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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Botulinum toxin type A
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Accession:CHEBI:3160 term browser browse the term
Synonyms:related_synonym: Botulin A
 alt_id: MESH:D019274
 xref: CAS:93384-43-1;   KEGG:C07946;   KEGG:D00783
 xref_mesh: MESH:D019274


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Botulinum toxin type A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd1 ankyrin repeat domain 1 increases expression EXP Botulinum Toxins, Type A results in increased expression of ANKRD1 mRNA CTD PMID:18603602 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Ankrd2 ankyrin repeat domain 2 increases expression EXP Botulinum Toxins, Type A results in increased expression of ANKRD2 mRNA CTD PMID:18603602 NCBI chr 1:261,281,859...261,291,307
Ensembl chr 1:261,281,543...261,291,394
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [[Potassium co-treated with Calcium] results in increased secretion of CALCA protein]; Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in decreased expression of CALCA protein] CTD PMID:17666428, PMID:30583000 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases expression EXP Botulinum Toxins, Type A results in increased expression of CSRP3 mRNA CTD PMID:18603602 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367
JBrowse link
G Fbxo32 F-box protein 32 affects expression
multiple interactions
ISO Botulinum Toxins, Type A affects the expression of FBXO32 mRNA
Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA]
CTD PMID:21139329 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein] CTD PMID:30583000 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein] CTD PMID:30583000 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Myh2 myosin heavy chain 2 increases expression EXP Botulinum Toxins, Type A results in increased expression of MYH2 protein CTD PMID:19260067 NCBI chr10:53,711,895...53,738,164
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Myh4 myosin heavy chain 4 decreases expression EXP Botulinum Toxins, Type A results in decreased expression of MYH4 protein CTD PMID:19260067 NCBI chr10:53,778,456...53,801,605
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Myod1 myogenic differentiation 1 increases expression EXP Botulinum Toxins, Type A results in increased expression of MYOD1 mRNA CTD PMID:18603602 NCBI chr 1:102,396,538...102,399,248
Ensembl chr 1:102,396,538...102,399,248
JBrowse link
G Notch1 notch receptor 1 decreases response to substance ISO NOTCH1 results in decreased susceptibility to Botulinum Toxins, Type A CTD PMID:23884415 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [Cyclophosphamide results in increased expression of PTGER4 protein] CTD PMID:18514386 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [Capsaicin results in increased expression of PTGS2 protein]; Botulinum Toxins, Type A inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein] CTD PMID:17141941, PMID:18514386 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions
increases cleavage
ISO
EXP
Botulinum Toxins, Type A results in increased cleavage of and results in decreased expression of SNAP25 protein; methylamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]; Zinc affects the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein]
[Botulinum Toxins, Type A co-treated with botulinum toxin type E] results in increased cleavage of SNAP25 protein
CTD PMID:10978741, PMID:11181932, PMID:11384718, PMID:17666428, PMID:22223483, PMID:26615023 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a multiple interactions ISO [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] promotes the reaction [SV2A protein binds to Botulinum Toxins, Type A] CTD PMID:28645175 NCBI chr 2:198,321,100...198,336,889
Ensembl chr 2:198,321,142...198,336,913
JBrowse link
G Sv2c synaptic vesicle glycoprotein 2c multiple interactions ISO Botulinum Toxins, Type A binds to [SV2C protein co-treated with trisialoganglioside GT1]; Sodium Chloride inhibits the reaction [Botulinum Toxins, Type A binds to [SV2C protein co-treated with trisialoganglioside GT1]] CTD PMID:30016653 NCBI chr 2:26,495,757...26,707,691
Ensembl chr 2:26,501,833...26,699,333
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Botulinum Toxins, Type A inhibits the reaction [Cyclophosphamide results in increased secretion of TAC1 protein]; Botulinum Toxins, Type A inhibits the reaction [Hydrochloric Acid results in increased secretion of TAC1 protein]; Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in decreased expression of TAC1 protein] CTD PMID:18184328, PMID:30583000 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Trim63 tripartite motif containing 63 increases expression
multiple interactions
EXP
ISO
Botulinum Toxins, Type A results in increased expression of TRIM63 mRNA
[Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA
CTD PMID:18603602, PMID:21139329 NCBI chr 5:152,533,362...152,547,138
Ensembl chr 5:152,533,349...152,547,179
JBrowse link
G Ttn titin decreases expression
increases expression
EXP Botulinum Toxins, Type A results in decreased expression of TTN protein
Botulinum Toxins, Type A results in increased expression of TTN mRNA
CTD PMID:18603602, PMID:19260067 NCBI chr 3:63,565,160...63,837,815 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          carbon atom 19597
            organic molecular entity 19597
              Botulinum toxin type A 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            Botulinum toxin type A 19
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.