ONTOLOGY REPORT - ANNOTATIONS
Term: domperidone
Accession: CHEBI:31515
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Definition: 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Synonyms: exact_synonym: 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
related_synonym: 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one; 5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone; 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; Formula=C22H24ClN5O2; InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30); InChIKey=FGXWKSZFVQUSTL-UHFFFAOYSA-N; SMILES=Clc1ccc2n(C3CCN(CCCn4c5ccccc5[nH]c4=O)CC3)c(=O)[nH]c2c1; domperidona; domperidonum
alt_id: CHEBI:464745
xref: Beilstein:903774 "Beilstein"; CAS:57808-66-9 "ChemIDplus"; CAS:57808-66-9 "KEGG DRUG"; DrugBank:DB01184; Drug_Central:945 "DrugCentral"; KEGG:D01745; LINCS:LSM-2850
xref_mesh: MESH:D004294
xref: Patent:DE2632870; Patent:US4066772
G
Abcb1a
ATP binding cassette subfamily B member 1A
4
22,339,829
22,517,642
RGD:6480464
G
Adra1d
adrenoceptor alpha 1D
3
124,129,558
124,145,566
RGD:6480464
G
Cxcl2
C-X-C motif chemokine ligand 2
14
18,731,346
18,733,391
RGD:6480464
G
Cxcl3
chemokine (C-X-C motif) ligand 3
14
18,820,168
18,839,659
RGD:6480464
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
8
62,472,087
62,478,122
RGD:6480464
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
8
62,451,360
62,458,244
RGD:6480464
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
1
83,163,103
83,236,615
RGD:6480464
G
Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
1
147,236,480
147,307,988
RGD:6480464
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
7
123,599,264
123,608,436
RGD:6480464
G
Drd1
dopamine receptor D1
17
11,099,736
11,104,352
RGD:6480464
G
Drd2
dopamine receptor D2
8
53,678,777
53,743,643
RGD:6480464
G
Il6
interleukin 6
4
3,043,231
3,047,807
RGD:6480464
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
4
7,355,066
7,387,282
RGD:6480464
G
Mpo
myeloperoxidase
10
75,087,892
75,098,260
RGD:6480464
G
Nos2
nitric oxide synthase 2
10
66,188,290
66,221,621
RGD:6480464
G
Prl
prolactin
17
39,814,236
39,824,299
RGD:6480464
G
Slc22a2
solute carrier family 22 member 2
1
48,318,025
48,360,219
RGD:6480464
G
Tgfb1
transforming growth factor, beta 1
1
82,480,875
82,497,196
RGD:6480464
G
Thra
thyroid hormone receptor alpha
10
86,657,285
86,684,935
RGD:6480464
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