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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cyclic ADP-beta-D-ribose
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Accession:CHEBI:31445 term browser browse the term
Definition:A cyclic purine nucleotide that is synthesised from NAD+ by ADP-ribosyl cyclase; acts as an agonist at ryanodine receptors.
Synonyms:related_synonym: E-NAD;   Enzyme-activated NAD;   Formula=C15H21N5O13P2;   InChI=1S/C15H21N5O13P2/c16-12-7-13-18-4-19(12)14-10(23)8(21)5(31-14)1-29-34(25,26)33-35(27,28)30-2-6-9(22)11(24)15(32-6)20(13)3-17-7/h3-6,8-11,14-16,21-24H,1-2H2,(H,25,26)(H,27,28)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1;   InChIKey=BQOHYSXSASDCEA-KEOHHSTQSA-N;   SMILES=O[C@@H]1[C@H]2COP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4n(cnc4c3=N)[C@H](O2)[C@@H]1O;   cADP-ribose;   cADPR;   cyclic ADP-ribose;   cyclic adenosine diphosphate ribose
 xref: CAS:119340-53-3;   KEGG:C13050
 xref_mesh: MESH:D036563
 xref: MetaCyc:CPD-14880;   PMID:21176119;   PMID:22274607;   PMID:22422046;   PMID:22547068;   PMID:22677461;   PMID:22822066;   PMID:22995315;   PMID:23183877;   PMID:23218671;   PMID:23343681;   PMID:32903769;   PMID:34662754;   PMID:35219154;   PMID:35457121;   PMID:36048923;   Patent:US2005065109;   Patent:US2005276762;   Patent:WO2006120681;   Reaxys:7064766;   Wikipedia:CADPR
 cyclic_relationship: is_conjugate_acid_of CHEBI:73672


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cyclic ADP-beta-D-ribose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd38 CD38 molecule decreases abundance ISO CD38 gene mutant form results in decreased abundance of Cyclic ADP-Ribose CTD PMID:23343681 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        biochemical role 19495
          metabolite 19480
            cyclic ADP-beta-D-ribose 3
              2'-phospho-cyclic ADP-ribose 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      chalcogen 19543
                        oxygen atom 19519
                          oxygen molecular entity 19519
                            hydroxides 19306
                              oxoacid 18683
                                pnictogen oxoacid 11813
                                  phosphorus oxoacid 10788
                                    phosphoric acids 9772
                                      phosphoric acid 9772
                                        phosphoric acid derivative 9515
                                          phosphate 9513
                                            organic phosphate 9513
                                              carbohydrate phosphate 1844
                                                phospho sugar 1688
                                                  aldose phosphate 1686
                                                    aldopentose phosphate 1678
                                                      ribose phosphate 1673
                                                        ribonucleotide 1632
                                                          purine ribonucleotide 1600
                                                            adenyl ribonucleotide 1301
                                                              adenosine phosphate 291
                                                                adenosine 5'-phosphate 290
                                                                  ADP 87
                                                                    ADP-sugar 7
                                                                      ADP-D-ribose 7
                                                                        ADP-beta-D-ribose 3
                                                                          cyclic ADP-beta-D-ribose 3
                                                                            2'-phospho-cyclic ADP-ribose 0
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