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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:edaravone
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Accession:CHEBI:31530 term browser browse the term
Definition:A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.
Synonyms:related_synonym: 1-phenyl-3-methyl-5-oxo-2-pyrazoline;   2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one;   3-methyl-1-phenyl-2-pyrazolin-5-one;   3-methyl-1-phenyl-5-pyrazolone;   3-methyl-1-phenylpyrazol-5-one;   C.I. developer 1;   Radicut;   developer Z;   methylphenylpyrazolone;   norphenazone;   phenyl methyl pyrazolone;   phenylmethylpyrazolone
 xref: Beilstein:609575;   CAS:89-25-8;   Gmelin:241147;   HMDB:HMDB0006240
 xref_mesh: MESH:C005435
 xref: drugcentral:4156;   kegg.compound:C13008;   kegg.drug:D01552;   lincs.smallmolecule:LSM-5486;   pubmed:12935312;   pubmed:14758002;   pubmed:15304976;   pubmed:16545576;   pubmed:17280782;   pubmed:17997244;   pubmed:18485133;   pubmed:25348283;   pubmed:26196041;   pubmed:26778341;   pubmed:27018216;   pubmed:27037019;   pubmed:27056755;   pubmed:27116382;   pubmed:27128210
 chemrof_formula: C10H10N2O
 chemrof_smiles: CC1=NN(c2ccccc2)C(=O)C1
 chemrof_inchi: InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
 chemrof_inchikey: QELUYTUMUWHWMC-UHFFFAOYSA-N


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edaravone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Edaravone inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA] CTD PMID:36343683 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503 		JBrowse link
G Adora1 adenosine A1 receptor multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of ADORA1 mRNA] CTD PMID:31344373 NCBI chr13:48,210,922...48,247,826
Ensembl chr13:48,213,273...48,247,190 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP Edaravone inhibits the reaction [Lipopolysaccharides results in decreased expression of AGTR1A mRNA] CTD PMID:19118600 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of AGTR2 mRNA] CTD PMID:19118600 NCBI chr  X:116,914,320...116,918,504
Ensembl chr  X:116,913,656...116,918,745 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein] CTD PMID:18078833 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP Edaravone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of ALOX5 protein]; Edaravone inhibits the reaction [Hydrogen Peroxide affects the localization of ALOX5 protein] CTD PMID:18951527 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Edaravone inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]; Edaravone inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; Edaravone inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO 		Edaravone inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]
Edaravone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BAX protein] 		CTD PMID:26111763 PMID:39326406 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Edaravone inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA] CTD PMID:26111763 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Casp12 caspase 12 multiple interactions EXP Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of CASP12 protein] CTD PMID:21429313 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity 		EXP
ISO 		Edaravone inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Edaravone inhibits the reaction [PRNP protein alternative form results in increased activity of CASP3 protein]
Edaravone analog results in increased activity of CASP3 protein
Edaravone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP3 protein] 		CTD PMID:20806394 PMID:25684395 PMID:25947082 PMID:39326406 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 increases activity ISO Edaravone analog results in increased activity of CASP7 protein CTD PMID:25684395 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 decreases expression EXP Edaravone results in decreased expression of CASP8 protein CTD PMID:17967739 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 increases activity ISO Edaravone analog results in increased activity of CASP9 protein CTD PMID:25684395 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions ISO Edaravone inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein] CTD PMID:32135237 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 multiple interactions EXP Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL12 mRNA] CTD PMID:12954792 NCBI chr10:67,567,876...67,569,426
Ensembl chr10:67,567,876...67,569,426 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression 		EXP
ISO 		Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of CCL2 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CCL2 protein]
Edaravone results in decreased expression of CCL2 mRNA; Edaravone results in decreased expression of CCL2 protein
Edaravone inhibits the reaction [Thioacetamide results in increased expression of CCL2 mRNA] 		CTD PMID:12954792 PMID:15948865 PMID:18803305 PMID:19381132 PMID:36343683 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression EXP Edaravone results in decreased expression of CCL3 mRNA CTD PMID:15948865 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO Edaravone inhibits the reaction [Thioacetamide results in increased expression of CCR2 mRNA] CTD PMID:36343683 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Edaravone inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA] CTD PMID:36343683 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of COMT mRNA] CTD PMID:31344373 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions 		EXP Edaravone results in decreased expression of CXCL1 mRNA; Edaravone results in decreased expression of CXCL1 protein
Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] 		CTD PMID:14654979 PMID:15629513 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions EXP Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of CXCL12 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CXCL12 protein] CTD PMID:18803305 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
multiple interactions 		EXP Edaravone results in decreased expression of CXCL2 mRNA
Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL2 mRNA] 		CTD PMID:12954792 PMID:15948865 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression EXP Edaravone results in decreased expression of CXCL3 mRNA CTD PMID:15948865 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Edaravone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CYBB mRNA] CTD PMID:18643790 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Edaravone inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Daxx death-domain associated protein decreases expression EXP Edaravone results in decreased expression of DAXX mRNA; Edaravone results in decreased expression of DAXX protein CTD PMID:17967739 NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO Edaravone inhibits the reaction [Cisplatin results in decreased expression of EPHX2 protein] CTD PMID:26165641 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression EXP Edaravone results in increased expression of ERN1 mRNA CTD PMID:19558813 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP Edaravone inhibits the reaction [Valproic Acid results in decreased activity of F3 protein] CTD PMID:25304967 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369 		JBrowse link
G Fadd Fas associated via death domain decreases expression EXP Edaravone results in decreased expression of FADD mRNA; Edaravone results in decreased expression of FADD protein CTD PMID:17967739 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of FKBP5 mRNA] CTD PMID:31344373 NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO Edaravone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 mRNA]; Edaravone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 protein] CTD PMID:24840734 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]] which affects the expression of VEGFA mRNA; Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] CTD PMID:17889387 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions 		ISO
EXP 		Edaravone results in increased expression of HMOX1 mRNA; Edaravone results in increased expression of HMOX1 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein] 		CTD PMID:25348283 PMID:25422538 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression EXP Edaravone results in decreased expression of HSPA1A mRNA; Edaravone results in decreased expression of HSPA1A protein CTD PMID:19338546 PMID:19694712 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Edaravone promotes the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 protein] CTD PMID:21429313 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Edaravone results in decreased expression of ICAM1 mRNA; Edaravone results in decreased expression of ICAM1 protein alternative form CTD PMID:15948865 PMID:16301206 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifng interferon gamma multiple interactions EXP Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNG mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] CTD PMID:12954792 PMID:15629513 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 mRNA] CTD PMID:12954792 PMID:14567445 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Edaravone inhibits the reaction [Thioacetamide results in increased expression of IL1A mRNA] CTD PMID:36343683 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases activity
decreases expression 		ISO
EXP 		Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Edaravone results in decreased activity of IL1B protein
Edaravone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein]; Edaravone inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [IL1B protein results in increased localization of and results in increased activity of RELA protein]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of IL1B protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of IL1B protein]
Edaravone results in decreased expression of IL1B mRNA
Edaravone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL1B protein]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Edaravone inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA] 		CTD PMID:15629513 PMID:15948865 PMID:16390820 PMID:18078833 PMID:18803305 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 mRNA]; Edaravone inhibits the reaction [[IL1B protein results in increased phosphorylation of AKT1 protein] which results in increased expression of IL1R1 protein] CTD PMID:18078833 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL4 mRNA] CTD PMID:14567445 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 affects activity
multiple interactions
decreases expression 		EXP
ISO 		Edaravone affects the activity of IL6 protein
Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Edaravone inhibits the reaction [Paraquat results in increased expression of IL6 protein]; Edaravone promotes the reaction [Taurocholic Acid results in increased expression of IL6 mRNA]
Edaravone results in decreased expression of IL6 mRNA
Edaravone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL6 protein] 		CTD PMID:12954792 PMID:14567445 PMID:15629865 PMID:18031376 PMID:20035747 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO Edaravone inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein] CTD PMID:18291360 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases activity ISO Edaravone results in decreased activity of MAP3K5 protein CTD PMID:15824197 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
decreases phosphorylation
multiple interactions 		ISO Edaravone results in increased phosphorylation of MAPK8 protein
Edaravone results in decreased phosphorylation of MAPK8 protein
Edaravone inhibits the reaction [mevastatin results in increased phosphorylation of MAPK8 protein] 		CTD PMID:15824197 PMID:19954754 PMID:39431643 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Edaravone inhibits the reaction [mevastatin results in increased phosphorylation of MAPK9 protein] CTD PMID:39431643 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions 		EXP Edaravone results in decreased expression of MMP2 protein
Edaravone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA] 		CTD PMID:19381132 PMID:21040696 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Edaravone inhibits the reaction [PLAT protein results in increased expression of and results in increased activity of MMP9 protein]; Edaravone inhibits the reaction [PLAT protein results in increased expression of MMP9 mRNA] CTD PMID:19095969 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase affects expression
decreases expression
multiple interactions
decreases activity 		EXP Edaravone affects the expression of MPO mRNA
Edaravone results in decreased expression of MPO protein
Edaravone inhibits the reaction [Taurocholic Acid results in increased activity of MPO protein]
Edaravone results in decreased activity of MPO protein 		CTD PMID:14654979 PMID:18031376 PMID:19694712 PMID:20035747 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Edaravone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NCF1 mRNA] CTD PMID:18643790 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions EXP Edaravone inhibits the reaction [Rotenone results in decreased expression of NDUFS1 mRNA] CTD PMID:27108097 NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions EXP Edaravone inhibits the reaction [Rotenone results in decreased expression of NDUFS4 mRNA] CTD PMID:27108097 NCBI chr 2:47,684,420...47,794,914
Ensembl chr 2:47,684,406...47,794,931 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions 		ISO
EXP 		Edaravone affects the localization of NFE2L2 protein
[Edaravone co-treated with Chlorpyrifos] results in increased expression of NFE2L2 protein; Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein] 		CTD PMID:25348283 PMID:25422538 PMID:30758894 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression EXP Edaravone results in increased expression of NFKBIA mRNA CTD PMID:18078833 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Ngf nerve growth factor increases expression
multiple interactions 		ISO Edaravone results in increased expression of NGF mRNA; Edaravone results in increased expression of NGF protein
pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF mRNA]; pyrazolanthrone inhibits the reaction [Edaravone results in increased expression of NGF protein]; U 0126 inhibits the reaction [Edaravone results in increased expression of NGF mRNA]; U 0126 inhibits the reaction [Edaravone results in increased expression of NGF protein] 		CTD PMID:19954754 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS1 protein] CTD PMID:18672383 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
increases degradation 		ISO
EXP 		Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
Edaravone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Edaravone inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Edaravone inhibits the reaction [Pilocarpine results in increased expression of NOS2 protein]
Edaravone results in decreased expression of NOS2 protein
Edaravone results in increased degradation of NOS2 mRNA 		CTD PMID:15629513 PMID:18078833 PMID:18496239 PMID:18672383 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
decreases degradation 		EXP
ISO 		Edaravone results in increased expression of NOS3 mRNA; Edaravone results in increased expression of NOS3 protein
Edaravone results in decreased degradation of NOS3 mRNA 		CTD PMID:12969758 PMID:15721014 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Edaravone results in decreased expression of NPPA mRNA CTD PMID:15824197 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Edaravone analog results in increased cleavage of PARP1 protein CTD PMID:25684395 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pepd peptidase D multiple interactions EXP Edaravone inhibits the reaction [Valproic Acid results in increased activity of PEPD protein] CTD PMID:34309930 NCBI chr 1:96,673,624...96,818,197
