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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclic ADP-ribose
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Accession:CHEBI:31445 term browser browse the term
Definition:A cyclic purine nucleotide that is synthesised from NAD+ by ADP-ribosyl cyclase; acts as an agonist at ryanodine receptors.
Synonyms:related_synonym: E-NAD;   Enzyme-activated NAD;   Formula=C15H21N5O13P2;   InChI=1S/C15H21N5O13P2/c16-12-7-13-18-4-19(12)14-10(23)8(21)5(31-14)1-29-34(25,26)33-35(27,28)30-2-6-9(22)11(24)15(32-6)20(13)3-17-7/h3-6,8-11,14-16,21-24H,1-2H2,(H,25,26)(H,27,28)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1;   InChIKey=BQOHYSXSASDCEA-KEOHHSTQSA-N;   SMILES=O[C@@H]1[C@H]2COP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4n(cnc4c3=N)[C@H](O2)[C@@H]1O;   cADPR;   cyclic ADP-D-ribose;   cyclic adenosine diphosphate ribose
 xref: CAS:119340-53-3;   KEGG:C13050
 xref_mesh: MESH:D036563
 xref: MetaCyc:CPD-14880;   PMID:21176119;   PMID:22274607;   PMID:22422046;   PMID:22547068;   PMID:22677461;   PMID:22822066;   PMID:22995315;   PMID:23183877;   PMID:23218671;   PMID:23343681;   Patent:US2005065109;   Patent:US2005276762;   Patent:WO2006120681;   Reaxys:7064766;   Wikipedia:CADPR
 cyclic_relationship: is_conjugate_acid_of CHEBI:73672


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cyclic ADP-ribose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd38 CD38 molecule decreases abundance ISO CD38 gene mutant form results in decreased abundance of Cyclic ADP-Ribose CTD PMID:23343681 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            cyclic ADP-ribose 3
              2'-phospho-cyclic ADP-ribose 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoric acid derivative 7473
                                          phosphate 7473
                                            organic phosphate 7472
                                              carbohydrate phosphate 1528
                                                phospho sugar 1454
                                                  aldose phosphate 1452
                                                    aldopentose phosphate 1446
                                                      ribose phosphate 1440
                                                        ribonucleotide 1401
                                                          purine ribonucleotide 1374
                                                            adenyl ribonucleotide 1243
                                                              adenosine phosphate 250
                                                                adenosine 5'-phosphate 249
                                                                  ADP 83
                                                                    ADP-sugar 7
                                                                      ADP-D-ribose 7
                                                                        cyclic ADP-ribose 3
                                                                          2'-phospho-cyclic ADP-ribose 0
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