|
G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
Colforsin promotes the reaction [Diethylhexyl Phthalate results in decreased expression of ABCA1 mRNA] |
CTD |
PMID:37536456 |
|
NCBI chr 5:72,473,676...72,596,563
|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions increases expression |
ISO |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of ABCB1 mRNA] |
CTD |
PMID:12926078 |
|
NCBI chr 4:26,312,403...26,488,456
|
|
G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
multiple interactions decreases expression |
ISO |
Colforsin inhibits the reaction [Doxorubicin results in increased expression of ABCB4 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in decreased expression of ABCB4 mRNA] |
CTD |
PMID:12926078 |
|
NCBI chr 4:26,106,895...26,164,440
|
|
G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO |
Colforsin results in increased expression of ABCC2 mRNA; Colforsin results in increased expression of ABCC2 protein |
CTD |
PMID:19580841 PMID:26049102 |
|
NCBI chr 1:252,613,875...252,672,459
|
|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
decreases expression multiple interactions |
ISO |
Colforsin results in decreased expression of ABCC4 mRNA Valproic Acid inhibits the reaction [Colforsin results in decreased expression of ABCC4 mRNA] |
CTD |
PMID:37385477 |
|
NCBI chr15:101,948,387...102,182,912
|
|
G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of ABCG2 mRNA Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]] |
CTD |
PMID:19580841 PMID:30610963 |
|
NCBI chr 4:89,006,056...89,132,915
|
|
G |
Acaca |
acetyl-CoA carboxylase alpha |
increases phosphorylation |
ISO |
Colforsin results in increased phosphorylation of ACACA protein |
CTD |
PMID:18390901 |
|
NCBI chr10:69,511,627...69,773,888
|
|
G |
Ache |
acetylcholinesterase |
increases activity increases expression |
EXP |
Colforsin results in increased activity of ACHE protein; Colforsin results in increased activity of ACHE protein alternative form Colforsin results in increased expression of ACHE mRNA |
CTD |
PMID:18514641 |
|
NCBI chr12:25,042,882...25,050,608
|
|
G |
Acsl3 |
acyl-CoA synthetase long-chain family member 3 |
increases expression |
ISO |
Colforsin results in increased expression of ACSL3 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 9:80,115,164...80,164,636
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
ISO EXP |
Colforsin results in decreased expression of ACTA2 protein Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:21603974 PMID:27590029 |
|
NCBI chr 1:241,159,723...241,172,503
|
|
G |
Adam12 |
ADAM metallopeptidase domain 12 |
decreases expression |
ISO |
Colforsin results in decreased expression of ADAM12 mRNA |
CTD |
PMID:15313392 PMID:15967414 |
|
NCBI chr 1:188,686,984...189,014,206
|
|
G |
Adamts1 |
ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
decreases expression |
ISO |
Colforsin results in decreased expression of ADAMTS1 mRNA |
CTD |
PMID:15313392 PMID:15967414 |
|
NCBI chr11:38,418,565...38,427,384
|
|
G |
Adcy5 |
adenylate cyclase 5 |
multiple interactions |
ISO |
ADCY5 protein results in increased susceptibility to [Colforsin co-treated with Quinpirole] |
CTD |
PMID:12223546 |
|
NCBI chr11:78,976,861...79,123,343
|
|
G |
Adcy6 |
adenylate cyclase 6 |
affects response to substance |
ISO |
ADCY6 protein affects the susceptibility to Colforsin |
CTD |
PMID:12393090 |
|
NCBI chr 7:131,621,860...131,642,923
|
|
G |
Adcy9 |
adenylate cyclase 9 |
multiple interactions increases activity |
ISO |
[Colforsin co-treated with Miconazole] results in increased activity of ADCY9 protein Colforsin results in increased activity of ADCY9 protein |
CTD |
PMID:30607468 |
|
NCBI chr10:11,645,373...11,768,462
|
|
G |
Adm |
adrenomedullin |
multiple interactions increases expression |
ISO |
cobaltous chloride inhibits the reaction [Valproic Acid inhibits the reaction [Colforsin results in increased expression of ADM mRNA]]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of ADM mRNA] |
CTD |
PMID:38296531 |
|
NCBI chr 1:174,164,178...174,182,372
|
|
G |
Adra1a |
adrenoceptor alpha 1A |
multiple interactions |
ISO |
[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium] |
CTD |
PMID:19419905 |
|
NCBI chr15:45,005,648...45,111,416
|
|
G |
Adra2c |
adrenoceptor alpha 2C |
multiple interactions increases expression affects localization |
ISO |
AKAP13 protein modified form affects the reaction [Colforsin affects the localization of ADRA2C protein]; AKAP13 protein modified form affects the reaction [Colforsin results in increased expression of ADRA2C mRNA] |
CTD |
PMID:24701590 |
|
NCBI chr14:75,470,884...75,472,846
|
|
G |
Adrb1 |
adrenoceptor beta 1 |
affects response to substance multiple interactions |
ISO |
ADRB1 protein polymorphism affects the susceptibility to Colforsin [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein] |
CTD |
PMID:14502278 PMID:19419905 |
|
NCBI chr 1:265,777,103...265,780,114
|
|
G |
Adrb2 |
adrenoceptor beta 2 |
multiple interactions increases phosphorylation increases expression |
ISO |
[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] promotes the reaction [[ADRB1 protein binds to ADRB2 protein] which results in increased abundance of Cyclic AMP]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein] Colforsin results in increased phosphorylation of ADRB2 protein Colforsin results in increased expression of ADRB2 mRNA |
CTD |
PMID:14722251 PMID:19419905 PMID:24705868 |
|
NCBI chr18:57,912,760...57,914,802
|
|
G |
Adrb3 |
adrenoceptor beta 3 |
decreases expression |
ISO |
Colforsin results in decreased expression of ADRB3 mRNA |
CTD |
PMID:10725275 |
|
NCBI chr16:64,839,820...64,844,552
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions affects localization |
ISO |
[Colforsin results in increased activity of AHR protein] which results in increased expression of CXCL8 mRNA; [Colforsin results in increased activity of AHR protein] which results in increased expression of CXCL8 protein; [Colforsin results in increased activity of AHR protein] which results in increased secretion of CXCL8 protein; Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]]; PDE2A protein inhibits the reaction [Colforsin affects the localization of AHR protein] AHR protein inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA] |
CTD |
PMID:15972329 PMID:17329248 PMID:17823304 PMID:23291558 |
|
NCBI chr 6:57,961,423...57,998,901
|
|
G |
Akap13 |
A-kinase anchoring protein 13 |
multiple interactions |
ISO |
AKAP13 protein modified form affects the reaction [Colforsin affects the localization of ADRA2C protein]; AKAP13 protein modified form affects the reaction [Colforsin results in increased expression of ADRA2C mRNA]; AKAP13 protein modified form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:24701590 |
|
NCBI chr 1:129,313,183...129,619,647
|
|
G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
decreases expression |
ISO |
Colforsin results in decreased expression of AKR1C3 mRNA |
CTD |
PMID:28235592 |
|
NCBI chr17:71,020,884...71,037,779
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:16339297 |
|
NCBI chr 6:137,534,810...137,555,131
|
|
G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions |
EXP |
Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein] |
CTD |
PMID:16339297 |
|
NCBI chr 1:92,004,705...92,061,420
|
|
G |
Akt3 |
AKT serine/threonine kinase 3 |
multiple interactions |
EXP |
Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] |
CTD |
PMID:16339297 |
|
NCBI chr13:91,475,839...91,758,060
|
|
G |
Alb |
albumin |
multiple interactions |
EXP |
Colforsin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein] |
CTD |
PMID:27590029 |
|
NCBI chr14:17,891,564...17,907,043
|
|
G |
Alpi |
alkaline phosphatase, intestinal |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Methotrexate results in increased activity of ALPI protein] |
CTD |
PMID:16598758 |
|
NCBI chr 9:95,221,314...95,224,780
|
|
G |
Alpp |
alkaline phosphatase, placental |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of ALPP mRNA [Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of ALPP mRNA; Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Desipramine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA] |
CTD |
PMID:16036225 |
|
NCBI chr 9:95,213,763...95,216,509
|
|
G |
Aoc1 |
amine oxidase, copper containing 1 |
increases activity |
EXP |
Colforsin results in increased activity of AOC1 protein |
CTD |
PMID:2860926 |
|
NCBI chr 4:79,143,126...79,162,705
|
|
G |
Appbp2 |
amyloid beta precursor protein binding protein 2 |
decreases expression |
ISO |
Colforsin results in decreased expression of APPBP2 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr10:70,555,212...70,597,267
|
|
G |
Ar |
androgen receptor |
multiple interactions increases expression |
ISO |
AR protein affects the reaction [Colforsin results in decreased expression of SESN1 protein]; AR protein promotes the reaction [Colforsin results in increased expression of HMGCR protein]; AR protein promotes the reaction [Colforsin results in increased expression of INSIG1 protein]; AR protein promotes the reaction [Colforsin results in increased expression of KLK2 protein]; AR protein promotes the reaction [Colforsin results in increased expression of KLK3 protein]; Colforsin promotes the reaction [Metribolone results in increased activity of AR protein] Colforsin results in increased expression of AR protein |
CTD |
PMID:16751804 PMID:17219378 |
|
NCBI chr X:63,104,771...63,273,934
|
|
G |
Areg |
amphiregulin |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of AREG mRNA N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG protein] |
CTD |
PMID:15284208 PMID:15313392 PMID:15474502 PMID:15967414 PMID:20378682 |
|
NCBI chr14:17,256,384...17,265,641
|
|
G |
Arrb1 |
arrestin, beta 1 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] |
CTD |
PMID:24334028 |
|
NCBI chr 1:163,249,654...163,321,711
|
|
G |
Atxn3 |
ataxin 3 |
decreases expression |
ISO |
Colforsin results in decreased expression of ATXN3 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 6:126,837,107...126,872,919
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[S-(1,2-dichlorovinyl)cysteine co-treated with Colforsin] results in decreased expression of BCL2 mRNA; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Colforsin results in increased expression of BCL2 mRNA] |
CTD |
PMID:36336211 PMID:37544576 |
|
NCBI chr13:23,204,464...23,366,900
|
|
G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions increases expression |
ISO EXP |
1-bromopropane inhibits the reaction [Colforsin results in increased expression of BDNF mRNA]; 1-bromopropane inhibits the reaction [Colforsin results in increased expression of BDNF protein] Colforsin results in increased expression of BDNF mRNA; Colforsin results in increased expression of BDNF protein Colforsin inhibits the reaction [Caffeine results in decreased expression of BDNF mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of BDNF protein] |
CTD |
PMID:19189864 PMID:35917217 |
|
NCBI chr 3:116,619,633...116,670,212
|
|
G |
Bmal1 |
basic helix-loop-helix ARNT like 1 |
increases expression |
ISO |
Colforsin results in increased expression of BMAL1 mRNA |
CTD |
PMID:30524225 |
|
NCBI chr 1:176,766,222...176,864,741
|
|
G |
Bmp6 |
bone morphogenetic protein 6 |
multiple interactions |
ISO |
BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of HSD3B1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of OXT mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]; FST protein inhibits the reaction [BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]] |
CTD |
PMID:18936084 |
|
NCBI chr17:26,523,704...26,785,558
|
|
G |
C4a |
complement C4A |
multiple interactions |
ISO |
[Colforsin co-treated with Diethylhexyl Phthalate] affects the expression of C4A mRNA |
CTD |
PMID:35892601 |
|
NCBI chr20:4,010,306...4,024,707
|
|
G |
Cacna1g |
calcium voltage-gated channel subunit alpha1 G |
multiple interactions |
EXP |
Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1G protein]; Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1G protein] |
CTD |
PMID:17110049 |
|
NCBI chr10:79,851,886...79,919,926
|
|
G |
Cacna1h |
calcium voltage-gated channel subunit alpha1 H |
multiple interactions |
EXP |
Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein]; Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1H protein] |
CTD |
PMID:17110049 |
|
NCBI chr10:14,894,630...14,952,317
|
|
G |
Cacna1i |
calcium voltage-gated channel subunit alpha1 I |
multiple interactions |
EXP |
Mibefradil inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein]; Nickel inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1I protein] |
CTD |
PMID:17110049 |
|
NCBI chr 7:113,716,266...113,827,670
|
|
G |
Calcrl |
calcitonin receptor like receptor |
multiple interactions |
ISO |
Colforsin inhibits the reaction [EDN1 protein results in increased expression of CALCRL mRNA] |
CTD |
PMID:25194819 |
|
NCBI chr 3:89,835,071...89,932,616
|
|
G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2 |
increases expression |
ISO |
Colforsin results in increased expression of CAMKK2 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr12:39,451,828...39,505,719
|
|
G |
Cask |
calcium/calmodulin dependent serine protein kinase |
multiple interactions increases phosphorylation |
EXP |
Colforsin promotes the reaction [CASK protein modified form binds to TBR1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CASK protein] |
CTD |
PMID:20067577 |
|
NCBI chr X:11,572,328...11,915,831
|
|
G |
Casp1 |
caspase 1 |
increases activity |
EXP |
Colforsin results in increased activity of CASP1 mRNA; Colforsin results in increased activity of CASP1 protein |
CTD |
PMID:21832250 |
|
NCBI chr 8:10,746,338...10,882,295
|
|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO EXP |
Colforsin results in increased activity of CASP3 protein Colforsin inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein] KT 5720 inhibits the reaction [Colforsin results in increased activity of CASP3 protein] Colforsin inhibits the reaction [Puromycin Aminonucleoside results in increased activity of CASP3 protein] |
CTD |
PMID:16396944 PMID:20131233 PMID:21745194 PMID:31278978 |
|
NCBI chr16:52,395,539...52,413,794
|
|
G |
Cat |
catalase |
multiple interactions |
EXP |
Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein] |
CTD |
PMID:29283200 |
|
NCBI chr 3:110,297,340...110,329,526
|
|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Reactive Oxygen Species results in increased expression of CCL5 mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] |
CTD |
PMID:10495789 |
|
NCBI chr10:68,820,330...68,824,906
|
|
G |
Cd55 |
CD55 molecule (Cromer blood group) |
multiple interactions increases expression |
ISO |
3',4'-dimethoxy-alpha-naphthoflavone inhibits the reaction [Colforsin results in increased expression of CD55 mRNA] |
CTD |
PMID:22553215 |
|
NCBI chr13:44,409,574...44,438,913
|
|
G |
Cdc6 |
cell division cycle 6 |
increases expression |
ISO |
Colforsin results in increased expression of CDC6 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr10:84,360,361...84,374,239
|
|
G |
Cdh1 |
cadherin 1 |
affects activity increases expression |
ISO |
Colforsin affects the activity of CDH1 protein Colforsin results in increased expression of CDH1 protein |
CTD |
PMID:10413674 PMID:30983542 |
|
NCBI chr19:51,402,178...51,471,572
|
|
G |
Cdrt4 |
CMT1A duplicated region transcript 4 |
multiple interactions |
ISO |
[Colforsin co-treated with Diethylhexyl Phthalate] affects the expression of CDRT4 mRNA |
CTD |
PMID:35892601 |
|
NCBI chr10:47,625,470...47,657,493
|
|
G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions increases expression |
