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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doxifluridine
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Accession:CHEBI:31521 term browser browse the term
Definition:A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
Synonyms:exact_synonym: 5'-deoxy-5-fluorouridine
 related_synonym: 1-(beta-D-5-desoxyribofuranoxyl)-5-fluoruracil;   5'-Dfur;   5'-dFUrd;   5-fluoro-5'-deoxyuridine;   Formula=C9H11FN2O5;   Furtulon;   InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1;   InChIKey=ZWAOHEXOSAUJHY-ZIYNGMLESA-N;   Ro 21-9738;   Ro 219738;   SMILES=C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(F)c(=O)[nH]c1=O;   doxifluridina;   doxifluridinum
 alt_id: CHEBI:74488
 xref: CAS:3094-09-5;   Drug_Central:958;   HMDB:HMDB0060406;   KEGG:C12739;   KEGG:D01309;   LINCS:LSM-6359
 xref_mesh: MESH:C025034
 xref: PMID:19101214;   PMID:21234714;   PMID:23564503;   PMID:2947416;   PMID:3020904;   Patent:US4071680;   Reaxys:890191


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doxifluridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A increases response to substance ISO ACAA1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member increases response to substance ISO AGR2 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases response to substance ISO AKR1B1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases response to substance ISO AKR1C3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Anxa8 annexin A8 decreases response to substance ISO ANXA8 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D decreases response to substance ISO ARL4D protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836
JBrowse link
G Axl Axl receptor tyrosine kinase decreases response to substance ISO AXL protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G Ccn1 cellular communication network factor 1 decreases response to substance ISO CCN1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Cib1 calcium and integrin binding 1 increases response to substance ISO CIB1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423
JBrowse link
G Cldn3 claudin 3 increases response to substance ISO CLDN3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Dapk1 death associated protein kinase 1 increases response to substance ISO DAPK1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase affects expression
affects response to substance
decreases response to substance
multiple interactions
ISO doxifluridine affects the expression of DPYD mRNA
DPYD protein affects the susceptibility to doxifluridine
DPYD protein results in decreased susceptibility to doxifluridine
[Paclitaxel co-treated with doxifluridine] affects the expression of DPYD mRNA
CTD PMID:16646564 PMID:16734730 PMID:18630517 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
JBrowse link
G Dse dermatan sulfate epimerase decreases response to substance ISO DSE protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992
JBrowse link
G Elf3 E74 like ETS transcription factor 3 increases response to substance ISO ELF3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 increases response to substance ISO EPS8 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 increases response to substance ISO ERBB3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Etnk1 ethanolamine kinase 1 increases response to substance ISO ETNK1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:176,126,056...176,170,325
Ensembl chr 4:176,126,180...176,193,770
JBrowse link
G Fhl1 four and a half LIM domains 1 decreases response to substance ISO FHL1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Flii FLII, actin remodeling protein decreases response to substance ISO FLII protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:45,394,032...45,408,051
Ensembl chr10:45,394,032...45,407,970
JBrowse link
G Fuca1 alpha-L-fucosidase 1 increases response to substance ISO FUCA1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 5:148,152,718...148,169,972
Ensembl chr 5:148,152,700...148,169,972
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases response to substance ISO HIF1A protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases response to substance ISO HRAS protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Ifng interferon gamma multiple interactions ISO [IFNG protein results in increased expression of TYMP protein] which results in increased susceptibility to doxifluridine CTD PMID:15301717 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il17rb interleukin 17 receptor B increases response to substance ISO IL17RB protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
JBrowse link
G Lgals4 galectin 4 increases response to substance ISO LGALS4 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:84,123,497...84,132,605
Ensembl chr 1:84,124,764...84,132,481
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases response to substance ISO MRE11 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases response to substance ISO MYB protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Nme7 NME/NM23 family member 7 decreases response to substance ISO NME7 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr13:76,657,303...76,786,768
Ensembl chr13:76,657,367...76,786,765
JBrowse link
G Osmr oncostatin M receptor decreases response to substance ISO OSMR protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel decreases response to substance ISO PKD2 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825
