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ONTOLOGY REPORT - ANNOTATIONS


Term:aripiprazole
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Accession:CHEBI:31236 term browser browse the term
Definition:A delta-lactam that has formula C23H27Cl2N3O2.
Synonyms:exact_synonym: 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
 related_synonym: Abilify;   Abilitat;   Formula=C23H27Cl2N3O2;   InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29);   InChIKey=CEUORZQYGODEFX-UHFFFAOYSA-N;   SMILES=Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl;   aripiprazol;   aripiprazolum
 alt_id: MESH:D000068180
 xref: CAS:129722-12-9;   DrugBank:DB01238;   Drug_Central:242;   HMDB:HMDB0005042;   KEGG:C12564;   KEGG:D01164;   LINCS:LSM-5776
 xref_mesh: MESH:C094645
 xref: Patent:EP367141;   Patent:US5006528;   Wikipedia:Aripiprazole


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aripiprazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acadl acyl-CoA dehydrogenase, long chain JBrowse link 9 73,833,368 73,871,857 RGD:6480464
G Adora2a adenosine A2a receptor JBrowse link 20 14,265,251 14,282,873 RGD:6480464
G Arpc1b actin related protein 2/3 complex, subunit 1B JBrowse link 12 11,252,300 11,265,849 RGD:6480464
G Bcl10 BCL10, immune signaling adaptor JBrowse link 2 251,805,392 251,814,957 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6480464
G C1r complement C1r JBrowse link 4 157,126,060 157,136,825 RGD:6480464
G C2 complement C2 JBrowse link 20 4,542,340 4,561,152 RGD:6480464
G Cbx7 chromobox 7 JBrowse link 7 121,136,067 121,153,503 RGD:6480464
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:6480464
G Ccl22 C-C motif chemokine ligand 22 JBrowse link 19 10,674,189 10,681,145 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Ccr3 C-C motif chemokine receptor 3 JBrowse link 8 133,026,539 133,040,999 RGD:6480464
G Cd274 CD274 molecule JBrowse link 1 247,519,890 247,539,659 RGD:6480464
G Cd33 CD33 molecule JBrowse link 1 98,388,811 98,403,539 RGD:6480464
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:6480464
G Cd70 Cd70 molecule JBrowse link 9 9,842,585 9,845,728 RGD:6480464
G Cd83 CD83 molecule JBrowse link 17 24,416,651 24,435,790 RGD:6480464
G Cdh5 cadherin 5 JBrowse link 19 1,025,122 1,074,333 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:6480464
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:6480464
G Cldn5 claudin 5 JBrowse link 11 86,356,292 86,357,718 RGD:6480464
G Cnr1 cannabinoid receptor 1 JBrowse link 5 49,307,584 49,333,064 RGD:6480464
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6480464
G Creb5 cAMP responsive element binding protein 5 JBrowse link 4 83,390,782 83,840,356 RGD:6480464
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6480464
G Crmp1 collapsin response mediator protein 1 JBrowse link 14 78,266,931 78,312,777 RGD:6480464
G Csf1 colony stimulating factor 1 JBrowse link 2 210,522,370 210,550,546 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:6480464
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:6480464
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:6480464
G Cxcl3 C-X-C motif chemokine ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cxcr5 C-X-C motif chemokine receptor 5 JBrowse link 8 48,835,688 48,852,032 RGD:6480464
G Cxcr6 C-X-C motif chemokine receptor 6 JBrowse link 8 132,869,712 132,870,766 RGD:6480464
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:6480464
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:6480464
G Ddr2 discoidin domain receptor tyrosine kinase 2 JBrowse link 13 88,311,639 88,436,561 RGD:6480464
G Ddx50 DExD-box helicase 50 JBrowse link 20 32,239,736 32,269,522 RGD:6480464
G Ddx58 DEXD/H-box helicase 58 JBrowse link 5 56,486,584 56,536,898 RGD:6480464
G Dnal4 dynein, axonemal, light chain 4 JBrowse link 7 120,987,438 121,000,272 RGD:6480464
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:6480464
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:6480464
G Dusp4 dual specificity phosphatase 4 JBrowse link 16 61,080,767 61,090,973 RGD:6480464
G Dusp6 dual specificity phosphatase 6 JBrowse link 7 41,475,163 41,479,393 RGD:6480464
G Ebi3 Epstein-Barr virus induced 3 JBrowse link 9 11,110,874 11,114,843 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Egr2 early growth response 2 JBrowse link 20 22,452,170 22,461,018 RGD:6480464
