CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: fluocinolone acetonide
Accession: CHEBI:31623
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Definition: A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders.
Synonyms: exact_synonym: (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
related_synonym: 6alpha,9alpha-difluoro-16alpha-hydroxyprednisolone 16,17-acetonide; 6alpha-fluorotriamcinolone acetonide; Coriphate; Cortiplastol; Derma-Smoothe/FS; Dermalar; Flucinar; Flucort; Fluocet; Fluonid; Fluotrex; Fluovitif; Flupollon; Fluzon; Formula=C24H30F2O6; Iluvien; InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1; InChIKey=FEBLZLNTKCEFIT-VSXGLTOVSA-N; Jellin; Localyn; Omniderm; Percutina; Prodermin; Radiocin; Retisert; SMILES=CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO; Sinalar; Synalar; Synamol; Synandone; Synandrone; Synemol; Synotic; Synsac; Tefunote; acetonide de fluocinolone; acetonido de fluocinolona; fluocinolone 16,17-acetonide; fluocinoloni acetonidum
xref: CAS:67-73-2; DrugBank:DB00591; Drug_Central:1204; HMDB:HMDB0014729; KEGG:D01825
xref_mesh: MESH:D005446
xref: PMID:21238799; PMID:21277557; PMID:21459216; PMID:23321234; PMID:23323586; Patent:US3014938; Patent:US3126375; Reaxys:1358396; Wikipedia:Fluocinolone_acetonide
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA]
CTD
PMID:8435107
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Xdh
xanthine dehydrogenase
multiple interactions
ISO
Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]
CTD
PMID:3677084
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all