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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluocinolone acetonide
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Accession:CHEBI:31623 term browser browse the term
Definition:A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders.
Synonyms:exact_synonym: (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
 related_synonym: 6alpha,9alpha-difluoro-16alpha-hydroxyprednisolone 16,17-acetonide;   6alpha-fluorotriamcinolone acetonide;   Coriphate;   Cortiplastol;   Derma-Smoothe/FS;   Dermalar;   Flucinar;   Flucort;   Fluocet;   Fluonid;   Fluotrex;   Fluovitif;   Flupollon;   Fluzon;   Formula=C24H30F2O6;   Iluvien;   InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1;   InChIKey=FEBLZLNTKCEFIT-VSXGLTOVSA-N;   Jellin;   Localyn;   Omniderm;   Percutina;   Prodermin;   Radiocin;   Retisert;   SMILES=CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO;   Sinalar;   Synalar;   Synamol;   Synandone;   Synandrone;   Synemol;   Synotic;   Synsac;   Tefunote;   acetonide de fluocinolone;   acetonido de fluocinolona;   fluocinolone 16,17-acetonide;   fluocinoloni acetonidum
 xref: CAS:67-73-2;   DrugBank:DB00591;   Drug_Central:1204;   HMDB:HMDB0014729;   KEGG:D01825
 xref_mesh: MESH:D005446
 xref: PMID:21238799;   PMID:21277557;   PMID:21459216;   PMID:23321234;   PMID:23323586;   Patent:US3014938;   Patent:US3126375;   Reaxys:1358396;   Wikipedia:Fluocinolone_acetonide



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fluocinolone acetonide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein] CTD PMID:3677084 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      application 19747
        anti-inflammatory agent 16333
          anti-inflammatory drug 14856
            fluocinolone acetonide 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      ketone 17090
                                        oxyketone 8732
                                          alpha-oxyketone 8732
                                            alpha-hydroxy ketone 8732
                                              primary alpha-hydroxy ketone 7594
                                                fluocinolone acetonide 2
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