ISO EXP |
Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPA mRNA] Colforsin results in increased expression of CEBPA protein Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CEBPA protein] |
CTD |
PMID:17407152 PMID:21832167 |
|
NCBI chr 1:87,759,631...87,762,303
|
|
G |
Cebpb |
CCAAT/enhancer binding protein beta |
increases expression multiple interactions |
ISO EXP |
Colforsin results in increased expression of CEBPB mRNA [Atrazine co-treated with Colforsin] results in increased expression of CEBPB protein |
CTD |
PMID:14684744 PMID:25253736 |
|
NCBI chr 3:176,817,005...176,818,436
|
|
G |
Cftr |
CF transmembrane conductance regulator |
affects localization increases activity multiple interactions |
ISO EXP |
Colforsin affects the localization of CFTR protein Colforsin analog results in increased activity of CFTR protein mutant form; Colforsin results in increased activity of CFTR protein; Colforsin results in increased activity of CFTR protein mutant form 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Colforsin results in increased activity of CFTR protein]; 5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; 6-hydroxy-10-chlorobenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; [1-Methyl-3-isobutylxanthine co-treated with Colforsin] results in increased activity of CFTR protein; [1-Methyl-3-isobutylxanthine co-treated with Colforsin] results in increased activity of CFTR protein mutant form; [5-butyl-6-hydroxy-10-chlorobenzo(c)quinolizinium chloride co-treated with Colforsin] results in increased activity of CFTR protein mutant form; [[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CFTR protein; [Colforsin co-treated with Genistein] results in increased activity of CFTR protein; [Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [Colforsin co-treated with NS 004] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin] results in increased activity of CFTR protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]; Colforsin binds to and results in decreased activity of CFTR protein; Colforsin promotes the reaction [CFTR protein affects the export of Chlorides]; Colforsin promotes the reaction [Nimodipine results in increased activity of CFTR protein]; Colforsin results in increased phosphorylation of and results in increased activity of CFTR protein; fenamic acid inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; fenamic acid inhibits the reaction [Colforsin results in increased activity of CFTR protein]; geldanamycin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; geldanamycin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Glyburide inhibits the reaction [[[Colforsin co-treated with Genistein] results in increased activity of CFTR protein] which results in increased transport of Iodides]; Glyburide inhibits the reaction [Colforsin results in increased activity of CFTR protein]; miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CFTR protein]; Ozone inhibits the reaction [Colforsin results in increased activity of CFTR protein]; Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; VRT 532 analog promotes the reaction [Colforsin results in increased activity of CFTR protein mutant form]; VRT 532 promotes the reaction [Colforsin results in increased activity of CFTR protein mutant form] [1-Methyl-3-isobutylxanthine co-treated with Colforsin] results in increased activity of CFTR protein; Colforsin promotes the reaction [Nimodipine results in increased activity of CFTR protein] [Colforsin co-treated with Genistein] results in increased activity of CFTR protein; AICA ribonucleotide inhibits the reaction [Colforsin results in increased activity of CFTR protein] |
CTD |
PMID:12519745 PMID:12914781 PMID:14502435 PMID:14967738 PMID:15163550 PMID:15194485 PMID:15246976 PMID:15389550 PMID:15517342 PMID:15763242 PMID:15790911 PMID:15986093 PMID:15994425 PMID:16027156 PMID:16038730 PMID:17596272 PMID:18230692 PMID:19061877 PMID:21724857 PMID:22074181 PMID:32374624 PMID:33872679 More...
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NCBI chr 4:47,422,084...47,694,646
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G |
Cga |
glycoprotein hormones, alpha polypeptide |
increases secretion multiple interactions increases expression |
ISO EXP |
Colforsin results in increased secretion of CGA protein Colforsin inhibits the reaction [ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]] Colforsin promotes the reaction [CGA protein results in increased abundance of Cyclic AMP]; perfluorobutanesulfonic acid inhibits the reaction [Colforsin results in increased expression of CGA protein]; perfluorooctane sulfonic acid inhibits the reaction [Colforsin results in increased expression of CGA protein] Colforsin results in increased expression of CGA mRNA |
CTD |
PMID:8404651 PMID:16503475 PMID:20378682 PMID:33144174 |
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NCBI chr 5:54,283,109...54,295,464
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G |
Cidec |
cell death-inducing DFFA-like effector c |
increases expression |
ISO |
Colforsin results in increased expression of CIDEC protein |
CTD |
PMID:21097823 |
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NCBI chr 4:146,569,288...146,582,173
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G |
Cnr1 |
cannabinoid receptor 1 |
multiple interactions increases activity affects response to substance |
ISO |
(1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (4-ethyl-1-naphthalenyl)(1-(5-fluoropentyl)-1H-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(2-cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-3-(1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Dronabinol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of CNR1 mRNA; AM 6527 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; AM 6527 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; CNR1 protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [Colforsin results in increased activity of CNR1 protein]; Dronabinol inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Dronabinol inhibits the reaction [Colforsin results in increased activity of CNR1 protein]; FDU-PB-22 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; FUB-PB-22 compound inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indazoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-pentylindazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; napht-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; THJ-2201 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]] CNR1 protein affects the susceptibility to Colforsin |
CTD |
PMID:27429655 PMID:27527584 PMID:28861508 PMID:31154070 |
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NCBI chr 5:53,204,867...53,230,396
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G |
Cnr2 |
cannabinoid receptor 2 |
multiple interactions affects response to substance increases activity |
ISO |
(1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; (4-ethyl-1-naphthalenyl)(1-(5-fluoropentyl)-1H-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(2-cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 1-pentyl-3-(1-naphthoyl)indole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 2-(4-methoxyphenyl)-1-(1-pentyl-indol-3-yl)methanone inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-((adamantan-1-yl)carbonyl)-1-pentylindole inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased activity of CNR2 protein]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Dronabinol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of CNR2 mRNA; [virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; AM 6527 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; AM 6527 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; CNR2 protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; Dronabinol inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Dronabinol inhibits the reaction [Colforsin results in increased activity of CNR2 protein]; FDU-PB-22 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; FUB-PB-22 compound inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indazoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Indoles analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(1-adamantyl)-1-pentylindazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-(adamtan-1-yl)-1-pentyl-1H-indole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; N-1-naphthalenyl-1-pentyl-1H-indazole-3-carboxamide inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; napht-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; Pertussis Toxin inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; SR 144528 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; SR 144528 inhibits the reaction [[virodhamine binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; THJ-2201 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 analog inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]]; XLR-11 inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]] CNR2 protein affects the susceptibility to Colforsin |
CTD |
PMID:17558435 PMID:27429655 PMID:27527584 PMID:28861508 PMID:30504240 PMID:31154070 More...
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NCBI chr 5:153,408,968...153,435,092
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases activity increases phosphorylation multiple interactions increases expression |
ISO EXP |
Colforsin results in increased activity of CREB1 protein Colforsin results in increased phosphorylation of CREB1 protein [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of CREB1 protein; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of CREB1 protein]; oxophenylarsine inhibits the reaction [Colforsin results in increased activity of CREB1 protein]; oxophenylarsine inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; RTKI cpd inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] AKAP13 protein modified form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; anandamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]; Colforsin results in increased phosphorylation of and results in increased activity of CREB1 protein 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; Colforsin inhibits the reaction [Caffeine results in decreased expression of CREB1 mRNA]; Colforsin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CREB1 protein modified form]; Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; Okadaic Acid inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; Resveratrol inhibits the reaction [Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]]; Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; SIRT1 protein inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; SIRT1 protein mutant form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] Colforsin results in increased expression of CREB1 mRNA; Colforsin results in increased expression of CREB1 protein modified form |
CTD |
PMID:10908723 PMID:11113530 PMID:15522277 PMID:17141199 PMID:17322281 PMID:17460731 PMID:17680988 PMID:18004999 PMID:20512473 PMID:21745194 PMID:23292070 PMID:24701590 PMID:27509375 PMID:27590029 PMID:28051915 PMID:28601556 PMID:29179997 PMID:30610963 PMID:35917217 More...
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|
NCBI chr 9:73,397,333...73,466,339
|
|
G |
Crebbp |
CREB binding protein |
multiple interactions |
ISO |
Colforsin promotes the reaction [GCM1 protein binds to CREBBP protein]; CREBBP protein affects the reaction [Colforsin results in increased activity of GCM1 protein] |
CTD |
PMID:16166624 |
|
NCBI chr10:11,842,307...11,968,266
|
|
G |
Crem |
cAMP responsive element modulator |
increases expression |
EXP |
Colforsin results in increased expression of CREM mRNA; Colforsin results in increased expression of CREM mRNA alternative form; Colforsin results in increased expression of CREM protein |
CTD |
PMID:8810303 PMID:12791704 |
|
NCBI chr17:58,932,011...59,001,160
|
|
G |
Crh |
corticotropin releasing hormone |
multiple interactions increases secretion |
EXP ISO |
CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]; CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [Colforsin results in increased chemical synthesis of Testosterone] [perfluorooctane sulfonic acid co-treated with Colforsin] results in increased expression of CRH mRNA Colforsin results in increased secretion of CRH protein |
CTD |
PMID:2153673 PMID:33144174 |
|
NCBI chr 2:104,059,184...104,061,048
|
|
G |
Crls1 |
cardiolipin synthase 1 |
increases expression |
ISO |
Colforsin results in increased expression of CRLS1 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 3:140,572,680...140,591,543
|
|
G |
Cryab |
crystallin, alpha B |
multiple interactions |
EXP |
Colforsin inhibits the reaction [arsenite results in increased expression of CRYAB protein] |
CTD |
PMID:8769853 |
|
NCBI chr 8:59,989,885...59,995,532
|
|
G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
affects expression increases expression multiple interactions |
ISO EXP |
Colforsin affects the expression of CYP11A1 mRNA Colforsin results in increased expression of CYP11A1 protein [Atrazine co-treated with Colforsin] results in increased expression of CYP11A1 mRNA; RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 protein] [Colforsin co-treated with triptolide] results in decreased expression of CYP11A1 mRNA; Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of CYP11A1 mRNA] [Colforsin co-treated with Zearalenone] results in increased expression of CYP11A1 mRNA |
CTD |
PMID:14691014 PMID:16935330 PMID:17080404 PMID:18936084 PMID:20726872 PMID:22446829 PMID:22948218 PMID:25253736 PMID:25765474 PMID:25871633 PMID:26783879 PMID:28235592 PMID:31557376 More...
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|
NCBI chr 8:67,318,665...67,330,196
|
|
G |
Cyp11b2 |
cytochrome P450, family 11, subfamily b, polypeptide 2 |
increases activity multiple interactions increases expression |
ISO |
Colforsin results in increased activity of CYP11B1 protein [1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B1 mRNA; [Colforsin co-treated with triptolide] results in decreased expression of CYP11B1 mRNA; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B1 mRNA] |
CTD |
PMID:12525251 PMID:17080404 PMID:19164467 PMID:19900470 PMID:21256172 PMID:25765474 PMID:25871633 PMID:28235592 PMID:31557376 More...
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|
NCBI chr 7:108,719,349...108,726,024
|
|
G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of CYP11B2 mRNA [1-chloro-4-(2,2-dichloro-1-(4-chlorophenyl)ethenyl)-3-(methylsulfonyl)benzene co-treated with Colforsin] affects the expression of CYP11B2 mRNA; [Colforsin co-treated with triptolide] results in decreased expression of CYP11B2 mRNA; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA]; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA] |
CTD |
PMID:16935330 PMID:17080404 PMID:19164467 PMID:19900470 PMID:21256172 PMID:22446829 PMID:25765474 PMID:25871633 PMID:28235592 PMID:31557376 More...
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|
NCBI chr 7:106,808,559...106,814,048
|
|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of CYP17A1 mRNA [Colforsin co-treated with triptolide] results in decreased expression of CYP17A1 mRNA; Apigenin inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Metyrapone inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; TGFB1 protein inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] |
CTD |
PMID:15625562 PMID:15886251 PMID:16935330 PMID:17080404 PMID:20726872 PMID:22446829 PMID:22461451 PMID:23370353 PMID:25871633 PMID:28235592 PMID:31100596 PMID:31557376 More...