JBrowse link
G Pkp2 plakophilin 2 increases response to substance ISO PKP2 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr11:84,661,783...84,727,730 JBrowse link
G Plce1 phospholipase C, epsilon 1 increases response to substance ISO PLCE1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases response to substance ISO PLOD2 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases response to substance ISO PRKACB protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases response to substance ISO PTPN13 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563
JBrowse link
G Pygb glycogen phosphorylase B increases response to substance ISO PYGB protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553
JBrowse link
G Rab40b Rab40b, member RAS oncogene family increases response to substance ISO RAB40B protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:106,631,514...106,659,090
Ensembl chr10:106,631,514...106,659,090
JBrowse link
G Rpa1 replication protein A1 decreases response to substance ISO RPA1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Rras2 RAS related 2 decreases response to substance ISO RRAS2 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111
JBrowse link
G Sinhcaf SIN3-HDAC complex associated factor increases response to substance ISO SINHCAF protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:181,888,301...181,913,294
Ensembl chr 4:181,888,312...181,910,276
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases response to substance ISO STIP1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Tead1 TEA domain transcription factor 1 decreases response to substance ISO TEAD1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369
JBrowse link
G Tff1 trefoil factor 1 increases response to substance ISO TFF1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Thbs1 thrombospondin 1 decreases response to substance ISO THBS1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO doxifluridine promotes the reaction [TNF protein results in increased expression of TYMP mRNA]
5-benzylacyclouridine inhibits the reaction [[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine]; [TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine; [TNF protein results in increased expression of UPP1 mRNA] which results in increased susceptibility to doxifluridine
CTD PMID:16397116 PMID:17988526 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tymp thymidine phosphorylase multiple interactions
increases metabolic processing
increases response to substance
affects expression
ISO
EXP
[5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] results in decreased susceptibility to [Zidovudine co-treated with doxifluridine]; [5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] which results in decreased susceptibility to doxifluridine; [IFNG protein results in increased expression of TYMP protein] which results in increased susceptibility to doxifluridine; [Paclitaxel co-treated with doxifluridine] affects the expression of TYMP mRNA; [TYMP protein results in increased expression of IFNA1 mRNA] which results in increased susceptibility to doxifluridine; [Zidovudine results in increased activity of TYMP protein] which results in increased susceptibility to doxifluridine; doxifluridine promotes the reaction [TNF protein results in increased expression of TYMP mRNA]
TYMP protein results in increased metabolism of doxifluridine
TYMP protein results in increased susceptibility to doxifluridine
doxifluridine affects the expression of TYMP mRNA
CTD PMID:15301717 PMID:15864645 PMID:16457948 PMID:17988526 PMID:18630517 More... NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874
JBrowse link
G Tyms thymidylate synthetase affects expression
multiple interactions
decreases response to substance
ISO doxifluridine affects the expression of TYMS mRNA
[Paclitaxel co-treated with doxifluridine] affects the expression of TYMS mRNA
TYMS protein results in decreased susceptibility to doxifluridine
CTD PMID:16734730 PMID:18630517 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Upp1 uridine phosphorylase 1 multiple interactions ISO 5-benzylacyclouridine inhibits the reaction [[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine]; [TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine; [TNF protein results in increased expression of UPP1 mRNA] which results in increased susceptibility to doxifluridine CTD PMID:16397116 NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          antimetabolite 8517
            doxifluridine 48
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            heteroorganic entity 19283
                              organochalcogen compound 19054
                                organooxygen compound 19004
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11945
                                        glycosyl compound 10978
                                          N-glycosyl compound 5515
                                            nucleoside 5376
                                              deoxyribonucleoside 2735
                                                pyrimidine deoxyribonucleoside 862
                                                  pyrimidine 5'-deoxyribonucleoside 48
                                                    doxifluridine 48
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