CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Ciclesonide
Accession: CHEBI:31397
browse the term
Synonyms: related_synonym: Formula=C32H44O7; InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1; InChIKey=LUKZNWIVRBCLON-GXOBDPJESA-N; SMILES=C(COC(C(C)C)=O)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(O[C@H](O2)C4CCCCC4)[H])([C@]5([C@]([C@H](C3)O)([C@]6(C)C(CC5)=CC(C=C6)=O)[H])[H])[H]; alvesco; omnaris
xref: CAS:126544-47-6; Drug_Central:633; KEGG:D01703
xref_mesh: MESH:C120481
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
ISO
ciclesonide results in increased expression of ABCB1 protein
CTD
PMID:22464980
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Ar
androgen receptor
multiple interactions
ISO
ciclesonide binds to and results in decreased activity of AR protein; ciclesonide binds to and results in increased activity of AR protein
CTD
PMID:25752796
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Esr1
estrogen receptor 1
multiple interactions
ISO
ciclesonide binds to and results in decreased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Pgr
progesterone receptor
multiple interactions
ISO
ciclesonide binds to and results in increased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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