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|
NCBI chr 1:245,535,462...245,543,148
|
|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases activity increases expression multiple interactions |
ISO EXP |
Colforsin results in increased activity of CYP19A1 protein Colforsin results in increased expression of CYP19A1 mRNA Colforsin results in increased expression of CYP19A1 mRNA; Colforsin results in increased expression of CYP19A1 protein RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 protein] 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; [Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA; [Colforsin results in increased activity of CYP19A1 protein] which results in increased abundance of Estradiol; [Colforsin results in increased activity of CYP19A1 protein] which results in increased abundance of Testosterone; Alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; Atrazine inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; BMP6 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; mono-(2-ethylhexyl)phthalate inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR4A1 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR4A2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR4A3 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased activity of CYP19A1 protein]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA]; ZNF461 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA] |
CTD |
PMID:14691014 PMID:16357189 PMID:16935330 PMID:16996190 PMID:17080404 PMID:18936084 PMID:19822197 PMID:20087668 PMID:20723554 PMID:20726872 PMID:22446829 PMID:22461451 PMID:22948218 PMID:24361490 PMID:25765474 PMID:25871633 PMID:28235592 PMID:28859905 PMID:29701941 PMID:31100596 PMID:37551828 More...
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|
NCBI chr 8:63,449,148...63,476,534
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions affects expression |
EXP ISO |
Colforsin inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein] Colforsin affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] Colforsin affects the expression of CYP1A1 mRNA Valproic Acid affects the reaction [Colforsin affects the expression of CYP1A1 mRNA] |
CTD |
PMID:1849469 PMID:15710352 PMID:20726872 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO EXP |
Colforsin affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] Colforsin inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein] |
CTD |
PMID:1849469 PMID:15710352 |
|
NCBI chr 8:66,971,261...66,978,149
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
EXP |
Colforsin results in increased expression of CYP1B1 mRNA; Colforsin results in increased expression of CYP1B1 protein |
CTD |
PMID:7588239 |
|
NCBI chr 6:21,093,927...21,103,091
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
[S-(1,2-dichlorovinyl)cysteine co-treated with Colforsin] results in decreased expression of CYP2E1 mRNA |
CTD |
PMID:37544576 |
|
NCBI chr 1:205,269,967...205,280,365
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of CYP3A4 mRNA [S-(1,2-dichlorovinyl)cysteine co-treated with Colforsin] results in increased expression of CYP3A4 mRNA |
CTD |
PMID:37544576 |
|
NCBI chr12:14,321,771...14,343,886
|
|
G |
Dbh |
dopamine beta-hydroxylase |
multiple interactions increases expression |
EXP |
Colforsin inhibits the reaction [Atrazine results in decreased expression of DBH protein]; Colforsin inhibits the reaction [Simazine results in decreased expression of DBH protein] Colforsin results in increased expression of DBH protein |
CTD |
PMID:14550852 |
|
NCBI chr 3:30,886,313...30,903,313
|
|
G |
Dct |
dopachrome tautomerase |
increases expression |
ISO |
Colforsin results in increased expression of DCT mRNA; Colforsin results in increased expression of DCT protein |
CTD |
PMID:17460731 PMID:28601556 |
|
NCBI chr15:101,469,159...101,508,029
|
|
G |
Dio2 |
iodothyronine deiodinase 2 |
increases activity increases expression multiple interactions |
ISO EXP |
Colforsin results in increased activity of DIO2 protein Colforsin results in increased expression of DIO2 mRNA Buthionine Sulfoximine inhibits the reaction [Colforsin results in increased activity of DIO2 protein]; Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]; Hydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]; Sodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]; U 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]; U 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]] |
CTD |
PMID:18420745 PMID:19036883 |
|
NCBI chr 6:115,396,308...115,410,594
|
|
G |
Dio3 |
iodothyronine deiodinase 3 |
multiple interactions |
EXP |
Colforsin promotes the reaction [Hydrogen Peroxide results in increased expression of DIO3 mRNA] |
CTD |
PMID:18420745 |
|
NCBI chr 6:129,285,747...129,287,608
|
|
G |
Dnm1l |
dynamin 1-like |
multiple interactions decreases expression |
ISO |
PINK1 protein affects the reaction [Colforsin results in decreased expression of DNM1L protein] |
CTD |
PMID:24792327 |
|
NCBI chr11:98,084,049...98,135,663
|
|
G |
Drd2 |
dopamine receptor D2 |
multiple interactions |
ISO |
[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] |
CTD |
PMID:17958328 |
|
NCBI chr 8:58,605,403...58,669,339
|
|
G |
Dynll2 |
dynein light chain LC8-type 2 |
increases expression |
ISO |
Colforsin results in increased expression of DYNLL2 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr10:73,264,260...73,283,042
|
|
G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [EDN1 protein results in increased expression of CALCRL mRNA]; Colforsin inhibits the reaction [EDN1 protein results in increased expression of ICAM2 mRNA] |
CTD |
PMID:25194819 |
|
NCBI chr17:22,660,799...22,666,687
|
|
G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein] |
CTD |
PMID:32092105 |
|
NCBI chr 2:220,893,660...220,976,331
|
|
G |
Egr1 |
early growth response 1 |
decreases expression multiple interactions |
ISO |
Colforsin results in decreased expression of EGR1 mRNA; Colforsin results in decreased expression of EGR1 protein Colforsin inhibits the reaction [Ethanol results in increased expression of EGR1 mRNA]; Colforsin inhibits the reaction [Ethanol results in increased expression of EGR1 protein]; Ethanol inhibits the reaction [Colforsin results in decreased expression of EGR1 mRNA]; Ethanol inhibits the reaction [Colforsin results in decreased expression of EGR1 protein] |
CTD |
PMID:29802914 |
|
NCBI chr18:26,737,078...26,740,877
|
|
G |
Eif2b5 |
eukaryotic translation initiation factor 2B subunit epsilon |
increases expression |
ISO |
Colforsin results in increased expression of EIF2B5 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr11:80,394,433...80,404,468
|
|
G |
Eif5a2 |
eukaryotic translation initiation factor 5A2 |
decreases expression |
ISO |
Colforsin results in decreased expression of EIF5A2 mRNA |
CTD |
PMID:30983542 |
|
NCBI chr 2:111,728,587...111,746,087
|
|
G |
Ephx1 |
epoxide hydrolase 1 |
affects expression multiple interactions |
ISO |
Colforsin affects the expression of EPHX1 mRNA Valproic Acid affects the reaction [Colforsin affects the expression of EPHX1 mRNA] |
CTD |
PMID:20726872 |
|
NCBI chr13:95,246,079...95,275,852
|
|
G |
Eps8 |
EGFR pathway substrate 8, signaling adaptor |
decreases expression |
ISO |
Colforsin results in decreased expression of EPS8 mRNA |
CTD |
PMID:15313392 PMID:15967414 |
|
NCBI chr 4:170,388,378...170,486,873
|
|
G |
Ereg |
epiregulin |
increases expression |
ISO |
Colforsin results in increased expression of EREG mRNA |
CTD |
PMID:15313392 PMID:15474502 PMID:15967414 PMID:20378682 |
|
NCBI chr14:17,311,485...17,325,260
|
|
G |
Ervfrd-1 |
endogenous retrovirus group FRD member 1, envelope |
multiple interactions increases secretion increases expression |
ISO |
[Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [Colforsin results in increased expression of ERVFRD-1 mRNA]; Colforsin promotes the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the reaction [Colforsin results in increased expression of ERVFRD-1 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of ERVFRD-1 mRNA] Colforsin results in increased secretion of ERVFRD-1 protein Colforsin results in increased expression of ERVFRD-1 mRNA; Colforsin results in increased expression of ERVFRD-1 protein |
CTD |
PMID:24361490 PMID:29679653 PMID:31278978 PMID:33144174 PMID:35908931 PMID:36336211 PMID:37385477 PMID:38296531 More...
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|
NCBI chr12:22,151,211...22,158,264
|
|
G |
Esr1 |
estrogen receptor 1 |
decreases expression |
ISO |
Colforsin results in decreased expression of ESR1 mRNA |
CTD |
PMID:31278978 |
|
NCBI chr 1:43,511,685...43,904,454
|
|
G |
Esr2 |
estrogen receptor 2 |
multiple interactions decreases expression |
ISO |
Colforsin inhibits the reaction [ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Cyclic AMP]] Colforsin results in decreased expression of ESR2 mRNA |
CTD |
PMID:20378682 PMID:31278978 |
|
NCBI chr 6:100,589,553...100,645,240
|
|
G |
Esrra |
estrogen related receptor, alpha |
increases expression |
ISO |
Colforsin results in increased expression of ESRRA mRNA; Colforsin results in increased expression of ESRRA protein |
CTD |
PMID:20351196 |
|
NCBI chr 1:204,104,100...204,114,182
|
|
G |
Evi5 |
ecotropic viral integration site 5 |
increases expression |
ISO |
Colforsin results in increased expression of EVI5 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr14:1,875,601...2,021,678
|
|
G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
ISO |
Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese] |
CTD |
PMID:2125206 |
|
NCBI chr 3:98,051,958...98,065,246
|
|
G |
F2r |
coagulation factor II (thrombin) receptor |
multiple interactions |
ISO |
[C186 65 binds to and results in increased activity of F2R protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] |
CTD |
PMID:22207716 |
|
NCBI chr 2:26,869,343...26,885,856
|
|
G |
F2rl3 |
F2R like thrombin or trypsin receptor 3 |
multiple interactions |
ISO |
[GYPGKF-NH(2) binds to and results in increased activity of F2RL3 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] |
CTD |
PMID:22207716 |
|
NCBI chr16:17,117,441...17,119,434
|
|
G |
Fads1 |
fatty acid desaturase 1 |
increases expression |
ISO |
Colforsin results in increased expression of FADS1 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 1:216,252,605...216,267,618
|
|
G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
[Colforsin co-treated with 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime] results in increased expression of FASN mRNA; [Colforsin co-treated with Leflunomide] results in increased expression of FASN mRNA; [Colforsin co-treated with teriflunomide] results in increased expression of FASN mRNA |
CTD |
PMID:30364229 |
|
NCBI chr10:106,570,415...106,588,581
|
|
G |
Fdx1 |
ferredoxin 1 |
multiple interactions increases expression |
ISO |
ferulic acid analog promotes the reaction [Colforsin results in increased expression of FDX1 mRNA] |
CTD |
PMID:36279966 |
|
NCBI chr 8:52,268,536...52,287,344
|
|
G |
Fgf10 |
fibroblast growth factor 10 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein]; Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:12533312 PMID:14975937 |
|
NCBI chr 2:50,801,171...50,878,218
|
|
G |
Fgf2 |
fibroblast growth factor 2 |
increases expression |
ISO |
Colforsin results in increased expression of FGF2 mRNA; Colforsin results in increased expression of FGF2 protein |
CTD |
PMID:10320526 |
|
NCBI chr 2:122,164,454...122,218,796
|
|
G |
Fgf5 |
fibroblast growth factor 5 |
decreases expression |
EXP |
Colforsin results in decreased expression of FGF5 mRNA |
CTD |
PMID:11598998 |
|
NCBI chr14:11,627,906...11,650,243
|
|
G |
Fgf8 |
fibroblast growth factor 8 |
increases activity |
ISO |
Colforsin results in increased activity of FGF8 protein |
CTD |
PMID:15193767 |
|
NCBI chr 1:244,584,477...244,590,578
|
|
G |
Fgf9 |
fibroblast growth factor 9 |
multiple interactions |
ISO |
FGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]; FGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]] |
CTD |
PMID:22798350 |
|
NCBI chr15:32,208,993...32,254,952
|
|
G |
Fgfr1 |
Fibroblast growth factor receptor 1 |
increases expression |
ISO |
Colforsin results in increased expression of FGFR1 mRNA |
CTD |
PMID:10320526 |
|
NCBI chr16:73,194,631...73,249,855
|
|
G |
Fgfr2 |
fibroblast growth factor receptor 2 |
increases expression |
ISO |
Colforsin results in increased expression of FGFR2 mRNA |
CTD |
PMID:10320526 |
|
NCBI chr 1:194,175,703...194,280,914
|
|
G |
Fkbp5 |
FKBP prolyl isomerase 5 |
multiple interactions |
ISO |
Colforsin promotes the reaction [Dexamethasone results in increased expression of FKBP5 mRNA] |
CTD |
PMID:19255438 |
|
NCBI chr20:6,458,931...6,577,227
|
|
G |
Flt1 |
Fms related receptor tyrosine kinase 1 |
increases expression |
ISO |
Colforsin results in increased expression of FLT1 mRNA |
CTD |
PMID:33144174 |
|
NCBI chr12:12,333,050...12,504,750
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP |
Colforsin results in increased expression of FOS protein Dexamethasone inhibits the reaction [Colforsin results in increased expression of FOS protein] |
