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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5,5-diethylbarbituric acid
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Accession:CHEBI:31252 term browser browse the term
Definition:A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by two ethyl groups. Formerly used as a hypnotic (sleeping aid).
Synonyms:related_synonym: 2,4,6(1H,3H,5H)-pyrimidinetrione;   5,5-Diethyl-pyrimidine-2,4,6-trione;   5,5-diethylpyrimidine-2,4,6(1H,3H,5H)-trione;   Barbital;   Barbitone;   DEBA;   Formula=C8H12N2O3;   InChI=1S/C8H12N2O3/c1-3-8(4-2)5(11)9-7(13)10-6(8)12/h3-4H2,1-2H3,(H2,9,10,11,12,13);   InChIKey=FTOAOBMCPZCFFF-UHFFFAOYSA-N;   SMILES=CCC1(CC)C(=O)NC(=O)NC1=O;   Veronal;   diethylmalonyl urea
 alt_id: CHEBI:102256
 xref: Beilstein:163999;   CAS:57-44-3;   DrugBank:DB01483;   Drug_Central:289;   Gmelin:4113;   KEGG:D01740
 xref_mesh: MESH:D001462
 xref: PMID:10866370;   PMID:15857133;   PMID:17827020;   PMID:20681553;   PMID:22467201;   PMID:3654008;   PMID:6864729;   Reaxys:163999;   Wikipedia:Barbital



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5,5-diethylbarbituric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase increases activity
increases expression
ISO Barbital results in increased activity of ALAD protein
Barbital results in increased expression of ALAD mRNA
CTD PMID:16309571 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Barbital results in decreased activity of BCHE protein CTD PMID:11929041 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP Barbital results in increased activity of CYP2B1 protein CTD PMID:7697745 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Barbital results in increased expression of HMOX1 mRNA CTD PMID:16309571 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link

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  CHEBI ontology 20050
    role 20001
      application 19737
        pharmaceutical 19610
          drug 19610
            drug allergen 10161
              5,5-diethylbarbituric acid 4
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  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                organic heterocyclic compound 18799
                                  organic heteromonocyclic compound 17157
                                    diazines 12336
                                      pyrimidines 12166
                                        pyrimidone 8875
                                          barbiturates 4392
                                            5,5-diethylbarbituric acid 4
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