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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Doramectin
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Accession:CHEBI:31516 term browser browse the term
Synonyms:related_synonym: Formula=C50H74O14;   InChI=1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35+,36-,37-,38?,39-,40-,41-,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1;   InChIKey=QLFZZSKTJWDQOS-DLZZRMBFSA-N;   SMILES=[C@@]12(O[C@@H]([C@@H](C)C=C1)C3CCCCC3)C[C@@H]4C[C@](O2)(CC=C([C@@H](O[C@H]5C[C@@H]([C@@H](O[C@H]6CC([C@@H](O)[C@@H](O6)C)OC)[C@@H](O5)C)OC)[C@H](C=CC=C7[C@]8([C@H](C(O4)=O)C=C(C)[C@H]([C@]8(OC7)[H])O)O)C)C)[H]
 xref: CAS:117704-25-3;   KEGG:D01129
 xref_mesh: MESH:C084101


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Doramectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
decreases activity		 ISO doramectin results in decreased expression of ABCB1 mRNA; doramectin results in decreased expression of ABCB1 protein
doramectin results in decreased expression of ABCB1A protein
doramectin results in decreased activity of ABCB1A protein		 CTD PMID:17134887 PMID:19879343 PMID:20487225 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Actb actin, beta decreases expression ISO doramectin results in decreased expression of ACTB protein CTD PMID:19879343 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression EXP doramectin results in decreased expression of AKT1 mRNA CTD PMID:35137919 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ano1 anoctamin 1 decreases activity ISO doramectin results in decreased activity of ANO1 protein CTD PMID:32201246 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069 		JBrowse link
G Atg5 autophagy related 5 increases expression EXP
ISO		 doramectin results in increased expression of ATG5 protein CTD PMID:35137919 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression EXP doramectin results in decreased expression of DAPK1 mRNA CTD PMID:35137919 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Deptor DEP domain containing MTOR-interacting protein decreases expression EXP doramectin results in decreased expression of DEPTOR mRNA CTD PMID:35137919 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 decreases expression EXP doramectin results in decreased expression of EIF2AK4 mRNA CTD PMID:35137919 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression EXP doramectin results in decreased expression of IGF1R mRNA CTD PMID:35137919 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression EXP doramectin results in decreased expression of ITPR1 mRNA CTD PMID:35137919 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha multiple interactions ISO
EXP		 doramectin results in increased expression of and results in increased lipidation of MAP1LC3A protein
Chloroquine inhibits the reaction [doramectin results in decreased expression of and results in increased lipidation of MAP1LC3A protein]; Chloroquine inhibits the reaction [doramectin results in decreased expression of MAP1LC3A protein]; doramectin results in decreased expression of and results in increased lipidation of MAP1LC3A protein; doramectin results in increased expression of and results in increased lipidation of MAP1LC3A protein		 CTD PMID:35137919 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mras muscle RAS oncogene homolog decreases expression EXP doramectin results in decreased expression of MRAS mRNA CTD PMID:35137919 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression EXP doramectin results in decreased expression of MTOR mRNA CTD PMID:35137919 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO doramectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO doramectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; doramectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; doramectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta decreases expression EXP doramectin results in decreased expression of PIK3CB mRNA CTD PMID:35137919 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression EXP doramectin results in decreased expression of PIK3CD mRNA CTD PMID:35137919 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 decreases expression EXP doramectin results in decreased expression of PIK3R3 mRNA CTD PMID:35137919 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases expression EXP doramectin results in decreased expression of PRKACA mRNA CTD PMID:35137919 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases expression EXP doramectin results in decreased expression of PRKACB mRNA CTD PMID:35137919 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Rragd Ras-related GTP binding D increases expression EXP doramectin results in increased expression of RRAGD mRNA CTD PMID:35137919 NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions		 EXP
ISO		 doramectin results in decreased expression of SQSTM1 protein
Chloroquine inhibits the reaction [doramectin results in decreased expression of SQSTM1 protein]		 CTD PMID:35137919 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tp53inp2 tumor protein p53 inducible nuclear protein 2 decreases expression EXP doramectin results in decreased expression of TP53INP2 mRNA CTD PMID:35137919 NCBI chr 3:143,881,427...143,890,104
Ensembl chr 3:143,882,021...143,890,097 		JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO doramectin results in decreased expression of TUBB3 protein CTD PMID:19879343 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      atom 19809
        nonmetal atom 19747
          oxygen atom 19520
            oxygen molecular entity 19490
              organooxygen compound 19137
                polyketide 10551
                  macrolide 5859
                    Doramectin 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  ester 17247
                                    carboxylic ester 16563
                                      lactone 12512
                                        macrocyclic lactone 5922
                                          macrolide 5859
                                            Doramectin 24
paths to the root