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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:azosemide
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Accession:CHEBI:31248 term browser browse the term
Definition:A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hypertension.
Synonyms:exact_synonym: 2-chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
 related_synonym: 2-chloro-5-(1H-tetrazol-5-yl)-N(4)-2-thenylsulfanilamide;   5-(4'-chloro-5'-sulfamoyl-2'-thenylaminophenyl)tetrazole;   Diart;   Formula=C12H11ClN6O2S2;   InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19);   InChIKey=HMEDEBAJARCKCT-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(-c2nnn[nH]2)c(NCc2cccs2)cc1Cl;   azosemida;   azosemidum
 xref: Beilstein:1178491;   CAS:27589-33-9;   Drug_Central:278;   KEGG:D01323
 xref_mesh: MESH:C018222
 xref: PMID:14520682;   PMID:1563700;   PMID:428188;   PMID:512891;   PMID:6617067;   PMID:8785379;   Patent:DE1815922;   Patent:US3665002;   Wikipedia:Azosemide



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azosemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions
ISO azosemide results in decreased activity of SLC12A2 protein
azosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
CTD PMID:15517342 PMID:29959396 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    role 19832
      application 19675
        pharmaceutical 19517
          drug 19517
            diuretic 4109
              loop diuretic 218
                azosemide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      chalcogen 19555
                        oxygen atom 19528
                          oxygen molecular entity 19528
                            hydroxides 19335
                              oxoacid 18769
                                chalcogen oxoacid 13777
                                  sulfur oxoacid 13564
                                    sulfonic acid 11605
                                      sulfonic acid derivative 11605
                                        sulfonamide 5304
                                          azosemide 1
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