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ONTOLOGY REPORT - ANNOTATIONS


Term:fluorescein
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Accession:CHEBI:31624 term browser browse the term
Definition:A xanthene dye that is highly fluorescent, detectable even when present in minute quantities. Used forensically to detect traces of blood, in analytical chemistry as an indicator in silver nitrate titrations and in microscopy.
Synonyms:exact_synonym: 3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one
 related_synonym: 3',6'-dihydroxyfluoran;   3,6-fluorandiol;   9-(o-carboxyphenyl)-6-hydroxy-3-isoxanthenone;   9-(o-carboxyphenyl)-6-hydroxy-3H-xanthen-3-one;   C.I. 45350;   C.I. Solvent Yellow 94;   D and C Yellow No. 7;   D&C Yellow No. 7;   Fluoreszein;   Formula=C20H12O5;   InChI=1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H;   InChIKey=GNBHRKFJIUUOQI-UHFFFAOYSA-N;   Japan Yellow 201;   SMILES=OC1=CC=C2C3(OC(C4=C3C=CC=C4)=O)C=5C(OC2=C1)=CC(=CC5)O;   Solvent Yellow 94;   Yellow fluorescein;   fluoresceine;   resorcinolphthalein
 alt_id: CHEBI:606590
 xref: Beilstein:94324 "Beilstein";   CAS:2321-07-5 "ChemIDplus";   DrugBank:DB00693;   Gmelin:248626 "Gmelin";   HMDB:HMDB0014831;   KEGG:D01261
 xref_mesh: MESH:D019793
 xref: PDB:4FAB;   PMID:1517825 "Europe PMC";   PMID:15465055 "Europe PMC";   PMID:16195545 "Europe PMC";   PMID:20371259 "Europe PMC";   PMID:2508085 "Europe PMC";   PMID:26756394 "Europe PMC";   PMID:7868912 "Europe PMC";   Reaxys:94324 "Reaxys";   Wikipedia:Fluorescein


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fluorescein term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Slc22a6 solute carrier family 22 member 6 JBrowse link 1 224,824,809 224,833,284 RGD:6480464
G Slco1b2 solute carrier organic anion transporter family, member 1B2 JBrowse link 4 175,814,118 175,881,775 RGD:6480464
G Slco3a1 solute carrier organic anion transporter family, member 3a1 JBrowse link 1 135,790,854 136,073,640 RGD:6480464
2',7'-bis-(2-carboxyethyl)carboxyfluorescein term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Abcc5 ATP binding cassette subfamily C member 5 JBrowse link 11 84,395,982 84,490,215 RGD:6480464
5(6)-carboxy-2',7'-dichlorofluorescein term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
5-carboxyfluorescein term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
5-chloromethylfluorescein diacetate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
6-carboxyfluorescein term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Slc22a6 solute carrier family 22 member 6 JBrowse link 1 224,824,809 224,833,284 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
fluorescein 5-isothiocyanate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb7 ATP binding cassette subfamily B member 7 JBrowse link X 75,150,511 75,291,950 RGD:6480464
G Akr1c2 aldo-keto reductase family 1, member C2 JBrowse link 17 69,388,337 69,435,160 RGD:6480464
G Anxa4 annexin A4 JBrowse link 4 118,538,775 118,595,591 RGD:6480464
G Arhgap6 Rho GTPase activating protein 6 JBrowse link X 26,314,561 26,845,242 RGD:6480464
G Azi2 5-azacytidine induced 2 JBrowse link 8 126,411,030 126,435,581 RGD:6480464
G Capzb capping actin protein of muscle Z-line subunit beta JBrowse link 5 157,642,742 157,742,487 RGD:6480464
G Cd109 CD109 molecule JBrowse link 8 85,951,420 86,065,411 RGD:6480464
G Cd180 CD180 molecule JBrowse link 2 32,820,275 32,833,223 RGD:6480464
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:6480464
G Cd93 CD93 molecule JBrowse link 3 142,778,798 142,783,774 RGD:6480464
G Cdc20 cell division cycle 20 JBrowse link 5 137,260,728 137,264,931 RGD:6480464
G Copa coatomer protein complex subunit alpha JBrowse link 13 90,467,285 90,508,894 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Dcaf4 DDB1 and CUL4 associated factor 4 JBrowse link 6 107,001,763 107,027,466 RGD:6480464
G Dot1l DOT1 like histone lysine methyltransferase JBrowse link 7 11,786,105 11,824,742 RGD:6480464
G Elac1 elaC ribonuclease Z 1 JBrowse link 18 69,706,522 69,723,869 RGD:6480464
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 JBrowse link 10 108,095,131 108,099,483 RGD:6480464
G Flrt3 fibronectin leucine rich transmembrane protein 3 JBrowse link 3 134,684,446 134,696,586 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Hspa9 heat shock protein family A (Hsp70) member 9 JBrowse link 18 27,731,072 27,749,235 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6480464
G Ikzf4 IKAROS family zinc finger 4 JBrowse link 7 3,061,422 3,098,142 RGD:6480464
G Il17re interleukin 17 receptor E JBrowse link 4 145,413,157 145,426,608 RGD:6480464
G Il31ra interleukin 31 receptor A JBrowse link 2 44,333,347 44,408,005 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Lypd3 Ly6/Plaur domain containing 3 JBrowse link 1 81,499,856 81,504,306 RGD:6480464
G Maff MAF bZIP transcription factor F JBrowse link 7 120,580,743 120,592,095 RGD:6480464
G Map3k20 mitogen-activated protein kinase kinase kinase 20 JBrowse link 3 58,965,025 59,120,507 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mt2A metallothionein 2A JBrowse link 19 11,307,966 11,308,740 RGD:6480464
G Mybpc1 myosin binding protein C, slow type JBrowse link 7 29,086,159 29,171,909 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Plce1 phospholipase C, epsilon 1 JBrowse link 1 257,156,023 257,465,440 RGD:6480464
G Postn periostin JBrowse link 2 143,656,820 143,688,087 RGD:6480464
G Pprc1 PPARG related coactivator 1 JBrowse link 1 265,809,892 265,826,319 RGD:6480464
