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ONTOLOGY REPORT - ANNOTATIONS


Term:doxifluridine
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Accession:CHEBI:31521 term browser browse the term
Definition:A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
Synonyms:exact_synonym: 5'-deoxy-5-fluorouridine
 related_synonym: 1-(beta-D-5-desoxyribofuranoxyl)-5-fluoruracil;   5'-Dfur;   5'-dFUrd;   5-fluoro-5'-deoxyuridine;   Formula=C9H11FN2O5;   Furtulon;   InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1;   InChIKey=ZWAOHEXOSAUJHY-ZIYNGMLESA-N;   Ro 21-9738;   Ro 219738;   SMILES=C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(F)c(=O)[nH]c1=O;   doxifluridina;   doxifluridinum
 alt_id: CHEBI:74488
 xref: CAS:3094-09-5 "ChemIDplus";   CAS:3094-09-5 "KEGG COMPOUND";   Drug_Central:958 "DrugCentral";   HMDB:HMDB0060406;   KEGG:C12739;   KEGG:D01309;   LINCS:LSM-6359
 xref_mesh: MESH:C025034
 xref: PMID:19101214 "Europe PMC";   PMID:21234714 "Europe PMC";   PMID:23564503 "Europe PMC";   PMID:2947416 "Europe PMC";   PMID:3020904 "Europe PMC";   Patent:US4071680;   Reaxys:890191 "Reaxys"


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doxifluridine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa1a acetyl-CoA acyltransferase 1A JBrowse link 8 128,027,880 128,036,471 RGD:6480464
G Agr2 anterior gradient 2, protein disulphide isomerase family member JBrowse link 6 55,465,782 55,487,087 RGD:6480464
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:6480464
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:6480464
G Anxa8 annexin A8 JBrowse link 16 10,417,174 10,432,388 RGD:6480464
G Arl4d ADP-ribosylation factor like GTPase 4D JBrowse link 10 89,577,556 89,580,368 RGD:6480464
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:6480464
G Ccn1 cellular communication network factor 1 JBrowse link 2 251,529,354 251,532,312 RGD:6480464
G Cib1 calcium and integrin binding 1 JBrowse link 1 142,014,962 142,020,461 RGD:6480464
G Cldn3 claudin 3 JBrowse link 12 21,831,341 21,832,813 RGD:6480464
G Dapk1 death associated protein kinase 1 JBrowse link 17 4,297,038 4,454,941 RGD:6480464
G Dpyd dihydropyrimidine dehydrogenase JBrowse link 2 221,823,692 222,694,627 RGD:6480464
G Dse dermatan sulfate epimerase JBrowse link 20 27,703,738 27,784,982 RGD:6480464
G Elf3 E74 like ETS transcription factor 3 JBrowse link 13 52,083,873 52,088,798 RGD:6480464
G Eps8 epidermal growth factor receptor pathway substrate 8 JBrowse link 4 171,475,155 171,645,620 RGD:6480464
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:6480464
G Etnk1 ethanolamine kinase 1 JBrowse link 4 177,402,904 177,447,047 RGD:6480464
G Fhl1 four and a half LIM domains 1 JBrowse link X 159,112,516 159,172,528 RGD:6480464
G Flii FLII, actin remodeling protein JBrowse link 10 46,955,460 46,969,468 RGD:6480464
G Fuca1 alpha-L-fucosidase 1 JBrowse link 5 154,269,296 154,286,545 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il17rb interleukin 17 receptor B JBrowse link 16 6,064,287 6,077,978 RGD:6480464
G Lgals4 galectin 4 JBrowse link 1 87,019,598 87,027,720 RGD:6480464
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:6480464
G Myb MYB proto-oncogene, transcription factor JBrowse link 1 16,658,178 16,690,135 RGD:6480464
G Nme7 NME/NM23 family member 7 JBrowse link 13 82,607,844 82,737,383 RGD:6480464
G Osmr oncostatin M receptor JBrowse link 2 56,107,491 56,163,522 RGD:6480464
G Pkd2 polycystin 2, transient receptor potential cation channel JBrowse link 14 6,602,004 6,645,257 RGD:6480464
G Pkp2 plakophilin 2 JBrowse link 11 88,912,163 88,972,213 RGD:6480464
G Plce1 phospholipase C, epsilon 1 JBrowse link 1 257,156,023 257,465,440 RGD:6480464
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 JBrowse link 8 99,977,334 100,059,736 RGD:6480464
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:6480464
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 JBrowse link 14 7,688,551 7,863,664 RGD:6480464
G Pygb glycogen phosphorylase B JBrowse link 3 146,581,063 146,629,504 RGD:6480464
G Rab40b Rab40b, member RAS oncogene family JBrowse link 10 110,557,798 110,585,424 RGD:6480464
G Rpa1 replication protein A1 JBrowse link 10 62,140,419 62,191,518 RGD:6480464
G Rras2 RAS related 2 JBrowse link 1 178,940,515 179,010,257 RGD:6480464
G Sinhcaf SIN3-HDAC complex associated factor JBrowse link 4 183,401,314 183,426,439 RGD:6480464
G Stip1 stress-induced phosphoprotein 1 JBrowse link 1 222,274,133 222,293,139 RGD:6480464
G Tead1 TEA domain transcription factor 1 JBrowse link 1 177,495,500 177,714,795 RGD:6480464
G Tff1 trefoil factor 1 JBrowse link 20 9,892,124 9,895,984 RGD:6480464
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tymp thymidine phosphorylase JBrowse link 7 130,342,481 130,347,845 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464
G Upp1 uridine phosphorylase 1 JBrowse link 14 89,314,234 89,334,060 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        biochemical role 19138
          antimetabolite 8461
            doxifluridine 48
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            heteroorganic entity 19003
                              organochalcogen compound 18718
                                organooxygen compound 18629
                                  carbohydrates and carbohydrate derivatives 11703
                                    carbohydrate 11703
                                      carbohydrate derivative 11314
                                        glycosyl compound 10294
                                          N-glycosyl compound 4200
                                            nucleoside 4023
                                              deoxyribonucleoside 982
                                                pyrimidine deoxyribonucleoside 821
                                                  pyrimidine 5'-deoxyribonucleoside 48
                                                    doxifluridine 48
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.