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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:capecitabine
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Accession:CHEBI:31348 term browser browse the term
Definition:A carbamate ester that is cytidine in which the hydrogen at position 5 is replaced by fluorine and in which the amino group attached to position 4 is converted into its N-(penyloxy)carbonyl derivative. Capecitabine is a antineoplastic agent used in the treatment of cancers.
Synonyms:exact_synonym: 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
 related_synonym: (1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester;   Capecitabin;   Formula=C15H22FN3O6;   InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1;   InChIKey=GAGWJHPBXLXJQN-UORFTKCHSA-N;   Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate;   SMILES=CCCCCOC(=O)Nc1nc(=O)n(cc1F)[C@@H]1O[C@H](C)[C@@H](O)[C@H]1O;   Xeloda;   capecitabina;   capecitabinum;   pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate
 alt_id: MESH:D000069287
 xref: CAS:154361-50-9;   DrugBank:DB01101;   Drug_Central:480;   HMDB:HMDB0015233;   KEGG:C12650;   KEGG:D01223;   LINCS:LSM-5705
 xref_mesh: MESH:C110904
 xref: Reaxys:8583270;   Wikipedia:Capecitabine



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capecitabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 decreases response to substance ISO ABCB7 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr  X:69,295,598...69,436,775
Ensembl chr  X:69,295,552...69,436,858
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases response to substance ISO ACAA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 increases response to substance ISO AGPAT2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 3:9,416,842...9,428,567
Ensembl chr 3:9,416,843...9,428,371
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member increases response to substance ISO AGR2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 decreases response to substance ISO AKR1B1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases response to substance ISO AKR1C3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO capecitabine decreases expression and phosphorylation of AKT1 protein in colon RGD PMID:30789971 RGD:151893289 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp8 aquaporin 8 increases expression ISO Capecitabine results in increased expression of AQP8 mRNA CTD PMID:36183961 NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D decreases response to substance ISO ARL4D protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836
JBrowse link
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit increases expression ISO Capecitabine results in increased expression of ATP12A mRNA CTD PMID:36183961 NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229
JBrowse link
G Axl Axl receptor tyrosine kinase decreases response to substance ISO AXL protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265
JBrowse link
G C3 complement C3 decreases expression ISO Capecitabine results in decreased expression of C3 mRNA CTD PMID:36183961 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Canx calnexin multiple interactions ISO CANX results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 decreases expression ISO Capecitabine results in decreased expression of CCL19 mRNA CTD PMID:36183961 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO Capecitabine results in decreased expression of CCL21 mRNA CTD PMID:36183961 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Ccn1 cellular communication network factor 1 decreases response to substance
decreases expression
ISO CCN1 protein results in decreased susceptibility to Capecitabine
Capecitabine results in decreased expression of CCN1 mRNA
CTD PMID:16734730 PMID:36183961 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO Capecitabine results in decreased expression of CDKN2A protein CTD PMID:17904787 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO CES1 protein results in increased hydrolysis of and results in increased activity of Capecitabine CTD PMID:15687373 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases response to substance
ISO CES2 protein results in increased hydrolysis of and results in increased activity of Capecitabine
CES2 gene polymorphism results in increased susceptibility to Capecitabine
CTD PMID:15687373 PMID:18473752 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cib1 calcium and integrin binding 1 increases response to substance ISO CIB1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423
JBrowse link
G Cldn3 claudin 3 increases response to substance ISO CLDN3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Capecitabine decreases expression of CXCL12 protein in liver and colon RGD PMID:30789971 RGD:151893289 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Capecitabine results in increased expression of CXCL1 CTD PMID:35147423 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Capecitabine decreases expression of CXCR4 protein in liver and colon RGD PMID:30789971 RGD:151893289 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase increases expression
decreases response to substance
affects response to substance
ISO Capecitabine results in increased expression of DPYD mRNA
DPYD protein results in decreased susceptibility to Capecitabine
DPYD protein affects the susceptibility to Capecitabine
CTD PMID:16734730 PMID:17611699 PMID:18846242 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
JBrowse link
