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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:crotamiton
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Accession:CHEBI:31439 term browser browse the term
Definition:An enamide resulting from the formal condensation of crotonic acid with N-ethyl-2-methylaniline. A colourless or pale yellow oily liquid, it is used in the treatment of pruritus (itching) by producing a counter-irritation: as it evaporates from the skin, it produces a cooling effect that diverts attention away from the itching. It has also been used as an acaricide in the treatment of scabies, though more effective drugs are usually preferred.
Synonyms:exact_synonym: N-ethyl-N-(2-methylphenyl)but-2-enamide
 related_synonym: Formula=C13H17NO;   InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3;   InChIKey=DNTGGZPQPQTDQF-UHFFFAOYSA-N;   N-ethyl-o-crotonotoluidide;   SMILES=CCN(C(=O)C=CC)c1ccccc1C;   crotalgin;   crotamitone;   crotamitonum;   crotonyl-N-ethyl-o-toluidine
 xref: Beilstein:3275497;   CAS:483-63-6;   DrugBank:DB00265;   Drug_Central:744;   KEGG:D01381;   LINCS:LSM-3274
 xref_mesh: MESH:C005553
 xref: Patent:GB615137


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crotamiton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO crotamiton results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
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Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pesticide 16432
          acaricide 9729
            scabicide 514
              crotamiton 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                alpha,beta-unsaturated carboxylic acid amide 4769
                                                  enamide 4769
                                                    crotamiton 1
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