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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:azosemide
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Accession:CHEBI:31248 term browser browse the term
Definition:A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hypertension.
Synonyms:exact_synonym: 2-chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
 related_synonym: 2-chloro-5-(1H-tetrazol-5-yl)-N(4)-2-thenylsulfanilamide;   5-(4'-chloro-5'-sulfamoyl-2'-thenylaminophenyl)tetrazole;   Diart;   Formula=C12H11ClN6O2S2;   InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19);   InChIKey=HMEDEBAJARCKCT-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(-c2nnn[nH]2)c(NCc2cccs2)cc1Cl;   azosemida;   azosemidum
 xref: Beilstein:1178491;   CAS:27589-33-9;   Drug_Central:278;   KEGG:D01323
 xref_mesh: MESH:C018222
 xref: PMID:14520682;   PMID:1563700;   PMID:428188;   PMID:512891;   PMID:6617067;   PMID:8785379;   Patent:DE1815922;   Patent:US3665002;   Wikipedia:Azosemide


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azosemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions 		ISO azosemide results in decreased activity of SLC12A2 protein
azosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium] 		CTD PMID:15517342 PMID:29959396 NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      application 20622
        pharmaceutical 20416
          drug 20416
            diuretic 4117
              loop diuretic 225
                azosemide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      chalcogen 20492
                        oxygen atom 20458
                          oxygen molecular entity 20446
                            hydroxides 20231
                              oxoacid 19291
                                chalcogen oxoacid 13882
                                  sulfur oxoacid 13687
                                    sulfonic acid 11714
                                      sulfonic acid derivative 11699
                                        sulfonamide 5381
                                          azosemide 1
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