G Egr4 early growth response 4 JBrowse link 4 117,293,620 117,296,082 RGD:6480464
G Elane elastase, neutrophil expressed JBrowse link 7 12,638,320 12,640,168 RGD:6480464
G Elavl2 ELAV like RNA binding protein 2 JBrowse link 5 109,499,410 109,651,829 RGD:6480464
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link 8 33,756,634 33,879,625 RGD:6480464
G Exoc2 exocyst complex component 2 JBrowse link 17 34,665,810 34,842,266 RGD:6480464
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:6480464
G Fez1 fasciculation and elongation protein zeta 1 JBrowse link 8 39,305,128 39,350,270 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Hbegf heparin-binding EGF-like growth factor JBrowse link 18 29,330,302 29,340,185 RGD:6480464
G Htr1a 5-hydroxytryptamine receptor 1A JBrowse link 2 36,246,628 36,247,896 RGD:6480464
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:6480464
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Icam4 intercellular adhesion molecule 4, Landsteiner-Wiener blood group JBrowse link 8 22,047,697 22,048,793 RGD:6480464
G Icoslg inducible T-cell co-stimulator ligand JBrowse link 20 11,330,000 11,340,307 RGD:6480464
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Ifngr1 interferon gamma receptor 1 JBrowse link 1 15,062,380 15,080,815 RGD:6480464
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon JBrowse link 13 48,031,325 48,056,394 RGD:6480464
G Il11 interleukin 11 JBrowse link 1 72,636,959 72,643,255 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:6480464
G Il1rap interleukin 1 receptor accessory protein JBrowse link 11 77,456,648 77,593,208 RGD:6480464
G Il1rapl2 interleukin 1 receptor accessory protein-like 2 JBrowse link X 108,287,034 109,851,075 RGD:6480464
G Il1rl1 interleukin 1 receptor-like 1 JBrowse link 9 47,133,483 47,184,316 RGD:6480464
G Il23a interleukin 23 subunit alpha JBrowse link 7 2,710,609 2,712,723 RGD:6480464
G Il24 interleukin 24 JBrowse link 13 47,618,451 47,623,849 RGD:6480464
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:6480464
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Il7r interleukin 7 receptor RGD:6480464
G Inpp5d inositol polyphosphate-5-phosphatase D JBrowse link 9 94,745,220 94,850,778 RGD:6480464
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:6480464
G Irf8 interferon regulatory factor 8 JBrowse link 19 54,314,859 54,336,643 RGD:6480464
G Isg20 interferon stimulated exonuclease gene 20 JBrowse link 1 140,602,553 140,608,892 RGD:6480464
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:6480464
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 JBrowse link 3 41,019,898 41,181,070 RGD:6480464
G Lif LIF, interleukin 6 family cytokine JBrowse link 14 84,482,652 84,500,574 RGD:6480464
G Lrrn3 leucine rich repeat neuronal 3 JBrowse link 6 61,374,328 61,405,195 RGD:6480464
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:6480464
G Ltb lymphotoxin beta JBrowse link 20 5,184,631 5,186,476 RGD:6480464
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:6480464
G Maob monoamine oxidase B JBrowse link X 6,430,694 6,533,520 RGD:6480464
G Mapk6 mitogen-activated protein kinase 6 JBrowse link 8 82,328,013 82,351,108 RGD:6480464
G Mapkapk2 MAPK activated protein kinase 2 JBrowse link 13 47,785,157 47,871,684 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:6480464
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:6480464
G Npdc1 neural proliferation, differentiation and control, 1 JBrowse link 3 2,624,231 2,630,672 RGD:6480464
G Nt5e 5' nucleotidase, ecto JBrowse link 8 95,969,002 96,012,733 RGD:6480464
G Ntm neurotrimin JBrowse link 8 30,039,332 31,041,755 RGD:6480464
G Pdcd1lg2 programmed cell death 1 ligand 2 JBrowse link 1 247,562,202 247,629,279 RGD:6480464
G Pdgfc platelet derived growth factor C JBrowse link 2 179,952,227 180,126,897 RGD:6480464
G Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 JBrowse link 5 25,577,593 25,584,325 RGD:6480464
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:6480464
G Plaur plasminogen activator, urokinase receptor JBrowse link 1 81,328,171 81,344,954 RGD:6480464
G Pou2f2 POU class 2 homeobox 2 JBrowse link 1 81,966,791 82,049,116 RGD:6480464
G Prg2 proteoglycan 2 JBrowse link 3 72,385,678 72,389,245 RGD:6480464
