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ONTOLOGY REPORT - ANNOTATIONS


Term:adefovir pivoxil
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Accession:CHEBI:31175 term browser browse the term
Definition:An organic phosphonate that is the dipivoxil ester of adefovir. A prodrug for adefovir, an HIV-1 reverse transcriptase inhibitor, adefovir pivoxil is used to treat chronic hepatitis B viral infection.
Synonyms:exact_synonym: bis{[(tert-butoxycarbonyl)oxy]methyl} {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonate
 related_synonym: (((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis(oxymethylene) 2,2-dimethylpropanoate;   9-(2-((Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine;   Adefovir dipivoxil;   Formula=C20H32N5O10P;   GS 840;   GS-0840;   InChI=1S/C20H32N5O10P/c1-19(2,3)34-17(26)30-11-32-36(28,33-12-31-18(27)35-20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23);   InChIKey=RXWOJYZFCFODMQ-UHFFFAOYSA-N;   SMILES=N1(C2=C(C(N)=NC=N2)N=C1)CCOCP(OCOC(OC(C)(C)C)=O)(=O)OCOC(OC(C)(C)C)=O;   hepsera;   preveon
 xref: CAS:142340-99-6 "ChemIDplus";   CAS:142340-99-6 "KEGG DRUG";   DrugBank:DB00718;   Drug_Central:88 "DrugCentral";   HMDB:HMDB0014856;   KEGG:D01655
 xref_mesh: MESH:C106812
 xref: PMID:10728465 "Europe PMC";   PMID:12099163 "Europe PMC";   PMID:25237370 "Europe PMC";   PMID:25493022 "Europe PMC";   PMID:25834334 "Europe PMC";   PMID:26082614 "Europe PMC";   PMID:26110616 "Europe PMC";   PMID:26427083 "Europe PMC";   PMID:26431662 "Europe PMC";   PMID:26447622 "Europe PMC";   PMID:26462447 "Europe PMC";   PMID:26885037 "Europe PMC";   PMID:26889227 "Europe PMC";   PMID:26908332 "Europe PMC";   PMID:27010143 "Europe PMC";   PMID:27079793 "Europe PMC";   PMID:27247753 "Europe PMC";   PMID:27301512 "Europe PMC";   PMID:27386642 "Europe PMC";   PMID:27664568 "Europe PMC";   PMID:27698751 "Europe PMC";   PMID:27877054 "Europe PMC";   PMID:27977591 "Europe PMC";   PMID:28123560 "Europe PMC";   Reaxys:29413415 "Reaxys";   Wikipedia:Adefovir


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adefovir pivoxil term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Ak4 adenylate kinase 4 JBrowse link 5 120,250,318 120,309,153 RGD:6480464
G Akr1c2 aldo-keto reductase family 1, member C2 JBrowse link 17 69,388,337 69,435,160 RGD:6480464
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 JBrowse link 1 259,641,673 259,674,521 RGD:6480464
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 JBrowse link 1 127,302,920 127,337,828 RGD:6480464
G Als2cl ALS2 C-terminal like JBrowse link 8 119,156,081 119,176,680 RGD:6480464
G Angptl4 angiopoietin-like 4 JBrowse link 7 18,627,814 18,634,043 RGD:6480464
G Asns asparagine synthetase (glutamine-hydrolyzing) JBrowse link 4 33,742,876 33,761,106 RGD:6480464
G Atad2 ATPase family, AAA domain containing 2 JBrowse link 7 97,984,754 98,027,379 RGD:6480464
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:6480464
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:6480464
G Axl Axl receptor tyrosine kinase JBrowse link 1 82,550,892 82,580,761 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcar3 BCAR3 adaptor protein, NSP family member JBrowse link 2 226,563,050 226,679,449 RGD:6480464
G Bend5 BEN domain containing 5 JBrowse link 5 131,257,127 131,312,335 RGD:6480464
G Bmf Bcl2 modifying factor JBrowse link 3 110,303,515 110,324,125 RGD:6480464
G Btg2 BTG anti-proliferation factor 2 JBrowse link 13 50,913,185 50,916,944 RGD:6480464
G Ccne2 cyclin E2 JBrowse link 5 24,434,077 24,446,406 RGD:6480464
