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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression |
ISO |
Carboplatin results in decreased expression of ABCB1 mRNA; Carboplatin results in decreased expression of ABCB1 protein |
CTD |
PMID:27692344 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases expression |
EXP |
Carboplatin results in decreased expression of ABCB4 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases expression |
ISO |
Carboplatin results in decreased expression of ABCC1 mRNA; Carboplatin results in decreased expression of ABCC1 protein |
CTD |
PMID:27692344 |
|
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases expression |
ISO |
Carboplatin results in decreased expression of ABCC2 mRNA; Carboplatin results in decreased expression of ABCC2 protein |
CTD |
PMID:27692344 |
|
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
decreases expression |
ISO |
Carboplatin results in decreased expression of ABCG2 mRNA; Carboplatin results in decreased expression of ABCG2 protein |
CTD |
PMID:27692344 |
|
NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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G |
Acvr1c |
activin A receptor type 1C |
increases response to substance |
ISO |
ACVR1C results in increased susceptibility to Carboplatin |
CTD |
PMID:21224400 |
|
NCBI chr 3:44,272,859...44,342,501
Ensembl chr 3:44,270,653...44,342,355
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G |
Akr1b1 |
aldo-keto reductase family 1 member B |
increases expression |
EXP |
Carboplatin results in increased expression of AKR1B1 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Pravastatin inhibits the reaction [Carboplatin results in increased activity of and results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:18483861 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Alas2 |
5'-aminolevulinate synthase 2 |
decreases expression |
EXP |
Carboplatin results in decreased expression of ALAS2 mRNA |
CTD |
PMID:21296123 |
|
NCBI chr X:23,167,576...23,187,356
Ensembl chr X:23,167,696...23,187,341
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
affects response to substance |
ISO |
ALDH1A1 protein affects the susceptibility to Carboplatin |
CTD |
PMID:18854779 |
|
NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
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G |
Aldh3a1 |
aldehyde dehydrogenase 3 family, member A1 |
affects response to substance |
ISO |
ALDH3A1 protein affects the susceptibility to Carboplatin |
CTD |
PMID:18854779 |
|
NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
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|
G |
Anxa4 |
annexin A4 |
decreases response to substance affects localization multiple interactions |
ISO |
ANXA4 protein results in decreased susceptibility to Carboplatin Carboplatin affects the localization of ANXA4 protein ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin] |
CTD |
PMID:24150977 |
|
NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
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|
G |
Arfgef1 |
ADP ribosylation factor guanine nucleotide exchange factor 1 |
increases response to substance |
ISO |
ARFGEF1 results in increased susceptibility to Carboplatin |
CTD |
PMID:21755009 |
|
NCBI chr 5:8,666,046...8,760,458
Ensembl chr 5:8,666,200...8,760,458
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G |
Atp1a1 |
ATPase Na+/K+ transporting subunit alpha 1 |
decreases expression |
EXP |
Carboplatin results in decreased expression of ATP1A1 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
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G |
Atp7a |
ATPase copper transporting alpha |
affects localization multiple interactions |
ISO |
Carboplatin affects the localization of ATP7A protein [MIR495 mRNA results in decreased expression of ATP7A protein] which results in increased susceptibility to Carboplatin; ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin] |
CTD |
PMID:24038379 PMID:24150977 |
|
NCBI chr X:77,076,085...77,193,644
Ensembl chr X:77,076,106...77,193,644
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G |
Atp7b |
ATPase copper transporting beta |
multiple interactions |
ISO |
ATP7B protein binds to and results in increased metabolism of Carboplatin |
CTD |
PMID:23751120 |
|
NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
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G |
Bax |
BCL2 associated X, apoptosis regulator |
decreases expression multiple interactions |
ISO |
Carboplatin results in decreased expression of BAX mRNA Carboplatin results in increased cleavage of and results in increased expression of BAX protein |
CTD |
PMID:15131059 PMID:15576332 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Carboplatin results in decreased expression of BCL2 mRNA; Carboplatin results in decreased expression of BCL2 protein |
CTD |
PMID:9664115 PMID:15576332 PMID:15996812 PMID:17404015 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression multiple interactions |
ISO EXP |
Carboplatin results in decreased expression of BCL2L1 protein Acetylcysteine inhibits the reaction [Carboplatin results in decreased expression of BCL2L1 protein] |
CTD |
PMID:18483861 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Bcl2l12 |
BCL2 like 12 |
increases expression |
ISO |
Carboplatin results in increased expression of BCL2L12 mRNA |
CTD |
PMID:15576332 |
|
NCBI chr 1:100,984,550...100,993,269
Ensembl chr 1:100,984,550...100,993,269