G Dse dermatan sulfate epimerase decreases response to substance ISO DSE protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992
JBrowse link
G Eps8 epidermal growth factor receptor pathway substrate 8 increases response to substance ISO EPS8 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 increases response to substance ISO ERBB3 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Fcrla Fc receptor-like A decreases expression ISO Capecitabine results in decreased expression of FCRLA mRNA CTD PMID:36183961 NCBI chr13:83,160,453...83,170,170
Ensembl chr13:83,160,398...83,170,762
JBrowse link
G Fhl1 four and a half LIM domains 1 decreases response to substance ISO FHL1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Flii FLII, actin remodeling protein decreases response to substance ISO FLII protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:45,394,032...45,408,051
Ensembl chr10:45,394,032...45,407,970
JBrowse link
G Fuca1 alpha-L-fucosidase 1 increases response to substance ISO FUCA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 5:148,152,718...148,169,972
Ensembl chr 5:148,152,700...148,169,972
JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A increases expression ISO Capecitabine results in increased expression of GATD3A mRNA CTD PMID:36183961 NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 decreases expression ISO Capecitabine results in decreased expression of HBA1 mRNA CTD PMID:36183961 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hba-a3 hemoglobin alpha, adult chain 3 decreases expression ISO Capecitabine results in decreased expression of HBA2 mRNA CTD PMID:36183961 NCBI chr10:15,311,637...15,312,481
Ensembl chr10:15,311,634...15,312,481
JBrowse link
G Hbb hemoglobin subunit beta decreases expression ISO Capecitabine results in decreased expression of HBB mRNA CTD PMID:36183961 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hdgfl3 HDGF like 3 decreases response to substance ISO HDGFL3 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:135,822,600...135,876,719
Ensembl chr 1:135,827,549...135,876,719
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases response to substance
ameliorates
ISO HIF1A protein results in decreased susceptibility to Capecitabine
capecitabine decreases expression of HIF1A protein in colon
CTD
RGD
PMID:16734730 PMID:30789971 RGD:151893289 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases response to substance ISO HRAS protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Il17rb interleukin 17 receptor B increases response to substance ISO IL17RB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases response to substance ISO IL1R2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Capecitabine metabolite results in increased expression of IL6 mRNA; Capecitabine results in increased expression of IL6
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Capecitabine metabolite results in increased expression of IL6 mRNA]
CTD PMID:35147423 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO JUNB results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Lgals4 galectin 4 increases response to substance ISO LGALS4 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:84,123,497...84,132,605
Ensembl chr 1:84,124,764...84,132,481
JBrowse link
G Lrrc15 leucine rich repeat containing 15 decreases expression ISO Capecitabine results in decreased expression of LRRC15 mRNA CTD PMID:36183961 NCBI chr11:70,469,775...70,484,268
Ensembl chr11:70,469,804...70,484,267
JBrowse link
G Mdm4 MDM4 regulator of p53 multiple interactions ISO MDM4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO MMP2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine]
capecitabine decreases expression of MMP2 protein in colon
CTD
RGD
PMID:18678097 PMID:30789971 RGD:151893289 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases response to substance ISO MRE11 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Ms4a1 membrane spanning 4-domains A1 decreases expression ISO Capecitabine results in decreased expression of MS4A1 mRNA CTD PMID:36183961 NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases response to substance ISO MYB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Myrf myelin regulatory factor increases response to substance ISO MYRF protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:206,854,175...206,886,276
Ensembl chr 1:206,854,175...206,886,157
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression ISO Capecitabine results in decreased expression of NR4A1 mRNA CTD PMID:36183961 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO Capecitabine results in decreased expression of NR4A2 mRNA CTD PMID:36183961 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Pax5 paired box 5 decreases expression ISO Capecitabine results in decreased expression of PAX5 mRNA CTD PMID:36183961 NCBI chr 5:58,763,334...58,945,719
Ensembl chr 5:58,765,036...58,944,326
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta multiple interactions ISO capecitabine decreases expression and phosphorylation of PIK3CB protein in colon RGD PMID:30789971 RGD:151893289 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel decreases response to substance ISO PKD2 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825
JBrowse link
G Pkp2 plakophilin 2 increases response to substance ISO PKP2 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730
JBrowse link
G Plce1 phospholipase C, epsilon 1 increases response to substance ISO PLCE1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438
