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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alfacalcidol
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Accession:CHEBI:31186 term browser browse the term
Definition:A member of the class of D3 vitamins that is calciol in which the hydrogen at the 1alpha position is replaced by a hydroxy group. It is an active metabolite of cholecalciferol, which performs important functions in regulation of the calcium balance and the bone metabolism.
Synonyms:exact_synonym: (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3-diol
 related_synonym: (5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol;   1alpha-hydroxy-vitamin D3;   1alpha-hydroxycholecalciferol;   1alpha-hydroxyvitamin D3;   9,10-secocholesta-5,7,10(19)-triene-1alpha,3beta-diol;   Alsiodol;   Formula=C27H44O2;   InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1;   InChIKey=OFHCOWSQAMBJIW-AVJTYSNKSA-N;   SMILES=CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@]1(C)CCC\\C2=C/C=C1/C[C@@H](O)C[C@H](O)C1=C;   alfacalcidolum
 xref: CAS:41294-56-8;   DrugBank:DB01436;   Drug_Central:130;   HMDB:HMDB0015504;   KEGG:D01518
 xref_mesh: MESH:C008088
 xref: PMID:17438884;   PMID:17668216;   PMID:20827552;   PMID:22527138;   PMID:22607568;   PMID:24119718;   PMID:24414552;   Reaxys:2064794


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alfacalcidol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO alfacalcidol results in increased expression of ABCC2 mRNA CTD PMID:19581390 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO alfacalcidol results in increased expression of ABCC3 mRNA CTD PMID:19581390 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO alfacalcidol results in increased expression of ABCC4 mRNA; alfacalcidol results in increased expression of ABCC4 protein CTD PMID:19581390 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Alb albumin increases expression ISO alfacalcidol results in increased expression of ALB protein CTD PMID:15044820 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cd14 CD14 molecule increases expression
multiple interactions
ISO alfacalcidol results in increased expression of CD14 protein
[alfacalcidol co-treated with Lipopolysaccharides] results in increased expression of CD14 protein
CTD PMID:15946915 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 increases expression
multiple interactions
EXP
ISO
alfacalcidol results in increased expression of CYP24A1 mRNA; alfacalcidol results in increased expression of CYP24A1 protein
[Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA
CTD PMID:8410379, PMID:16824767, PMID:18180267, PMID:19581390 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO alfacalcidol results in increased expression of CYP7A1 mRNA CTD PMID:19581390 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form] CTD PMID:20947021 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form] CTD PMID:20947021 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; alfacalcidol promotes the reaction [Polyphenols inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; alfacalcidol promotes the reaction [Tea inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Polyphenols promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Tea promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]] CTD PMID:20069278 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pth parathyroid hormone decreases expression EXP alfacalcidol results in decreased expression of PTH protein CTD PMID:11675047 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Rxra retinoid X receptor alpha affects binding
multiple interactions
ISO alfacalcidol binds to [VDR protein binds to RXRA protein]
alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form]; alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form]
CTD PMID:20947021 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G S100g S100 calcium binding protein G increases expression ISO alfacalcidol results in increased expression of S100G mRNA CTD PMID:18180267 NCBI chr  X:33,442,820...33,445,714
Ensembl chr  X:33,443,186...33,445,709
JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression ISO alfacalcidol results in increased expression of SLC10A2 mRNA CTD PMID:19581390 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc51a solute carrier family 51 subunit alpha increases expression ISO alfacalcidol results in increased expression of SLC51A mRNA CTD PMID:19581390 NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476
JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects response to substance ISO TGFB1 gene SNP affects the susceptibility to alfacalcidol CTD PMID:10750555 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tk1 thymidine kinase 1 multiple interactions ISO alfacalcidol inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TK1 mRNA] CTD PMID:17893519 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO alfacalcidol results in decreased expression of TLR2 protein CTD PMID:15946915 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; alfacalcidol promotes the reaction [Polyphenols inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; alfacalcidol promotes the reaction [Tea inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Polyphenols promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Tea promotes the reaction [alfacalcidol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:20069278 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B decreases expression ISO alfacalcidol results in decreased expression of TNFRSF1B protein modified form CTD PMID:15044820 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 increases expression ISO alfacalcidol results in increased expression of TRPV5 mRNA CTD PMID:18180267 NCBI chr 4:70,947,615...70,974,004
Ensembl chr 4:70,947,717...70,974,006
JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 increases expression ISO alfacalcidol results in increased expression of TRPV6 mRNA CTD PMID:18180267 NCBI chr 4:70,918,631...70,934,291
Ensembl chr 4:70,918,632...70,934,295
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO alfacalcidol promotes the reaction [Methimazole results in increased expression of TSHB protein] CTD PMID:9322804 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Vdr vitamin D receptor affects binding
multiple interactions
increases activity
ISO alfacalcidol binds to [VDR protein binds to RXRA protein]; alfacalcidol binds to VDR protein modified form
[alfacalcidol results in increased activity of VDR protein] which results in increased metabolism of Bile Acids and Salts
alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to MED1 protein modified form]; alfacalcidol promotes the reaction [[VDR protein binds to RXRA protein] which binds to NCOA1 protein modified form]
CTD PMID:17997857, PMID:19581390, PMID:20947021 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link

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  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            bone density conservation agent 5976
              alfacalcidol 24
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  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic polycyclic compound 16393
                                  steroid 12793
                                    hydroxy steroid 12375
                                      hydroxy seco-steroid 2662
                                        vitamin D 2657
                                          D3 vitamins 2609
                                            calciol 2609
                                              hydroxycalciol 2468
                                                alfacalcidol 24
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.