expression ISO gadodiamide results in increased expression of RSAD2 mRNA CTD PMID:20959327 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Slc39a10 solute carrier family 39 member 10 increases expression ISO gadodiamide results in increased expression of SLC39A10 mRNA CTD PMID:20959327 NCBI chr 9:59,947,562...60,070,549
Ensembl chr 9:60,021,534...60,070,552
JBrowse link
G Spn sialophorin increases expression ISO gadodiamide results in increased expression of SPN mRNA CTD PMID:20959327 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP gadodiamide results in increased expression of SPP1 protein CTD PMID:20938346 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO
EXP
gadodiamide results in increased expression of TGFB1 mRNA; gadodiamide results in increased expression of TGFB1 protein CTD PMID:19404939 PMID:20938346 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO
EXP
gadodiamide results in increased expression of TIMP1 mRNA; gadodiamide results in increased expression of TIMP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [gadodiamide results in increased expression of TIMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of TIMP1 protein]
CTD PMID:19561517 PMID:20938346 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Ubd ubiquitin D increases expression ISO gadodiamide results in increased expression of UBD mRNA CTD PMID:20959327 NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO
EXP
gadodiamide results in increased expression of VEGFA mRNA; gadodiamide results in increased expression of VEGFA protein CTD PMID:19404939 PMID:20938346 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wdr5 WD repeat domain 5 increases expression ISO gadodiamide results in increased expression of WDR5 mRNA CTD PMID:20959327 NCBI chr 3:6,061,892...6,080,724
Ensembl chr 3:6,061,940...6,080,680
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression ISO gadodiamide results in increased expression of XIAP mRNA CTD PMID:20959327 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Zfp652 zinc finger protein 652 increases expression ISO gadodiamide results in increased expression of ZNF652 mRNA CTD PMID:20959327 NCBI chr10:83,556,809...83,572,014
Ensembl chr10:83,556,809...83,572,019
JBrowse link

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  CHEBI ontology 19767
    role 19714
      chemical role 19255
        greenhouse gas 10966
          water 642
            hydrate 609
              gadodiamide hydrate 43
Path 2
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  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    main group molecular entity 19657
                      s-block molecular entity 19421
                        hydrogen molecular entity 19414
                          hydrides 18754
                            inorganic hydride 17459
                              chalcogen hydride 2453
                                oxygen hydride 650
                                  water 642
                                    hydrate 609
                                      gadodiamide hydrate 43
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