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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aklavinone
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Accession:CHEBI:31181 term browser browse the term
Definition:A tetracenequinone that has formula C22H20O8.
Synonyms:exact_synonym: methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
 related_synonym: Aclavinone;   Aklavinon;   Formula=C22H20O8;   InChI=1S/C22H20O8/c1-3-22(29)8-13(24)15-10(17(22)21(28)30-2)7-11-16(20(15)27)19(26)14-9(18(11)25)5-4-6-12(14)23/h4-7,13,17,23-24,27,29H,3,8H2,1-2H3/t13-,17-,22+/m0/s1;   InChIKey=RACGRCLGVYXIAO-YOKWENHESA-N;   SMILES=CC[C@@]1(O)C[C@H](O)c2c(O)c3C(=O)c4c(O)cccc4C(=O)c3cc2[C@H]1C(=O)OC
 xref: Beilstein:3041138;   CAS:16234-96-1;   KEGG:C12424


show annotations for term's descendants           Sort by:
aclacinomycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 increases response to substance ISO CASP1 results in increased susceptibility to Aclarubicin CTD PMID:9491796 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Aclarubicin results in increased activity of CASP3 protein
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Aclarubicin results in increased activity of CASP3 protein]		 CTD PMID:16215684 PMID:20399885 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO Aclarubicin results in increased activity of CASP8 protein CTD PMID:20399885 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases degradation ISO Aclarubicin results in increased degradation of DFFA protein CTD PMID:12370496 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Gata1 GATA binding protein 1 multiple interactions
increases activity
increases expression		 ISO Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]; Aclarubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]
Aclarubicin results in increased activity of GATA1 protein		 CTD PMID:10656287 PMID:14623254 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions		 ISO Aclarubicin results in increased expression of GSTP1 mRNA; Aclarubicin results in increased expression of GSTP1 protein
Aclarubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter]		 CTD PMID:14623254 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmbs hydroxymethylbilane synthase increases expression
multiple interactions		 ISO Aclarubicin results in increased expression of HMBS mRNA
Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]		 CTD PMID:10656287 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Nfe2 nuclear factor, erythroid 2 increases expression
multiple interactions		 ISO Aclarubicin results in increased expression of NFE2 mRNA
Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]		 CTD PMID:10656287 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects activity ISO Aclarubicin affects the activity of PARP1 protein CTD PMID:20399885 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Aclarubicin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity ISO Aclarubicin results in decreased activity of SOD1 protein CTD PMID:10656287 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Xiap X-linked inhibitor of apoptosis increases response to substance ISO XIAP protein results in increased susceptibility to Aclarubicin CTD PMID:10815900 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      application 19682
        fuel 11355
          methanol 3971
            methyl ester 3917
              aklavinone 12
                15-demethylaclacinomycin T 0
                2-deoxy-alpha-L-fucosylaclacinomycin S 0
                4-O-methylrhodomycin D 0
                aclacinomycin A 12
                aclacinomycin N 0
                aclacinomycin S 0
                aclacinomycin T 0
                aclacinomycin Y 0
                rhodomycin D 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  carbonyl compound 18915
                                    ketone 17264
                                      cyclic ketone 15909
                                        quinone 9907
                                          acenoquinone 7725
                                            tetracenequinones 7604
                                              aklavinone 12
                                                15-demethylaclacinomycin T 0
                                                2-deoxy-alpha-L-fucosylaclacinomycin S 0
                                                4-O-methylrhodomycin D 0
                                                aclacinomycin A 12
                                                aclacinomycin N 0
                                                aclacinomycin S 0
                                                aclacinomycin T 0
                                                aclacinomycin Y 0
                                                rhodomycin D 0
paths to the root