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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Fidarestat
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Accession:CHEBI:31611 term browser browse the term
Synonyms:related_synonym: Aldos (TN);   Formula=C12H10FN3O4;   SNK 860
 xref: CAS:136087-85-9;   KEGG:D01842
 xref_mesh: MESH:C077139


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Fidarestat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO fidarestat inhibits the reaction [Glucose results in decreased expression of AKR1A1 mRNA] CTD PMID:16805838 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions
affects binding
ISO fidarestat binds to and results in decreased activity of AKR1B1 protein
NADP binds to AKR1B1 protein binds to fidarestat
CTD PMID:23295227 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 affects binding
multiple interactions
ISO NADP binds to AKR1B10 protein mutant form binds to fidarestat
fidarestat binds to and results in decreased activity of AKR1B10 protein mutant form
CTD PMID:23295227 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 decreases activity EXP fidarestat results in decreased activity of AKR1B8 protein CTD PMID:18845131 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:22253906 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Il13 interleukin 13 multiple interactions
decreases response to substance
ISO fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]; fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein]
fidarestat inhibits the reaction [Plant Extracts results in increased expression of IL13 mRNA]
fidarestat results in decreased susceptibility to IL13 protein
CTD PMID:21203431 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:22253906 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22253906 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak1 Janus kinase 1 multiple interactions
decreases phosphorylation
ISO fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]
fidarestat results in decreased phosphorylation of JAK1 protein
CTD PMID:21203431 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein]
fidarestat results in decreased phosphorylation of MAPK1 protein
CTD PMID:21203431 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO fidarestat results in decreased phosphorylation of MAPK3 protein
fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:21203431 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]; fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA] CTD PMID:21203431 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22253906 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Spdef SAM pointed domain containing ets transcription factor multiple interactions ISO fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein] CTD PMID:21203431 NCBI chr20:7,292,823...7,308,053
Ensembl chr20:7,292,824...7,307,284
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions
decreases phosphorylation
ISO fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein]
fidarestat inhibits the reaction [Plant Extracts results in increased phosphorylation of STAT6 protein]
fidarestat results in decreased phosphorylation of STAT6 protein
CTD PMID:21203431 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22253906 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          carbon atom 19597
            organic molecular entity 19597
              Fidarestat 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            Fidarestat 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.