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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doxifluridine
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Accession:CHEBI:31521 term browser browse the term
Definition:A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
Synonyms:exact_synonym: 5'-deoxy-5-fluorouridine
 related_synonym: 1-(beta-D-5-desoxyribofuranoxyl)-5-fluoruracil;   5'-Dfur;   5'-dFUrd;   5-fluoro-5'-deoxyuridine;   Formula=C9H11FN2O5;   Furtulon;   InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1;   InChIKey=ZWAOHEXOSAUJHY-ZIYNGMLESA-N;   Ro 21-9738;   Ro 219738;   SMILES=C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(F)c(=O)[nH]c1=O;   doxifluridina;   doxifluridinum
 alt_id: CHEBI:74488
 xref: CAS:3094-09-5;   Drug_Central:958;   HMDB:HMDB0060406;   KEGG:C12739;   KEGG:D01309;   LINCS:LSM-6359
 xref_mesh: MESH:C025034
 xref: PMID:19101214;   PMID:21234714;   PMID:23564503;   PMID:2947416;   PMID:3020904;   Patent:US4071680;   Reaxys:890191


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doxifluridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A increases response to substance ISO ACAA1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member increases response to substance ISO AGR2 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases response to substance ISO AKR1B1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases response to substance ISO AKR1C3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Anxa8 annexin A8 decreases response to substance ISO ANXA8 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr16:10,417,174...10,432,388
Ensembl chr16:10,417,185...10,432,393
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D decreases response to substance ISO ARL4D protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:89,577,556...89,580,368
Ensembl chr10:89,578,212...89,580,368
JBrowse link
G Axl Axl receptor tyrosine kinase decreases response to substance ISO AXL protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Ccn1 cellular communication network factor 1 decreases response to substance ISO CCN1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Cib1 calcium and integrin binding 1 increases response to substance ISO CIB1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:142,014,962...142,020,461
Ensembl chr 1:142,014,958...142,020,525
JBrowse link
G Cldn3 claudin 3 increases response to substance ISO CLDN3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Dapk1 death associated protein kinase 1 increases response to substance ISO DAPK1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase affects expression
affects response to substance
decreases response to substance
multiple interactions
ISO doxifluridine affects the expression of DPYD mRNA
DPYD protein affects the susceptibility to doxifluridine
DPYD protein results in decreased susceptibility to doxifluridine
[Paclitaxel co-treated with doxifluridine] affects the expression of DPYD mRNA
CTD PMID:16646564, PMID:16734730, PMID:18630517 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Dse dermatan sulfate epimerase decreases response to substance ISO DSE protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr20:27,703,738...27,784,982
Ensembl chr20:27,703,732...27,782,586
JBrowse link
G Elf3 E74 like ETS transcription factor 3 increases response to substance ISO ELF3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr13:52,083,873...52,088,798
Ensembl chr13:52,083,859...52,088,780
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 increases response to substance ISO EPS8 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:171,475,155...171,645,620
Ensembl chr 4:171,475,567...171,591,882
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 increases response to substance ISO ERBB3 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Etnk1 ethanolamine kinase 1 increases response to substance ISO ETNK1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:177,402,904...177,447,047
Ensembl chr 4:177,402,904...177,447,028
JBrowse link
G Fhl1 four and a half LIM domains 1 decreases response to substance ISO FHL1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Flii FLII, actin remodeling protein decreases response to substance ISO FLII protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:46,955,460...46,969,468
Ensembl chr10:46,955,487...46,969,406
JBrowse link
G Fuca1 alpha-L-fucosidase 1 increases response to substance ISO FUCA1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 5:154,269,296...154,286,545
Ensembl chr 5:154,269,118...154,286,544
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases response to substance ISO HIF1A protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases response to substance ISO HRAS protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Ifng interferon gamma multiple interactions ISO [IFNG protein results in increased expression of TYMP protein] which results in increased susceptibility to doxifluridine CTD PMID:15301717 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il17rb interleukin 17 receptor B increases response to substance ISO IL17RB protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr16:6,064,287...6,077,978
Ensembl chr16:6,064,288...6,077,978
JBrowse link
G Lgals4 galectin 4 increases response to substance ISO LGALS4 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:87,019,598...87,027,720
Ensembl chr 1:87,019,975...87,027,691
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases response to substance ISO MRE11 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases response to substance ISO MYB protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nme7 NME/NM23 family member 7 decreases response to substance ISO NME7 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr13:82,607,844...82,737,383
Ensembl chr13:82,626,685...82,737,343
JBrowse link
G Osmr oncostatin M receptor decreases response to substance ISO OSMR protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 2:56,107,491...56,163,522