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cmbl carboxymethylenebutenolidase homolog JBrowse link 2 84,645,084 84,666,836 RGD:6480464
G Coch cochlin JBrowse link 6 72,359,702 72,373,710 RGD:6480464
G Col4a1 collagen type IV alpha 1 chain JBrowse link 16 83,522,162 83,632,153 RGD:6480464
G Cth cystathionine gamma-lyase JBrowse link 2 264,266,959 264,293,040 RGD:6480464
G Ctsc cathepsin C JBrowse link 1 151,918,514 151,949,979 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Ddb2 damage specific DNA binding protein 2 JBrowse link 3 80,030,437 80,052,984 RGD:6480464
G Dgka diacylglycerol kinase, alpha JBrowse link 7 3,143,826 3,170,764 RGD:6480464
G Dlgap5 DLG associated protein 5 JBrowse link 15 24,167,484 24,199,417 RGD:6480464
G Dlx1 distal-less homeobox 1 JBrowse link 3 58,164,931 58,169,521 RGD:6480464
G Dpysl3 dihydropyrimidinase-like 3 JBrowse link 18 37,716,371 37,819,347 RGD:6480464
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:6480464
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha JBrowse link 15 19,619,947 19,655,381 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fbxo22 F-box protein 22 JBrowse link 8 59,770,032 59,786,061 RGD:6480464
G Gabarapl1 GABA type A receptor associated protein like 1 JBrowse link 4 163,293,724 163,302,866 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 JBrowse link 6 104,069,853 104,250,177 RGD:6480464
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type JBrowse link 8 76,449,078 76,459,431 RGD:6480464
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:6480464
G Got1 glutamic-oxaloacetic transaminase 1 JBrowse link 1 263,246,248 263,269,762 RGD:6480464
G Gpr87 G protein-coupled receptor 87 JBrowse link 2 149,398,949 149,418,041 RGD:6480464
G H1f2 H1.2 linker histone, cluster member JBrowse link 17 43,638,938 43,640,445 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il19 interleukin 19 JBrowse link 13 47,663,592 47,677,869 RGD:6480464
G Kat6b lysine acetyltransferase 6B JBrowse link 15 2,811,933 2,966,833 RGD:6480464
G Kdm3a lysine demethylase 3A JBrowse link 4 99,503,160 99,547,315 RGD:6480464
G Krt15 keratin 15 JBrowse link 10 88,046,803 88,050,622 RGD:6480464
G Lama3 laminin subunit alpha 3 JBrowse link 18 3,704,866 3,941,215 RGD:6480464
G Lcn2 lipocalin 2 JBrowse link 3 11,414,189 11,417,534 RGD:6480464
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 17 56,109,403 56,129,925 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Mxi1 MAX interactor 1, dimerization protein JBrowse link 1 274,030,748 274,090,071 RGD:6480464
G Ncapd2 non-SMC condensin I complex, subunit D2 JBrowse link 4 157,682,855 157,705,903 RGD:6480464
G Ninj1 ninjurin 1 JBrowse link 17 15,866,235 15,881,284 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Nrep neuronal regeneration related protein JBrowse link 18 26,183,753 26,212,796 RGD:6480464
G Ntpcr nucleoside-triphosphatase, cancer-related JBrowse link 19 58,565,576 58,579,276 RGD:6480464
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 JBrowse link 20 28,920,616 28,972,576 RGD:6480464
G Pank1 pantothenate kinase 1 JBrowse link 1 253,115,400 253,189,643 RGD:6480464
G Pdia5 protein disulfide isomerase family A, member 5 JBrowse link 11 68,493,035 68,578,999 RGD:6480464
G Pdlim1 PDZ and LIM domain 1 JBrowse link 1 259,308,326 259,357,006 RGD:6480464
G Pgr progesterone receptor JBrowse link 8 7,128,656 7,187,796 RGD:6480464
G Phlda3 pleckstrin homology-like domain, family A, member 3 JBrowse link 13 52,588,917 52,592,002 RGD:6480464
G Pidd1 p53-induced death domain protein 1 JBrowse link 1 214,418,751 214,423,959 RGD:6480464