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G |
Becn1 |
beclin 1 |
decreases expression multiple interactions |
ISO |
Carboplatin results in decreased expression of BECN1 protein Carboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]; Chloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein] |
CTD |
PMID:27692344 |
|
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases response to substance |
ISO |
BIRC2 protein results in decreased susceptibility to Carboplatin |
CTD |
PMID:10815900 |
|
NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
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G |
Blmh |
bleomycin hydrolase |
decreases expression |
EXP |
Carboplatin results in decreased expression of BLMH mRNA |
CTD |
PMID:18172885 |
|
NCBI chr10:63,197,367...63,240,447
Ensembl chr10:63,197,364...63,240,332
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G |
Brca1 |
BRCA1, DNA repair associated |
decreases activity |
ISO |
Carboplatin results in decreased activity of BRCA1 protein |
CTD |
PMID:20878461 |
|
NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
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G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2 |
affects response to substance |
ISO |
CAMKK2 protein affects the susceptibility to Carboplatin |
CTD |
PMID:28634229 |
|
NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601
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G |
Canx |
calnexin |
decreases expression |
EXP |
Carboplatin results in decreased expression of CANX mRNA |
CTD |
PMID:18172885 |
|
NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
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G |
Casp2 |
caspase 2 |
decreases expression |
EXP |
Carboplatin results in decreased expression of CASP2 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity increases expression |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein]; Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein] Carboplatin results in increased expression of CASP3 protein Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein] Carboplatin results in increased expression of CASP3 mRNA |
CTD |
PMID:15576332 PMID:16275998 PMID:18483861 PMID:20368269 PMID:22302033 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp7 |
caspase 7 |
increases activity multiple interactions |
ISO |
Carboplatin results in increased activity of CASP7 protein palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP7 protein] |
CTD |
PMID:22302033 |
|
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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G |
Casp9 |
caspase 9 |
increases activity decreases expression multiple interactions increases expression |
ISO EXP |
Carboplatin results in increased activity of CASP9 protein Carboplatin results in decreased expression of CASP9 mRNA Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP9 protein] |
CTD |
PMID:15576332 PMID:15996812 PMID:17404015 PMID:18483861 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Cat |
catalase |
decreases activity decreases expression multiple interactions |
EXP |
Carboplatin results in decreased activity of CAT protein Carboplatin results in decreased expression of CAT protein Carboplatin results in decreased expression of and results in decreased activity of CAT protein |
CTD |
PMID:11124453 PMID:15109710 PMID:15225673 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Cd274 |
CD274 molecule |
decreases expression |
ISO |
Carboplatin results in decreased expression of CD274; Carboplatin results in decreased expression of CD274 protein |
CTD |
PMID:21765211 PMID:27692344 |
|
NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
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G |
Cd44 |
CD44 molecule (Indian blood group) |
decreases expression |
EXP |
Carboplatin results in decreased expression of CD44 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
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G |
Cdc25b |
cell division cycle 25B |
decreases expression |
EXP |
Carboplatin results in decreased expression of CDC25B mRNA |
CTD |
PMID:21296123 |
|
NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
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G |
Cdc42 |
cell division cycle 42 |
decreases expression |
EXP |
Carboplatin results in decreased expression of CDC42 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO EXP |
Carboplatin results in increased expression of CDKN1A protein Carboplatin results in increased expression of CDKN1A mRNA |
CTD |
PMID:9664115 PMID:18172885 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cited2 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 |
increases expression |
EXP |
Carboplatin results in increased expression of CITED2 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
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G |
Clu |
clusterin |
decreases expression |
EXP |
Carboplatin results in decreased expression of CLU mRNA |
CTD |
PMID:18172885 |
|
NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
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G |
Cops5 |
COP9 signalosome subunit 5 |
increases response to substance |
ISO |
COPS5 results in increased susceptibility to Carboplatin |
CTD |
PMID:21755009 |
|
NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
EXP |
Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CYCS protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CYCS protein] |
CTD |
PMID:18483861 |
|
