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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclic ADP-beta-D-ribose
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Accession:CHEBI:31445 term browser browse the term
Definition:A cyclic purine nucleotide that is synthesised from NAD+ by ADP-ribosyl cyclase; acts as an agonist at ryanodine receptors.
Synonyms:related_synonym: E-NAD;   Enzyme-activated NAD;   Formula=C15H21N5O13P2;   InChI=1S/C15H21N5O13P2/c16-12-7-13-18-4-19(12)14-10(23)8(21)5(31-14)1-29-34(25,26)33-35(27,28)30-2-6-9(22)11(24)15(32-6)20(13)3-17-7/h3-6,8-11,14-16,21-24H,1-2H2,(H,25,26)(H,27,28)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1;   InChIKey=BQOHYSXSASDCEA-KEOHHSTQSA-N;   SMILES=O[C@@H]1[C@H]2COP(O)(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4n(cnc4c3=N)[C@H](O2)[C@@H]1O;   cADP-ribose;   cADPR;   cyclic ADP-ribose;   cyclic adenosine diphosphate ribose
 xref: CAS:119340-53-3;   KEGG:C13050
 xref_mesh: MESH:D036563
 xref: MetaCyc:CPD-14880;   PMID:21176119;   PMID:22274607;   PMID:22422046;   PMID:22547068;   PMID:22677461;   PMID:22822066;   PMID:22995315;   PMID:23183877;   PMID:23218671;   PMID:23343681;   PMID:32903769;   PMID:34662754;   PMID:35219154;   PMID:35457121;   PMID:36048923;   Patent:US2005065109;   Patent:US2005276762;   Patent:WO2006120681;   Reaxys:7064766;   Wikipedia:CADPR
 cyclic_relationship: is_conjugate_acid_of CHEBI:73672



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cyclic ADP-beta-D-ribose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd38 CD38 molecule decreases abundance ISO CD38 gene mutant form results in decreased abundance of Cyclic ADP-Ribose CTD PMID:23343681 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            cyclic ADP-beta-D-ribose 3
              2'-phospho-cyclic ADP-ribose 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      chalcogen 19612
                        oxygen atom 19586
                          oxygen molecular entity 19586
                            hydroxides 19389
                              oxoacid 18783
                                pnictogen oxoacid 13194
                                  phosphorus oxoacid 12437
                                    phosphoric acids 11433
                                      phosphoric acid 11433
                                        phosphoric acid derivative 11242
                                          phosphate 11241
                                            organic phosphate 11241
                                              carbohydrate phosphate 1856
                                                phospho sugar 1701
                                                  aldose phosphate 1698
                                                    aldopentose phosphate 1690
                                                      ribose phosphate 1685
                                                        ribonucleotide 1646
                                                          purine ribonucleotide 1613
                                                            adenyl ribonucleotide 1306
                                                              adenosine phosphate 297
                                                                adenosine 5'-phosphate 296
                                                                  ADP 88
                                                                    ADP-sugar 7
                                                                      ADP-D-ribose 7
                                                                        ADP-beta-D-ribose 3
                                                                          cyclic ADP-beta-D-ribose 3
                                                                            2'-phospho-cyclic ADP-ribose 0
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