Ensembl chr 1:96,673,607...96,818,190 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions EXP Edaravone inhibits the reaction [PLAT protein results in increased activity of RELA protein]; Edaravone inhibits the reaction [PLAT protein results in increased expression of and results in increased activity of MMP9 protein]; Edaravone inhibits the reaction [PLAT protein results in increased expression of MMP9 mRNA] CTD PMID:19095969 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP Edaravone inhibits the reaction [Valproic Acid results in decreased activity of PON1 protein] CTD PMID:34309930 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Edaravone inhibits the reaction [Rotenone results in decreased expression of PPARGC1A mRNA] CTD PMID:30240821 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Prnp prion protein multiple interactions EXP Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD1 protein]; Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD2 protein]; Edaravone inhibits the reaction [PRNP protein alternative form results in increased activity of CASP3 protein] CTD PMID:20806394 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression 		EXP
ISO 		Edaravone inhibits the reaction [IL1B protein results in increased localization of and results in increased activity of RELA protein]; Edaravone inhibits the reaction [PLAT protein results in increased activity of RELA protein]
Edaravone results in decreased expression of RELA protein
Edaravone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] 		CTD PMID:18078833 PMID:19095969 PMID:19381132 PMID:36343683 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sdc2 syndecan 2 multiple interactions EXP Edaravone inhibits the reaction [SDC2 protein promotes the reaction [Oxygen deficiency results in increased abundance of Reactive Oxygen Species]]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CCL2 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of CXCL12 protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of IL1B protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of TNF protein] CTD PMID:18803305 NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:66,108,853...66,126,294 		JBrowse link
G Sele selectin E decreases expression EXP Edaravone results in decreased expression of SELE mRNA; Edaravone results in decreased expression of SELE protein CTD PMID:17064733 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO Edaravone inhibits the reaction [Corticosterone results in decreased expression of SLC6A15 mRNA] CTD PMID:31344373 NCBI chr 7:40,439,607...40,493,788
Ensembl chr 7:40,439,658...40,493,786 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD1 protein] CTD PMID:20806394 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Edaravone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD2 protein] CTD PMID:20806394 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Edaravone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:21040696 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Edaravone inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:27108097 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Edaravone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA] CTD PMID:21040696 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression 		EXP
ISO 		Edaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Edaravone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased secretion of TNF protein]; Edaravone inhibits the reaction [Paraquat results in increased expression of TNF protein]; Edaravone inhibits the reaction [SDC2 protein results in increased expression of and results in increased secretion of TNF protein]; Edaravone promotes the reaction [Taurocholic Acid results in increased expression of TNF mRNA]
Edaravone results in decreased expression of TNF mRNA; Edaravone results in decreased expression of TNF protein
Edaravone inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of TNF protein]; Edaravone inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA] 		CTD PMID:12954792 PMID:14567445 PMID:15629513 PMID:15948865 PMID:17064733 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions EXP Edaravone inhibits the reaction [Isoproterenol results in increased expression of UCP2 mRNA]; Edaravone inhibits the reaction [Isoproterenol results in increased expression of UCP2 protein] CTD PMID:16580698 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Edaravone results in decreased expression of VCAM1 protein CTD PMID:19381132 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]] which affects the expression of VEGFA mRNA; Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein] CTD PMID:17889387 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Wdr35 WD repeat domain 35 multiple interactions EXP Edaravone inhibits the reaction [domoic acid results in increased expression of WDR35 protein] CTD PMID:23289926 NCBI chr 6:37,490,557...37,550,391
Ensembl chr 6:37,490,545...37,550,664 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Edaravone inhibits the reaction [Valproic Acid results in increased activity of XDH protein] CTD PMID:34309930 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      chemical role 20219
        antioxidant 16310
          edaravone 84
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  heteroarene 17357
                                    monocyclic heteroarene 15176
                                      azole 14629
                                        diazole 10862
                                          pyrazoles 2369
                                            pyrazolone 89
                                              edaravone 84
paths to the root