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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G |
Dct |
dopachrome tautomerase |
decreases response to substance |
ISO |
DCT protein results in decreased susceptibility to Carboplatin |
CTD |
PMID:15897911 |
|
NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
EXP |
Carboplatin results in increased expression of DDIT3 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Dpyd |
dihydropyrimidine dehydrogenase |
multiple interactions |
ISO |
PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin] |
CTD |
PMID:16685392 |
|
NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
affects phosphorylation |
ISO |
Carboplatin affects the phosphorylation of EIF2S1 protein |
CTD |
PMID:29053414 |
|
NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
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G |
Epcam |
epithelial cell adhesion molecule |
multiple interactions |
ISO |
[Paclitaxel co-treated with Carboplatin] results in increased expression of EPCAM protein |
CTD |
PMID:12695858 |
|
NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
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G |
Epo |
erythropoietin |
increases expression |
EXP |
Carboplatin results in increased expression of EPO protein |
CTD |
PMID:17891399 |
|
NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions |
ISO |
ERBB2 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Thiotepa co-treated with Carboplatin] |
CTD |
PMID:16446318 |
|
NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
|
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
Carboplatin results in increased expression of FAS mRNA |
CTD |
PMID:15576332 |
|
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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G |
Fshb |
follicle stimulating hormone subunit beta |
increases expression |
EXP |
Carboplatin results in increased expression of FSHB protein |
CTD |
PMID:8776818 |
|
NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
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G |
Gsr |
glutathione-disulfide reductase |
decreases activity |
EXP |
Carboplatin results in decreased activity of GSR protein |
CTD |
PMID:11124453 |
|
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
|
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G |
Gstp1 |
glutathione S-transferase pi 1 |
affects response to substance |
ISO |
GSTP1 gene affects the susceptibility to Carboplatin |
CTD |
PMID:12360105 |
|
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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G |
H2ax |
H2A.X variant histone |
increases expression multiple interactions |
ISO |
Carboplatin results in increased expression of H2AX protein palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein] |
CTD |
PMID:22302033 |
|
NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
|
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G |
Hax1 |
HCLS1 associated protein X-1 |
multiple interactions |
EXP |
Pravastatin inhibits the reaction [Carboplatin results in decreased expression of HAX1 protein] |
CTD |
PMID:18483861 |
|
NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322
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G |
Hbb |
hemoglobin subunit beta |
decreases expression |
EXP |
Carboplatin results in decreased expression of HBB mRNA |
CTD |
PMID:21296123 |
|
NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression decreases response to substance decreases expression |
ISO EXP |
HMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4] Carboplatin results in increased expression of HMOX1 mRNA HMOX1 protein results in decreased susceptibility to Carboplatin Carboplatin results in decreased expression of HMOX1 mRNA |
CTD |
PMID:18172885 PMID:20368269 PMID:21198546 PMID:26260164 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
|
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G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
decreases expression |
EXP |
Carboplatin results in decreased expression of HSD17B4 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
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G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
increases expression |
EXP |
Carboplatin results in increased expression of HSPA1A mRNA |
CTD |
PMID:18172885 |
|
NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
|
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression |
EXP |
Carboplatin results in increased expression of HSPA1B mRNA |
CTD |
PMID:18172885 |
|
NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
decreases expression |
EXP |
Carboplatin results in decreased expression of HSPA5 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
|
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
increases expression |
EXP |
Carboplatin results in increased expression of HSPB1 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
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G |
Igf2r |
insulin-like growth factor 2 receptor |
decreases expression |
EXP |
Carboplatin results in decreased expression of IGF2R mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 1:48,176,095...48,264,482
Ensembl chr 1:48,176,106...48,264,477
|
|
G |
Il6 |
interleukin 6 |
decreases response to substance |
ISO |
IL6 protein results in decreased susceptibility to Carboplatin |
CTD |
PMID:7834629 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
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G |
Il6r |
interleukin 6 receptor |
