Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Fidarestat
go back to main search page
Accession:CHEBI:31611 term browser browse the term
Synonyms:related_synonym: Aldos (TN);   Formula=C12H10FN3O4;   SNK 860
 xref: CAS:136087-85-9;   KEGG:D01842
 xref_mesh: MESH:C077139



show annotations for term's descendants           Sort by:
 
Fidarestat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO fidarestat inhibits the reaction [Glucose results in decreased expression of AKR1A1 mRNA] CTD PMID:16805838 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions
affects binding
ISO fidarestat binds to and results in decreased activity of AKR1B1 protein
NADP binds to AKR1B1 protein binds to fidarestat
CTD PMID:23295227 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 affects binding
multiple interactions
ISO NADP binds to AKR1B10 protein mutant form binds to fidarestat
fidarestat binds to and results in decreased activity of AKR1B10 protein mutant form
CTD PMID:23295227 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 decreases activity EXP fidarestat results in decreased activity of AKR1B8 protein CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:22253906 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Il13 interleukin 13 multiple interactions
decreases response to substance
ISO fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]; fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein]
fidarestat inhibits the reaction [Plant Extracts results in increased expression of IL13 mRNA]
fidarestat results in decreased susceptibility to IL13 protein
CTD PMID:21203431 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:22253906 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22253906 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak1 Janus kinase 1 multiple interactions
decreases phosphorylation
ISO fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]
fidarestat results in decreased phosphorylation of JAK1 protein
CTD PMID:21203431 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein]
fidarestat results in decreased phosphorylation of MAPK1 protein
CTD PMID:21203431 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO fidarestat results in decreased phosphorylation of MAPK3 protein
fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:21203431 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]; fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA] CTD PMID:21203431 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22253906 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Spdef SAM pointed domain containing ets transcription factor multiple interactions ISO fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein] CTD PMID:21203431 NCBI chr20:5,771,434...5,786,793
Ensembl chr20:5,771,441...5,785,893
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions
decreases phosphorylation
ISO fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein]
fidarestat inhibits the reaction [Plant Extracts results in increased phosphorylation of STAT6 protein]
fidarestat results in decreased phosphorylation of STAT6 protein
CTD PMID:21203431 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22253906 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          carbon atom 19609
            organic molecular entity 19609
              Fidarestat 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            Fidarestat 16
paths to the root