The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A member of the class of D3 vitamins that is calciol in which the hydrogen at the 1alpha position is replaced by a hydroxy group. It is an active metabolite of cholecalciferol, which performs important functions in regulation of the calcium balance and the bone metabolism.
alfacalcidol results in increased expression of CD14 protein [alfacalcidol co-treated with Lipopolysaccharides] results in increased expression of CD14 protein
alfacalcidol results in increased expression of CYP24A1 mRNA; alfacalcidol results in increased expression of CYP24A1 protein [Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA
alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; alfacalcidol promotes the reaction [Polyphenols inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; alfacalcidol promotes the reaction [Tea inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Polyphenols promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Tea promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
alfacalcidol binds to [VDR protein binds to RXRA protein] alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form]; alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form]
alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; alfacalcidol promotes the reaction [Polyphenols inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; alfacalcidol promotes the reaction [Tea inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Polyphenols promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Tea promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
alfacalcidol binds to [VDR protein binds to RXRA protein]; alfacalcidol binds to VDR protein modified form [alfacalcidol results in increased activity of VDR protein] which results in increased metabolism of Bile Acids and Salts alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form]; alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form]