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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bithionol
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Accession:CHEBI:3131 term browser browse the term
Definition:An aryl sulfide that is diphenyl sulfide in which each phenyl group is substituted at position 2 by hydroxy and at positions 3 and 5 by chlorine. A fungicide and anthelmintic, it was used in various topical drug products for the treatment of liver flukes, but withdrawn after being shown to be a potent photosensitizer with the potential to cause serious skin disorders.
Synonyms:exact_synonym: 2,2'-sulfanediylbis(4,6-dichlorophenol)
 related_synonym: 2,2'-Dihydroxy-3,3',5,5'-tetrachlorodiphenyl sulfide;   2,2'-Thiobis(4,6-dichlorophenol);   2-Hydroxy-3,5-dichlorophenyl sulfide;   Bis(3,5-dichloro-2-hydroxyphenyl) sulfide;   Bithin;   Bithionol sulfide;   Formula=C12H6Cl4O2S;   InChI=1S/C12H6Cl4O2S/c13-5-1-7(15)11(17)9(3-5)19-10-4-6(14)2-8(16)12(10)18/h1-4,17-18H;   InChIKey=JFIOVJDNOJYLKP-UHFFFAOYSA-N;   SMILES=Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O
 xref: Beilstein:2003535;   CAS:97-18-7;   DrugBank:DB04813;   Drug_Central:3032;   KEGG:C07967;   KEGG:D00802;   LINCS:LSM-2862
 xref_mesh: MESH:D001735
 xref: PDBeChem:B1T;   PMID:17129675;   PMID:24495391;   PPDB:2889;   Pesticides:bithionol;   VSDB:2889;   Wikipedia:Bithionol


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bithionol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bithionol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Thra thyroid hormone receptor alpha increases activity EXP Bithionol results in increased activity of THRA protein CTD PMID:22015988 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta increases activity EXP Bithionol results in increased activity of THRB protein CTD PMID:22015988 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      application 19411
        pesticide 16587
          organochlorine pesticide 6295
            bithionol 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                carbocyclic compound 18302
                                  benzenoid aromatic compound 17403
                                    benzenes 17173
                                      chlorobenzenes 13585
                                        dichlorobenzene 10603
                                          bithionol 3
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