CTD |
PMID:11113530 |
|
NCBI chr 6:110,852,188...110,855,054
|
|
G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Colforsin results in increased expression of FOSB mRNA; Colforsin results in increased expression of FOSB protein |
CTD |
PMID:11113530 PMID:17324382 |
|
NCBI chr 1:88,082,324...88,089,506
|
|
G |
Fshb |
follicle stimulating hormone subunit beta |
increases expression |
EXP |
Colforsin results in increased expression of FSHB mRNA; Colforsin results in increased expression of FSHB protein |
CTD |
PMID:8404651 |
|
NCBI chr 3:114,003,262...114,007,072
|
|
G |
Fst |
follistatin |
multiple interactions |
ISO |
FST protein inhibits the reaction [BMP6 protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]; FST protein inhibits the reaction [INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]] |
CTD |
PMID:18936084 |
|
NCBI chr 2:47,856,345...47,863,670
|
|
G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions |
EXP ISO |
[Dexamethasone co-treated with Colforsin] results in increased expression of G6PC1 mRNA Colforsin inhibits the reaction [Leflunomide results in increased expression of G6PC1 mRNA]; Colforsin inhibits the reaction [teriflunomide results in increased expression of G6PC1 mRNA] |
CTD |
PMID:18972406 PMID:30364229 |
|
NCBI chr10:86,307,400...86,318,766
|
|
G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
increases expression |
EXP |
Colforsin results in increased expression of GABRA1 |
CTD |
PMID:9147380 |
|
NCBI chr10:27,096,731...27,152,563
|
|
G |
Gabra6 |
gamma-aminobutyric acid type A receptor subunit alpha6 |
decreases expression |
EXP |
Colforsin results in decreased expression of GABRA6 |
CTD |
PMID:9147380 |
|
NCBI chr10:26,810,411...26,825,768
|
|
G |
Gas6 |
growth arrest specific 6 |
decreases expression |
ISO |
Colforsin results in decreased expression of GAS6 mRNA |
CTD |
PMID:15313392 |
|
NCBI chr16:82,747,676...82,778,090
|
|
G |
Gast |
gastrin |
multiple interactions increases secretion |
ISO EXP |
Calcium promotes the reaction [Colforsin results in increased secretion of GAST protein]; Nitrendipine inhibits the reaction [Colforsin results in increased secretion of GAST protein] 2',5'-dideoxyadenosine inhibits the reaction [Colforsin results in increased secretion of GAST protein] |
CTD |
PMID:9277405 PMID:19208342 |
|
NCBI chr10:85,264,832...85,269,393
|
|
G |
Gcg |
glucagon |
multiple interactions increases secretion |
EXP |
Colforsin promotes the reaction [Pyruvic Acid results in increased secretion of GCG protein] Colforsin results in increased secretion of GCG protein |
CTD |
PMID:15919803 |
|
NCBI chr 3:67,522,489...67,531,533
|
|
G |
Gcm1 |
glial cells missing transcription factor 1 |
multiple interactions decreases expression increases expression |
ISO |
Colforsin promotes the reaction [GCM1 protein binds to CREBBP protein]; Colforsin results in increased acetylation of and results in increased activity of GCM1 protein; CREBBP protein affects the reaction [Colforsin results in increased activity of GCM1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased activity of GCM1 protein]; trichostatin A promotes the reaction [Colforsin results in increased acetylation of and results in increased activity of GCM1 protein]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of GCM1 mRNA] Colforsin results in decreased expression of GCM1 mRNA |
CTD |
PMID:16166624 PMID:31278978 PMID:37385477 |
|
NCBI chr 8:78,925,687...78,938,924
|
|
G |
Gfap |
glial fibrillary acidic protein |
decreases expression |
ISO |
Colforsin results in decreased expression of GFAP protein |
CTD |
PMID:34897981 |
|
NCBI chr10:88,352,987...88,361,661
|
|
G |
Gh1 |
growth hormone 1 |
increases secretion multiple interactions |
ISO EXP |
Colforsin results in increased secretion of GH1 protein GH1 protein promotes the reaction [Colforsin results in increased metabolism of Lipids] |
CTD |
PMID:14981226 PMID:19952226 |
|
NCBI chr10:91,727,883...91,729,860
|
|
G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions decreases expression |
ISO |
Valproic Acid inhibits the reaction [Colforsin results in decreased expression of GJA1 mRNA] |
CTD |
PMID:37385477 |
|
NCBI chr20:36,302,490...36,315,010
|
|
G |
Gli1 |
GLI family zinc finger 1 |
decreases expression |
ISO |
Colforsin results in decreased expression of GLI1 mRNA; Colforsin results in decreased expression of GLI1 protein |
CTD |
PMID:30983542 |
|
NCBI chr 7:65,042,237...65,054,888
|
|
G |
Gli2 |
GLI family zinc finger 2 |
multiple interactions |
EXP |
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of GLI2 mRNA] |
CTD |
PMID:27590029 |
|
NCBI chr13:29,946,882...30,163,589
|
|
G |
Gnai3 |
G protein subunit alpha i3 |
increases expression |
ISO |
Colforsin results in increased expression of GNAI3 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 2:198,430,920...198,468,874
|
|
G |
Gpbar1 |
G protein-coupled bile acid receptor 1 |
multiple interactions |
ISO |
[Colforsin binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Cyclic AMP; Colforsin binds to and results in increased activity of GPBAR1 protein |
CTD |
PMID:17963371 |
|
NCBI chr 9:75,860,758...75,863,260
|
|
G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
increases phosphorylation multiple interactions |
EXP |
Colforsin results in increased phosphorylation of GRIN1 protein N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of GRIN1 protein] |
CTD |
PMID:14622123 |
|
NCBI chr 3:28,501,836...28,528,754
|
|
G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions increases expression |
EXP |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of GRIN2B protein] Colforsin results in increased expression of GRIN2B mRNA; Colforsin results in increased expression of GRIN2B protein |
CTD |
PMID:20067577 |
|
NCBI chr 4:170,297,811...170,775,420
|
|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
EXP |
Colforsin results in increased phosphorylation of and results in decreased activity of GSK3B protein |
CTD |
PMID:15950778 |
|
NCBI chr11:76,004,502...76,154,665
|
|
G |
Hamp |
hepcidin antimicrobial peptide |
affects expression multiple interactions |
ISO |
Colforsin affects the expression of HAMP mRNA Colforsin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] |
CTD |
PMID:25633564 |
|
NCBI chr 1:95,298,332...95,300,271
|
|
G |
Hcar2 |
hydroxycarboxylic acid receptor 2 |
multiple interactions |
ISO |
[3-Hydroxybutyric Acid results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Niacin results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Nicotinic Acids binds to and results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Pertussis Toxin inhibits the reaction [[Nicotinic Acids binds to and results in increased activity of HCAR2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] |
CTD |
PMID:17124637 PMID:19223991 |
|
NCBI chr12:32,726,252...32,728,238
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of HIF1A protein [cobaltous chloride co-treated with Valproic Acid co-treated with Colforsin] results in increased expression of HIF1A protein; Valproic Acid inhibits the reaction [Colforsin results in increased expression of HIF1A protein] |
CTD |
PMID:38296531 |
|
NCBI chr 6:98,357,788...98,405,068
|
|
G |
Hk2 |
hexokinase 2 |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of HK2 mRNA cobaltous chloride inhibits the reaction [Valproic Acid inhibits the reaction [Colforsin results in increased expression of HK2 mRNA]]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of HK2 mRNA] |
CTD |
PMID:38296531 |
|
NCBI chr 4:116,792,258...116,841,275
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
affects expression multiple interactions increases expression |
ISO |
Colforsin affects the expression of HMGCR mRNA [Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA; [Colforsin co-treated with triptolide] results in decreased expression of HMGCR mRNA; AR protein promotes the reaction [Colforsin results in increased expression of HMGCR protein]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of HMGCR mRNA] Colforsin results in increased expression of HMGCR mRNA |
CTD |
PMID:16751804 PMID:16935330 PMID:20726872 PMID:30825513 PMID:31557376 |
|
NCBI chr 2:29,732,163...29,754,276
|
|
G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA] |
CTD |
PMID:30825513 |
|
NCBI chr 2:53,379,457...53,399,807
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO EXP |
Colforsin results in increased expression of HMOX1 protein N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of HMOX1 protein] Colforsin results in increased expression of HMOX1 mRNA; Colforsin results in increased expression of HMOX1 protein |
CTD |
PMID:15179140 PMID:16439612 PMID:19483313 |
|
NCBI chr19:13,452,365...13,479,823
|
|
G |
Hnrnpa1 |
heterogeneous nuclear ribonucleoprotein A1 |
multiple interactions |
EXP |
HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of RUNX1 exon]; HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of SNAP25 exon] |
CTD |
PMID:22684629 |
|
NCBI chr 7:136,253,633...136,260,085
|
|
G |
Hnrnpk |
heterogeneous nuclear ribonucleoprotein K |
multiple interactions |
EXP |
Colforsin promotes the reaction [HNRNPK protein binds to SNAP25 exon] |
CTD |
PMID:22684629 |
|
NCBI chr17:6,269,302...6,280,429
|
|
G |
Hrh2 |
histamine receptor H 2 |
multiple interactions |
ISO |
Dimaprit inhibits the reaction [HRH2 protein promotes the reaction [Colforsin results in increased abundance of Cyclic AMP]]; HRH2 protein promotes the reaction [Colforsin results in increased abundance of Cyclic AMP] |
CTD |
PMID:9187264 |
|
NCBI chr17:10,366,004...10,407,791
|
|
G |
Hrh3 |
histamine receptor H3 |
multiple interactions |
EXP |
[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; ciproxifan inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; Pertussis Toxin inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; thioperamide inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] |
CTD |
PMID:21276809 |
|
NCBI chr 3:167,191,551...167,196,642
|
|
G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
multiple interactions increases expression |
ISO |
Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [1,7-dimethylxanthine results in decreased expression of HSD11B2 mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]; Colforsin inhibits the reaction [Ethanol results in decreased expression of HSD11B2 mRNA]; Colforsin inhibits the reaction [Ethanol results in decreased expression of HSD11B2 protein]; Ethanol inhibits the reaction [Colforsin results in increased expression of HSD11B2 mRNA]; Ethanol inhibits the reaction [Colforsin results in increased expression of HSD11B2 protein] Colforsin results in increased expression of HSD11B2 mRNA; Colforsin results in increased expression of HSD11B2 protein |
CTD |
PMID:22701600 PMID:24361490 PMID:29802914 PMID:33144174 |
|
NCBI chr19:50,307,569...50,312,812
|
|
G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
affects expression multiple interactions increases expression |
ISO |
Colforsin affects the expression of HSD17B1 mRNA [Colforsin co-treated with Aminoglutethimide] results in decreased expression of HSD17B1 mRNA; [Colforsin co-treated with Metyrapone] results in decreased expression of HSD17B1 mRNA; Valproic Acid affects the reaction [Colforsin affects the expression of HSD17B1 mRNA] Colforsin results in increased expression of HSD17B1 mRNA |
CTD |
PMID:16935330 PMID:20726872 PMID:22446829 |
|
NCBI chr10:86,009,728...86,011,928
|
|
G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
increases expression |
ISO |
Colforsin results in increased expression of HSD17B3 mRNA |
CTD |
PMID:22461451 |
|
NCBI chr17:1,027,229...1,058,554
|
|
G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
affects expression increases expression multiple interactions |
ISO |
Colforsin affects the expression of HSD17B4 mRNA Colforsin results in increased expression of HSD17B4 mRNA Aminoglutethimide inhibits the reaction [Colforsin results in increased expression of HSD17B4 mRNA]; Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA]; Valproic Acid affects the reaction [Colforsin affects the expression of HSD17B4 mRNA] |
CTD |
PMID:16935330 PMID:20726872 PMID:22446829 |
|
NCBI chr18:45,515,427...45,604,467
|
|
G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions |
ISO |
BMP6 protein inhibits the reaction [Colforsin results in increased expression of HSD3B1 mRNA] |
CTD |
PMID:18936084 |
|
NCBI chr 2:186,169,864...186,175,984
|
|
G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of HSD3B2 mRNA [Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNA; [Colforsin co-treated with Metyrapone] results in decreased expression of HSD3B2 mRNA; [Colforsin co-treated with triptolide] results in decreased expression of HSD3B2 mRNA; Apigenin inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]; daidzein inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA] |
CTD |
PMID:16935330 PMID:17080404 PMID:20726872 PMID:21256172 PMID:22446829 PMID:23370353 PMID:25765474 PMID:25871633 PMID:28235592 PMID:31100596 PMID:31557376 More...