JBrowse link
G Ppa1 inorganic pyrophosphatase 1 increases response to substance ISO PPA1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta decreases response to substance ISO PRKACB protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Capecitabine results in decreased expression of PTGS2 protein
Capecitabine metabolite results in decreased expression of PTGS2
CTD PMID:17904787 PMID:35147423 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 decreases response to substance ISO PTPN13 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563
JBrowse link
G Pygb glycogen phosphorylase B increases response to substance ISO PYGB protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553
JBrowse link
G Rab40b Rab40b, member RAS oncogene family increases response to substance ISO RAB40B protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:106,631,514...106,659,090
Ensembl chr10:106,631,514...106,659,090
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO RB1 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO RBBP4 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr 5:141,655,863...141,675,157
Ensembl chr 5:141,638,421...141,675,284
JBrowse link
G Rpa1 replication protein A1 decreases response to substance ISO RPA1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Rras2 RAS related 2 decreases response to substance ISO RRAS2 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111
JBrowse link
G RT1-Ba RT1 class II, locus Ba decreases expression ISO Capecitabine results in decreased expression of HLA-DQA1 mRNA CTD PMID:36183961 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression ISO Capecitabine results in decreased expression of SIK1 mRNA CTD PMID:36183961 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
JBrowse link
G Slc26a3 solute carrier family 26 member 3 increases expression ISO Capecitabine results in increased expression of SLC26A3 mRNA CTD PMID:36183961 NCBI chr 6:48,023,892...48,064,829
Ensembl chr 6:48,023,892...48,064,772
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Capecitabine inhibits the reaction [SLCO2B1 protein results in increased uptake of Cascade Blue] CTD PMID:30863990 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases response to substance ISO STIP1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Tcf7l2 transcription factor 7 like 2 multiple interactions ISO TCF7L2 results in decreased susceptibility to [Fluorouracil co-treated with Capecitabine] CTD PMID:18678097 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
JBrowse link
G Tead1 TEA domain transcription factor 1 decreases response to substance ISO TEAD1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369
JBrowse link
G Tff1 trefoil factor 1 increases response to substance ISO TFF1 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Trim15 tripartite motif containing 15 increases response to substance ISO TRIM15 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr20:1,700,905...1,710,249
Ensembl chr20:1,700,905...1,710,249
JBrowse link
G Trim31 tripartite motif-containing 31 increases expression ISO Capecitabine results in increased expression of TRIM31 mRNA CTD PMID:36183961 NCBI chr20:1,653,165...1,666,494
Ensembl chr20:1,653,165...1,666,494
JBrowse link
G Tyms thymidylate synthetase affects expression
decreases response to substance
multiple interactions
ISO Capecitabine affects the expression of TYMS mRNA
TYMS protein results in decreased susceptibility to Capecitabine
[TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]
CTD PMID:16438929 PMID:16734730 PMID:21048041 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Upk3a uroplakin 3A increases expression ISO Capecitabine results in increased expression of UPK3A mRNA CTD PMID:36183961 NCBI chr 7:116,128,981...116,139,950
Ensembl chr 7:116,134,874...116,139,948
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO [TYMS enhancer polymorphism co-treated with VEGFA gene SNP] affects the susceptibility to [Capecitabine co-treated with oxaliplatin]
capecitabine decreases expression of VEGFA protein in blood serum and colon
CTD
RGD
PMID:21048041 PMID:30789971 RGD:151893289 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Zfp706 zinc finger protein 706 increases response to substance ISO ZNF706 protein results in increased susceptibility to Capecitabine CTD PMID:16734730 NCBI chr 7:68,167,499...68,174,042
Ensembl chr 7:68,166,323...68,174,148
JBrowse link

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      biological role 19788
        biochemical role 19501
          antimetabolite 8575
            capecitabine 82
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            heteroorganic entity 19453
                              organochalcogen compound 19240
                                organooxygen compound 19152
                                  carbohydrates and carbohydrate derivatives 14950
                                    carbohydrate 14950
                                      carbohydrate derivative 14223
                                        glycosyl compound 12952
                                          N-glycosyl compound 5634
                                            nucleoside 5484
                                              ribonucleoside 730
                                                pyrimidine ribonucleosides 184
                                                  cytidines 97
                                                    capecitabine 82
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