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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluorometholone
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Accession:CHEBI:31625 term browser browse the term
Definition:A member of the class of glucocorticoids that is Delta(1)-progesterone substituted at positions 11beta and 17 by hydroxy groups, at position 6alpha by a methyl group and at position 9 by a fluoro group. Used for the treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe.
Synonyms:exact_synonym: (6alpha,11beta)-9-fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
 related_synonym: 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione;   Fluor-op;   Fluorometholon;   Formula=C22H29FO4;   InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1;   InChIKey=FAOZLTXFLGPHNG-KNAQIMQKSA-N;   NSC 33001;   Oxylone;   SMILES=C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]2(C)C=CC(=O)C=C12;   fluorometholonum;   fluorometolona
 xref: CAS:426-13-1;   DrugBank:DB00324;   Drug_Central:1208;   HMDB:HMDB0014469;   KEGG:D01367
 xref_mesh: MESH:D005469
 xref: PMID:22821643;   PMID:23023407;   PMID:23225837;   PMID:23429038;   PMID:23865053;   PMID:24074291;   PMID:24227962;   PMID:24493163;   Reaxys:3172388;   Wikipedia:Fluorometholone



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fluorometholone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Fluorometholone inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein] CTD PMID:35264022 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Fluorometholone inhibits the reaction [Glucose results in increased activity of CASP3 protein] CTD PMID:35264022 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Fluorometholone inhibits the reaction [Glucose results in increased expression of CDKN1A protein] CTD PMID:35264022 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Fluorometholone inhibits the reaction [Glucose results in increased expression of F3 mRNA]; Fluorometholone inhibits the reaction [Glucose results in increased expression of F3 protein] CTD PMID:35264022 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fluorometholone inhibits the reaction [Glucose results in increased activity of GLB1 protein]]; Fluorometholone inhibits the reaction [Glucose results in increased activity of GLB1 protein] CTD PMID:35264022 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fluorometholone inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Fluorometholone inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:35264022 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Fluorometholone inhibits the reaction [Glucose results in increased expression of RB1 protein] CTD PMID:35264022 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Fluorometholone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO Fluorometholone inhibits the reaction [Glucose results in decreased activity of TERT protein] CTD PMID:35264022 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fluorometholone inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Fluorometholone inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:35264022 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fluorometholone inhibits the reaction [Glucose results in increased expression of TP53 protein]]; Fluorometholone inhibits the reaction [Glucose results in increased expression of TP53 protein] CTD PMID:35264022 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Fluorometholone inhibits the reaction [Glucose results in increased expression of VEGFA mRNA]; Fluorometholone inhibits the reaction [Glucose results in increased expression of VEGFA protein] CTD PMID:35264022 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        anti-inflammatory agent 16531
          anti-inflammatory drug 14962
            fluorometholone 12
              fluorometholone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      ketone 17210
                                        oxo steroid 10546
                                          3-oxo steroid 9937
                                            3-oxo-Delta(4) steroid 9176
                                              progesterone 2730
                                                Delta(1)-progesterone 252
                                                  fluorometholone 12
                                                    fluorometholone acetate 0
paths to the root