|
|
NCBI chr 2:186,095,897...186,105,354
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases response to substance |
ISO |
HSPA5 protein results in increased susceptibility to Colforsin |
CTD |
PMID:22912664 |
|
NCBI chr 3:38,453,016...38,457,475
|
|
G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
multiple interactions |
ISO |
[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of HSPD1 mRNA] |
CTD |
PMID:32092105 |
|
NCBI chr 9:64,073,610...64,084,332
|
|
G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions |
ISO |
[JB-788 binds to and results in increased activity of HTR1A protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Arachidonic Acid metabolite inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Melitten inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] |
CTD |
PMID:11356925 PMID:20580787 |
|
NCBI chr 2:38,427,169...38,431,733
|
|
G |
Htr1b |
5-hydroxytryptamine receptor 1B |
multiple interactions |
ISO |
HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] |
CTD |
PMID:11134654 |
|
NCBI chr 8:91,395,405...91,414,815
|
|
G |
Htr2a |
5-hydroxytryptamine receptor 2A |
multiple interactions |
EXP |
Colforsin inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA] |
CTD |
PMID:22791651 |
|
NCBI chr15:56,360,647...56,428,703
|
|
G |
Htr7 |
5-hydroxytryptamine receptor 7 |
multiple interactions |
ISO |
[Bromocriptine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Lisuride binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Metergoline binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Methiothepin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Paliperidone Palmitate binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; [Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP] |
CTD |
PMID:19509219 |
|
NCBI chr 1:243,049,064...243,173,636
|
|
G |
Iapp |
islet amyloid polypeptide |
increases expression |
EXP |
Colforsin results in increased expression of IAPP mRNA |
CTD |
PMID:9142872 |
|
NCBI chr 4:175,237,107...175,244,373
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Reactive Oxygen Species results in increased expression of ICAM1 mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] |
CTD |
PMID:10495789 |
|
NCBI chr 8:27,829,688...27,841,618
|
|
G |
Icam2 |
intercellular adhesion molecule 2 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [EDN1 protein results in increased expression of ICAM2 mRNA] |
CTD |
PMID:25194819 |
|
NCBI chr10:91,308,608...91,319,536
|
|
G |
Ier3 |
immediate early response 3 |
affects response to substance |
ISO |
IER3 protein affects the susceptibility to Colforsin |
CTD |
PMID:20713914 |
|
NCBI chr20:2,933,173...2,934,377
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Colforsin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] |
CTD |
PMID:18953428 |
|
NCBI chr 7:55,789,180...55,793,216
|
|
G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]; FGF9 protein inhibits the reaction [Colforsin promotes the reaction [IGF1 protein results in increased abundance of Estradiol]]; FGF9 protein inhibits the reaction [IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone]]; IGF1 protein promotes the reaction [Colforsin results in increased abundance of Progesterone] |
CTD |
PMID:22798350 |
|
NCBI chr 7:24,169,608...24,249,446
|
|
G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of IGFBP1 [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of IGFBP1 mRNA |
CTD |
PMID:12093828 PMID:31154070 |
|
NCBI chr14:86,261,277...86,266,344
|
|
G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IKBKB mRNA] |
CTD |
PMID:17407152 |
|
NCBI chr16:76,021,968...76,075,717
|
|
G |
Il10 |
interleukin 10 |
decreases expression |
ISO |
Colforsin results in decreased expression of IL10 protein |
CTD |
PMID:10996031 |
|
NCBI chr13:45,024,921...45,029,586
|
|
G |
Il11 |
interleukin 11 |
increases expression |
ISO |
Colforsin results in increased expression of IL11 mRNA |
CTD |
PMID:22138297 |
|
NCBI chr 1:69,069,829...69,076,129
|
|
G |
Il12a |
interleukin 12A |
decreases expression |
ISO |
Colforsin results in decreased expression of IL12A protein |
CTD |
PMID:10996031 |
|
NCBI chr 2:155,275,734...155,282,997
|
|
G |
Il12b |
interleukin 12B |
multiple interactions increases expression |
ISO |
Colforsin inhibits the reaction [oxophenylarsine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Colforsin results in increased expression of [IL12B protein binds to IL23A protein] Colforsin results in increased expression of IL12B protein |
CTD |
PMID:10996031 PMID:15180965 PMID:20512473 |
|
NCBI chr10:29,390,300...29,405,194
|
|
G |
Il13 |
interleukin 13 |
decreases secretion decreases expression |
ISO |
Colforsin results in decreased secretion of IL13 protein Colforsin results in decreased expression of IL13 mRNA |
CTD |
PMID:16083514 |
|
NCBI chr10:38,290,926...38,293,483
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
Colforsin promotes the reaction [IL1B protein results in increased expression of PTGS2 protein] Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein] |
CTD |
PMID:11112151 PMID:27590029 |
|
NCBI chr 3:137,030,200...137,036,581
|
|
G |
Il23a |
interleukin 23 subunit alpha |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of IL23A protein Colforsin results in increased expression of [IL12B protein binds to IL23A protein] |
CTD |
PMID:15180965 |
|
NCBI chr 7:1,306,320...1,308,434
|
|
G |
Il2ra |
interleukin 2 receptor subunit alpha |
decreases expression |
ISO |
Colforsin results in decreased expression of IL2RA protein |
CTD |
PMID:1709825 |
|
NCBI chr17:66,849,974...66,898,665
|
|
G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Miconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Miconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein] |
CTD |
PMID:11886533 |
|
NCBI chr10:38,272,003...38,277,549
|
|
G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Miconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Miconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein] |
CTD |
PMID:11886533 |
|
NCBI chr10:38,375,132...38,378,003
|
|
G |
Il6 |
interleukin 6 |
multiple interactions increases secretion |
EXP ISO |
Colforsin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] oxophenylarsine inhibits the reaction [Colforsin results in increased secretion of IL6 protein] Colforsin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]; Colforsin promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Colforsin promotes the reaction [TNF protein results in increased expression of IL6 mRNA] |
CTD |
PMID:17141199 PMID:20388727 PMID:21803157 PMID:24771768 PMID:25633564 |
|
NCBI chr 4:5,889,999...5,894,575
|
|
G |
Inhba |
inhibin subunit beta A |
multiple interactions |
ISO |
FST protein inhibits the reaction [INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone]]; INHBA protein inhibits the reaction [Colforsin results in increased secretion of Progesterone] |
CTD |
PMID:18936084 |
|
NCBI chr17:53,787,159...53,810,942
|
|
G |
Ins1 |
insulin 1 |
multiple interactions increases secretion |
EXP ISO |
1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin results in increased secretion of INS1 protein]; Budesonide inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]; Dexamethasone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Fluticasone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Hydrocortisone inhibits the reaction [Colforsin promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Melatonin inhibits the reaction [Colforsin results in increased secretion of INS1 protein]; Probenecid promotes the reaction [Colforsin results in increased secretion of INS1 protein] |
CTD |
PMID:10221768 PMID:12153439 PMID:25851902 PMID:37217659 |
|
NCBI chr 1:261,186,119...261,186,686
|
|
G |
Insig1 |
insulin induced gene 1 |
multiple interactions increases expression |
ISO |
AR protein promotes the reaction [Colforsin results in increased expression of INSIG1 protein] Colforsin results in increased expression of INSIG1 mRNA; Colforsin results in increased expression of INSIG1 protein |
CTD |
PMID:16751804 |
|
NCBI chr 4:8,049,339...8,057,812
|
|
G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] |
CTD |
PMID:17407152 |
|
NCBI chr 9:91,001,137...91,053,959
|
|
G |
Itga1 |
integrin subunit alpha 1 |
affects response to substance |
EXP |
ITGA1 protein affects the susceptibility to Colforsin |
CTD |
PMID:15836982 |
|
NCBI chr 2:48,379,181...48,545,336
|
|
G |
Itga3 |
integrin subunit alpha 3 |
affects response to substance |
EXP |
ITGA3 protein affects the susceptibility to Colforsin |
CTD |
PMID:15836982 |
|
NCBI chr10:79,990,160...80,022,206
|
|
G |
Itgb1 |
integrin subunit beta 1 |
affects response to substance |
EXP |
ITGB1 protein affects the susceptibility to Colforsin |
CTD |
PMID:15836982 |
|
NCBI chr19:73,602,277...73,650,271
|
|
G |
Itgb5 |
integrin subunit beta 5 |
increases expression |
ISO |
Colforsin results in increased expression of ITGB5 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr11:66,828,428...66,944,231
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Colforsin results in increased expression of JUN protein |
CTD |
PMID:11113530 |
|
NCBI chr 5:115,009,900...115,012,993
|
|
G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Colforsin results in increased expression of JUNB protein |
CTD |
PMID:11113530 |
|
NCBI chr19:23,176,265...23,178,049
|
|
G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Colforsin results in increased expression of JUND protein |
CTD |
PMID:11113530 |
|
NCBI chr16:18,734,121...18,735,799
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions |
ISO |
[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium] |
CTD |
PMID:19419905 |
|
NCBI chr 4:11,719,357...11,751,424
|
|
G |
Klhl23 |
kelch-like family member 23 |
multiple interactions |
ISO |
[Colforsin co-treated with Diethylhexyl Phthalate] affects the expression of PHOSPHO2-KLHL23 mRNA |
CTD |
PMID:35892601 |
|
NCBI chr 3:54,580,788...54,594,530
|
|
G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
multiple interactions increases expression |
ISO |
AR protein promotes the reaction [Colforsin results in increased expression of KLK3 protein] Colforsin results in increased expression of KLK3 mRNA; Colforsin results in increased expression of KLK3 protein |
CTD |
PMID:16751804 |
|
NCBI chr 1:94,402,993...94,407,052
|
|
G |
Kyat1 |
kynurenine aminotransferase 1 |
multiple interactions increases expression |
ISO |
S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Colforsin results in increased expression of KYAT1 mRNA] |
CTD |
PMID:37544576 |
|
NCBI chr 3:33,857,407...33,891,153
|
|
G |
Lep |
leptin |
decreases expression multiple interactions decreases secretion |
ISO |
Colforsin results in decreased expression of LEP mRNA Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] Colforsin results in decreased secretion of LEP protein |
CTD |
PMID:9002984 PMID:26367767 PMID:27381457 |
|
NCBI chr 4:58,626,529...58,640,663
|
|
G |
Lhb |
luteinizing hormone subunit beta |
increases expression multiple interactions |
EXP |
Colforsin results in increased expression of LHB protein [Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP; [Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone; CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]; CRH protein inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone]; Tetradecanoylphorbol Acetate inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Cyclic AMP]; Tetradecanoylphorbol Acetate inhibits the reaction [[Colforsin co-treated with CGB3 protein] results in increased chemical synthesis of Testosterone] |
CTD |
PMID:2153673 PMID:8404651 |
|
NCBI chr 1:105,037,457...105,038,446
|
|
G |
Lhcgr |
luteinizing hormone/choriogonadotropin receptor |
multiple interactions |
ISO |
[Colforsin co-treated with deoxynivalenol] results in increased expression of LHCGR mRNA; [Colforsin co-treated with Zearalenone] results in increased expression of LHCGR mRNA |
CTD |
PMID:26783879 |
|
NCBI chr 6:5,661,871...5,728,109
|
|
G |
Lipe |
lipase E, hormone sensitive type |
affects localization |
EXP |
Colforsin affects the localization of LIPE protein |
CTD |
PMID:11160373 |
|
NCBI chr 1:80,965,612...80,984,313
|
|
G |
Lpl |
lipoprotein lipase |
increases expression |
EXP |
Colforsin results in increased expression of LPL mRNA |
CTD |
PMID:9032464 |
|
NCBI chr16:25,596,205...25,621,928
|
|
G |
Ltbp2 |
latent transforming growth factor beta binding protein 2 |
decreases expression |
ISO |
Colforsin results in decreased expression of LTBP2 mRNA |
CTD |
PMID:15313392 |
|
NCBI chr 6:110,161,029...110,261,586
|
|
G |
Ltc4s |
leukotriene C4 synthase |
decreases secretion |
ISO |
Colforsin results in decreased secretion of LTC4S protein |
CTD |
PMID:16083514 |
|
NCBI chr10:35,060,002...35,066,466
|
|
G |
Lyz2 |
lysozyme 2 |
multiple interactions increases secretion decreases secretion |
ISO |
3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Colforsin results in increased secretion of LYZ protein]; [Thapsigargin co-treated with Colforsin] results in increased secretion of LYZ protein Colforsin results in decreased secretion of LYZ protein |
CTD |
PMID:15194485 PMID:15234967 |
|
NCBI chr 7:52,906,810...52,912,154
|
|
G |
Maf |
MAF bZIP transcription factor |
decreases expression |
ISO |
Colforsin results in decreased expression of MAF mRNA |
CTD |
PMID:16751804 |
|
NCBI chr19:43,353,867...43,713,162
|
|
G |
Map2 |
microtubule-associated protein 2 |
increases expression |
ISO |
Colforsin results in increased expression of MAP2 protein |
CTD |
PMID:34897981 |
|
NCBI chr 9:75,173,038...75,431,606
|
|
G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
ISO |
[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAP2K1 protein; alisol B promotes the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAP2K1 protein] |
CTD |
PMID:28051915 |
|
NCBI chr 8:73,578,747...73,650,184
|
|
G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
multiple interactions |
ISO |
[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAP2K2 protein; alisol B promotes the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAP2K2 protein] |
CTD |
PMID:28051915 |
|
NCBI chr 7:9,241,449...9,264,216
|
|
G |
Map7 |
microtubule-associated protein 7 |
increases expression |
ISO |
Colforsin results in increased expression of MAP7 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 1:14,910,433...15,037,574
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation increases activity |
ISO EXP |
Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK1 protein]; Colforsin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Colforsin inhibits the reaction [Shiga Toxin results in increased activity of MAPK1 protein] Colforsin results in increased phosphorylation of MAPK1 protein [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAPK1 protein; alisol B promotes the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK1 protein] Colforsin results in increased activity of MAPK1 protein 1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]; [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein; Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]; Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]; Colforsin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK1 protein]; Propranolol inhibits the reaction [Colforsin results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Colforsin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:11093795 PMID:11675405 PMID:12533312 PMID:14975937 PMID:15385614 PMID:17322281 PMID:18004999 PMID:20378682 PMID:21177760 PMID:22875961 PMID:28051915 PMID:35137321 More...
|
|
NCBI chr11:97,462,025...97,529,193
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions increases activity |
ISO EXP |
Colforsin results in increased phosphorylation of MAPK3 protein Colforsin inhibits the reaction [FGF10 protein results in increased phosphorylation of MAPK3 protein]; Colforsin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Colforsin inhibits the reaction [Shiga Toxin results in increased activity of MAPK3 protein] [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAPK3 protein; alisol B promotes the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK3 protein] 1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]; [Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein; Colforsin inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]; Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]; Dieldrin promotes the reaction [[Colforsin co-treated with Rolipram co-treated with Picrotoxin] results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Colforsin results in increased activity of MAPK3 protein] |
CTD |
PMID:11093795 PMID:11675405 PMID:12533312 PMID:14975937 PMID:15385614 PMID:17322281 PMID:18004999 PMID:20378682 PMID:21177760 PMID:22875961 PMID:28051915 PMID:35137321 More...
