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ONTOLOGY REPORT - ANNOTATIONS
Term:alfacalcidol
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Accession:CHEBI:31186 term browser browse the term
Definition:A member of the class of D3 vitamins that is calciol in which the hydrogen at the 1alpha position is replaced by a hydroxy group. It is an active metabolite of cholecalciferol, which performs important functions in regulation of the calcium balance and the bone metabolism.
Synonyms:exact_synonym: (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3-diol
 related_synonym: (5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol;   1alpha-hydroxy-vitamin D3;   1alpha-hydroxycholecalciferol;   1alpha-hydroxyvitamin D3;   9,10-secocholesta-5,7,10(19)-triene-1alpha,3beta-diol;   Alsiodol;   Formula=C27H44O2;   InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1;   InChIKey=OFHCOWSQAMBJIW-AVJTYSNKSA-N;   SMILES=CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@]1(C)CCC\\C2=C/C=C1/C[C@@H](O)C[C@H](O)C1=C;   alfacalcidolum
 xref: CAS:41294-56-8 "ChemIDplus";   CAS:41294-56-8 "KEGG DRUG";   DrugBank:DB01436;   Drug_Central:130 "DrugCentral";   HMDB:HMDB0015504;   KEGG:D01518
 xref_mesh: MESH:C008088
 xref: PMID:17438884 "Europe PMC";   PMID:17668216 "Europe PMC";   PMID:20827552 "Europe PMC";   PMID:22527138 "Europe PMC";   PMID:22607568 "Europe PMC";   PMID:24119718 "Europe PMC";   PMID:24414552 "Europe PMC";   Reaxys:2064794 "Reaxys"

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alfacalcidol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6480464
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 JBrowse link 3 168,097,484 168,111,920 RGD:6480464
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:6480464
G Med1 mediator complex subunit 1 JBrowse link 10 86,101,560 86,145,271 RGD:6480464
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6480464
G S100g S100 calcium binding protein G JBrowse link X 33,442,820 33,445,714 RGD:6480464
G Slc10a2 solute carrier family 10 member 2 JBrowse link 16 90,324,420 90,350,254 RGD:6480464
G Slc51a solute carrier family 51, alpha subunit JBrowse link 11 71,533,078 71,547,476 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tk1 thymidine kinase 1 JBrowse link 10 106,817,556 106,828,888 RGD:6480464
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:6480464
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 JBrowse link 4 70,947,615 70,974,004 RGD:6480464
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 JBrowse link 4 70,918,631 70,934,291 RGD:6480464
G Tshb thyroid stimulating hormone subunit beta JBrowse link 2 205,207,799 205,215,199 RGD:6480464
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:6480464
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            bone density conservation agent 5913
              alfacalcidol 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic polycyclic compound 16028
                                  steroid 12767
                                    hydroxy steroid 12357
                                      hydroxy seco-steroid 2638
                                        vitamin D 2634
                                          D3 vitamins 2590
                                            calciol 2590
                                              hydroxycalciol 2454
                                                alfacalcidol 24
paths to the root

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