decreases response to substance |
ISO |
IL6R protein results in decreased susceptibility to Carboplatin |
CTD |
PMID:7834629 |
|
NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
|
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
EXP |
Carboplatin results in decreased expression of JUN mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
|
|
G |
Map3k1 |
mitogen-activated protein kinase kinase kinase 1 |
decreases expression |
EXP |
Carboplatin results in decreased expression of MAP3K1 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
|
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G |
Map3k12 |
mitogen activated protein kinase kinase kinase 12 |
decreases expression |
EXP |
Carboplatin results in decreased expression of MAP3K12 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 7:144,102,275...144,120,306
Ensembl chr 7:144,102,680...144,109,116
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|
G |
Mapk14 |
mitogen activated protein kinase 14 |
decreases expression |
EXP |
Carboplatin results in decreased expression of MAPK14 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
|
|
G |
Mapk6 |
mitogen-activated protein kinase 6 |
decreases expression |
EXP |
Carboplatin results in decreased expression of MAPK6 mRNA |
CTD |
PMID:18172885 |
|
NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108
|
|
G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
decreases expression |
EXP |
Carboplatin results in decreased expression of MGMT mRNA |
CTD |
PMID:18172885 |
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NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
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Mir155 |
microRNA 155 |
multiple interactions |
ISO |
[Carboplatin co-treated with Chloroquine] results in increased expression of MIR155 mRNA |
CTD |
PMID:27692344 |
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NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
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Mpo |
myeloperoxidase |
multiple interactions |
EXP |
[Carboplatin co-treated with Carnitine deficiency] results in increased expression of MPO protein |
CTD |
PMID:18852009 |
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NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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Msh2 |
mutS homolog 2 |
decreases expression |
EXP |
Carboplatin results in decreased expression of MSH2 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
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Mt1 |
metallothionein 1 |
decreases expression |
EXP |
Carboplatin results in decreased expression of MT1A mRNA |
CTD |
PMID:18172885 |
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NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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Myc |
MYC proto-oncogene, bHLH transcription factor |
increases response to substance |
ISO |
MYC protein results in increased susceptibility to Carboplatin |
CTD |
PMID:21324178 |
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NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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Nanog |
Nanog homeobox |
increases expression |
ISO |
Carboplatin results in increased expression of NANOG mRNA |
CTD |
PMID:25605917 |
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NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
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Nbas |
NBAS subunit of NRZ tethering complex |
affects response to substance |
ISO |
NBAS intron polymorphism affects the susceptibility to Carboplatin |
CTD |
PMID:21844884 |
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NCBI chr 6:38,474,773...38,777,146
Ensembl chr 6:38,474,804...38,777,806
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G |
Nckap1 |
NCK-associated protein 1 |
decreases expression |
EXP |
Carboplatin results in decreased expression of NCKAP1 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 3:67,725,180...67,804,680
Ensembl chr 3:67,725,947...67,787,990
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Nfatc4 |
nuclear factor of activated T-cells 4 |
multiple interactions increases activity |
ISO EXP |
HMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4] |
CTD |
PMID:21198546 |
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NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions decreases expression |
ISO EXP |
Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]; Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]] Carboplatin results in decreased expression of NFKB1 mRNA |
CTD |
PMID:12675310 PMID:18172885 |
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NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Nfkbia |
NFKB inhibitor alpha |
decreases phosphorylation multiple interactions |
ISO |
Carboplatin results in decreased phosphorylation of NFKBIA protein NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:12675310 PMID:15120608 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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Nodal |
nodal growth differentiation factor |
increases response to substance |
ISO |
NODAL results in increased susceptibility to Carboplatin |
CTD |
PMID:21224400 |
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NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
EXP |
Carboplatin results in increased expression of NQO1 mRNA |
CTD |
PMID:18172885 |