|
|
NCBI chr 1:190,797,189...190,803,411
|
|
G |
Mc2r |
melanocortin 2 receptor |
multiple interactions increases expression |
ISO |
Valproic Acid inhibits the reaction [Colforsin results in increased expression of MC2R mRNA] |
CTD |
PMID:20726872 PMID:25765474 |
|
NCBI chr18:62,001,980...62,015,567
|
|
G |
Med28 |
mediator complex subunit 28 |
increases expression |
ISO |
Colforsin results in increased expression of MED28 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr14:65,594,785...65,603,583
|
|
G |
Mir190a |
microRNA 190a |
multiple interactions |
ISO |
Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] |
CTD |
PMID:24334028 |
|
NCBI chr 8:67,850,987...67,851,071
|
|
G |
Mitf |
melanocyte inducing transcription factor |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of MITF mRNA; Colforsin results in increased expression of MITF protein [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MITF mRNA; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MITF protein; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MITF mRNA]; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MITF protein] |
CTD |
PMID:17460731 PMID:28051915 PMID:28601556 |
|
NCBI chr 4:131,965,676...132,177,790
|
|
G |
Mmp16 |
matrix metallopeptidase 16 |
increases expression |
ISO |
Colforsin results in increased expression of MMP16 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 5:31,312,280...31,556,276
|
|
G |
Mterf4 |
mitochondrial transcription termination factor 4 |
decreases expression |
ISO |
Colforsin results in decreased expression of MTERF4 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 9:101,281,560...101,286,236
|
|
G |
Muc4 |
mucin 4, cell surface associated |
increases expression |
ISO |
Colforsin results in increased expression of MUC4 protein |
CTD |
PMID:28049186 |
|
NCBI chr11:68,008,245...68,053,242
|
|
G |
Myh7 |
myosin heavy chain 7 |
multiple interactions |
EXP |
Colforsin inhibits the reaction [Dinoprostone results in increased expression of MYH7 protein]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA] |
CTD |
PMID:18851973 |
|
NCBI chr15:32,416,525...32,439,851
|
|
G |
Nav1 |
neuron navigator 1 |
decreases expression |
ISO |
Colforsin results in decreased expression of NAV1 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr13:46,866,972...47,119,368
|
|
G |
Nes |
nestin |
decreases expression |
ISO |
Colforsin results in decreased expression of NES protein |
CTD |
PMID:34897981 |
|
NCBI chr 2:175,735,715...175,745,631
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKB1 mRNA] |
CTD |
PMID:17407152 |
|
NCBI chr 2:226,689,745...226,805,897
|
|
G |
Ngf |
nerve growth factor |
multiple interactions increases expression |
EXP |
[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of NGF mRNA Colforsin results in increased expression of NGF mRNA |
CTD |
PMID:2174743 PMID:2853697 |
|
NCBI chr 2:192,589,580...192,642,971
|
|
G |
Ngly1 |
N-glycanase 1 |
increases expression |
ISO |
Colforsin results in increased expression of NGLY1 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr15:9,153,738...9,210,228
|
|
G |
Nmu |
neuromedin U |
increases expression |
EXP |
Colforsin results in increased expression of NMU mRNA |
CTD |
PMID:23423171 |
|
NCBI chr14:31,844,564...31,872,196
|
|
G |
Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
Colforsin inhibits the reaction [Dinoprostone results in increased expression of NPPA protein]; Colforsin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] |
CTD |
PMID:11470465 PMID:18851973 |
|
NCBI chr 5:163,712,184...163,713,493
|
|
G |
Nr0b1 |
nuclear receptor subfamily 0, group B, member 1 |
decreases expression multiple interactions |
ISO |
Colforsin results in decreased expression of NR0B1 mRNA Valproic Acid inhibits the reaction [Colforsin results in decreased expression of NR0B1 mRNA] |
CTD |
PMID:20726872 |
|
NCBI chr X:50,756,886...50,761,014
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity decreases expression |
EXP ISO |
Colforsin results in increased activity of NR1I2 protein Colforsin results in decreased expression of NR1I2 mRNA |
CTD |
PMID:27732639 PMID:29933105 |
|
NCBI chr11:75,965,717...76,006,733
|
|
G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
increases activity |
ISO |
Colforsin results in increased activity of NR3C1 protein |
CTD |
PMID:19255438 |
|
NCBI chr18:31,522,783...31,644,508
|
|
G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of NR4A1 mRNA; Colforsin results in increased expression of NR4A1 protein NR4A1 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA] [Colforsin co-treated with deoxynivalenol] results in increased expression of NR4A1 mRNA; Colforsin promotes the reaction [Zearalenone results in increased expression of NR4A1 mRNA]; NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 protein]; W 7 inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; W 7 inhibits the reaction [Colforsin results in increased expression of NR4A1 protein] |
CTD |
PMID:8164692 PMID:19822197 PMID:23183170 PMID:26783879 |
|
NCBI chr 7:132,368,399...132,389,300
|
|
G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
multiple interactions increases expression |
ISO |
666-15 compound inhibits the reaction [Colforsin results in increased expression of NR4A2 mRNA]; NR4A2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA] Colforsin results in increased expression of NR4A2 mRNA; Colforsin results in increased expression of NR4A2 protein |
CTD |
PMID:19732956 PMID:19822197 PMID:26023867 |
|
NCBI chr 3:41,689,847...41,707,036
|
|
G |
Nr4a3 |
nuclear receptor subfamily 4, group A, member 3 |
multiple interactions |
ISO |
NR4A3 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA] |
CTD |
PMID:19822197 |
|
NCBI chr 5:67,157,141...67,198,287
|
|
G |
Nr5a1 |
nuclear receptor subfamily 5, group A, member 1 |
affects expression |
ISO |
Colforsin affects the expression of NR5A1 mRNA |
CTD |
PMID:20726872 |
|
NCBI chr 3:22,464,786...22,486,328
|
|
G |
Nr5a2 |
nuclear receptor subfamily 5, group A, member 2 |
multiple interactions increases expression |
ISO |
alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA] Colforsin results in increased expression of NR5A2 mRNA |
CTD |
PMID:16357189 |
|
NCBI chr13:50,865,253...50,985,107
|
|
G |
Nrg1 |
neuregulin 1 |
multiple interactions |
ISO |
[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA; U 0126 inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NRG1 mRNA] |
CTD |
PMID:21047912 |
|
NCBI chr16:65,954,084...67,007,484
|
|
G |
Ntf3 |
neurotrophin 3 |
increases expression |
EXP |
Colforsin results in increased expression of NTF3 protein |
CTD |
PMID:19854260 |
|
NCBI chr 4:158,914,984...158,984,453
|
|
G |
Ntrk2 |
neurotrophic receptor tyrosine kinase 2 |
increases expression |
EXP |
Colforsin results in increased expression of NTRK2 mRNA |
CTD |
PMID:35917217 |
|
NCBI chr17:5,560,558...5,875,899
|
|
G |
Numa1 |
nuclear mitotic apparatus protein 1 |
decreases expression |
ISO |
Colforsin results in decreased expression of NUMA1 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 1:165,709,893...165,784,848
|
|
G |
Oxt |
oxytocin/neurophysin I prepropeptide |
multiple interactions |
ISO |
BMP6 protein inhibits the reaction [Colforsin results in increased expression of OXT mRNA] |
CTD |
PMID:18936084 |
|
NCBI chr 3:117,782,650...117,783,490
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
[Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein] Colforsin results in increased cleavage of PARP1 protein |
CTD |
PMID:9454737 PMID:31278978 |
|
NCBI chr13:94,839,484...94,871,295
|
|
G |
Pax8 |
paired box 8 |
increases expression |
ISO |
Colforsin results in increased expression of PAX8 mRNA; Colforsin results in increased expression of PAX8 protein |
CTD |
PMID:15961562 |
|
NCBI chr 3:27,584,000...27,641,094
|
|
G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
increases expression multiple interactions |
EXP ISO |
Colforsin results in increased expression of PCK1 mRNA Dexamethasone promotes the reaction [Colforsin results in increased expression of PCK1 mRNA] Colforsin inhibits the reaction [Leflunomide results in increased expression of PCK1 mRNA]; Colforsin inhibits the reaction [teriflunomide results in increased expression of PCK1 mRNA] |
CTD |
PMID:25851902 PMID:30364229 |
|
NCBI chr 3:182,348,572...182,354,521
|
|
G |
Pde1b |
phosphodiesterase 1B |
multiple interactions |
ISO |
PDE1B protein affects the reaction [Colforsin results in increased phosphorylation of PPP1R1B protein] |
CTD |
PMID:12077213 |
|
NCBI chr 7:134,627,378...134,654,581
|
|
G |
Pde2a |
phosphodiesterase 2A |
multiple interactions |
ISO |
PDE2A protein inhibits the reaction [Colforsin affects the localization of AHR protein] |
CTD |
PMID:17329248 |
|
NCBI chr 1:155,823,590...155,915,434
|
|
G |
Pde4b |
phosphodiesterase 4B |
increases expression |
ISO |
Colforsin results in increased expression of PDE4B mRNA |
CTD |
PMID:15967414 |
|
NCBI chr 5:122,028,956...122,598,267
|
|
G |
Pde4d |
phosphodiesterase 4D |
increases expression |
ISO |
Colforsin results in increased expression of PDE4D mRNA |
CTD |
PMID:15967414 |
|
NCBI chr 2:41,748,337...43,262,567
|
|
G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
affects response to substance multiple interactions |
ISO |
PDK1 protein affects the susceptibility to Colforsin [PDK1 protein affects the susceptibility to Colforsin] which affects the abundance of Cyclic AMP; tubacin affects the reaction [[PDK1 protein affects the susceptibility to Colforsin] which affects the abundance of Cyclic AMP] |
CTD |
PMID:28887310 |
|
NCBI chr 3:77,113,464...77,144,145
|
|
G |
Penk |
proenkephalin |
multiple interactions increases expression |
EXP |
Cycloheximide promotes the reaction [Colforsin results in increased expression of PENK mRNA]; Dexamethasone promotes the reaction [Colforsin results in increased expression of PENK mRNA] |
CTD |
PMID:11113530 |
|
NCBI chr 5:21,981,381...21,987,074
|
|
G |
Per1 |
period circadian regulator 1 |
multiple interactions increases expression |
ISO |
[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA; AHR protein inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA]; beta-Naphthoflavone inhibits the reaction [Colforsin results in increased expression of PER1 mRNA] |
CTD |
PMID:23291558 |
|
NCBI chr10:54,299,002...54,313,804
|
|
G |
Pgf |
placental growth factor |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of PGF mRNA perfluorooctane sulfonic acid inhibits the reaction [Colforsin results in increased expression of PGF mRNA] |
CTD |
PMID:33144174 |
|
NCBI chr 6:110,547,165...110,557,747
|
|
G |
Pgr |
progesterone receptor |
increases expression |
ISO |
Colforsin results in increased expression of PGR mRNA |
CTD |
PMID:20378682 |
|
NCBI chr 8:14,354,398...14,413,271
|
|
G |
Pias1 |
protein inhibitor of activated STAT, 1 |
decreases expression |
ISO |
Colforsin results in decreased expression of PIAS1 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 8:63,338,150...63,451,670
|
|
G |
Pink1 |
PTEN induced kinase 1 |
multiple interactions |
ISO |
PINK1 protein affects the reaction [Colforsin results in decreased expression of DNM1L protein] |
CTD |
PMID:24792327 |
|
NCBI chr 5:155,813,838...155,825,950
|
|
G |
Pla2g2a |
phospholipase A2 group IIA |
multiple interactions |
ISO |
Colforsin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] |
CTD |
PMID:18953428 |
|
NCBI chr 5:156,359,725...156,362,302
|
|
G |
Pnpla2 |
patatin-like phospholipase domain containing 2 |
multiple interactions |
ISO |
PNPLA2 protein affects the reaction [Colforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein] |
CTD |
PMID:18390901 |
|
NCBI chr 1:196,552,723...196,557,805
|
|
G |
Pnpla6 |
patatin-like phospholipase domain containing 6 |
multiple interactions increases expression |
ISO |
1-Methyl-3-isobutylxanthine promotes the reaction [Colforsin results in increased expression of and results in increased activity of PNPLA6 protein]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PNPLA6 mRNA; Colforsin results in increased expression of and results in increased activity of PNPLA6 protein; Cycloheximide inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of PNPLA6 protein]; Cycloheximide inhibits the reaction [Colforsin results in increased activity of PNPLA6 protein] Colforsin results in increased expression of PNPLA6 mRNA |
CTD |
PMID:20380879 |
|
NCBI chr12:1,574,387...1,603,735
|
|
G |
Pomc |
proopiomelanocortin |
multiple interactions |
ISO |
Colforsin inhibits the reaction [diethyl phosphate results in decreased secretion of POMC protein] |
CTD |
PMID:35777568 |
|
NCBI chr 6:32,659,137...32,665,175
|
|
G |
Pou1f1 |
POU class 1 homeobox 1 |
multiple interactions |
EXP |
Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]; resveratrol inhibits the reaction [Colforsin promotes the reaction [CREB1 protein binds to POU1F1 promoter]] |
CTD |
PMID:23292070 |
|
NCBI chr11:3,316,818...3,334,804
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression |
ISO |
Colforsin results in decreased expression of PPARG mRNA |
CTD |
PMID:31278978 |
|
NCBI chr 4:150,095,743...150,221,104
|
|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
ISO |
Colforsin results in increased expression of PPARGC1A mRNA |
CTD |
PMID:16357189 |
|
NCBI chr14:63,073,505...63,729,215
|
|
G |
Ppargc1b |
PPARG coactivator 1 beta |
increases expression |
ISO |
Colforsin results in increased expression of PPARGC1B mRNA |
CTD |
PMID:16357189 |
|
NCBI chr18:54,758,891...54,861,103
|
|
G |
Ppp1r12a |
protein phosphatase 1, regulatory subunit 12A |
increases phosphorylation multiple interactions |
ISO |
Colforsin results in increased phosphorylation of PPP1R12A protein Capsaicin inhibits the reaction [Colforsin results in increased phosphorylation of PPP1R12A protein]; capsazepine inhibits the reaction [Colforsin results in increased phosphorylation of PPP1R12A protein] |
CTD |
PMID:21474433 |
|
NCBI chr 7:45,368,922...45,480,158
|
|
G |
Ppp1r1b |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
increases phosphorylation multiple interactions |
ISO |
Colforsin results in increased phosphorylation of PPP1R1B protein PDE1B protein affects the reaction [Colforsin results in increased phosphorylation of PPP1R1B protein] |
CTD |
PMID:12077213 |
|
NCBI chr10:83,843,948...83,853,063
|
|
G |
Prdx2 |
peroxiredoxin 2 |
increases expression decreases expression multiple interactions |
ISO |
Colforsin results in increased expression of PRDX2 mRNA Colforsin results in decreased expression of PRDX2 mRNA S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Colforsin results in increased expression of PRDX2 mRNA] |
CTD |
PMID:36336211 |
|
NCBI chr19:23,180,927...23,186,217
|
|
G |
Prima1 |
proline rich membrane anchor 1 |
increases expression |
EXP |
Colforsin results in increased expression of PRIMA1 mRNA |
CTD |
PMID:18514641 |
|
NCBI chr 6:122,338,365...122,390,955
|
|
G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
ISO |
Colforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PNPLA2 protein affects the reaction [Colforsin results in increased phosphorylation of and results in increased activity of PRKAA1 protein] |
CTD |
PMID:18390901 |
|
NCBI chr 2:55,967,766...56,003,450
|
|
G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
multiple interactions increases activity |
EXP ISO |
Colforsin inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein] Colforsin results in increased activity of PRKACA protein |
CTD |
PMID:16339297 PMID:28601556 |
|
NCBI chr19:41,059,843...41,083,189
|
|
G |
Prkacb |
protein kinase cAMP-activated catalytic subunit beta |
multiple interactions |
ISO |
[PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1A protein]; [PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1B protein]; PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] |
CTD |
PMID:29669941 |
|
NCBI chr 2:238,297,140...238,389,317
|
|
G |
Prkar1a |
protein kinase cAMP-dependent type I regulatory subunit alpha |
multiple interactions |
ISO |
[PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1A protein] |
CTD |
PMID:29669941 |
|
NCBI chr10:94,621,042...94,639,534
|
|
G |
Prkar1b |
protein kinase cAMP-dependent type I regulatory subunit beta |
multiple interactions |
ISO |
[PRKACB protein mutant form results in increased susceptibility to [Colforsin co-treated with 1-Methyl-3-isobutylxanthine]] results in decreased stability of [PRKACB protein mutant form binds to PRKAR1B protein] |
CTD |
PMID:29669941 |
|
NCBI chr12:15,492,233...15,624,942
|
|
G |
Prkar2a |
protein kinase cAMP-dependent type II regulatory subunit alpha |
increases phosphorylation |
ISO |
Colforsin results in increased phosphorylation of PRKAR2A protein |
CTD |
PMID:25943029 |
|
NCBI chr 8:118,271,608...118,337,332
|
|
G |
Prl |
prolactin |
multiple interactions increases expression |
EXP ISO |
Colforsin inhibits the reaction [Octreotide results in decreased secretion of PRL protein]; Octreotide inhibits the reaction [Colforsin results in increased expression of PRL protein] [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA; [Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein; Cannabidiol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Cannabidiol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein]; Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein]; Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein]; Rimonabant inhibits the reaction [Dronabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]] |
CTD |
PMID:1322274 PMID:31154070 |
|
NCBI chr17:38,287,355...38,298,234
|
|
G |
Ptcd1 |
pentatricopeptide repeat domain 1 |
multiple interactions |
ISO |
[Colforsin co-treated with Diethylhexyl Phthalate] affects the expression of ATP5MF-PTCD1 mRNA |
CTD |
PMID:35892601 |
|
NCBI chr12:9,445,656...9,463,434
|
|
G |
Ptch1 |
patched 1 |
multiple interactions |
EXP |
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTCH1 mRNA] |
CTD |
PMID:27590029 |
|
NCBI chr17:1,548,449...1,613,461
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO EXP |
Colforsin promotes the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]; Colforsin promotes the reaction [IL1B protein results in increased expression of PTGS2 protein] Colforsin results in increased expression of PTGS2 mRNA Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; Colforsin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] bifenthrin inhibits the reaction [Colforsin results in increased expression of PTGS2 mRNA]; Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] |
CTD |
PMID:11112151 PMID:12493747 PMID:15213229 PMID:17407152 PMID:19063610 PMID:20378682 PMID:21251947 PMID:27590029 More...
