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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bisoprolol
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Accession:CHEBI:3127 term browser browse the term
Definition:A secondary amine that has formula C18H31NO4.
Synonyms:exact_synonym: 1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol
 related_synonym: (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol;   (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol;   Formula=C18H31NO4;   InChI=1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3;   InChIKey=VHYCDWMUTMEGQY-UHFFFAOYSA-N;   SMILES=CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1;   bisoprololum
 xref: CAS:66722-44-9;   DrugBank:DB00612;   Drug_Central:380;   KEGG:C06852;   KEGG:D02342;   LINCS:LSM-1886
 xref_mesh: MESH:D017298
 xref: Patent:BE859425;   Patent:US4258062;   Wikipedia:Bisoprolol

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bisoprolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions		 ISO ABCB1 protein results in increased transport of Bisoprolol
Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Bisoprolol]		 CTD PMID:16671962 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Adrb1 adrenoceptor beta 1 decreases activity
increases expression
multiple interactions
affects binding		 ISO
EXP		 Bisoprolol results in decreased activity of ADRB1 protein
Bisoprolol results in increased expression of ADRB1 mRNA
[Bisoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; Bisoprolol binds to and results in decreased activity of ADRB1 protein; Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Bisoprolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]
Bisoprolol binds to ADRB1 protein		 CTD PMID:1389726 PMID:2897299 PMID:10372227 PMID:11562432 PMID:12535855 More... NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression		 ISO
EXP		 [Bisoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Bisoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Bisoprolol binds to and results in decreased activity of ADRB2 protein; Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Bisoprolol results in increased expression of ADRB2 mRNA		 CTD PMID:14730417 PMID:17925438 PMID:20668454 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Bisoprolol results in decreased expression of CCL2 protein CTD PMID:19840533 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Gnas GNAS complex locus increases expression EXP Bisoprolol results in increased expression of GNAS mRNA CTD PMID:20668454 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Il10 interleukin 10 increases expression ISO Bisoprolol results in increased expression of IL10 protein CTD PMID:19840533 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Bisoprolol results in decreased expression of IL1B protein CTD PMID:19840533 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression ISO Bisoprolol results in decreased expression of IL6 protein CTD PMID:19840533 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO Bisoprolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Prkca protein kinase C, alpha decreases expression EXP Bisoprolol results in decreased expression of PRKCA protein CTD PMID:20668454 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcd protein kinase C, delta decreases expression EXP Bisoprolol results in decreased expression of PRKCD protein CTD PMID:20668454 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Bisoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bisoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin] CTD PMID:19740083 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Bisoprolol results in decreased expression of TNF protein CTD PMID:19840533 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            cardiovascular drug 7679
              antihypertensive agent 1848
                bisoprolol 15
                  bisoprolol fumarate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        secondary amino compound 6586
                                          secondary amine 1724
                                            bisoprolol 15
                                              bisoprolol fumarate 0
paths to the root