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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:azosemide
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Accession:CHEBI:31248 term browser browse the term
Definition:A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hypertension.
Synonyms:exact_synonym: 2-chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
 related_synonym: 2-chloro-5-(1H-tetrazol-5-yl)-N(4)-2-thenylsulfanilamide;   5-(4'-chloro-5'-sulfamoyl-2'-thenylaminophenyl)tetrazole;   Diart;   Formula=C12H11ClN6O2S2;   InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19);   InChIKey=HMEDEBAJARCKCT-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(-c2nnn[nH]2)c(NCc2cccs2)cc1Cl;   azosemida;   azosemidum
 xref: Beilstein:1178491;   CAS:27589-33-9;   Drug_Central:278;   KEGG:D01323
 xref_mesh: MESH:C018222
 xref: PMID:14520682;   PMID:1563700;   PMID:428188;   PMID:512891;   PMID:6617067;   PMID:8785379;   Patent:DE1815922;   Patent:US3665002;   Wikipedia:Azosemide

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azosemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions		 ISO azosemide results in decreased activity of SLC12A2 protein
azosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]		 CTD PMID:15517342, PMID:29959396 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            diuretic 1120
              loop diuretic 206
                azosemide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                chalcogen oxoacid 11479
                                  sulfur oxoacid 11082
                                    sulfonic acid 7331
                                      sulfonic acid derivative 7331
                                        sulfonamide 3167
                                          azosemide 1
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