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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:epalrestat
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Accession:CHEBI:31539 term browser browse the term
Definition:A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
Synonyms:exact_synonym: {(5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid
 related_synonym: 5-((1Z,2E)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid;   5-((Z,E)-beta-methylcinnamylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid;   Formula=C15H13NO3S2;   InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-;   InChIKey=CHNUOJQWGUIOLD-NFZZJPOKSA-N;   Kinedak;   ONO-2;   Ono 2235;   SMILES=C\\C(\\C=C1/SC(=S)N(CC(O)=O)C1=O)=C/c1ccccc1;   epalrestatum
 xref: CAS:82159-09-9;   Drug_Central:1021;   KEGG:D01688
 xref_mesh: MESH:C038131
 xref: PDBeChem:EPR;   PMID:19716319;   PMID:22820572;   PMID:23426701;   PMID:24363998;   PMID:3025043;   Patent:EP47109;   Patent:US4464382;   Reaxys:4236712;   Wikipedia:Epalrestat


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epalrestat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO epalrestat results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:28204799 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO epalrestat results in increased expression of COL1A1 mRNA; epalrestat results in increased expression of COL1A1 protein CTD PMID:28204799 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cygb cytoglobin increases expression ISO epalrestat results in increased expression of CYGB mRNA; epalrestat results in increased expression of CYGB protein CTD PMID:28204799 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression ISO epalrestat results in increased expression of FGF21 mRNA CTD PMID:28204799 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO epalrestat results in increased expression of HIF1A mRNA CTD PMID:28204799 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO epalrestat results in increased expression of HMOX1 mRNA CTD PMID:28204799 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Itgad integrin subunit alpha D increases expression ISO epalrestat results in increased expression of ITGAD mRNA CTD PMID:28204799 NCBI chr 1:182,759,785...182,788,422
Ensembl chr 1:182,759,740...182,788,161
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO epalrestat results in increased expression of ITGAM mRNA CTD PMID:28204799 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO epalrestat affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:28204799 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngf nerve growth factor multiple interactions
increases secretion
increases expression
EXP epalrestat inhibits the reaction [Streptozocin results in decreased expression of NGF protein]
epalrestat results in increased secretion of NGF protein
epalrestat results in increased expression of NGF protein
CTD PMID:9628756 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO epalrestat results in increased expression of NQO1 mRNA CTD PMID:28204799 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO epalrestat inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO epalrestat results in increased expression of SOD2 mRNA CTD PMID:28204799 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO epalrestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol] CTD PMID:32367058 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Tnf tumor necrosis factor increases expression ISO epalrestat results in increased expression of TNF mRNA CTD PMID:28204799 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      chemical role 19336
        donor 18644
          Bronsted acid 18526
            oxoacid 18488
              carbon oxoacid 18369
                carboxylic acid 18364
                  monocarboxylic acid 17632
                    epalrestat 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          epalrestat 15
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