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NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Nras |
NRAS proto-oncogene, GTPase |
decreases expression |
EXP |
Carboplatin results in decreased expression of NRAS mRNA |
CTD |
PMID:18172885 |
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NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
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Olr325 |
olfactory receptor 325 |
affects response to substance |
ISO |
OR4D6 gene SNP affects the susceptibility to Carboplatin |
CTD |
PMID:26378035 |
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NCBI chr 1:228,545,913...228,546,857
Ensembl chr 1:228,545,913...228,546,857
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Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
Carboplatin results in increased cleavage of PARP1 protein |
CTD |
PMID:15996812 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Pawr |
pro-apoptotic WT1 regulator |
decreases expression |
EXP |
Carboplatin results in decreased expression of PAWR mRNA |
CTD |
PMID:18172885 |
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NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
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Pcna |
proliferating cell nuclear antigen |
multiple interactions increases expression |
ISO EXP |
PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin]; PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin] Carboplatin results in increased expression of PCNA mRNA |
CTD |
PMID:16685392 PMID:18172885 |
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NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
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Pdcd1lg2 |
programmed cell death 1 ligand 2 |
decreases expression multiple interactions |
ISO |
Carboplatin results in decreased expression of PDCD1LG2 STAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2] |
CTD |
PMID:21765211 |
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NCBI chr 1:247,562,202...247,629,279
Ensembl chr 1:247,562,202...247,627,193
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Pdia4 |
protein disulfide isomerase family A, member 4 |
decreases expression |
EXP |
Carboplatin results in decreased expression of PDIA4 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
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Pdia6 |
protein disulfide isomerase family A, member 6 |
decreases expression |
EXP |
Carboplatin results in decreased expression of PDIA6 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
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G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression |
ISO |
Carboplatin results in increased expression of PMAIP1 protein |
CTD |
PMID:20802529 |
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NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
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G |
Psmb2 |
proteasome 20S subunit beta 2 |
increases expression |
EXP |
Carboplatin results in increased expression of PSMB2 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 5:144,702,004...144,734,220
Ensembl chr 5:144,701,949...144,734,257
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G |
Psmb4 |
proteasome 20S subunit beta 4 |
decreases expression |
EXP |
Carboplatin results in decreased expression of PSMB4 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 2:196,043,546...196,046,320
Ensembl chr 2:196,043,618...196,046,311
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases response to substance multiple interactions |
ISO |
PTGS2 protein results in decreased susceptibility to Carboplatin wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin] |
CTD |
PMID:18089846 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Rab10 |
RAB10, member RAS oncogene family |
decreases expression |
EXP |
Carboplatin results in decreased expression of RAB10 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 6:27,668,387...27,721,120
Ensembl chr 6:27,668,403...27,721,120
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G |
Rbm17 |
RNA binding motif protein 17 |
decreases response to substance |
ISO |
RBM17 protein results in decreased susceptibility to Carboplatin |
CTD |
PMID:16061639 |
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NCBI chr17:70,586,345...70,603,289
Ensembl chr17:70,586,394...70,603,267
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Carboplatin results in decreased localization of and results in decreased activity of RELA protein; Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:12675310 PMID:15120608 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Scd2 |
stearoyl-Coenzyme A desaturase 2 |
decreases expression |
EXP |
Carboplatin results in decreased expression of SCD2 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
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G |
Sik1 |
salt-inducible kinase 1 |
increases response to substance |
ISO |
SIK1 results in increased susceptibility to Carboplatin |
CTD |
PMID:21755009 |
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NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
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G |
Slc31a1 |
solute carrier family 31 member 1 |
decreases response to substance multiple interactions increases import increases uptake increases response to substance |
ISO EXP |
