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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flunitrazepam
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Accession:CHEBI:31622 term browser browse the term
Definition:A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.
Synonyms:exact_synonym: 5-(2-fluorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
 related_synonym: 1,3-dihydro-5-(o-fluorophenyl)-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-one;   1-methyl-7-nitro-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2(1H)-one;   Fluninoc;   Flunita;   Fluscand;   Formula=C16H12FN3O3;   Hipnosedon;   Hypnodorm;   Hypnor;   InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3;   InChIKey=PPTYJKAXVCCBDU-UHFFFAOYSA-N;   Narcozep;   Primum;   RO-5-4200;   RO-54200;   RO54200;   Rohypnol;   Roipnol;   SMILES=C=12C(C=3C=CC=CC3F)=NCC(N(C1C=CC(=C2)[N+](=O)[O-])C)=O;   Silece;   Valsera;   flunidazepam;   flunipam;   flunitrazepamum;   fluridrazepam
 xref: CAS:1622-62-4;   DrugBank:DB01544;   Drug_Central:1202;   HMDB:HMDB0015510;   KEGG:D01230
 xref_mesh: MESH:D005445
 xref: PMID:11393809;   PMID:17889;   PMID:18070;   PMID:19839;   PMID:23506;   PMID:23971077;   PMID:25467462;   PMID:25895512;   PMID:26990972;   PMID:27143233;   PMID:27747877;   PMID:27778423;   PMID:28403803;   PMID:29657737;   PMID:29713800;   PMID:30870640;   PMID:31233253;   PMID:31512527;   PMID:31679602;   PMID:862358;   Reaxys:0702691;   Wikipedia:Flunitrazepam


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flunitrazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C4 protein CTD PMID:11995921 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Flunitrazepam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Casp3 caspase 3 multiple interactions ISO CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP3 protein] CTD PMID:19005028 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP7 protein] CTD PMID:19005028 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Crp C-reactive protein multiple interactions ISO [bromperidol co-treated with Flunitrazepam] results in increased expression of CRP protein CTD PMID:15298663 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Flunitrazepam CTD PMID:10911933 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases hydroxylation ISO CYP3A5 protein results in increased hydroxylation of Flunitrazepam CTD PMID:15383492 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions
affects binding
ISO
EXP
2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flunitrazepam binds to GABRA1 protein
alphaxalone promotes the reaction [Flunitrazepam binds to GABRA1 protein]; Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA1 protein]
CTD PMID:8397295, PMID:8632757, PMID:22029276 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 affects binding
multiple interactions
EXP Flunitrazepam binds to GABRA2 protein
alphaxalone promotes the reaction [Flunitrazepam binds to GABRA2 protein]; Pentobarbital promotes the reaction [Flunitrazepam binds to GABRA2 protein]
CTD PMID:8397295 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:8632757, PMID:22029276 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding
ISO 2,6-diisopropyl-4-(3-(3-methyl-3H-diazirin-3-yl)propyl)phenol promotes the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Flunitrazepam binds to and results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:8632757, PMID:22029276 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Sstr3 somatostatin receptor 3 affects expression EXP Flunitrazepam affects the expression of SSTR3 mRNA CTD PMID:16162846 NCBI chr 7:119,760,881...119,768,082
Ensembl chr 7:119,760,888...119,768,082
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity ISO Flunitrazepam results in decreased activity of UGT1A1 protein CTD PMID:15334623 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 decreases activity ISO Flunitrazepam results in decreased activity of UGT1A3 protein CTD PMID:15334623 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      group 19698
        inorganic group 19148
          nitro group 7267
            nitro compound 7267
              C-nitro compound 6870
                flunitrazepam 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                carbocyclic compound 18183
                                  benzenoid aromatic compound 17180
                                    benzenes 16922
                                      fluorobenzenes 1648
                                        monofluorobenzenes 1316
                                          flunitrazepam 15
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