Ensembl chr 2:56,110,777...56,151,531
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel decreases response to substance ISO PKD2 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Pkp2 plakophilin 2 increases response to substance ISO PKP2 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr11:88,912,163...88,972,213 JBrowse link
G Plce1 phospholipase C, epsilon 1 increases response to substance ISO PLCE1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases response to substance ISO PLOD2 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 8:99,977,334...100,059,736
Ensembl chr 8:99,977,334...100,059,736
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases response to substance ISO PRKACB protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases response to substance ISO PTPN13 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr14:7,688,551...7,863,664
Ensembl chr14:7,688,551...7,863,664
JBrowse link
G Pygb glycogen phosphorylase B increases response to substance ISO PYGB protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
JBrowse link
G Rab40b Rab40b, member RAS oncogene family increases response to substance ISO RAB40B protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:110,557,798...110,585,424
Ensembl chr10:110,557,729...110,585,376
JBrowse link
G Rpa1 replication protein A1 decreases response to substance ISO RPA1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512
JBrowse link
G Rras2 RAS related 2 decreases response to substance ISO RRAS2 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:178,940,515...179,010,257
Ensembl chr 1:178,940,516...179,010,257
JBrowse link
G Sinhcaf SIN3-HDAC complex associated factor increases response to substance ISO SINHCAF protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 4:183,401,314...183,426,439
Ensembl chr 4:183,401,318...183,426,439
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases response to substance ISO STIP1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Tead1 TEA domain transcription factor 1 decreases response to substance ISO TEAD1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 1:177,495,500...177,714,795
Ensembl chr 1:177,495,782...177,707,061
JBrowse link
G Tff1 trefoil factor 1 increases response to substance ISO TFF1 protein results in increased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Thbs1 thrombospondin 1 decreases response to substance ISO THBS1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO doxifluridine promotes the reaction [TNF protein results in increased expression of TYMP mRNA]
5-benzylacyclouridine inhibits the reaction [[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine]; [TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine; [TNF protein results in increased expression of UPP1 mRNA] which results in increased susceptibility to doxifluridine
CTD PMID:16397116, PMID:17988526 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tymp thymidine phosphorylase multiple interactions
increases metabolic processing
increases response to substance
affects expression
ISO
EXP
[5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] results in decreased susceptibility to [Zidovudine co-treated with doxifluridine]; [5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride results in decreased activity of TYMP protein] which results in decreased susceptibility to doxifluridine; [IFNG protein results in increased expression of TYMP protein] which results in increased susceptibility to doxifluridine; [Paclitaxel co-treated with doxifluridine] affects the expression of TYMP mRNA; [TYMP protein results in increased expression of IFNA1 mRNA] which results in increased susceptibility to doxifluridine; [Zidovudine results in increased activity of TYMP protein] which results in increased susceptibility to doxifluridine; doxifluridine promotes the reaction [TNF protein results in increased expression of TYMP mRNA]
TYMP protein results in increased metabolism of doxifluridine
TYMP protein results in increased susceptibility to doxifluridine
doxifluridine affects the expression of TYMP mRNA
CTD PMID:15301717, PMID:15864645, PMID:16457948, PMID:17988526, PMID:18630517, PMID:21804305 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyms thymidylate synthetase affects expression
multiple interactions
decreases response to substance
ISO doxifluridine affects the expression of TYMS mRNA
[Paclitaxel co-treated with doxifluridine] affects the expression of TYMS mRNA
TYMS protein results in decreased susceptibility to doxifluridine
CTD PMID:16734730, PMID:18630517 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Upp1 uridine phosphorylase 1 multiple interactions ISO 5-benzylacyclouridine inhibits the reaction [[TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine]; [TNF protein results in increased activity of UPP1 protein] which results in increased susceptibility to doxifluridine; [TNF protein results in increased expression of UPP1 mRNA] which results in increased susceptibility to doxifluridine CTD PMID:16397116 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          antimetabolite 8484
            doxifluridine 48
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbohydrates and carbohydrate derivatives 12178
                                    carbohydrate 12178
                                      carbohydrate derivative 11802
                                        glycosyl compound 10846
                                          N-glycosyl compound 5334
                                            nucleoside 5194
                                              deoxyribonucleoside 2723
                                                pyrimidine deoxyribonucleoside 855
                                                  pyrimidine 5'-deoxyribonucleoside 48
                                                    doxifluridine 48
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.