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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:capecitabine
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Accession:CHEBI:31348 term browser browse the term
Definition:A carbamate ester that is cytidine in which the hydrogen at position 5 is replaced by fluorine and in which the amino group attached to position 4 is converted into its N-(penyloxy)carbonyl derivative. Capecitabine is a antineoplastic agent used in the treatment of cancers.
Synonyms:exact_synonym: 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
 related_synonym: (1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester;   Capecitabin;   Formula=C15H22FN3O6;   InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1;   InChIKey=GAGWJHPBXLXJQN-UORFTKCHSA-N;   Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate;   SMILES=CCCCCOC(=O)Nc1nc(=O)n(cc1F)[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O;   Xeloda;   capecitabina;   capecitabinum;   pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
 alt_id: MESH:D000069287
 xref: CAS:154361-50-9;   DrugBank:DB01101;   Drug_Central:480;   HMDB:HMDB0015233;   KEGG:C12650;   KEGG:D01223;   LINCS:LSM-5705
 xref_mesh: MESH:C110904
 xref: Reaxys:8583270;   Wikipedia:Capecitabine


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capecitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 decreases response to substance ISO ABCB7 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr  X:73,361,296...73,502,464
Ensembl chr  X:69,295,552...69,436,858 		JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases response to substance ISO ACAA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 8:127,956,126...127,966,348
Ensembl chr 8:119,079,775...119,088,624 		JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 increases response to substance ISO AGPAT2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 3:29,814,924...29,826,569
Ensembl chr 3:9,416,843...9,428,371 		JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member increases response to substance ISO AGR2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 6:58,435,908...58,456,678
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 decreases response to substance ISO AKR1B1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases response to substance ISO AKR1C3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO capecitabine decreases expression and phosphorylation of AKT1 protein in colon RGD PMID:30789971 RGD:151893289 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aqp8 aquaporin 8 increases expression ISO Capecitabine results in increased expression of AQP8 mRNA CTD PMID:36183961 NCBI chr 1:187,424,314...187,430,243
Ensembl chr 1:177,993,305...177,999,158 		JBrowse link
G Arl4d ARF like GTPase 4D decreases response to substance ISO ARL4D protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:87,092,276...87,103,079
Ensembl chr10:86,595,661...86,602,836 		JBrowse link
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit increases expression ISO Capecitabine results in increased expression of ATP12A mRNA CTD PMID:36183961 NCBI chr15:34,559,209...34,583,866
Ensembl chr15:30,443,571...30,468,229 		JBrowse link
G Axl Axl receptor tyrosine kinase decreases response to substance ISO AXL protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G C3 complement C3 decreases expression ISO Capecitabine results in decreased expression of C3 mRNA CTD PMID:36183961 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Canx calnexin multiple interactions ISO CANX results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr10:35,124,941...35,157,954
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Cat catalase decreases activity EXP Capecitabine results in decreased activity of CAT protein CTD PMID:29117755 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 decreases expression ISO Capecitabine results in decreased expression of CCL19 mRNA CTD PMID:36183961 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO Capecitabine results in decreased expression of CCL21 mRNA CTD PMID:36183961 NCBI chr 5:61,776,411...61,777,515
Ensembl chr 5:56,980,558...56,981,686 		JBrowse link
G Ccn1 cellular communication network factor 1 decreases response to substance
decreases expression		 ISO CCN1 protein results in decreased susceptibility to Capecitabine
Capecitabine results in decreased expression of CCN1 mRNA		 CTD PMID:16734730 PMID:36183961 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO Capecitabine results in decreased expression of CDKN2A protein CTD PMID:17904787 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO CES1 protein results in increased hydrolysis of and results in increased activity of Capecitabine CTD PMID:15687373 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases response to substance		 ISO CES2 protein results in increased hydrolysis of and results in increased activity of Capecitabine
CES2 gene polymorphism results in increased susceptibility to Capecitabine		 CTD PMID:15687373 PMID:18473752 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Cib1 calcium and integrin binding 1 increases response to substance ISO CIB1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:143,587,591...143,593,153
Ensembl chr 1:134,178,331...134,213,423 		JBrowse link
G Cldn3 claudin 3 increases response to substance ISO CLDN3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr12:27,345,075...27,346,547
Ensembl chr12:21,708,398...21,711,001 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Capecitabine decreases expression of CXCL12 protein in liver and colon RGD PMID:30789971 RGD:151893289 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Capecitabine results in increased expression of CXCL1 CTD PMID:35147423 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Capecitabine decreases expression of CXCR4 protein in liver and colon RGD PMID:30789971 RGD:151893289 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase increases expression
decreases response to substance
affects response to substance		 ISO Capecitabine results in increased expression of DPYD mRNA
DPYD protein results in decreased susceptibility to Capecitabine