|
|
NCBI chr13:64,714,063...64,722,320
|
|
G |
Rap1a |
RAP1A, member of RAS oncogene family |
increases activity multiple interactions |
EXP |
Colforsin results in increased activity of RAP1A protein Rolipram affects the reaction [Colforsin results in increased activity of RAP1A protein] |
CTD |
PMID:10908723 |
|
NCBI chr 2:195,896,967...195,974,851
|
|
G |
Rap1b |
RAP1B, member of RAS oncogene family |
multiple interactions increases activity |
EXP |
Rolipram affects the reaction [Colforsin results in increased activity of RAP1B protein] |
CTD |
PMID:10908723 |
|
NCBI chr 7:53,423,039...53,456,349
|
|
G |
Rarres2 |
retinoic acid receptor responder 2 |
multiple interactions |
EXP |
RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP11A1 protein]; RARRES2 protein inhibits the reaction [Colforsin results in increased expression of CYP19A1 protein] |
CTD |
PMID:22948218 |
|
NCBI chr 4:77,522,549...77,525,733
|
|
G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
[Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in decreased phosphorylation of RB1 protein] |
CTD |
PMID:9454737 |
|
NCBI chr15:54,780,858...54,911,989
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP ISO |
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; Colforsin inhibits the reaction [Morphine results in increased phosphorylation of RELA protein] RELA affects the reaction [[monobutyl phthalate co-treated with Colforsin] results in increased secretion of Progesterone] |
CTD |
PMID:22258905 PMID:26745512 PMID:27590029 |
|
NCBI chr 1:212,354,336...212,364,815
|
|
G |
Relb |
RELB proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]] |
CTD |
PMID:17823304 |
|
NCBI chr 1:88,385,717...88,413,380
|
|
G |
Ren |
renin |
increases expression increases secretion multiple interactions |
ISO |
Colforsin results in increased expression of REN mRNA Colforsin results in increased secretion of REN protein [Sodium, Dietary deficiency results in increased susceptibility to Colforsin] which results in increased secretion of REN protein |
CTD |
PMID:9256163 PMID:10432392 |
|
NCBI chr13:47,348,312...47,359,539
|
|
G |
Rnf4 |
ring finger protein 4 |
multiple interactions |
EXP |
[Tetradecanoylphorbol Acetate co-treated with Colforsin] results in increased expression of RNF4 mRNA |
CTD |
PMID:14749358 |
|
NCBI chr14:76,401,292...76,423,270
|
|
G |
Rrp12 |
ribosomal RNA processing 12 |
increases expression |
ISO |
Colforsin results in increased expression of RRP12 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 1:240,672,378...240,705,992
|
|
G |
Runx1 |
RUNX family transcription factor 1 |
affects splicing multiple interactions |
EXP |
Colforsin affects the splicing of RUNX1 exon HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of RUNX1 exon] |
CTD |
PMID:22684629 |
|
NCBI chr11:45,325,778...45,560,300
|
|
G |
Runx2 |
RUNX family transcription factor 2 |
increases expression |
EXP |
Colforsin results in increased expression of RUNX2 mRNA |
CTD |
PMID:20197312 |
|
NCBI chr 9:23,661,278...23,990,248
|
|
G |
Sdc1 |
syndecan 1 |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of SDC1 mRNA [Cadmium Chloride results in increased abundance of Cadmium] inhibits the reaction [Colforsin results in increased expression of SDC1 mRNA] |
CTD |
PMID:35908931 PMID:38296531 |
|
NCBI chr 6:31,562,799...31,585,267
|
|
G |
Sele |
selectin E |
multiple interactions |
ISO |
[Colforsin co-treated with Rolipram] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased secretion of SELE protein] |
CTD |
PMID:8780174 |
|
NCBI chr13:78,935,997...78,945,905
|
|
G |
Selenop |
selenoprotein P |
multiple interactions |
EXP |
Colforsin promotes the reaction [Dexamethasone results in increased expression of SELENOP mRNA] |
CTD |
PMID:18972406 |
|
NCBI chr 2:52,498,123...52,508,409
|
|
G |
Sesn1 |
sestrin 1 |
decreases expression multiple interactions |
ISO |
Colforsin results in decreased expression of SESN1 mRNA; Colforsin results in decreased expression of SESN1 protein AR protein affects the reaction [Colforsin results in decreased expression of SESN1 protein] |
CTD |
PMID:16751804 |
|
NCBI chr20:46,876,918...46,970,010
|
|
G |
Sftpc |
surfactant protein C |
increases expression |
ISO |
Colforsin results in increased expression of SFTPC mRNA |
CTD |
PMID:2539393 |
|
NCBI chr15:45,596,565...45,599,615
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP ISO |
SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; SIRT1 protein inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; SIRT1 protein mutant form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] Colforsin inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA] |
CTD |
PMID:23292070 PMID:30825513 |
|
NCBI chr20:25,305,953...25,328,000
|
|
G |
Slc1a5 |
solute carrier family 1 member 5 |
multiple interactions decreases expression |
ISO |
Valproic Acid promotes the reaction [Colforsin results in decreased expression of SLC1A5 protein] Colforsin results in decreased expression of SLC1A5 mRNA; Colforsin results in decreased expression of SLC1A5 protein |
CTD |
PMID:37385477 |
|
NCBI chr 1:77,456,849...77,470,952
|
|
G |
Slc26a4 |
solute carrier family 26 member 4 |
increases expression |
ISO |
Colforsin results in increased expression of SLC26A4 protein |
CTD |
PMID:22811483 |
|
NCBI chr 6:53,835,102...53,873,968
|
|
G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions increases expression |
ISO |
cobaltous chloride inhibits the reaction [Valproic Acid inhibits the reaction [Colforsin results in increased expression of SLC2A1 protein]]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of SLC2A1 protein] |
CTD |
PMID:38296531 |
|
NCBI chr 5:138,002,522...138,030,742
|
|
G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SLC2A4 mRNA] |
CTD |
PMID:17407152 |
|
NCBI chr10:55,164,721...55,170,289
|
|
G |
Slc2a5 |
solute carrier family 2 member 5 |
multiple interactions increases expression |
ISO EXP |
Colforsin promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Colforsin promotes the reaction [Glucose results in increased expression of SLC2A5 mRNA] Colforsin results in increased expression of SLC2A5 mRNA [[Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein] which results in increased uptake of Fructose; [Colforsin results in increased abundance of Cyclic AMP] which results in increased expression of SLC2A5 protein; Colforsin results in increased expression of and results in decreased degradation of SLC2A5 mRNA |
CTD |
PMID:8037665 PMID:12820898 |
|
NCBI chr 5:160,583,055...160,609,994
|
|
G |
Slc30a1 |
solute carrier family 30 member 1 |
increases expression |
ISO |
Colforsin results in increased expression of SLC30A1 mRNA |
CTD |
PMID:16503475 |
|
NCBI chr13:106,022,019...106,025,892
|
|
G |
Slc30a2 |
solute carrier family 30 member 2 |
increases expression |
ISO |
Colforsin results in increased expression of SLC30A2 mRNA |
CTD |
PMID:16503475 |
|
NCBI chr 5:151,843,451...151,855,674
|
|
G |
Slc30a4 |
solute carrier family 30 member 4 |
increases expression |
ISO |
Colforsin results in increased expression of SLC30A4 mRNA |
CTD |
PMID:16503475 |
|
NCBI chr 3:109,753,270...109,775,306
|
|
G |
Slc30a7 |
solute carrier family 30 member 7 |
decreases expression |
ISO |
Colforsin results in decreased expression of SLC30A7 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 2:203,855,484...203,922,155
|
|
G |
Slc3a2 |
solute carrier family 3 member 2 |
increases expression |
ISO |
Colforsin results in increased expression of SLC3A2 mRNA |
CTD |
PMID:28786956 |
|
NCBI chr 1:215,033,601...215,048,064
|
|
G |
Slc45a2 |
solute carrier family 45, member 2 |
increases expression |
ISO |
Colforsin results in increased expression of SLC45A2 mRNA |
CTD |
PMID:17460731 |
|
NCBI chr 2:59,963,599...59,996,408
|
|
G |
Slc5a5 |
solute carrier family 5 member 5 |
multiple interactions increases expression |
ISO EXP |
Colforsin inhibits the reaction [[Tretinoin co-treated with Hydrocortisone] results in increased activity of SLC5A5 protein] Colforsin results in increased expression of SLC5A5 mRNA; Colforsin results in increased expression of SLC5A5 protein |
CTD |
PMID:16439463 PMID:16954431 |
|
NCBI chr16:18,546,709...18,556,698
|
|
G |
Slc7a5 |
solute carrier family 7 member 5 |
increases expression |
ISO |
Colforsin results in increased expression of SLC7A5 mRNA; Colforsin results in increased expression of SLC7A5 protein |
CTD |
PMID:28786956 |
|
NCBI chr19:66,843,808...66,872,412
|
|
G |
Slc7a8 |
solute carrier family 7 member 8 |
increases expression |
ISO |
Colforsin results in increased expression of SLC7A8 mRNA |
CTD |
PMID:28786956 |
|
NCBI chr15:28,183,013...28,242,717
|
|
G |
Smo |
smoothened, frizzled class receptor |
multiple interactions |
EXP |
Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMO mRNA] |
CTD |
PMID:27590029 |
|
NCBI chr 4:59,311,084...59,341,280
|
|
G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
Colforsin results in decreased expression of SNAI1 mRNA |
CTD |
PMID:30983542 |
|
NCBI chr 3:176,667,476...176,671,965
|
|
G |
Snai2 |
snail family transcriptional repressor 2 |
decreases expression |
ISO |
Colforsin results in decreased expression of SNAI2 mRNA |
CTD |
PMID:30983542 |
|
NCBI chr11:99,686,934...99,690,349
|
|
G |
Snap25 |
synaptosome associated protein 25 |
affects splicing multiple interactions |
EXP |
Colforsin affects the splicing of SNAP25 exon Colforsin promotes the reaction [HNRNPK protein binds to SNAP25 exon]; HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of SNAP25 exon]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin affects the splicing of SNAP25 exon] |
CTD |
PMID:22684629 |
|
NCBI chr 3:144,494,579...144,576,449
|
|
G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions increases expression |
ISO |
Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA] 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein]; [[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein; dorsomorphin inhibits the reaction [[[Colforsin co-treated with Rolipram] results in increased abundance of Cyclic AMP] which results in increased expression of SOCS3 protein] Colforsin results in increased expression of SOCS3 protein |
CTD |
PMID:17407152 PMID:23782265 |
|
NCBI chr10:103,692,579...103,695,975
|
|
G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD1 protein] |
CTD |
PMID:32092105 |
|
NCBI chr11:42,942,742...42,948,399
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases expression increases activity multiple interactions |
ISO |
Colforsin results in increased expression of SOD2 mRNA Colforsin results in increased activity of SOD2 protein [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA; [EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 mRNA]; Acetylcysteine inhibits the reaction [[EGF co-treated with Colforsin co-treated with Rotenone] results in increased expression of SOD2 protein] |
CTD |
PMID:12093828 PMID:32092105 |
|
NCBI chr 1:50,043,323...50,050,168
|
|
G |
Sox2 |
SRY-box transcription factor 2 |
decreases expression |
ISO |
Colforsin results in decreased expression of SOX2 protein |
CTD |
PMID:34897981 |
|
NCBI chr 2:117,536,929...117,539,340
|
|
G |
Spcs3 |
signal peptidase complex subunit 3 |
increases expression |
ISO |
Colforsin results in increased expression of SPCS3 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr16:37,305,358...37,310,792
|
|
G |
Sqstm1 |
sequestosome 1 |
increases degradation |
ISO |
Colforsin results in increased degradation of SQSTM1 protein |
CTD |
PMID:25943029 |
|
NCBI chr10:35,026,598...35,037,750
|
|
G |
Srd5a1 |
steroid 5 alpha-reductase 1 |
increases expression |
ISO |
Colforsin results in increased expression of SRD5A1 mRNA |
CTD |
PMID:22461451 |
|
NCBI chr 1:35,514,914...35,548,898
|
|
G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
Colforsin promotes the reaction [Diethylhexyl Phthalate results in decreased expression of SREBF1 protein] |
CTD |
PMID:37536456 |
|
NCBI chr10:45,507,152...45,529,164
|
|
G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA] |
CTD |
PMID:30825513 |
|
NCBI chr 7:115,542,774...115,600,945
|
|
G |
Sst |
somatostatin |
multiple interactions |
ISO |
[SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] |
