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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cilnidipine
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Accession:CHEBI:31399 term browser browse the term
Definition:A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
Synonyms:exact_synonym: 2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: (+-)-(E)-cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;   Formula=C27H28N2O7;   InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+;   InChIKey=KJEBULYHNRNJTE-DHZHZOJOSA-N;   SMILES=COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC\\C=C\\c1ccccc1
 alt_id: CHEBI:551341
 xref: CAS:132203-70-4;   Drug_Central:642;   KEGG:D01173
 xref_mesh: MESH:C065927
 xref: Patent:EP161877;   Patent:US4672068;   Wikipedia:Cilnidipine



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cilnidipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions ISO cilnidipine inhibits the reaction [Iohexol results in increased expression of BAX protein] CTD PMID:36207783 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO cilnidipine inhibits the reaction [Iohexol results in decreased expression of BCL2 protein] CTD PMID:36207783 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma multiple interactions ISO cilnidipine inhibits the reaction [CAMK2G protein promotes the reaction [Iohexol results in increased cleavage of CASP3 protein]] CTD PMID:36207783 NCBI chr14:20,784,943...20,844,225
Ensembl chr14:20,784,943...20,844,156
JBrowse link
G Casp3 caspase 3 multiple interactions ISO cilnidipine inhibits the reaction [CAMK2G protein promotes the reaction [Iohexol results in increased cleavage of CASP3 protein]]; cilnidipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein] CTD PMID:36207783 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 decreases activity ISO cilnidipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815
JBrowse link
G Esr1 estrogen receptor 1 (alpha) decreases activity ISO cilnidipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO cilnidipine results in decreased expression of FGF2 mRNA CTD PMID:16333380 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO cilnidipine inhibits the reaction [Iohexol results in increased expression of HAVCR1 protein] CTD PMID:36207783 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO cilnidipine inhibits the reaction [Iohexol results in increased expression of LCN2 protein] CTD PMID:36207783 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO cilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity
ISO cilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; cilnidipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; cilnidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
cilnidipine results in increased activity of NR1H4 protein
CTD PMID:25257666 PMID:27773686 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
JBrowse link
G Ppard peroxisome proliferator activator receptor delta decreases activity ISO cilnidipine results in decreased activity of PPARD protein CTD PMID:25257666 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma decreases activity ISO cilnidipine results in decreased activity of PPARG protein CTD PMID:25257666 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
JBrowse link
G Ppif peptidylprolyl isomerase F (cyclophilin F) multiple interactions ISO cilnidipine inhibits the reaction [Iohexol results in increased expression of PPIF protein] CTD PMID:36207783 NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO cilnidipine results in decreased expression of TGFB1 mRNA CTD PMID:16333380 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22188
    role 22173
      application 21755
        solvent 18220
          2-methoxyethanol 349
            2-methoxyethyl ester 56
              cilnidipine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      chalcogen 21436
                        oxygen atom 21414
                          oxygen molecular entity 21414
                            hydroxides 20789
                              organic hydroxy compound 19718
                                polyol 11673
                                  diol 3893
                                    glycol 3659
                                      glycol ether 919
                                        2-methoxyethanol 349
                                          2-methoxyethyl ester 56
                                            cilnidipine 15
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