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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:azosemide
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Accession:CHEBI:31248 term browser browse the term
Definition:A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hypertension.
Synonyms:exact_synonym: 2-chloro-5-(1H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide
 related_synonym: 2-chloro-5-(1H-tetrazol-5-yl)-N(4)-2-thenylsulfanilamide;   5-(4'-chloro-5'-sulfamoyl-2'-thenylaminophenyl)tetrazole;   Diart;   Formula=C12H11ClN6O2S2;   InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19);   InChIKey=HMEDEBAJARCKCT-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc(-c2nnn[nH]2)c(NCc2cccs2)cc1Cl;   azosemida;   azosemidum
 xref: Beilstein:1178491;   CAS:27589-33-9;   Drug_Central:278;   KEGG:D01323
 xref_mesh: MESH:C018222
 xref: PMID:14520682;   PMID:1563700;   PMID:428188;   PMID:512891;   PMID:6617067;   PMID:8785379;   Patent:DE1815922;   Patent:US3665002;   Wikipedia:Azosemide


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azosemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions		 ISO azosemide results in decreased activity of SLC12A2 protein
azosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]		 CTD PMID:15517342 PMID:29959396 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        pharmaceutical 19499
          drug 19499
            diuretic 4092
              loop diuretic 218
                azosemide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      chalcogen 19548
                        oxygen atom 19524
                          oxygen molecular entity 19524
                            hydroxides 19312
                              oxoacid 18688
                                chalcogen oxoacid 12916
                                  sulfur oxoacid 12654
                                    sulfonic acid 10056
                                      sulfonic acid derivative 10056
                                        sulfonamide 3229
                                          azosemide 1
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