CTD |
PMID:22056254 |
|
NCBI chr11:76,956,896...76,958,173
|
|
G |
Sstr2 |
somatostatin receptor 2 |
multiple interactions |
ISO |
[64Cu-CB-TE2A-Y3-TATE co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]; [SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] |
CTD |
PMID:22056254 |
|
NCBI chr10:99,163,353...99,170,519
|
|
G |
Star |
steroidogenic acute regulatory protein |
multiple interactions increases expression |
ISO EXP |
[Colforsin co-treated with Diethylhexyl Phthalate] results in increased expression of STAR protein; BMP6 protein inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Valproic Acid inhibits the reaction [Colforsin results in increased expression of STAR mRNA] Colforsin results in increased expression of STAR mRNA; Colforsin results in increased expression of STAR protein [Atrazine co-treated with Colforsin] results in increased expression of STAR mRNA [Colforsin co-treated with deoxynivalenol] results in increased expression of STAR mRNA; Colforsin affects the reaction [Zearalenone results in increased expression of STAR mRNA]; ferulic acid analog promotes the reaction [Colforsin results in increased expression of STAR mRNA]; ferulic acid analog promotes the reaction [Colforsin results in increased expression of STAR protein]; NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]; W 7 inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; W 7 inhibits the reaction [Colforsin results in increased expression of STAR protein] |
CTD |
PMID:14691014 PMID:15967414 PMID:16254025 PMID:16935330 PMID:17080404 PMID:18936084 PMID:20726872 PMID:22461451 PMID:23183170 PMID:25253736 PMID:25765474 PMID:25871633 PMID:26745512 PMID:26783879 PMID:28235592 PMID:28859905 PMID:31100596 PMID:34929288 PMID:35892601 PMID:36279966 PMID:37536456 More...
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|
NCBI chr16:72,969,824...72,974,447
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|
G |
Sult1e1 |
sulfotransferase family 1E member 1 |
decreases expression |
ISO |
Colforsin results in decreased expression of SULT1E1 mRNA |
CTD |
PMID:22446829 |
|
NCBI chr14:20,422,324...20,439,562
|
|
G |
Sult2a1 |
sulfotransferase family 2A member 1 |
decreases expression multiple interactions |
ISO |
Colforsin results in decreased expression of SULT2A1 mRNA Hexachlorocyclohexane promotes the reaction [Colforsin results in decreased expression of SULT2A1 mRNA] |
CTD |
PMID:17080404 PMID:22446829 |
|
NCBI chr 1:84,582,011...84,639,001
|
|
G |
Sult2b1 |
sulfotransferase family 2B member 1 |
decreases expression |
ISO |
Colforsin results in decreased expression of SULT2B1 mRNA |
CTD |
PMID:22446829 |
|
NCBI chr 1:96,200,155...96,261,295
|
|
G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions |
EXP |
Colforsin promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; HU 211 inhibits the reaction [Colforsin promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] |
CTD |
PMID:15750287 |
|
NCBI chr 4:36,645,344...36,653,548
|
|
G |
Tbr1 |
T-box brain transcription factor 1 |
multiple interactions |
EXP |
Colforsin promotes the reaction [CASK protein modified form binds to TBR1 protein] |
CTD |
PMID:20067577 |
|
NCBI chr 3:46,350,237...46,368,397
|
|
G |
Testin |
testin gene |
affects expression |
EXP |
Colforsin affects the expression of TESTIN mRNA |
CTD |
PMID:11090432 |
|
NCBI chr17:3,824,222...3,859,385
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO EXP |
Colforsin inhibits the reaction [Dronabinol results in increased expression of TGFB1 protein]; TGFB1 protein inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] |
CTD |
PMID:11779138 PMID:15625562 PMID:27590029 |
|
NCBI chr 1:90,324,312...90,340,627
|
|
G |
Tgs1 |
trimethylguanosine synthase 1 |
increases expression |
ISO |
Colforsin results in increased expression of TGS1 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 5:16,524,864...16,558,399
|
|
G |
Th |
tyrosine hydroxylase |
multiple interactions increases expression increases activity |
EXP ISO |
3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Colforsin results in increased expression of TH mRNA]; bisindolylmaleimide I inhibits the reaction [Colforsin results in increased expression of TH mRNA]; HU 211 inhibits the reaction [Colforsin results in increased expression of TH mRNA]; KT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of TH mRNA] Colforsin results in increased expression of TH mRNA; Colforsin results in increased expression of TH protein Colforsin results in increased activity of TH protein |
CTD |
PMID:9288946 PMID:14550852 PMID:18992715 PMID:34897981 |
|
NCBI chr 1:207,500,959...207,508,276
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
Colforsin results in increased expression of TIMP1 mRNA |
CTD |
PMID:20378682 |
|
NCBI chr X:3,766,509...3,772,578
|
|
G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
multiple interactions increases expression |
EXP |
Colforsin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of TIMP2 protein] Colforsin results in increased expression of TIMP2 protein |
CTD |
PMID:21832167 |
|
NCBI chr10:104,041,604...104,089,214
|
|
G |
Tmem50a |
transmembrane protein 50A |
increases expression |
ISO |
Colforsin results in increased expression of TMEM50A mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 5:147,123,670...147,138,859
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
ISO EXP |
Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Colforsin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] Colforsin results in decreased expression of TNF protein Colforsin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Colforsin inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; Colforsin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; Colforsin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased expression of SELE protein]; [Colforsin co-treated with Rolipram] inhibits the reaction [TNF protein results in increased secretion of SELE protein]; Colforsin inhibits the reaction [3,4-dihydroxyphenylethanol promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Colforsin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Colforsin inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]; Colforsin promotes the reaction [TNF protein results in increased expression of IL6 mRNA] |
CTD |
PMID:8780174 PMID:10495789 PMID:10996031 PMID:11675405 PMID:12509806 PMID:15081246 PMID:17407152 PMID:20388727 PMID:21803157 PMID:24771768 PMID:25866079 PMID:27590029 More...
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|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Tob1 |
transducer of ErbB-2.1 |
increases expression |
ISO |
Colforsin results in increased expression of TOB1 mRNA |
CTD |
PMID:15313392 |
|
NCBI chr10:79,163,093...79,165,131
|
|
G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
Colforsin results in increased expression of TP53 protein |
CTD |
PMID:10642304 |
|
NCBI chr10:54,798,871...54,810,300
|
|
G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions |
EXP ISO |
Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1] Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Colforsin promotes the reaction [Capsaicin results in increased activity of TRPV1] |
CTD |
PMID:12886029 PMID:17913835 |
|
NCBI chr10:58,349,936...58,375,021
|
|
G |
Tubb3 |
tubulin, beta 3 class III |
increases expression |
ISO |
Colforsin results in increased expression of TUBB3 protein |
CTD |
PMID:34897981 |
|
NCBI chr19:68,365,687...68,374,741
|
|
G |
Txnip |
thioredoxin interacting protein |
increases activity |
EXP |
Colforsin results in increased activity of TXNIP mRNA |
CTD |
PMID:21832250 |
|
NCBI chr 2:186,781,933...186,785,736
|
|
G |
Tyr |
tyrosinase |
increases activity multiple interactions increases expression decreases expression |
ISO |
Colforsin results in increased activity of TYR protein [resveratrol co-treated with Colforsin] results in decreased activity of TYR protein; [Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA]; Colforsin results in increased expression of and results in increased activity of TYR protein; Particulate Matter inhibits the reaction [Colforsin results in increased expression of TYR mRNA] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Colforsin results in increased expression of TYR protein]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of TYR protein; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TYR mRNA; [Colforsin co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of TYR protein]; alisol B inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TYR mRNA]; glabridin inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of TYR protein] Colforsin results in decreased expression of TYR protein |
CTD |
PMID:17460731 PMID:23700242 PMID:28051915 PMID:28601556 PMID:28849034 |
|
NCBI chr 1:150,527,687...150,622,857
|
|
G |
Tyrp1 |
tyrosinase-related protein 1 |
increases expression multiple interactions |
ISO |
Colforsin results in increased expression of TYRP1 mRNA; Colforsin results in increased expression of TYRP1 protein [Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYRP1 mRNA]; Particulate Matter inhibits the reaction [Colforsin results in increased expression of TYRP1 mRNA] |
CTD |
PMID:17460731 PMID:23700242 PMID:28601556 |
|
NCBI chr 5:100,327,111...100,345,657
|
|
G |
Ube2j1 |
ubiquitin-conjugating enzyme E2, J1 |
increases expression |
ISO |
Colforsin results in increased expression of UBE2J1 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 5:52,218,807...52,237,805
|
|
G |
Ucp1 |
uncoupling protein 1 |
multiple interactions |
ISO |
Colforsin inhibits the reaction [geniposide results in decreased expression of UCP1 mRNA]; Colforsin inhibits the reaction [geniposide results in decreased expression of UCP1 protein] |
CTD |
PMID:34718029 |
|
NCBI chr19:41,713,350...41,721,421
|
|
G |
Usf1 |
upstream transcription factor 1 |
multiple interactions |
ISO |
USF1 gene polymorphism promotes the reaction [Colforsin results in increased metabolism of Lipids]; USF1 protein affects the reaction [Colforsin results in increased metabolism of Lipids] |
CTD |
PMID:15985485 |
|
NCBI chr13:86,377,679...86,385,523
|
|
G |
Vasp |
vasodilator-stimulated phosphoprotein |
increases phosphorylation multiple interactions |
ISO |
Colforsin results in increased phosphorylation of VASP protein N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of VASP protein] |
CTD |
PMID:18182247 PMID:32409581 |
|
NCBI chr 1:88,038,026...88,053,783
|
|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions increases expression |
ISO |
Colforsin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of VEGFA mRNA] |
CTD |
PMID:10788502 PMID:19063610 |
|
NCBI chr 9:22,452,854...22,468,194
|
|
G |
Vim |
vimentin |
multiple interactions |
ISO |
VIM affects the reaction [[monobutyl phthalate co-treated with Colforsin] results in increased secretion of Progesterone] |
CTD |
PMID:26745512 |
|
NCBI chr17:81,577,261...81,585,746
|
|
G |
Wt1 |
WT1 transcription factor |
increases expression |
ISO |
Colforsin results in increased expression of WT1 mRNA |
CTD |
PMID:15961562 |
|
NCBI chr 3:112,019,721...112,068,454
|
|
G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions |
ISO |
[[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein] which results in decreased susceptibility to Cisplatin; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP mRNA; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of XIAP protein |
CTD |
PMID:21255191 |
|
NCBI chr X:125,756,107...125,803,979
|
|
G |
Zbtb10 |
zinc finger and BTB domain containing 10 |
decreases expression |
ISO |
Colforsin results in decreased expression of ZBTB10 mRNA |
CTD |
PMID:16751804 |
|
NCBI chr 2:94,382,670...94,417,308
|
|
G |
Zfp36l1 |
zinc finger protein 36, C3H type-like 1 |
increases expression |
EXP |
Colforsin results in increased expression of ZFP36L1 mRNA |
CTD |
PMID:23423171 |
|
NCBI chr 6:98,930,705...98,935,748
|
|
G |
Zfp36l2 |
zinc finger protein 36, C3H type-like 2 |
decreases expression |
ISO |
Colforsin results in decreased expression of ZFP36L2 mRNA |
CTD |
PMID:15967414 |
|
NCBI chr 6:16,242,622...16,246,662
|
|