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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:domperidone
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Accession:CHEBI:31515 term browser browse the term
Definition:1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Synonyms:exact_synonym: 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
 related_synonym: 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one;   5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone;   5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one;   Formula=C22H24ClN5O2;   InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30);   InChIKey=FGXWKSZFVQUSTL-UHFFFAOYSA-N;   SMILES=Clc1ccc2n(C3CCN(CCCn4c5ccccc5[nH]c4=O)CC3)c(=O)[nH]c2c1;   domperidona;   domperidonum
 alt_id: CHEBI:464745
 xref: Beilstein:903774;   CAS:57808-66-9;   DrugBank:DB01184;   Drug_Central:945;   KEGG:D01745;   LINCS:LSM-2850
 xref_mesh: MESH:D004294
 xref: Patent:DE2632870;   Patent:US4066772

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domperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1 gene SNP affects the susceptibility to Domperidone CTD PMID:21063774 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Adra1d adrenoceptor alpha 1D affects response to substance ISO ADRA1D gene SNP affects the susceptibility to Domperidone CTD PMID:21063774 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Domperidone inhibits the reaction [Indomethacin results in increased expression of CXCL2 mRNA] CTD PMID:21691039 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Domperidone inhibits the reaction [Indomethacin results in increased expression of CXCL1 mRNA] CTD PMID:21691039 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Domperidone results in increased expression of CYP1A1 mRNA CTD PMID:9860486 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation ISO CYP1A2 protein results in increased hydroxylation of Domperidone CTD PMID:15327587 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases hydroxylation ISO CYP2B6 protein results in increased hydroxylation of Domperidone CTD PMID:15327587 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Domperidone CTD PMID:15327587 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases hydroxylation ISO CYP2D6 protein results in increased hydroxylation of Domperidone CTD PMID:15327587 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO CYP3A4 protein results in increased hydroxylation of and results in decreased alkylation of Domperidone CTD PMID:15327587 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
affects binding		 ISO Cyclosporine promotes the reaction [Domperidone binds to DRD1 protein] CTD PMID:12673668 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding		 ISO
EXP		 Cyclosporine promotes the reaction [Domperidone binds to DRD2 protein]
Domperidone binds to and results in decreased activity of DRD2 protein		 CTD PMID:2571179 PMID:8103596 PMID:10626749 PMID:12071432 PMID:12130853 PMID:12673668 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Il6 interleukin 6 decreases expression ISO Domperidone results in decreased expression of IL6 protein CTD PMID:10568223 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
affects response to substance		 ISO Domperidone results in decreased activity of KCNH2 protein
Domperidone inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
KCNH2 gene SNP affects the susceptibility to Domperidone		 CTD PMID:15640612 PMID:19583963 PMID:21063774 PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Domperidone inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:21691039 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Domperidone inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:21691039 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Prl prolactin multiple interactions
increases expression		 ISO
EXP		 Domperidone inhibits the reaction [Deoxyepinephrine results in decreased expression of PRL protein]; Domperidone inhibits the reaction [Dopamine results in decreased expression of PRL protein]
Domperidone results in increased expression of PRL protein		 CTD PMID:1304515 PMID:1874184 PMID:6736848 PMID:8532072 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Domperidone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Domperidone results in decreased expression of TGFB1 protein CTD PMID:10568223 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Domperidone binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        pharmaceutical 19304
          drug 19304
            antiemetic 5156
              domperidone 20
                domperidone maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                organic heterocyclic compound 18512
                                  organic heteropolycyclic compound 17977
                                    organic heterobicyclic compound 16784
                                      benzimidazoles 864
                                        domperidone 20
                                          domperidone maleate 0
paths to the root