G Psd4 pleckstrin and Sec7 domain containing 4 JBrowse link 3 1,478,432 1,515,094 RGD:6480464
G Psmd14 proteasome 26S subunit, non-ATPase 14 JBrowse link 3 47,578,449 47,673,330 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:6480464
G Skor1 SKI family transcriptional corepressor 1 JBrowse link 8 68,029,930 68,040,504 RGD:6480464
G Slc38a10 solute carrier family 38, member 10 JBrowse link 10 109,284,054 109,333,907 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:6480464
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:6480464
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 JBrowse link 5 3,783,247 3,836,485 RGD:6480464
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:6480464
G Txn1 thioredoxin 1 JBrowse link 5 75,049,735 75,057,731 RGD:6480464
G Usp3 ubiquitin specific peptidase 3 JBrowse link 8 72,207,970 72,284,871 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        dye 1230
          xanthene dye 74
            fluorescein 66
              2',4',5',7'-tetrabromo-2,3,4,5-tetrachlorofluorescein 0
              2',7'-bis-(2-carboxyethyl)-5-carboxyfluorescein 0
              2',7'-bis-(2-carboxyethyl)-6-carboxyfluorescein 0
              2',7'-bis-(2-carboxyethyl)carboxyfluorescein + 2
              2,7-dibromo-4-hydroxymercurifluorescein 0
              3-O-methylfluorescein 6-phosphate 0
              5(6)-carboxy-2',7'-dichlorofluorescein 2
              5-CM-H2DCFDA + 0
              5-aminofluorescein 0
              5-carboxyfluorescein + 1
              5-carboxynaphthofluorescein 0
              5-chloromethylfluorescein diacetate 1
              6-CM-H2DCFDA + 0
              6-O-(carboxymethyl)fluorescein ethyl ester 0
              6-carboxy-2',4,4',5'7,7'-hexachlorofluorescein succinimidyl ester 0
              6-carboxy-2',4,7,7'-tetrachlorofluorescein succinimiyl ester 0
              6-carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein 0
              6-carboxyfluorescein + 4
              6-carboxyfluorescein succinimidyl ester 0
              6-carboxynaphthofluorescein 0
              7-glycidyloxy-9-(2-glycidyloxycarbonylphenyl)-2-xanthone 0
              bromoeosin 0
              calcium green 1 0
              calcium green 1(6-) + 0
              carboxynaphthofluorescein + 0
              eosin 5-isothiocyanate 0
              eosin b diphenol 0
              erythrosin 0
              fluorescein isothiocyanate + 55
              magnesium green 0
              magnesium green(5-) 0
              oregon green 488 0
              yakima yellow phosphoramidite 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic ester 13934
                                        lactone 5859
                                          gamma-lactone 1192
                                            fluorescein 66
                                              2',4',5',7'-tetrabromo-2,3,4,5-tetrachlorofluorescein 0
                                              2',7'-bis-(2-carboxyethyl)-5-carboxyfluorescein 0
                                              2',7'-bis-(2-carboxyethyl)-6-carboxyfluorescein 0
                                              2',7'-bis-(2-carboxyethyl)carboxyfluorescein + 2
                                              2,7-dibromo-4-hydroxymercurifluorescein 0
                                              3-O-methylfluorescein 6-phosphate 0
                                              5(6)-carboxy-2',7'-dichlorofluorescein 2
                                              5-CM-H2DCFDA + 0
                                              5-aminofluorescein 0
                                              5-carboxyfluorescein + 1
                                              5-carboxynaphthofluorescein 0
                                              5-chloromethylfluorescein diacetate 1
                                              6-CM-H2DCFDA + 0
                                              6-O-(carboxymethyl)fluorescein ethyl ester 0
                                              6-carboxy-2',4,4',5'7,7'-hexachlorofluorescein succinimidyl ester 0
                                              6-carboxy-2',4,7,7'-tetrachlorofluorescein succinimiyl ester 0
                                              6-carboxy-4',5'-dichloro-2',7'-dimethoxyfluorescein 0
                                              6-carboxyfluorescein + 4
                                              6-carboxyfluorescein succinimidyl ester 0
                                              6-carboxynaphthofluorescein 0
                                              7-glycidyloxy-9-(2-glycidyloxycarbonylphenyl)-2-xanthone 0
                                              bromoeosin 0
                                              calcium green 1 0
                                              calcium green 1(6-) + 0
                                              carboxynaphthofluorescein + 0
                                              eosin 5-isothiocyanate 0
                                              eosin b diphenol 0
                                              erythrosin 0
                                              fluorescein isothiocyanate + 55
                                              magnesium green 0
                                              magnesium green(5-) 0
                                              oregon green 488 0
                                              yakima yellow phosphoramidite 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.