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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Botulinum toxin type A
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Accession:CHEBI:3160 term browser browse the term
Synonyms:related_synonym: Botulin A
 alt_id: MESH:D019274
 xref: CAS:93384-43-1;   KEGG:C07946;   KEGG:D00783
 xref_mesh: MESH:D019274


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Botulinum toxin type A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP [Botulinum Toxins, Type A results in increased expression of and results in increased activity of ACHE protein] which results in decreased abundance of Acetylcholine; Rivastigmine inhibits the reaction [[Botulinum Toxins, Type A results in increased expression of and results in increased activity of ACHE protein] which results in decreased abundance of Acetylcholine] CTD PMID:37507053 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression EXP Botulinum Toxins, Type A results in increased expression of ANKRD1 mRNA CTD PMID:18603602 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919 		JBrowse link
G Ankrd2 ankyrin repeat domain 2 increases expression EXP Botulinum Toxins, Type A results in increased expression of ANKRD2 mRNA CTD PMID:18603602 NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [[Potassium co-treated with Calcium] results in increased secretion of CALCA protein]; Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in decreased expression of CALCA protein] CTD PMID:17666428 PMID:30583000 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression ISO Botulinum Toxins, Type A results in increased expression of CCL17 mRNA CTD PMID:33529366 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Botulinum Toxins, Type A results in increased expression of CCL20 mRNA CTD PMID:33529366 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Cd14 CD14 molecule increases expression ISO Botulinum Toxins, Type A results in increased expression of CD14 mRNA CTD PMID:33529366 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Crp C-reactive protein increases expression
multiple interactions		 EXP Botulinum Toxins, Type A results in increased expression of CRP protein
Rivastigmine inhibits the reaction [Botulinum Toxins, Type A results in increased expression of CRP protein]		 CTD PMID:29739252 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Botulinum Toxins, Type A results in increased expression of CSF2 mRNA CTD PMID:33529366 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases expression EXP Botulinum Toxins, Type A results in increased expression of CSRP3 mRNA CTD PMID:18603602 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Botulinum Toxins, Type A results in increased expression of CXCL2 mRNA CTD PMID:33529366 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Botulinum Toxins, Type A results in increased expression of CXCL1 mRNA; Botulinum Toxins, Type A results in increased expression of CXCL3 mRNA CTD PMID:33529366 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Fbxo32 F-box protein 32 affects expression
multiple interactions		 ISO Botulinum Toxins, Type A affects the expression of FBXO32 mRNA
Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA]		 CTD PMID:21139329 NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Botulinum Toxins, Type A results in increased expression of FOSL1 mRNA CTD PMID:33529366 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Botulinum Toxins, Type A results in increased expression of GADD45B mRNA CTD PMID:33529366 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Il6 interleukin 6 increases expression ISO Botulinum Toxins, Type A results in increased expression of IL6 mRNA CTD PMID:33529366 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Botulinum Toxins, Type A results in increased expression of LCN2 mRNA CTD PMID:33529366 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein] CTD PMID:30583000 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein] CTD PMID:30583000 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myh2 myosin heavy chain 2 increases expression EXP Botulinum Toxins, Type A results in increased expression of MYH2 protein CTD PMID:19260067 NCBI chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236
Ensembl chr10:51,856,738...51,883,236 		JBrowse link
G Myh4 myosin heavy chain 4 decreases expression EXP Botulinum Toxins, Type A results in decreased expression of MYH4 protein CTD PMID:19260067 NCBI chr10:51,923,149...51,946,297
Ensembl chr10:51,885,913...51,946,295 		JBrowse link
G Myod1 myogenic differentiation 1 increases expression EXP Botulinum Toxins, Type A results in increased expression of MYOD1 mRNA CTD PMID:18603602 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554 		JBrowse link
G Notch1 notch receptor 1 decreases response to substance ISO NOTCH1 results in decreased susceptibility to Botulinum Toxins, Type A CTD PMID:23884415 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [Cyclophosphamide results in increased expression of PTGER4 protein] CTD PMID:18514386 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [Capsaicin results in increased expression of PTGS2 protein]; Botulinum Toxins, Type A inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein] CTD PMID:17141941 PMID:18514386 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO Botulinum Toxins, Type A results in increased expression of RELB mRNA CTD PMID:33529366 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions
increases cleavage		 ISO
EXP		 Botulinum Toxins, Type A results in increased cleavage of and results in decreased expression of SNAP25 protein; methylamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]; Zinc affects the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]
[Botulinum Toxins, Type A co-treated with botulinum toxin type E] results in increased cleavage of SNAP25 protein		 CTD PMID:10978741 PMID:11181932 PMID:11384718 PMID:17666428 PMID:22223483 More... NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a multiple interactions ISO [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] promotes the reaction [SV2A protein binds to Botulinum Toxins, Type A] CTD PMID:28645175 NCBI chr 2:183,741,489...183,757,290
Ensembl chr 2:183,741,547...183,756,927 		JBrowse link
G Sv2c synaptic vesicle glycoprotein 2c multiple interactions ISO Botulinum Toxins, Type A binds to [SV2C protein co-treated with trisialoganglioside GT1]; Sodium Chloride inhibits the reaction [Botulinum Toxins, Type A binds to [SV2C protein co-treated with trisialoganglioside GT1]] CTD PMID:30016653 NCBI chr 2:27,232,933...27,428,479
Ensembl chr 2:27,232,933...27,428,477 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [Cyclophosphamide results in increased secretion of TAC1 protein]; Botulinum Toxins, Type A inhibits the reaction [Hydrochloric Acid results in increased secretion of TAC1 protein]; Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in decreased expression of TAC1 protein] CTD PMID:18184328 PMID:30583000 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 Rivastigmine inhibits the reaction [Botulinum Toxins, Type A results in increased expression of TNF protein]
Botulinum Toxins, Type A results in increased expression of TNF mRNA		 CTD PMID:29739252 PMID:33529366 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Botulinum Toxins, Type A results in increased expression of TNFAIP3 mRNA CTD PMID:33529366 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Trim63 tripartite motif containing 63 increases expression
multiple interactions		 EXP
ISO		 Botulinum Toxins, Type A results in increased expression of TRIM63 mRNA
[Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA		 CTD PMID:18603602 PMID:21139329 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322 		JBrowse link
G Ttn titin decreases expression
increases expression		 EXP Botulinum Toxins, Type A results in decreased expression of TTN protein
Botulinum Toxins, Type A results in increased expression of TTN mRNA		 CTD PMID:18603602 PMID:19260067 NCBI chr 3:61,652,432...61,924,912
Ensembl chr 3:61,652,439...61,924,741 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19932
    chemical entity 19930
      atom 19930
        nonmetal atom 19859
          carbon atom 19812
            organic molecular entity 19812
              Botulinum toxin type A 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            Botulinum toxin type A 34
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