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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluocinolone acetonide
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Accession:CHEBI:31623 term browser browse the term
Definition:A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders.
Synonyms:exact_synonym: (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
 related_synonym: 6alpha,9alpha-difluoro-16alpha-hydroxyprednisolone 16,17-acetonide;   6alpha-fluorotriamcinolone acetonide;   Coriphate;   Cortiplastol;   Derma-Smoothe/FS;   Dermalar;   Flucinar;   Flucort;   Fluocet;   Fluonid;   Fluotrex;   Fluovitif;   Flupollon;   Fluzon;   Formula=C24H30F2O6;   Iluvien;   InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1;   InChIKey=FEBLZLNTKCEFIT-VSXGLTOVSA-N;   Jellin;   Localyn;   Omniderm;   Percutina;   Prodermin;   Radiocin;   Retisert;   SMILES=CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO;   Sinalar;   Synalar;   Synamol;   Synandone;   Synandrone;   Synemol;   Synotic;   Synsac;   Tefunote;   acetonide de fluocinolone;   acetonido de fluocinolona;   fluocinolone 16,17-acetonide;   fluocinoloni acetonidum
 xref: CAS:67-73-2;   DrugBank:DB00591;   Drug_Central:1204;   HMDB:HMDB0014729;   KEGG:D01825
 xref_mesh: MESH:D005446
 xref: PMID:21238799;   PMID:21277557;   PMID:21459216;   PMID:23321234;   PMID:23323586;   Patent:US3014938;   Patent:US3126375;   Reaxys:1358396;   Wikipedia:Fluocinolone_acetonide


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fluocinolone acetonide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1a interleukin 1 alpha multiple interactions ISO Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO Fluocinolone Acetonide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein] CTD PMID:3677084 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        anti-inflammatory agent 15771
          anti-inflammatory drug 13626
            fluocinolone acetonide 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16829
                                        oxyketone 8661
                                          alpha-oxyketone 8661
                                            alpha-hydroxy ketone 8661
                                              primary alpha-hydroxy ketone 7539
                                                fluocinolone acetonide 2
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