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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:epalrestat
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Accession:CHEBI:31539 term browser browse the term
Definition:A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
Synonyms:exact_synonym: {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
 related_synonym: 5-((1Z,2E)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid;   5-((Z,E)-beta-methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid;   Formula=C15H13NO3S2;   InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-;   InChIKey=CHNUOJQWGUIOLD-NFZZJPOKSA-N;   Kinedak;   ONO-2;   Ono 2235;   SMILES=C\\C(\\C=C1/SC(=S)N(CC(O)=O)C1=O)=C/c1ccccc1;   epalrestatum
 xref: CAS:82159-09-9;   Drug_Central:1021;   KEGG:D01688
 xref_mesh: MESH:C038131
 xref: PDBeChem:EPR;   PMID:19716319;   PMID:22820572;   PMID:23426701;   PMID:24363998;   PMID:3025043;   Patent:EP47109;   Patent:US4464382;   Reaxys:4236712;   Wikipedia:Epalrestat


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epalrestat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO epalrestat results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:28204799 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO epalrestat results in increased expression of COL1A1 mRNA; epalrestat results in increased expression of COL1A1 protein CTD PMID:28204799 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cygb cytoglobin increases expression ISO epalrestat results in increased expression of CYGB mRNA; epalrestat results in increased expression of CYGB protein CTD PMID:28204799 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression ISO epalrestat results in increased expression of FGF21 mRNA CTD PMID:28204799 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO epalrestat results in increased expression of HIF1A mRNA CTD PMID:28204799 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO epalrestat results in increased expression of HMOX1 mRNA CTD PMID:28204799 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Itgad integrin subunit alpha D increases expression ISO epalrestat results in increased expression of ITGAD mRNA CTD PMID:28204799 NCBI chr 1:199,595,968...199,623,931
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO epalrestat results in increased expression of ITGAM mRNA CTD PMID:28204799 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO epalrestat affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:28204799 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngf nerve growth factor multiple interactions
increases secretion
increases expression
EXP epalrestat inhibits the reaction [Streptozocin results in decreased expression of NGF protein]
epalrestat results in increased secretion of NGF protein
epalrestat results in increased expression of NGF protein
CTD PMID:9628756 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO epalrestat results in increased expression of NQO1 mRNA CTD PMID:28204799 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO epalrestat inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO epalrestat results in increased expression of SOD2 mRNA CTD PMID:28204799 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO epalrestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol] CTD PMID:32367058 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Tnf tumor necrosis factor increases expression ISO epalrestat results in increased expression of TNF mRNA CTD PMID:28204799 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        donor 18377
          Bronsted acid 18240
            oxoacid 18192
              carbon oxoacid 18071
                carboxylic acid 18060
                  monocarboxylic acid 17406
                    epalrestat 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          epalrestat 15
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