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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amlexanox
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Accession:CHEBI:31205 term browser browse the term
Definition:A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Synonyms:exact_synonym: 2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
 related_synonym: 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid;   Formula=C16H14N2O4;   InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21);   InChIKey=SGRYPYWGNKJSDL-UHFFFAOYSA-N;   SMILES=CC(C)c1ccc2oc3nc(N)c(cc3c(=O)c2c1)C(O)=O;   amlexanoxo;   amlexanoxum
 alt_id: CHEBI:250549
 xref: Beilstein:556384;   CAS:68302-57-8;   DrugBank:DB01025;   Drug_Central:182;   KEGG:D01828;   LINCS:LSM-5432
 xref_mesh: MESH:C045742
 xref: PMID:12873507;   PMID:3989816;   Wikipedia:Amlexanox


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amlexanox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
amlexanox results in decreased expression of BAX protein
CTD PMID:31697998 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein] CTD PMID:31697998 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA] CTD PMID:31697998 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL2 mRNA] CTD PMID:31697998 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA] CTD PMID:31697998 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein]; amlexanox binds to and results in increased stability of and results in decreased secretion of FGF1 protein; amlexanox inhibits the reaction [FGF1 protein binds to FGF1 protein] CTD PMID:16300395 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA; [Acetaminophen co-treated with amlexanox] affects the expression of GCLC mRNA
amlexanox results in increased expression of GCLC mRNA
CTD PMID:31697998 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLM mRNA CTD PMID:31697998 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31697998 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO amlexanox affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA; amlexanox promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; dorsomorphin inhibits the reaction [[amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA]
amlexanox results in increased expression of HMOX1 mRNA
CTD PMID:31697998 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases activity
multiple interactions
ISO amlexanox results in decreased activity of IKBKE protein
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of IKBKE protein]
CTD PMID:25321315, PMID:31697998 NCBI chr13:48,031,325...48,056,394
Ensembl chr13:48,031,410...48,056,394
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA] CTD PMID:31697998 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA] CTD PMID:31697998 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
ISO amlexanox results in increased expression of NFE2L2 protein
[Acetaminophen co-treated with amlexanox] results in increased expression of NFE2L2 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]]
CTD PMID:31697998 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO dorsomorphin inhibits the reaction [[Acetaminophen co-treated with amlexanox] affects the expression of NQO1 mRNA] CTD PMID:31697998 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation
multiple interactions
ISO amlexanox results in increased phosphorylation of PRKAA1 protein
[Acetaminophen co-treated with amlexanox] results in increased phosphorylation of PRKAA1 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]]
CTD PMID:31697998 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of RELA protein] CTD PMID:31697998 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tbk1 TANK-binding kinase 1 decreases activity
decreases phosphorylation
multiple interactions
ISO amlexanox results in decreased activity of TBK1 protein
amlexanox results in decreased phosphorylation of TBK1 protein
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of TBK1 protein]
CTD PMID:25321315, PMID:31697998 NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA] CTD PMID:31697998 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization ISO amlexanox affects the localization of UPF1 protein CTD PMID:28743738 NCBI chr16:20,824,888...20,845,632
Ensembl chr16:20,824,864...20,845,243
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-inflammatory agent 14950
          anti-inflammatory drug 13613
            non-steroidal anti-inflammatory drug 12696
              amlexanox 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          amlexanox 21
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.