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ONTOLOGY REPORT - ANNOTATIONS


Term:adefovir pivoxil
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Accession:CHEBI:31175 term browser browse the term
Definition:An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection.
Synonyms:exact_synonym: bis{[(tert-butoxycarbonyl)oxy]methyl} {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonate
 related_synonym: (((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis(oxymethylene) 2,2-dimethylpropanoate;   9-(2-((Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine;   Adefovir dipivoxil;   Formula=C20H32N5O10P;   GS 840;   GS-0840;   InChI=1S/C20H32N5O10P/c1-19(2,3)34-17(26)30-11-32-36(28,33-12-31-18(27)35-20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23);   InChIKey=RXWOJYZFCFODMQ-UHFFFAOYSA-N;   SMILES=N1(C2=C(C(N)=NC=N2)N=C1)CCOCP(OCOC(OC(C)(C)C)=O)(=O)OCOC(OC(C)(C)C)=O;   hepsera;   preveon
 xref: CAS:142340-99-6 "ChemIDplus";   CAS:142340-99-6 "KEGG DRUG";   DrugBank:DB00718;   Drug_Central:88 "DrugCentral";   HMDB:HMDB0014856;   KEGG:D01655
 xref_mesh: MESH:C106812
 xref: PMID:10728465 "Europe PMC";   PMID:12099163 "Europe PMC";   PMID:25237370 "Europe PMC";   PMID:25493022 "Europe PMC";   PMID:25834334 "Europe PMC";   PMID:26082614 "Europe PMC";   PMID:26110616 "Europe PMC";   PMID:26427083 "Europe PMC";   PMID:26431662 "Europe PMC";   PMID:26447622 "Europe PMC";   PMID:26462447 "Europe PMC";   PMID:26885037 "Europe PMC";   PMID:26889227 "Europe PMC";   PMID:26908332 "Europe PMC";   PMID:27010143 "Europe PMC";   PMID:27079793 "Europe PMC";   PMID:27247753 "Europe PMC";   PMID:27301512 "Europe PMC";   PMID:27386642 "Europe PMC";   PMID:27664568 "Europe PMC";   PMID:27698751 "Europe PMC";   PMID:27877054 "Europe PMC";   PMID:27977591 "Europe PMC";   PMID:28123560 "Europe PMC";   Reaxys:29413415 "Reaxys";   Wikipedia:Adefovir


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adefovir pivoxil term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl-hydrocarbon receptor JBrowse link 12 35,497,979 35,534,989 RGD:6480464
G Ak4 adenylate kinase 4 JBrowse link 4 101,416,478 101,467,771 RGD:6480464
G Akr1c21 aldo-keto reductase family 1, member C21 JBrowse link 13 4,574,075 4,586,543 RGD:6480464
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 JBrowse link 19 40,550,257 40,588,463 RGD:6480464
G Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 JBrowse link 7 66,390,892 66,427,477 RGD:6480464
G Als2cl ALS2 C-terminal like JBrowse link 9 110,880,120 110,900,530 RGD:6480464
G Angptl4 angiopoietin-like 4 JBrowse link 17 33,774,900 33,781,575 RGD:6480464
G Asns asparagine synthetase JBrowse link 6 7,675,165 7,693,209 RGD:6480464
G Atad2 ATPase family, AAA domain containing 2 JBrowse link 15 58,094,044 58,135,525 RGD:6480464
G Atf3 activating transcription factor 3 JBrowse link 1 191,170,296 191,183,333 RGD:6480464
G Aurkb aurora kinase B JBrowse link 11 69,045,624 69,051,664 RGD:6480464
G Axl AXL receptor tyrosine kinase JBrowse link 7 25,756,500 25,788,924 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bcar3 breast cancer anti-estrogen resistance 3 JBrowse link 3 122,419,757 122,530,191 RGD:6480464
G Bend5 BEN domain containing 5 JBrowse link 4 111,413,794 111,460,298 RGD:6480464
G Bmf BCL2 modifying factor JBrowse link 2 118,528,757 118,549,686 RGD:6480464
G Btg2 BTG anti-proliferation factor 2 JBrowse link 1 134,074,865 134,079,155 RGD:6480464
G Ccne2 cyclin E2 JBrowse link 4 11,190,433 11,204,779 RGD:6480464
G Cdk6 cyclin-dependent kinase 6 JBrowse link 5 3,341,004 3,531,008 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) JBrowse link 17 29,090,979 29,100,722 RGD:6480464
G Cmbl carboxymethylenebutenolidase-like (Pseudomonas) JBrowse link 15 31,565,342 31,590,119 RGD:6480464
G Coch cochlin JBrowse link 12 51,593,283 51,606,619 RGD:6480464
G Col4a1 collagen, type IV, alpha 1 JBrowse link 8 11,198,423 11,312,889 RGD:6480464
G Cth cystathionase (cystathionine gamma-lyase) JBrowse link 3 157,894,248 157,925,081 RGD:6480464
G Ctsc cathepsin C JBrowse link 7 88,278,024 88,315,861 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 17 79,706,940 79,715,061 RGD:6480464
