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ONTOLOGY REPORT - ANNOTATIONS


Term:epalrestat
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Accession:CHEBI:31539 term browser browse the term
Definition:A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
Synonyms:exact_synonym: {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
 related_synonym: 5-((1Z,2E)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid;   5-((Z,E)-beta-methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid;   Formula=C15H13NO3S2;   InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-;   InChIKey=CHNUOJQWGUIOLD-NFZZJPOKSA-N;   Kinedak;   ONO-2;   Ono 2235;   SMILES=C\\C(\\C=C1/SC(=S)N(CC(O)=O)C1=O)=C/c1ccccc1;   epalrestatum
 xref: CAS:82159-09-9 "ChemIDplus";   Drug_Central:1021 "DrugCentral";   KEGG:D01688
 xref_mesh: MESH:C038131
 xref: PDBeChem:EPR;   PMID:19716319 "Europe PMC";   PMID:22820572 "Europe PMC";   PMID:23426701 "Europe PMC";   PMID:24363998 "Europe PMC";   PMID:3025043 "Europe PMC";   Patent:EP47109;   Patent:US4464382;   Reaxys:4236712 "Reaxys";   Wikipedia:Epalrestat


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epalrestat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Cygb cytoglobin JBrowse link 10 105,618,325 105,628,091 RGD:6480464
G Fgf21 fibroblast growth factor 21 JBrowse link 1 101,595,579 101,596,822 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Itgad integrin subunit alpha D JBrowse link 1 199,595,968 199,623,931 RGD:6480464
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      chemical role 19128
        donor 18277
          Bronsted acid 18134
            oxoacid 18076
              carbon oxoacid 17938
                carboxylic acid 17923
                  monocarboxylic acid 17256
                    epalrestat 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          epalrestat 14
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