G Pir pirin JBrowse link X 31,852,322 31,968,152 RGD:6480464
G Plec plectin JBrowse link 7 117,230,319 117,291,859 RGD:6480464
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D JBrowse link 10 72,909,550 72,945,884 RGD:6480464
G Prc1 protein regulator of cytokinesis 1 JBrowse link 1 142,087,181 142,108,746 RGD:6480464
G Prdm1 PR/SET domain 1 JBrowse link 20 49,464,921 49,556,623 RGD:6480464
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 JBrowse link 2 199,831,990 199,847,623 RGD:6480464
G Psat1 phosphoserine aminotransferase 1 JBrowse link 1 233,124,089 233,145,941 RGD:6480464
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:6480464
G Rps27l ribosomal protein S27-like JBrowse link 8 72,741,155 72,746,090 RGD:6480464
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B JBrowse link 7 76,750,045 76,780,817 RGD:6480464
G Serpinb5 serpin family B member 5 JBrowse link 13 26,903,052 26,923,250 RGD:6480464
G Sesn1 sestrin 1 JBrowse link 20 46,667,116 46,758,306 RGD:6480464
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6480464
G Sh3tc1 SH3 domain and tetratricopeptide repeats 1 JBrowse link 14 80,184,814 80,229,207 RGD:6480464
G Slc27a2 solute carrier family 27 member 2 JBrowse link 3 119,014,620 119,052,531 RGD:6480464
G Slc6a9 solute carrier family 6 member 9 JBrowse link 5 136,669,674 136,703,702 RGD:6480464
G Slco2b1 solute carrier organic anion transporter family, member 2b1 JBrowse link 1 164,623,313 164,671,612 RGD:6480464
G Smap1 small ArfGAP 1 JBrowse link 9 30,068,888 30,161,753 RGD:6480464
G Sulf2 sulfatase 2 JBrowse link 3 162,791,349 162,872,984 RGD:6480464
G Thra thyroid hormone receptor alpha JBrowse link 10 86,657,285 86,684,935 RGD:6480464
G Tigar TP53 induced glycolysis regulatory phosphatase JBrowse link 4 159,635,145 159,654,108 RGD:6480464
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase JBrowse link 2 157,316,293 157,342,979 RGD:6480464
G Tnfsf9 TNF superfamily member 9 JBrowse link 9 9,909,942 9,912,276 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 JBrowse link 5 24,402,895 24,419,651 RGD:6480464
G Trafd1 TRAF type zinc finger domain containing 1 JBrowse link 12 40,695,520 40,709,438 RGD:6480464
G Triap1 TP53 regulated inhibitor of apoptosis 1 JBrowse link 12 46,987,404 46,989,906 RGD:6480464
G Ube2o ubiquitin-conjugating enzyme E2O JBrowse link 10 105,505,721 105,553,167 RGD:6480464
G Wdr63 WD repeat domain 63 JBrowse link 2 251,912,432 251,970,699 RGD:6480464
G Yars1 tyrosyl-tRNA synthetase 1 JBrowse link 5 147,375,350 147,403,578 RGD:6480464
G Zmat3 zinc finger, matrin type 3 JBrowse link 2 118,715,229 118,746,109 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      application 19308
        pro-agent 8823
          prodrug 8612
            adefovir pivoxil 101
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic molecule 19402
                              organic cyclic compound 19158
                                organic heterocyclic compound 18245
                                  organic heteropolycyclic compound 17500
                                    organic heterobicyclic compound 15910
                                      imidazopyrimidine 5415
                                        purines 5413
                                          aminopurine 4372
                                            6-aminopurines 757
                                              adenine 751
                                                adefovir 110
                                                  adefovir pivoxil 101
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.