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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alclofenac
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Accession:CHEBI:31183 term browser browse the term
Definition:An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and rash.
Synonyms:exact_synonym: [3-chloro-4-(prop-2-en-1-yloxy)phenyl]acetic acid
 related_synonym: (4-Allyloxy-3-chlorphenyl)essigsaeure;   3-Chloro-4-(2-propenyloxy)benzeneacetic acid;   Formula=C11H11ClO3;   InChI=1S/C11H11ClO3/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14/h2-4,6H,1,5,7H2,(H,13,14);   InChIKey=ARHWPKZXBHOEEE-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1ccc(OCC=C)c(Cl)c1;   [4-(allyloxy)-3-chlorophenyl]acetic acid;   alclofenaco;   alclofenacum
 xref: CAS:22131-79-9;   Drug_Central:107;   KEGG:D01252
 xref_mesh: MESH:C084615
 xref: PMID:18796;   PMID:19205;   PMID:21068;   PMID:236805;   PMID:237493;   PMID:241593;   PMID:241595;   PMID:241596;   PMID:241597;   PMID:241598;   PMID:241600;   PMID:241601;   PMID:241602;   PMID:241603;   PMID:24426;   PMID:4279126;   PMID:509935;   PMID:6103793;   PMID:6106453;   PMID:6109575;   PMID:6120697;   PMID:6141199;   PMID:7853459;   PMID:7905004;   Patent:BE704368;   Reaxys:2116510;   Wikipedia:Alclofenac


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alclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein decreases expression ISO alclofenac results in decreased expression of CRP protein CTD PMID:241598 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Hp haptoglobin decreases expression ISO alclofenac results in decreased expression of HP protein CTD PMID:241598 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO alclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; alclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      application 19747
        anti-inflammatory agent 16333
          anti-inflammatory drug 14856
            non-steroidal anti-inflammatory drug 14236
              alclofenac 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        monocarboxylic acid 17748
                                          alclofenac 3
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