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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alclofenac
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Accession:CHEBI:31183 term browser browse the term
Definition:An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and rash.
Synonyms:exact_synonym: [3-chloro-4-(prop-2-en-1-yloxy)phenyl]acetic acid
 related_synonym: (4-Allyloxy-3-chlorphenyl)essigsaeure;   3-Chloro-4-(2-propenyloxy)benzeneacetic acid;   Formula=C11H11ClO3;   InChI=1S/C11H11ClO3/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14/h2-4,6H,1,5,7H2,(H,13,14);   InChIKey=ARHWPKZXBHOEEE-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1ccc(OCC=C)c(Cl)c1;   [4-(allyloxy)-3-chlorophenyl]acetic acid;   alclofenaco;   alclofenacum
 xref: CAS:22131-79-9;   Drug_Central:107;   KEGG:D01252
 xref_mesh: MESH:C084615
 xref: PMID:18796;   PMID:19205;   PMID:21068;   PMID:236805;   PMID:237493;   PMID:241593;   PMID:241595;   PMID:241596;   PMID:241597;   PMID:241598;   PMID:241600;   PMID:241601;   PMID:241602;   PMID:241603;   PMID:24426;   PMID:4279126;   PMID:509935;   PMID:6103793;   PMID:6106453;   PMID:6109575;   PMID:6120697;   PMID:6141199;   PMID:7853459;   PMID:7905004;   Patent:BE704368;   Reaxys:2116510;   Wikipedia:Alclofenac


show annotations for term's descendants           Sort by:
alclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein decreases expression ISO alclofenac results in decreased expression of CRP protein CTD PMID:241598 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Hp haptoglobin decreases expression ISO alclofenac results in decreased expression of HP protein CTD PMID:241598 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO alclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; alclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19757
    role 19730
      application 19563
        anti-inflammatory agent 16462
          anti-inflammatory drug 14920
            non-steroidal anti-inflammatory drug 14234
              alclofenac 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19757
    subatomic particle 19755
      composite particle 19755
        hadron 19755
          baryon 19755
            nucleon 19755
              atomic nucleus 19755
                atom 19755
                  main group element atom 19703
                    p-block element atom 19703
                      carbon group element atom 19649
                        carbon atom 19645
                          organic molecular entity 19645
                            organic group 18859
                              organic divalent group 18845
                                organodiyl group 18845
                                  carbonyl group 18809
                                    carbonyl compound 18809
                                      carboxylic acid 18530
                                        monocarboxylic acid 17860
                                          alclofenac 3
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