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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:clobazam
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Accession:CHEBI:31413 term browser browse the term
Definition:7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
Synonyms:exact_synonym: 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
 related_synonym: 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine;   7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione;   Formula=C16H13ClN2O2;   InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3;   InChIKey=CXOXHMZGEKVPMT-UHFFFAOYSA-N;   SMILES=CN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc12;   clobazamum
 alt_id: CHEBI:211390
 xref: Beilstein:758410;   CAS:22316-47-8;   DrugBank:DB00349;   Drug_Central:682;   HMDB:HMDB0014493;   KEGG:D01253
 xref_mesh: MESH:C012255
 xref: PMID:11129898;   PMID:12873507;   PMID:16190747;   PMID:1977910;   PMID:19810886;   PMID:21982812;   PMID:22128252;   PMID:22145708;   PMID:22242724;   PMID:22293514;   PMID:22345881;   PMID:22383262;   PMID:22422635;   PMID:22449211;   PMID:22695038;   PMID:22727658;   PMID:22749457;   PMID:22883278;   PMID:22955137;   PMID:22964442;   PMID:22982618;   PMID:23006671;   Patent:BE707667;   Patent:US3984398;   Reaxys:758410;   Wikipedia:Clobazam


show annotations for term's descendants           Sort by:
clobazam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects response to substance ISO ABCC2 protein affects the susceptibility to clobazam CTD PMID:22982618 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions EXP [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506 		JBrowse link
G SELE selectin E multiple interactions EXP [clobazam co-treated with Phenytoin] results in increased expression of SELE protein CTD PMID:16376047 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G SERPINC1 serpin family C member 1 multiple interactions EXP [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 1:173,903,800...173,917,327
Ensembl chr 1:173,903,800...173,917,327 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        biophysical role 14835
          membrane transport modulator 14648
            GABA modulator 5149
              clobazam 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  organonitrogen heterocyclic compound 20349
                                    benzodiazepine 921
                                      1,4-benzodiazepinone 126
                                        clobazam 4
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