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ONTOLOGY REPORT - ANNOTATIONS


Term:epothilone B
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Accession:CHEBI:31550 term browser browse the term
Definition:An epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer).
Synonyms:exact_synonym: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
 related_synonym: EPO 906;   Epo B;   EpoB;   Formula=C27H41NO6S;   InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1;   InChIKey=QXRSDHAAWVKZLJ-PVYNADRNSA-N;   SMILES=C1[C@](OC(C[C@@H](C(C([C@@H]([C@H]([C@H](CCC[C@@]2([C@]1(O2)[H])C)C)O)C)=O)(C)C)O)=O)(/C(=C/C=3N=C(SC3)C)/C)[H];   patupilona;   patupilone;   patupilonum
 alt_id: CHEBI:42432
 xref: CAS:152044-54-7 "ChemIDplus";   CAS:152044-54-7 "KEGG COMPOUND";   DrugBank:DB03010;   KEGG:C12154;   KNApSAcK:C00044747;   LIPID_MAPS_instance:LMPK04000041 "LIPID MAPS"
 xref_mesh: MESH:C093788
 xref: PDBeChem:EPB;   PMID:10831849 "Europe PMC";   PMID:21743064 "Europe PMC";   PMID:22234539 "Europe PMC";   PMID:22688083 "Europe PMC";   PMID:22918719 "Europe PMC";   PMID:23205945 "Europe PMC";   PMID:23214997 "Europe PMC";   PMID:23801302 "Europe PMC";   PMID:24374386 "Europe PMC";   PMID:24470546 "Europe PMC";   PMID:24583341 "Europe PMC";   PMID:24913659 "Europe PMC";   PMID:25694444 "Europe PMC";   PMID:25721485 "Europe PMC";   PMID:25765066 "Europe PMC";   PMID:25919223 "Europe PMC";   PMID:26081685 "Europe PMC";   PMID:26308485 "Europe PMC";   PMID:26316786 "Europe PMC";   Reaxys:7556514 "Reaxys"


show annotations for term's descendants       view all columns           Sort by:
 
epothilone B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          apoptosis inducer 10823
            epothilone B 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic ester 13954
                                        lactone 5864
                                          macrocyclic lactone 1519
                                            macrolide 1458
                                              epothilone 5
                                                epothilone B 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.