Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:capecitabine
go back to main search page
Accession:CHEBI:31348 term browser browse the term
Definition:A carbamate ester that is cytidine in which the hydrogen at position 5 is replaced by fluorine and in which the amino group attached to position 4 is converted into its N-(penyloxy)carbonyl derivative. Capecitabine is a antineoplastic agent used in the treatment of cancers.
Synonyms:exact_synonym: 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
 related_synonym: (1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester;   Capecitabin;   Formula=C15H22FN3O6;   InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1;   InChIKey=GAGWJHPBXLXJQN-UORFTKCHSA-N;   Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate;   SMILES=CCCCCOC(=O)Nc1nc(=O)n(cc1F)[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O;   Xeloda;   capecitabina;   capecitabinum;   pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
 alt_id: MESH:D000069287
 xref: CAS:154361-50-9;   DrugBank:DB01101;   Drug_Central:480;   HMDB:HMDB0015233;   KEGG:C12650;   KEGG:D01223;   LINCS:LSM-5705
 xref_mesh: MESH:C110904
 xref: Reaxys:8583270;   Wikipedia:Capecitabine


show annotations for term's descendants           Sort by:
 
capecitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 decreases response to substance ISO ABCB7 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr  X:75,150,511...75,291,950
Ensembl chr  X:75,150,608...75,291,938
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases response to substance ISO ACAA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 increases response to substance ISO AGPAT2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 3:4,044,741...4,055,384
Ensembl chr 3:4,044,542...4,055,806
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member increases response to substance ISO AGR2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases response to substance ISO AKR1B1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases response to substance ISO AKR1C3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D decreases response to substance ISO ARL4D protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:89,577,556...89,580,368
Ensembl chr10:89,578,212...89,580,368
JBrowse link
G Axl Axl receptor tyrosine kinase decreases response to substance ISO AXL protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Canx calnexin multiple interactions ISO CANX results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Ccn1 cellular communication network factor 1 decreases response to substance ISO CCN1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO Capecitabine results in decreased expression of CDKN2A protein CTD PMID:17904787 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO CES1 protein results in increased hydrolysis of and results in increased activity of Capecitabine CTD PMID:15687373 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases response to substance
ISO CES2 protein results in increased hydrolysis of and results in increased activity of Capecitabine
CES2 gene polymorphism results in increased susceptibility to Capecitabine
CTD PMID:15687373 PMID:18473752 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cib1 calcium and integrin binding 1 increases response to substance ISO CIB1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:142,014,962...142,020,461
Ensembl chr 1:142,014,958...142,020,525
JBrowse link
G Cldn3 claudin 3 increases response to substance ISO CLDN3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase increases expression
decreases response to substance
affects response to substance
ISO Capecitabine results in increased expression of DPYD mRNA
DPYD protein results in decreased susceptibility to Capecitabine
DPYD protein affects the susceptibility to Capecitabine
CTD PMID:16734730 PMID:17611699 PMID:18846242 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
JBrowse link
G Dse dermatan sulfate epimerase decreases response to substance ISO DSE protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:27,703,738...27,784,982
Ensembl chr20:27,703,732...27,782,586
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 increases response to substance ISO EPS8 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 4:171,475,155...171,645,620
Ensembl chr 4:171,475,567...171,591,882
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 increases response to substance ISO ERBB3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Fhl1 four and a half LIM domains 1 decreases response to substance ISO FHL1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Flii FLII, actin remodeling protein decreases response to substance ISO FLII protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:46,955,460...46,969,468
Ensembl chr10:46,955,487...46,969,406
JBrowse link
G Fuca1 alpha-L-fucosidase 1 increases response to substance ISO FUCA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 5:154,269,296...154,286,545
Ensembl chr 5:154,269,118...154,286,544
JBrowse link
G Hdgfl3 HDGF like 3 decreases response to substance ISO HDGFL3 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:143,702,864...143,752,060
Ensembl chr 1:143,702,853...143,751,789
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases response to substance ISO HIF1A protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases response to substance ISO HRAS protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Il17rb interleukin 17 receptor B increases response to substance ISO IL17RB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr16:6,064,287...6,077,978
Ensembl chr16:6,064,288...6,077,978
JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases response to substance ISO IL1R2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 9:46,840,646...46,881,241
Ensembl chr 9:46,840,992...46,881,264
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO JUNB results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Lgals4 galectin 4 increases response to substance ISO LGALS4 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:87,019,598...87,027,720
Ensembl chr 1:87,019,975...87,027,691
JBrowse link
G Mdm4 MDM4 regulator of p53 multiple interactions ISO MDM4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO MMP2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases response to substance ISO MRE11 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases response to substance ISO MYB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Myrf myelin regulatory factor increases response to substance ISO MYRF protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:226,260,558...226,292,650
Ensembl chr 1:226,260,558...226,292,480
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel decreases response to substance ISO PKD2 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Pkp2 plakophilin 2 increases response to substance ISO PKP2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr11:88,912,163...88,972,213 JBrowse link
G Plce1 phospholipase C, epsilon 1 increases response to substance ISO PLCE1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 increases response to substance ISO PPA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:31,265,519...31,292,451
Ensembl chr20:31,265,483...31,310,674
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases response to substance ISO PRKACB protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Capecitabine results in decreased expression of PTGS2 protein CTD PMID:17904787 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases response to substance ISO PTPN13 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr14:7,688,551...7,863,664
Ensembl chr14:7,688,551...7,863,664
JBrowse link
G Pygb glycogen phosphorylase B increases response to substance ISO PYGB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
JBrowse link
G Rab40b Rab40b, member RAS oncogene family increases response to substance ISO RAB40B protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:110,557,798...110,585,424
Ensembl chr10:110,557,729...110,585,376
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO RB1 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO RBBP4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr 5:147,499,880...147,535,240
Ensembl chr 5:147,499,882...147,535,240
JBrowse link
G Rpa1 replication protein A1 decreases response to substance ISO RPA1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512
JBrowse link
G Rras2 RAS related 2 decreases response to substance ISO RRAS2 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:178,940,515...179,010,257
Ensembl chr 1:178,940,516...179,010,257
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Capecitabine inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases response to substance ISO STIP1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
JBrowse link
G Tcf7l2 transcription factor 7 like 2 multiple interactions ISO TCF7L2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514
JBrowse link
G Tead1 TEA domain transcription factor 1 decreases response to substance ISO TEAD1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:177,495,500...177,714,795
Ensembl chr 1:177,495,782...177,707,061
JBrowse link
G Tff1 trefoil factor 1 increases response to substance ISO TFF1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Trim15 tripartite motif containing 15 increases response to substance ISO TRIM15 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:2,194,293...2,203,636
Ensembl chr20:2,194,709...2,201,668
JBrowse link
G Tyms thymidylate synthetase affects expression
decreases response to substance
multiple interactions
ISO Capecitabine affects the expression of TYMS mRNA
TYMS protein results in decreased susceptibility to Capecitabine
[TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]
CTD PMID:16438929 PMID:16734730 PMID:21048041 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO [TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin] CTD PMID:21048041 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Zfp706 zinc finger protein 706 increases response to substance ISO ZNF706 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 7:75,803,310...75,809,853
Ensembl chr 7:75,801,735...75,809,836
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        biochemical role 19304
          antimetabolite 8506
            capecitabine 56
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            heteroorganic entity 19199
                              organochalcogen compound 18946
                                organooxygen compound 18873
                                  carbohydrates and carbohydrate derivatives 12285
                                    carbohydrate 12285
                                      carbohydrate derivative 11893
                                        glycosyl compound 10967
                                          N-glycosyl compound 5487
                                            nucleoside 5347
                                              ribonucleoside 669
                                                pyrimidine ribonucleosides 148
                                                  cytidines 67
                                                    capecitabine 56
paths to the root