DPYD protein affects the susceptibility to Capecitabine		 CTD PMID:16734730 PMID:17611699 PMID:18846242 NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Dse dermatan sulfate epimerase decreases response to substance ISO DSE protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:26,661,326...26,740,011
Ensembl chr20:26,118,196...26,196,992 		JBrowse link
G Eps8 EGFR pathway substrate 8, signaling adaptor increases response to substance ISO EPS8 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 4:172,119,497...172,291,670
Ensembl chr 4:170,388,378...170,486,873 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 increases response to substance ISO ERBB3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Fcrla Fc receptor-like A decreases expression ISO Capecitabine results in decreased expression of FCRLA mRNA CTD PMID:36183961 NCBI chr13:83,160,453...83,170,170
Ensembl chr13:83,160,398...83,170,762 		JBrowse link
G Fhl1 four and a half LIM domains 1 decreases response to substance ISO FHL1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr  X:139,592,794...139,652,290
Ensembl chr  X:134,555,479...134,614,928 		JBrowse link
G Flii FLII, actin remodeling protein decreases response to substance ISO FLII protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:45,394,032...45,408,051
Ensembl chr10:45,394,032...45,407,970 		JBrowse link
G Fuca1 alpha-L-fucosidase 1 increases response to substance ISO FUCA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 5:153,436,262...153,453,512
Ensembl chr 5:148,152,700...148,169,972 		JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A increases expression ISO Capecitabine results in increased expression of GATD3A mRNA CTD PMID:36183961 NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity EXP Capecitabine results in decreased activity of GPX1 protein CTD PMID:29117755 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 decreases expression ISO Capecitabine results in decreased expression of HBA1 mRNA CTD PMID:36183961 NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hba-a3 hemoglobin alpha, adult chain 3 decreases expression ISO Capecitabine results in decreased expression of HBA2 mRNA CTD PMID:36183961 NCBI chr10:15,816,099...15,816,943
Ensembl chr10:15,311,634...15,312,481 		JBrowse link
G Hbb hemoglobin subunit beta decreases expression ISO Capecitabine results in decreased expression of HBB mRNA CTD PMID:36183961 NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hdgfl3 HDGF like 3 decreases response to substance ISO HDGFL3 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:135,822,600...135,876,719
Ensembl chr 1:135,827,549...135,876,719 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases response to substance
ameliorates		 ISO HIF1A protein results in decreased susceptibility to Capecitabine
capecitabine decreases expression of HIF1A protein in colon		 CTD
RGD		 PMID:16734730 PMID:30789971 RGD:151893289 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hras HRas proto-oncogene, GTPase decreases response to substance ISO HRAS protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Il17rb interleukin 17 receptor B increases response to substance ISO IL17RB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr16:5,186,961...5,200,657
Ensembl chr16:5,180,432...5,194,125 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases response to substance ISO IL1R2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:42,384,433...42,424,725 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Capecitabine metabolite results in increased expression of IL6 mRNA; Capecitabine results in increased expression of IL6
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Capecitabine metabolite results in increased expression of IL6 mRNA]		 CTD PMID:35147423 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO JUNB results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Lgals4 galectin 4 increases response to substance ISO LGALS4 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:93,248,463...93,260,002
Ensembl chr 1:84,124,764...84,132,481 		JBrowse link
G Lrrc15 leucine rich repeat containing 15 decreases expression ISO Capecitabine results in decreased expression of LRRC15 mRNA CTD PMID:36183961 NCBI chr11:70,469,817...70,484,268
Ensembl chr11:70,469,804...70,484,267 		JBrowse link
G Mdm4 MDM4 regulator of p53 multiple interactions ISO MDM4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr13:46,922,236...47,068,241
Ensembl chr13:44,406,213...44,474,226 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO MMP2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]
capecitabine decreases expression of MMP2 protein in colon		 CTD
RGD		 PMID:18678097 PMID:30789971 RGD:151893289 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases response to substance ISO MRE11 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Ms4a1 membrane spanning 4-domains A1 decreases expression ISO Capecitabine results in decreased expression of MS4A1 mRNA CTD PMID:36183961 NCBI chr 1:217,331,274...217,351,934
Ensembl chr 1:207,906,374...207,918,512 		JBrowse link
G Myb MYB proto-oncogene, transcription factor increases response to substance ISO MYB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Myrf myelin regulatory factor increases response to substance ISO MYRF protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:216,279,057...216,311,155
Ensembl chr 1:206,854,175...206,886,157 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression ISO Capecitabine results in decreased expression of NR4A1 mRNA CTD PMID:36183961 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO Capecitabine results in decreased expression of NR4A2 mRNA CTD PMID:36183961 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Pax5 paired box 5 decreases expression ISO Capecitabine results in decreased expression of PAX5 mRNA CTD PMID:36183961 NCBI chr 5:58,763,334...58,945,719
Ensembl chr 5:58,765,036...58,944,326 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta multiple interactions ISO capecitabine decreases expression and phosphorylation of PIK3CB protein in colon RGD PMID:30789971 RGD:151893289 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel decreases response to substance ISO PKD2 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr14:5,541,821...5,585,140