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 JBrowse link 19 39,061,006 39,093,948 RGD:6480464
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 JBrowse link 19 39,113,898 39,186,756 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Ddb2 damage specific DNA binding protein 2 JBrowse link 2 91,211,545 91,237,132 RGD:6480464
G Dgka diacylglycerol kinase, alpha JBrowse link 10 128,720,131 128,745,084 RGD:6480464
G Dlgap5 DLG associated protein 5 JBrowse link 14 47,387,779 47,418,407 RGD:6480464
G Dlx1 distal-less homeobox 1 JBrowse link 2 71,528,113 71,533,981 RGD:6480464
G Dpysl3 dihydropyrimidinase-like 3 JBrowse link 18 43,320,979 43,438,286 RGD:6480464
G Efna1 ephrin A1 JBrowse link 3 89,271,730 89,280,951 RGD:6480464
G Ero1l ERO1-like (S. cerevisiae) JBrowse link 14 45,283,087 45,318,572 RGD:6480464
G Fas Fas (TNF receptor superfamily member 6) JBrowse link 19 34,290,647 34,327,775 RGD:6480464
G Fbxo22 F-box protein 22 JBrowse link 9 55,208,935 55,224,433 RGD:6480464
G Gabarapl1 gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 JBrowse link 6 129,533,192 129,542,331 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha JBrowse link 6 67,035,096 67,037,407 RGD:6480464
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 JBrowse link 12 80,518,282 80,603,898 RGD:6480464
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type JBrowse link 9 70,031,495 70,039,890 RGD:6480464
G Gdf15 growth differentiation factor 15 JBrowse link 8 70,629,393 70,632,470 RGD:6480464
G Got1 glutamic-oxaloacetic transaminase 1, soluble JBrowse link 19 43,499,752 43,524,605 RGD:6480464
G Gpr87 G protein-coupled receptor 87 JBrowse link 3 59,178,904 59,195,163 RGD:6480464
G H1f2 H1.2 linker histone, cluster member JBrowse link 13 23,738,807 23,739,531 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:6480464
G Hspa1b heat shock protein 1B JBrowse link 17 34,956,429 34,959,238 RGD:6480464
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:6480464
G Il19 interleukin 19 JBrowse link 1 130,932,656 130,945,457 RGD:6480464
G Kat6b K(lysine) acetyltransferase 6B JBrowse link 14 21,499,216 21,672,478 RGD:6480464
G Kdm3a lysine (K)-specific demethylase 3A JBrowse link 6 71,588,970 71,632,990 RGD:6480464
G Krt15 keratin 15 JBrowse link 11 100,131,759 100,135,949 RGD:6480464
G Lama3 laminin, alpha 3 JBrowse link 18 12,333,417 12,583,013 RGD:6480464
G Lcn2 lipocalin 2 JBrowse link 2 32,384,637 32,387,739 RGD:6480464
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 18 4,331,325 4,352,953 RGD:6480464
G Mdm2 transformed mouse 3T3 cell double minute 2 JBrowse link 10 117,688,875 117,710,758 RGD:6480464
G Mxi1 MAX interactor 1, dimerization protein JBrowse link 19 53,310,128 53,373,293 RGD:6480464
G Ncapd2 non-SMC condensin I complex, subunit D2 JBrowse link 6 125,168,007 125,192,100 RGD:6480464
G Ninj1 ninjurin 1 JBrowse link 13 49,187,529 49,196,251 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Nqo1 NAD(P)H dehydrogenase, quinone 1 JBrowse link 8 107,388,225 107,403,205 RGD:6480464
G Nrep neuronal regeneration related protein JBrowse link 18 33,437,019 33,464,365 RGD:6480464
G Ntpcr nucleoside-triphosphatase, cancer-related JBrowse link 8 125,729,975 125,748,235 RGD:6480464
G P4ha1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide JBrowse link 10 59,323,197 59,373,304 RGD:6480464
G Pank1 pantothenate kinase 1 JBrowse link 19 34,806,935 34,883,423 RGD:6480464
G Pdia5 protein disulfide isomerase associated 5 JBrowse link 16 35,397,308 35,490,919 RGD:6480464
G Pdlim1 PDZ and LIM domain 1 (elfin) JBrowse link 19 40,222,239 40,271,616 RGD:6480464
G Pgr progesterone receptor JBrowse link 9 8,898,900 8,968,611 RGD:6480464
G Phlda3 pleckstrin homology like domain, family A, member 3 JBrowse link 1 135,766,085 135,769,134 RGD:6480464
G Pidd1 p53 induced death domain protein 1 JBrowse link 7 141,438,113 141,447,565 RGD:6480464
G Pir pirin JBrowse link X 164,269,431 164,373,013 RGD:6480464
G Plec plectin JBrowse link 15 76,170,974 76,231,378 RGD:6480464
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 66,458,604 66,465,558 RGD:6480464
G Pparg peroxisome proliferator activated receptor gamma JBrowse link 6 115,360,879 115,490,404 RGD:6480464
G Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform JBrowse link 11 85,311,254 85,347,071 RGD:6480464
G Prc1 protein regulator of cytokinesis 1 JBrowse link 7 80,294,445 80,316,259 RGD:6480464
G Prdm1 PR domain containing 1, with ZNF domain JBrowse link 10 44,437,174 44,528,558 RGD:6480464
G Prkab2 protein kinase, AMP-activated, beta 2 non-catalytic subunit JBrowse link 3 97,658,211 97,673,812 RGD:6480464
G Psat1 phosphoserine aminotransferase 1 JBrowse link 19 15,905,123 15,925,059 RGD:6480464
G Rara retinoic acid receptor, alpha JBrowse link 11 98,927,800 98,974,942 RGD:6480464
G Rps27l ribosomal protein S27-like JBrowse link 9 66,944,624 66,949,522 RGD:6480464
G Rrm2b ribonucleotide reductase M2 B (TP53 inducible) JBrowse link 15 37,923,952 37,961,119 RGD:6480464
G Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 JBrowse link 1 106,861,175 106,883,348 RGD:6480464
G Sesn1 sestrin 1 JBrowse link 10 41,810,574 41,908,436 RGD:6480464
G Sfn stratifin JBrowse link 4 133,600,556 133,602,168 RGD:6480464
G Sh3tc1 SH3 domain and tetratricopeptide repeats 1 JBrowse link 5 35,697,180 35,739,987 RGD:6480464
G Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 JBrowse link 2 126,553,024 126,588,243 RGD:6480464
G Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 JBrowse link 4 117,835,258 117,869,305 RGD:6480464
G Slco2b1 solute carrier organic anion transporter family, member 2b1 JBrowse link 7 99,657,804 99,711,340 RGD:6480464
G Smap1 small ArfGAP 1 JBrowse link 1 23,844,825 23,922,381 RGD:6480464
G Sulf2 sulfatase 2 JBrowse link 2 166,073,899 166,155,683 RGD:6480464
G Thra thyroid hormone receptor alpha JBrowse link 11 98,740,776 98,769,006 RGD:6480464
G Tigar Trp53 induced glycolysis regulatory phosphatase JBrowse link 6 127,085,116 127,109,552 RGD:6480464
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase JBrowse link 3 65,528,447 65,555,518 RGD:6480464
G Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 JBrowse link 17 57,105,287 57,107,758 RGD:6480464
G Trafd1 TRAF type zinc finger domain containing 1 JBrowse link 5 121,371,725 121,386,570 RGD:6480464
G Triap1 TP53 regulated inhibitor of apoptosis 1 JBrowse link 5 115,341,231 115,343,553 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Trp53inp1 transformation related protein 53 inducible nuclear protein 1 JBrowse link 4 11,156,441 11,174,379 RGD:6480464
G Ube2o ubiquitin-conjugating enzyme E2O JBrowse link 11 116,537,740 116,581,503 RGD:6480464
G Wdr63 WD repeat domain 63 JBrowse link 3 146,040,526 146,108,100 RGD:6480464
G Yars tyrosyl-tRNA synthetase JBrowse link 4 129,189,734 129,219,240 RGD:6480464
G Zmat3 zinc finger matrin type 3 JBrowse link 3 32,334,792 32,365,665 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20971
    role 20952
      application 20373
        pro-agent 8734
          prodrug 8507
            adefovir pivoxil 104
Path 2
Term Annotations click to browse term
  CHEBI ontology 20971
    subatomic particle 20965
      composite particle 20965
        hadron 20965
          baryon 20965
            nucleon 20965
              atomic nucleus 20965
                atom 20965
                  main group element atom 20803
                    p-block element atom 20803
                      carbon group element atom 20543
                        carbon atom 20519
                          organic molecular entity 20519
                            organic molecule 20371
                              organic cyclic compound 20047
                                organic heterocyclic compound 18970
                                  organic heteropolycyclic compound 18397
                                    organic heterobicyclic compound 17029
                                      imidazopyrimidine 5442
                                        purines 5440
                                          aminopurine 4402
                                            6-aminopurines 765
                                              adenine 759
                                                adefovir 113
                                                  adefovir pivoxil 104
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.