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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:clobazam
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Accession:CHEBI:31413 term browser browse the term
Definition:7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
Synonyms:exact_synonym: 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
 related_synonym: 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine;   7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione;   Formula=C16H13ClN2O2;   InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3;   InChIKey=CXOXHMZGEKVPMT-UHFFFAOYSA-N;   SMILES=CN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc12;   clobazamum
 alt_id: CHEBI:211390
 xref: Beilstein:758410;   CAS:22316-47-8;   DrugBank:DB00349;   Drug_Central:682;   HMDB:HMDB0014493;   KEGG:D01253
 xref_mesh: MESH:C012255
 xref: PMID:11129898;   PMID:12873507;   PMID:16190747;   PMID:1977910;   PMID:19810886;   PMID:21982812;   PMID:22128252;   PMID:22145708;   PMID:22242724;   PMID:22293514;   PMID:22345881;   PMID:22383262;   PMID:22422635;   PMID:22449211;   PMID:22695038;   PMID:22727658;   PMID:22749457;   PMID:22883278;   PMID:22955137;   PMID:22964442;   PMID:22982618;   PMID:23006671;   Patent:BE707667;   Patent:US3984398;   Reaxys:758410;   Wikipedia:Clobazam


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clobazam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance EXP ABCC2 protein affects the susceptibility to clobazam CTD PMID:22982618 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G F2 coagulation factor II multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Sele selectin E multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of SELE protein CTD PMID:16376047 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biophysical role 12282
          membrane transport modulator 12063
            GABA modulator 4648
              clobazam 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organonitrogen heterocyclic compound 17460
                                    benzodiazepine 542
                                      1,4-benzodiazepinone 116
                                        clobazam 4
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