Ensembl chr14:5,237,135...5,280,825 		JBrowse link
G Pkp2 plakophilin 2 increases response to substance ISO PKP2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr11:98,165,974...98,231,916
Ensembl chr11:84,661,783...84,727,730 		JBrowse link
G Plce1 phospholipase C, epsilon 1 increases response to substance ISO PLCE1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:245,655,855...245,964,966
Ensembl chr 1:236,244,683...236,551,438 		JBrowse link
G Ppa1 inorganic pyrophosphatase 1 increases response to substance ISO PPA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:30,132,088...30,160,492
Ensembl chr20:29,590,707...29,619,215 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases response to substance ISO PRKACB protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Capecitabine results in decreased expression of PTGS2 protein
Capecitabine metabolite results in decreased expression of PTGS2		 CTD PMID:17904787 PMID:35147423 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases response to substance ISO PTPN13 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr14:6,412,841...6,587,238
Ensembl chr14:6,108,211...6,282,563 		JBrowse link
G Pygb glycogen phosphorylase B increases response to substance ISO PYGB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 3:160,072,141...160,118,930
Ensembl chr 3:139,611,749...139,663,553 		JBrowse link
G Rab40b Rab40b, member RAS oncogene family increases response to substance ISO RAB40B protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:106,631,514...106,659,090
Ensembl chr10:106,631,514...106,659,090 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO RB1 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO RBBP4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr 5:146,940,207...146,959,501
Ensembl chr 5:141,638,421...141,675,284
Ensembl chr 2:141,638,421...141,675,284 		JBrowse link
G Rpa1 replication protein A1 decreases response to substance ISO RPA1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:60,647,185...60,698,279
Ensembl chr10:60,148,793...60,199,949 		JBrowse link
G Rras2 RAS related 2 decreases response to substance ISO RRAS2 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:177,668,143...177,737,551
Ensembl chr 1:168,233,693...168,303,111 		JBrowse link
G RT1-Ba RT1 class II, locus Ba decreases expression ISO Capecitabine results in decreased expression of HLA-DQA1 mRNA CTD PMID:36183961 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,575,134...4,579,744 		JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression ISO Capecitabine results in decreased expression of SIK1 mRNA CTD PMID:36183961 NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
G Slc26a3 solute carrier family 26 member 3 increases expression ISO Capecitabine results in increased expression of SLC26A3 mRNA CTD PMID:36183961 NCBI chr 6:53,751,415...53,792,300
Ensembl chr 6:48,023,892...48,064,772 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Capecitabine inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity EXP Capecitabine results in decreased activity of SOD1 protein CTD PMID:29117755 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases response to substance ISO STIP1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 multiple interactions ISO TCF7L2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tead1 TEA domain transcription factor 1 decreases response to substance ISO TEAD1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:176,227,175...176,445,122
Ensembl chr 1:166,792,628...167,003,369 		JBrowse link
G Tff1 trefoil factor 1 increases response to substance ISO TFF1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Trim15 tripartite motif containing 15 increases response to substance ISO TRIM15 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:1,703,723...1,715,465
Ensembl chr20:1,700,905...1,710,249 		JBrowse link
G Trim31 tripartite motif-containing 31 increases expression ISO Capecitabine results in increased expression of TRIM31 mRNA CTD PMID:36183961 NCBI chr20:1,658,386...1,671,711
Ensembl chr20:1,653,165...1,666,494 		JBrowse link
G Tyms thymidylate synthetase affects expression
decreases response to substance
multiple interactions		 ISO Capecitabine affects the expression of TYMS mRNA
TYMS protein results in decreased susceptibility to Capecitabine
[TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]		 CTD PMID:16438929 PMID:16734730 PMID:21048041 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Upk3a uroplakin 3A increases expression ISO Capecitabine results in increased expression of UPK3A mRNA CTD PMID:36183961 NCBI chr 7:116,128,981...116,139,950
Ensembl chr 7:116,134,874...116,139,948 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression 		ISO [TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]
capecitabine decreases expression of VEGFA protein in blood serum and colon		 CTD
RGD		 PMID:21048041 PMID:30789971 RGD:151893289 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Zfp706 zinc finger protein 706 increases response to substance ISO ZNF706 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 7:68,167,496...68,174,121
Ensembl chr 7:68,166,323...68,174,148 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        biochemical role 19586
          antimetabolite 10331
            capecitabine 85
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbohydrates and carbohydrate derivatives 15321
                                    carbohydrate 15321
                                      carbohydrate derivative 14345
                                        glycosyl compound 13086
                                          N-glycosyl compound 5887
                                            nucleoside 5746
                                              ribonucleoside 1169
                                                pyrimidine ribonucleosides 418
                                                  cytidines 331
                                                    capecitabine 85
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