benzethonium chloride - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	benzethonium chloride	go back to main search page
Accession:	CHEBI:31264	browse the term
Definition:	A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses.
Synonyms:	exact_synonym:	N-benzyl-N,N-dimethyl-2-{2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethanaminium chloride
	related_synonym:	Anti-germ 77; Antiseptol; BZT; Banagerm; Diapp; Disilyn; Formula=C27H42ClNO2; Hyamine; Hyamine 1622; InChI=1S/C27H42NO2.ClH/c1-26(2,3)22-27(4,5)24-13-15-25(16-14-24)30-20-19-29-18-17-28(6,7)21-23-11-9-8-10-12-23;/h8-16H,17-22H2,1-7H3;1H/q+1;/p-1; InChIKey=UREZNYTWGJKWBI-UHFFFAOYSA-M; Inactisol; Kylacol; Microklenz; N,N-dimethyl-N-(2-{2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy}ethyl)-benzenemethanaminium chloride; Neostelin green; Phemeride; Phemerol chloride; Phemithyn; Polymine D; QAC; Quatrachlor; SMILES=[Cl-].CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1; Salanine; Sanizol; Solamin; Solamine; benzethonii chloridum; benzetonium chloride; benzyldimethyl(2-{2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy}ethyl)ammonium chloride; benzyldimethyl(2-{2-[p-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy}ethyl)ammonium chloride; benzyldimethyl-p-(1,1,3,3-tetramethylbutyl)phenoxyethoxy-ethylammonium chloride; chlorure de benzethonium; cloruro de benzetonio; diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride; diisobutylphenoxyethoxyethyldimethyl benzyl ammonium chloride; p-diisobutyl phenoxyethoxyethyl dimethyl benzylammonium chloride; p-tert-octylphenoxyethoxyethyldimethylbenzylammonium chloride; {2-[2-(4-diisobutylphenoxy)ethoxy]ethyl}dimethylbenzylammonium chloride
	xref:	CAS:121-54-0; KEGG:C12539; KEGG:D01140
	xref_mesh:	MESH:D001558
	xref:	PMID:11453769; PMID:11606328; PMID:12595925; PMID:16750419; PMID:17867553; PMID:22828255; PMID:2310164; PMID:2735743; PMID:3416474; PMID:3995765; Patent:US2115250; Wikipedia:3898548; Wikipedia:Benzethonium_chloride

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Genes (12)

benzethonium chloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

decreases expression

Benzethonium results in decreased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

decreases expression

Benzethonium results in decreased expression of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

decreases expression

Benzethonium results in decreased expression of CCL4 protein

NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 5

decreases expression

Benzethonium results in decreased expression of CCL5 protein

NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377

G

interferon gamma

multiple interactions

[Benzethonium co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 1 beta

decreases expression

Benzethonium results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

[Benzethonium co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6 receptor

decreases expression

Benzethonium results in decreased expression of IL6R protein modified form

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

potassium voltage-gated channel subfamily A member 3

decreases activity
multiple interactions

Benzethonium results in decreased activity of KCNA3 protein
[Benzethonium results in decreased activity of KCNA3 protein] which results in decreased import of Thallium

NCBI chr 2:194,632,360...194,633,937
Ensembl chr 2:194,632,196...194,650,138

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

[Benzethonium results in decreased activity of KCNH2 protein] which results in decreased import of Thallium

PMID:21362439 PMID:23313619 PMID:24052561

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

solute carrier family 22 member 2

multiple interactions

Benzethonium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

vascular endothelial growth factor A

decreases expression

Benzethonium results in decreased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19800
role	19751
biological role	19751
antimicrobial agent	17472
antiviral agent	10459
benzethonium chloride	12
Path 2
Term	Annotations
CHEBI ontology	19800
subatomic particle	19799
composite particle	19799
hadron	19799
baryon	19799
nucleon	19799
atomic nucleus	19799
atom	19799
main group element atom	19698
main group molecular entity	19698
s-block molecular entity	19479
hydrogen molecular entity	19471
hydrides	18834
inorganic hydride	17691
pnictogen hydride	17671
nitrogen hydride	17543
ammonium	8235
ammonium ion derivative	8231
ammonium compound	5087
organoammonium salt	426
quaternary ammonium salt	309
benzethonium chloride	12

paths to the root