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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flunitrazepam
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Accession:CHEBI:31622 term browser browse the term
Definition:A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Synonyms:exact_synonym: 5-(2-fluorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
 related_synonym: 1,3-dihydro-5-(o-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one;   1-methyl-7-nitro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one;   Fluninoc;   Flunipam;   Flunita;   Fluscand;   Formula=C16H12FN3O3;   Hipnosedon;   Hypnodorm;   Hypnor;   InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3;   InChIKey=PPTYJKAXVCCBDU-UHFFFAOYSA-N;   Narcozep;   Primum;   RO-5-4200;   RO-54200;   RO54200;   Rohypnol;   Roipnol;   SMILES=C=12C(C=3C=CC=CC3F)=NCC(N(C1C=CC(=C2)[N+](=O)[O-])C)=O;   Silece;   Valsera;   flunidazepam;   flunitrazepamum;   fluridrazepam
 xref: CAS:1622-62-4;   DrugBank:DB01544;   Drug_Central:1202;   HMDB:HMDB0015510;   KEGG:D01230
 xref_mesh: MESH:D005445
 xref: PMID:11393809;   PMID:17889;   PMID:18070;   PMID:19839;   PMID:23506;   PMID:23971077;   PMID:25467462;   PMID:25895512;   PMID:26990972;   PMID:27143233;   PMID:27747877;   PMID:27778423;   PMID:28403803;   PMID:29657737;   PMID:29713800;   PMID:30870640;   PMID:31233253;   PMID:31512527;   PMID:31679602;   PMID:862358;   Reaxys:0702691;   Wikipedia:Flunitrazepam



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flunitrazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Crp C-reactive protein multiple interactions ISO [bromperidol co-treated with Flunitrazepam] results in increased expression of CRP protein CTD PMID:15298663 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Flunitrazepam CTD PMID:10911933 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation
multiple interactions
ISO CYP3A4 protein results in increased hydroxylation of Flunitrazepam
CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP3 protein]; CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP7 protein]; CYP3A4 protein results in increased metabolism of and results in increased activity of Flunitrazepam; Flunitrazepam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CTD PMID:15383492 PMID:19005028 PMID:19299527 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Flunitrazepam CTD PMID:15383492 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
affects binding
ISO
EXP
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flunitrazepam binds to GABRA1 protein
alphaxalone promotes the reaction [Flunitrazepam binds to GABRA1 protein]; Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]
CTD PMID:8397295 PMID:8632757 PMID:22029276 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 affects binding
multiple interactions
EXP Flunitrazepam binds to GABRA2 protein
alphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein]; Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]
CTD PMID:8397295 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:8632757 PMID:22029276 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:8632757 PMID:22029276 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Sstr3 somatostatin receptor 3 affects expression EXP Flunitrazepam affects the expression of SSTR3 mRNA CTD PMID:16162846 NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO Flunitrazepam results in decreased activity of UGT1A1 protein CTD PMID:15334623 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Flunitrazepam results in decreased activity of UGT1A3 protein CTD PMID:15334623 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      group 19986
        inorganic group 19494
          nitro group 10790
            nitro compound 10790
              C-nitro compound 10512
                flunitrazepam 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                carbocyclic compound 18521
                                  benzenoid aromatic compound 17760
                                    benzenes 17560
                                      fluorobenzenes 1789
                                        monofluorobenzenes 1448
                                          flunitrazepam 16
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