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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alclofenac
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Accession:CHEBI:31183 term browser browse the term
Definition:An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and rash.
Synonyms:exact_synonym: [3-chloro-4-(prop-2-en-1-yloxy)phenyl]acetic acid
 related_synonym: (4-Allyloxy-3-chlorphenyl)essigsaeure;   3-Chloro-4-(2-propenyloxy)benzeneacetic acid;   Formula=C11H11ClO3;   InChI=1S/C11H11ClO3/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14/h2-4,6H,1,5,7H2,(H,13,14);   InChIKey=ARHWPKZXBHOEEE-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1ccc(OCC=C)c(Cl)c1;   [4-(allyloxy)-3-chlorophenyl]acetic acid;   alclofenaco;   alclofenacum
 xref: CAS:22131-79-9;   Drug_Central:107;   KEGG:D01252
 xref_mesh: MESH:C084615
 xref: PMID:18796;   PMID:19205;   PMID:21068;   PMID:236805;   PMID:237493;   PMID:241593;   PMID:241595;   PMID:241596;   PMID:241597;   PMID:241598;   PMID:241600;   PMID:241601;   PMID:241602;   PMID:241603;   PMID:24426;   PMID:4279126;   PMID:509935;   PMID:6103793;   PMID:6106453;   PMID:6109575;   PMID:6120697;   PMID:6141199;   PMID:7853459;   PMID:7905004;   Patent:BE704368;   Reaxys:2116510;   Wikipedia:Alclofenac

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alclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein decreases expression ISO alclofenac results in decreased expression of CRP protein CTD PMID:241598 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Hp haptoglobin decreases expression ISO alclofenac results in decreased expression of HP protein CTD PMID:241598 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO alclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; alclofenac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr14:22,597,103...22,619,968 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        anti-inflammatory agent 15771
          anti-inflammatory drug 13626
            non-steroidal anti-inflammatory drug 12719
              alclofenac 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        monocarboxylic acid 17530
                                          alclofenac 3
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