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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Fidarestat
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Accession:CHEBI:31611 term browser browse the term
Synonyms:related_synonym: Aldos (TN);   Formula=C12H10FN3O4;   SNK 860
 xref: CAS:136087-85-9;   KEGG:D01842
 xref_mesh: MESH:C077139


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Fidarestat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO fidarestat inhibits the reaction [Glucose results in decreased expression of AKR1A1 mRNA] CTD PMID:16805838 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions
affects binding		 ISO fidarestat binds to and results in decreased activity of AKR1B1 protein
NADP binds to AKR1B1 protein binds to fidarestat		 CTD PMID:23295227 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 affects binding
multiple interactions		 ISO NADP binds to AKR1B10 protein mutant form binds to fidarestat
fidarestat binds to and results in decreased activity of AKR1B10 protein mutant form		 CTD PMID:23295227 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:22253906 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Il13 interleukin 13 multiple interactions
decreases response to substance		 ISO fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]; fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein]
fidarestat inhibits the reaction [Plant Extracts results in increased expression of IL13 mRNA]
fidarestat results in decreased susceptibility to IL13 protein		 CTD PMID:21203431 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:22253906 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:22253906 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak1 Janus kinase 1 multiple interactions
decreases phosphorylation		 ISO fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]
fidarestat results in decreased phosphorylation of JAK1 protein		 CTD PMID:21203431 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein]
fidarestat results in decreased phosphorylation of MAPK1 protein		 CTD PMID:21203431 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO fidarestat results in decreased phosphorylation of MAPK3 protein
fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:21203431 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]; fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA] CTD PMID:21203431 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22253906 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Spdef SAM pointed domain containing ets transcription factor multiple interactions ISO fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein] CTD PMID:21203431 NCBI chr20:5,771,440...5,785,893
Ensembl chr20:5,771,441...5,785,893 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions
decreases phosphorylation		 ISO fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein]
fidarestat inhibits the reaction [Plant Extracts results in increased phosphorylation of STAT6 protein]
fidarestat results in decreased phosphorylation of STAT6 protein		 CTD PMID:21203431 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:22253906 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      atom 19872
        nonmetal atom 19794
          carbon atom 19748
            organic molecular entity 19748
              Fidarestat 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            Fidarestat 15
paths to the root