SLC31A1 gene mutant form results in decreased susceptibility to Carboplatin [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin SLC31A1 protein results in increased import of Carboplatin SLC31A1 protein results in increased uptake of Carboplatin SLC31A1 protein results in increased susceptibility to Carboplatin |
CTD |
PMID:15634647 PMID:16847145 PMID:19509135 PMID:22914438 PMID:23123662 |
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NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
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G |
Slc31a2 |
solute carrier family 31 member 2 |
decreases uptake |
ISO |
SLC31A2 protein results in decreased uptake of Carboplatin |
CTD |
PMID:19509135 |
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NCBI chr 5:78,120,606...78,131,111
Ensembl chr 5:78,120,607...78,131,114
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Smo |
smoothened, frizzled class receptor |
increases expression |
ISO |
Carboplatin results in increased expression of SMO mRNA |
CTD |
PMID:25605917 |
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NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions decreases expression |
EXP |
Carboplatin results in decreased expression of and results in decreased activity of SOD1 protein Carboplatin results in decreased expression of SOD1 protein |
CTD |
PMID:15109710 PMID:15225673 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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Sod2 |
superoxide dismutase 2 |
multiple interactions decreases expression |
EXP |
Carboplatin results in increased expression of and results in increased activity of SOD2 protein Carboplatin results in decreased expression of SOD2 protein |
CTD |
PMID:15109710 PMID:15225673 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Sox2 |
SRY-box transcription factor 2 |
increases expression |
ISO |
Carboplatin results in increased expression of SOX2 mRNA |
CTD |
PMID:25605917 |
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NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
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Stat6 |
signal transducer and activator of transcription 6 |
multiple interactions |
ISO |
STAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2] |
CTD |
PMID:21765211 |
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NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
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Stk39 |
serine threonine kinase 39 |
decreases expression |
EXP |
Carboplatin results in decreased expression of STK39 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 3:54,359,449...54,625,702
Ensembl chr 3:54,359,451...54,625,414
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G |
Stx2 |
syntaxin 2 |
increases response to substance |
ISO |
STX2 protein results in increased susceptibility to Carboplatin |
CTD |
PMID:24039787 |
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NCBI chr12:31,324,203...31,360,249
Ensembl chr12:31,335,372...31,360,254
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G |
Tfap2a |
transcription factor AP-2 alpha |
increases response to substance |
ISO |
TFAP2A protein results in increased susceptibility to Carboplatin |
CTD |
PMID:16204029 |
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NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
[Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein |
CTD |
PMID:18852009 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Top2a |
DNA topoisomerase II alpha |
multiple interactions |
ISO |
TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] |
CTD |
PMID:11325482 |
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NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
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Tp53 |
tumor protein p53 |
increases expression |
ISO |
Carboplatin results in increased expression of TP53 protein |
CTD |
PMID:9664115 PMID:15131059 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Tyms |
thymidylate synthetase |
multiple interactions |
ISO |
PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin] |
CTD |
PMID:16685392 |
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NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
decreases expression |
EXP |
Carboplatin results in decreased expression of UGT1A6 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Vim |
vimentin |
decreases expression |
EXP |
Carboplatin results in decreased expression of VIM mRNA |
CTD |
PMID:18172885 |
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NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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G |
Xdh |
xanthine dehydrogenase |
affects activity |
EXP |
Carboplatin affects the activity of XDH protein |
CTD |
PMID:15225673 |
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NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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G |
Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
decreases response to substance |
ISO |
XPC results in decreased susceptibility to Carboplatin |
CTD |
PMID:19372135 |
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NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
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G |
Zfp36l1 |
zinc finger protein 36, C3H type-like 1 |
decreases expression |
EXP |
Carboplatin results in decreased expression of ZFP36L1 mRNA |
CTD |
PMID:18172885 |
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NCBI chr 6:103,308,032...103,313,074
Ensembl chr 6:103,308,045...103,313,074
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