CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: cilnidipine
Accession: CHEBI:31399
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Definition: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
Synonyms: exact_synonym: 2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
related_synonym: (+-)-(E)-cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; Formula=C27H28N2O7; InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+; InChIKey=KJEBULYHNRNJTE-DHZHZOJOSA-N; SMILES=COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC\\C=C\\c1ccccc1
alt_id: CHEBI:551341
xref: CAS:132203-70-4; Drug_Central:642; KEGG:D01173
xref_mesh: MESH:C065927
xref: Patent:EP161877; Patent:US4672068; Wikipedia:Cilnidipine
G
Bax
BCL2-associated X protein
multiple interactions
ISO
cilnidipine inhibits the reaction [Iohexol results in increased expression of BAX protein]
CTD
PMID:36207783
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
G
Bcl2
B cell leukemia/lymphoma 2
multiple interactions
ISO
cilnidipine inhibits the reaction [Iohexol results in decreased expression of BCL2 protein]
CTD
PMID:36207783
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
G
Camk2g
calcium/calmodulin-dependent protein kinase II gamma
multiple interactions
ISO
cilnidipine inhibits the reaction [CAMK2G protein promotes the reaction [Iohexol results in increased cleavage of CASP3 protein]]
CTD
PMID:36207783
NCBI chr14:20,784,943...20,844,225
Ensembl chr14:20,784,943...20,844,156
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Casp3
caspase 3
multiple interactions
ISO
cilnidipine inhibits the reaction [CAMK2G protein promotes the reaction [Iohexol results in increased cleavage of CASP3 protein]]; cilnidipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein]
CTD
PMID:36207783
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
decreases activity
ISO
cilnidipine results in decreased activity of CYP2J2 protein
CTD
PMID:30965050
NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815
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Esr1
estrogen receptor 1 (alpha)
decreases activity
ISO
cilnidipine results in decreased activity of ESR1 protein
CTD
PMID:25257666
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
G
Fgf2
fibroblast growth factor 2
decreases expression
ISO
cilnidipine results in decreased expression of FGF2 mRNA
CTD
PMID:16333380
NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
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Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
ISO
cilnidipine inhibits the reaction [Iohexol results in increased expression of HAVCR1 protein]
CTD
PMID:36207783
NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
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Lcn2
lipocalin 2
multiple interactions
ISO
cilnidipine inhibits the reaction [Iohexol results in increased expression of LCN2 protein]
CTD
PMID:36207783
NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
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Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
cilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
CTD
PMID:27773686
NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions increases activity
ISO
cilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; cilnidipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; cilnidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] cilnidipine results in increased activity of NR1H4 protein
CTD
PMID:25257666 PMID:27773686
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
G
Ppard
peroxisome proliferator activator receptor delta
decreases activity
ISO
cilnidipine results in decreased activity of PPARD protein
CTD
PMID:25257666
NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448
G
Pparg
peroxisome proliferator activated receptor gamma
decreases activity
ISO
cilnidipine results in decreased activity of PPARG protein
CTD
PMID:25257666
NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360
G
Ppif
peptidylprolyl isomerase F (cyclophilin F)
multiple interactions
ISO
cilnidipine inhibits the reaction [Iohexol results in increased expression of PPIF protein]
CTD
PMID:36207783
NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892
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Tgfb1
transforming growth factor, beta 1
decreases expression
ISO
cilnidipine results in decreased expression of TGFB1 mRNA
CTD
PMID:16333380
NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
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