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Prodh1 proline dehydrogenase 1 JBrowse link 11 87,058,478 87,075,785 RGD:6480464
G Psmc6 proteasome 26S subunit, ATPase 6 JBrowse link 15 19,667,453 19,688,916 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:6480464
G Rab3a RAB3A, member RAS oncogene family JBrowse link 16 20,435,098 20,439,206 RGD:6480464
G Rasd1 ras related dexamethasone induced 1 JBrowse link 10 46,330,361 46,339,326 RGD:6480464
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:6480464
G Sae1 SUMO1 activating enzyme subunit 1 JBrowse link 1 78,277,524 78,333,281 RGD:6480464
G Sbno2 strawberry notch homolog 2 JBrowse link 7 12,471,805 12,515,700 RGD:6480464
G Serpinb2 serpin family B member 2 JBrowse link 13 27,449,907 27,463,015 RGD:6480464
G Sh2b2 SH2B adaptor protein 2 JBrowse link 12 23,471,477 23,501,043 RGD:6480464
G Slamf6 SLAM family member 6 JBrowse link 13 90,300,160 90,321,781 RGD:6480464
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:6480464
G Slco2b1 solute carrier organic anion transporter family, member 2b1 JBrowse link 1 164,623,313 164,671,612 RGD:6480464
G Slit3 slit guidance ligand 3 JBrowse link 10 19,924,200 20,517,918 RGD:6480464
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:6480464
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:6480464
G Syt17 synaptotagmin 17 JBrowse link 1 188,034,614 188,101,590 RGD:6480464
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:6480464
G Tacr3 tachykinin receptor 3 JBrowse link 2 240,021,152 240,118,971 RGD:6480464
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:6480464
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:6480464
G Ticam1 toll-like receptor adaptor molecule 1 JBrowse link 9 10,780,185 10,790,280 RGD:6480464
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:6480464
G Tlr5 toll-like receptor 5 JBrowse link 13 101,364,784 101,385,764 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:6480464
G Tnfrsf11b TNF receptor superfamily member 11B JBrowse link 7 93,798,580 93,826,586 RGD:6480464
G Tnfrsf12a TNF receptor superfamily member 12A JBrowse link 10 12,995,904 12,997,930 RGD:6480464
G Tnfrsf14 TNF receptor superfamily member 14 JBrowse link 5 172,328,259 172,337,221 RGD:6480464
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:6480464
G Tnfrsf8 TNF receptor superfamily member 8 JBrowse link 5 163,186,349 163,231,578 RGD:6480464
G Tnfrsf9 TNF receptor superfamily member 9 JBrowse link 5 168,009,245 168,035,813 RGD:6480464
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:6480464
G Tnfsf12 TNF superfamily member 12 JBrowse link 10 56,290,780 56,300,137 RGD:6480464
G Tnfsf15 TNF superfamily member 15 JBrowse link 5 79,553,935 79,569,974 RGD:6480464
G Tnfsf18 TNF superfamily member 18 JBrowse link 13 79,378,412 79,388,687 RGD:6480464
G Tubb2a tubulin, beta 2A class IIa JBrowse link 17 31,493,145 31,496,827 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Wee1 WEE1 G2 checkpoint kinase JBrowse link 1 174,765,228 174,790,882 RGD:6480464
G Zfp354c zinc finger protein 354C JBrowse link 10 36,311,343 36,322,356 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      biological role 19726
        pharmacological role 18808
          neurotransmitter agent 16439
            serotonergic drug 3932
              serotonergic agonist 979
                aripiprazole 163
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            organic group 18463
                              organic divalent group 18456
                                organodiyl group 18456
                                  carbonyl group 18356
                                    carbonyl compound 18356
                                      carboxylic acid 18027
                                        carboacyl group 17185
                                          univalent carboacyl group 17185
                                            carbamoyl group 16924
                                              carboxamide 16924
                                                lactam 7828
                                                  delta-lactam 1197
                                                    aripiprazole 163
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.