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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alfacalcidol
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Accession:CHEBI:31186 term browser browse the term
Definition:A member of the class of D3 vitamins that is calciol in which the hydrogen at the 1alpha position is replaced by a hydroxy group. It is an active metabolite of cholecalciferol, which performs important functions in regulation of the calcium balance and the bone metabolism.
Synonyms:exact_synonym: (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3-diol
 related_synonym: (5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol;   1alpha-hydroxy-vitamin D3;   1alpha-hydroxycholecalciferol;   1alpha-hydroxyvitamin D3;   9,10-secocholesta-5,7,10(19)-triene-1alpha,3beta-diol;   Alsiodol;   Formula=C27H44O2;   InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1;   InChIKey=OFHCOWSQAMBJIW-AVJTYSNKSA-N;   SMILES=CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@]1(C)CCC\\C2=C/C=C1/C[C@@H](O)C[C@H](O)C1=C;   alfacalcidolum
 xref: CAS:41294-56-8;   DrugBank:DB01436;   Drug_Central:130;   HMDB:HMDB0015504;   KEGG:D01518
 xref_mesh: MESH:C008088
 xref: PMID:17438884;   PMID:17668216;   PMID:20827552;   PMID:22527138;   PMID:22607568;   PMID:24119718;   PMID:24414552;   Reaxys:2064794


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alfacalcidol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO alfacalcidol results in increased expression of ABCC2 mRNA CTD PMID:19581390 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO alfacalcidol results in increased expression of ABCC3 mRNA CTD PMID:19581390 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO alfacalcidol results in increased expression of ABCC4 mRNA; alfacalcidol results in increased expression of ABCC4 protein CTD PMID:19581390 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Alb albumin increases expression ISO alfacalcidol results in increased expression of ALB protein CTD PMID:15044820 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cd14 CD14 molecule increases expression
multiple interactions		 ISO alfacalcidol results in increased expression of CD14 protein
[alfacalcidol co-treated with Lipopolysaccharides] results in increased expression of CD14 protein		 CTD PMID:15946915 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP
ISO		 alfacalcidol results in increased expression of CYP24A1 mRNA; alfacalcidol results in increased expression of CYP24A1 protein
[Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA		 CTD PMID:8410379 PMID:16824767 PMID:18180267 PMID:19581390 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of alfacalcidol CTD PMID:15005856 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO alfacalcidol results in increased expression of CYP7A1 mRNA CTD PMID:19581390 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form] CTD PMID:20947021 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form] CTD PMID:20947021 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; alfacalcidol promotes the reaction [Polyphenols inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; alfacalcidol promotes the reaction [Tea inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Polyphenols promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Tea promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] CTD PMID:20069278 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pth parathyroid hormone decreases expression EXP alfacalcidol results in decreased expression of PTH protein CTD PMID:11675047 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Rxra retinoid X receptor alpha affects binding
multiple interactions		 ISO alfacalcidol binds to [VDR protein binds to RXRA protein]
alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form]; alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form]		 CTD PMID:20947021 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G S100g S100 calcium binding protein G increases expression ISO alfacalcidol results in increased expression of S100G mRNA CTD PMID:18180267 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression ISO alfacalcidol results in increased expression of SLC10A2 mRNA CTD PMID:19581390 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475 		JBrowse link
G Slc51a solute carrier family 51 subunit alpha increases expression ISO alfacalcidol results in increased expression of SLC51A mRNA CTD PMID:19581390 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects response to substance ISO TGFB1 gene SNP affects the susceptibility to alfacalcidol CTD PMID:10750555 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tk1 thymidine kinase 1 multiple interactions ISO alfacalcidol inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TK1 mRNA] CTD PMID:17893519 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO alfacalcidol results in decreased expression of TLR2 protein CTD PMID:15946915 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; alfacalcidol promotes the reaction [Polyphenols inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; alfacalcidol promotes the reaction [Tea inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Polyphenols promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Tea promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:20069278 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B decreases expression ISO alfacalcidol results in decreased expression of TNFRSF1B protein modified form CTD PMID:15044820 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 increases expression ISO alfacalcidol results in increased expression of TRPV5 mRNA CTD PMID:18180267 NCBI chr 4:70,536,432...70,562,743
Ensembl chr 4:70,536,440...70,562,745 		JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 increases expression ISO alfacalcidol results in increased expression of TRPV6 mRNA CTD PMID:18180267 NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO alfacalcidol promotes the reaction [Methimazole results in increased expression of TSHB protein] CTD PMID:9322804 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Vdr vitamin D receptor affects binding
multiple interactions
increases activity		 ISO alfacalcidol binds to [VDR protein binds to RXRA protein]; alfacalcidol binds to VDR protein modified form
[alfacalcidol results in increased activity of VDR protein] which results in increased metabolism of Bile Acids and Salts
alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form]; alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form]		 CTD PMID:17997857 PMID:19581390 PMID:20947021 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        pharmaceutical 19624
          drug 19655
            bone density conservation agent 5996
              alfacalcidol 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic polycyclic compound 17201
                                  steroid 14380
                                    hydroxy steroid 14111
                                      hydroxy seco-steroid 2683
                                        vitamin D 2677
                                          D3 vitamins 2626
                                            calciol 2625
                                              hydroxycalciol 2480
                                                alfacalcidol 25
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