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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Apafant
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Accession:CHEBI:31226 term browser browse the term
Synonyms:related_synonym: Formula=C22H22ClN5O2S
 xref: CAS:105219-56-5;   KEGG:D01652
 xref_mesh: MESH:C052518


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Apafant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO
EXP
WEB 2086 inhibits the reaction [IL1B protein results in increased expression of TNF protein]
WEB 2086 inhibits the reaction [Doxorubicin results in increased secretion of IL1B protein]
CTD PMID:7575673, PMID:8132220 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO WEB 2086 results in decreased expression of MYB mRNA CTD PMID:11923217 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 multiple interactions EXP WEB 2086 binds to and results in decreased activity of PAFAH1B1 protein CTD PMID:12013527 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions ISO [WEB 2086 binds to and results in decreased activity of PTAFR protein] which results in decreased susceptibility to lipoxin A4; WEB 2086 binds to and results in decreased activity of PTAFR protein CTD PMID:7602232, PMID:8666909 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO WEB 2086 inhibits the reaction [IL1B protein results in increased expression of TNF protein] CTD PMID:7575673 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          carbon atom 19588
            organic molecular entity 19588
              Apafant 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            Apafant 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.