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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:amlexanox
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Accession:CHEBI:31205 term browser browse the term
Definition:A pyridochromene-derived monocarboxylic acid having an amino substituent at the 2-position, an oxo substituent at the 5-position and an isopropyl substituent at the 7-position.
Synonyms:exact_synonym: 2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
 related_synonym: 2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid;   Formula=C16H14N2O4;   InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21);   InChIKey=SGRYPYWGNKJSDL-UHFFFAOYSA-N;   SMILES=CC(C)c1ccc2oc3nc(N)c(cc3c(=O)c2c1)C(O)=O;   amlexanoxo;   amlexanoxum
 alt_id: CHEBI:250549
 xref: Beilstein:556384;   CAS:68302-57-8;   DrugBank:DB01025;   Drug_Central:182;   KEGG:D01828;   LINCS:LSM-5432
 xref_mesh: MESH:C045742
 xref: PMID:12873507;   PMID:3989816;   Wikipedia:Amlexanox



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amlexanox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of ACACA mRNA] CTD PMID:32905826 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions
decreases expression
ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of ADGRE1 mRNA]
amlexanox results in decreased expression of ADGRE1 mRNA
CTD PMID:32905826 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Arg1 arginase 1 multiple interactions ISO amlexanox affects the reaction [Palmitic Acid affects the expression of ARG1 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 protein] CTD PMID:32905826 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]
amlexanox results in decreased expression of BAX protein
CTD PMID:31697998 PMID:32905826 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein] CTD PMID:31697998 PMID:32905826 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased cleavage of CASP3 protein] CTD PMID:32905826 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA] CTD PMID:31697998 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CD14 mRNA] CTD PMID:32905826 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CD68 mRNA] CTD PMID:32905826 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of CPT1A mRNA] CTD PMID:32905826 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL2 mRNA] CTD PMID:31697998 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA] CTD PMID:31697998 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CYP2E1 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CYP2E1 protein] CTD PMID:32905826 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of DGAT1 mRNA] CTD PMID:32905826 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of FASN mRNA] CTD PMID:32905826 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein]; amlexanox binds to and results in increased stability of and results in decreased secretion of FGF1 protein; amlexanox inhibits the reaction [FGF1 protein binds to FGF1 protein] CTD PMID:16300395 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA; [Acetaminophen co-treated with amlexanox] affects the expression of GCLC mRNA
amlexanox results in increased expression of GCLC mRNA
CTD PMID:31697998 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLM mRNA CTD PMID:31697998 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31697998 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO amlexanox affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA; [amlexanox co-treated with Palmitic Acid] results in increased expression of HMOX1 mRNA; amlexanox promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; dorsomorphin inhibits the reaction [[amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA]
amlexanox results in increased expression of HMOX1 mRNA
CTD PMID:31697998 PMID:32905826 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of IFNB1 mRNA]; amlexanox inhibits the reaction [Paraquat results in increased secretion of IFNB1 protein] CTD PMID:32763286 PMID:32905826 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases activity
multiple interactions
ISO amlexanox results in decreased activity of IKBKE protein
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of IKBKE protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased phosphorylation of IKBKE protein]
CTD PMID:25321315 PMID:31697998 PMID:32905826 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Il10 interleukin 10 multiple interactions ISO amlexanox affects the reaction [Palmitic Acid affects the expression of IL10 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of IL10 protein] CTD PMID:32905826 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of IL1B mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein]; amlexanox inhibits the reaction [Paraquat results in increased secretion of IL1B protein] CTD PMID:31697998 PMID:32763286 PMID:32905826 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein] CTD PMID:31697998 PMID:32905826 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein]; amlexanox inhibits the reaction [Paraquat affects the localization of IRF3 protein] CTD PMID:32763286 PMID:32905826 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
ISO amlexanox results in increased expression of NFE2L2 protein
[Acetaminophen co-treated with amlexanox] results in increased expression of NFE2L2 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]]
CTD PMID:31697998 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of NOS2 protein]; mifobate inhibits the reaction [amlexanox inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]] CTD PMID:32905826 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO dorsomorphin inhibits the reaction [[Acetaminophen co-treated with amlexanox] affects the expression of NQO1 mRNA] CTD PMID:31697998 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of PPARA mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of PPARA protein]; amlexanox promotes the reaction [Palmitic Acid results in increased expression of PPARA protein] CTD PMID:32905826 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation
multiple interactions
ISO amlexanox results in increased phosphorylation of PRKAA1 protein
[Acetaminophen co-treated with amlexanox] results in increased phosphorylation of PRKAA1 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]]
CTD PMID:31697998 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of RELA protein]; amlexanox inhibits the reaction [Paraquat affects the localization of RELA protein] CTD PMID:31697998 PMID:32763286 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
multiple interactions
ISO amlexanox results in decreased expression of SREBF1 mRNA
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]
CTD PMID:32905826 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tbk1 TANK-binding kinase 1 decreases activity
decreases phosphorylation
multiple interactions
ISO amlexanox results in decreased activity of TBK1 protein
amlexanox results in decreased phosphorylation of TBK1 protein
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of TBK1 protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased phosphorylation of TBK1 protein]; amlexanox inhibits the reaction [Paraquat results in increased phosphorylation of TBK1 protein]
CTD PMID:25321315 PMID:31697998 PMID:32763286 PMID:32905826 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased secretion of TNF protein] CTD PMID:31697998 PMID:32905826 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization ISO amlexanox affects the localization of UPF1 protein CTD PMID:28743738 NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
JBrowse link

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  CHEBI ontology 19823
    role 19773
      application 19486
        anti-inflammatory agent 15835
          anti-inflammatory drug 13630
            non-steroidal anti-inflammatory drug 12717
              amlexanox 37
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  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        monocarboxylic acid 17639
                                          amlexanox 37
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