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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acemetacin
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Accession:CHEBI:31162 term browser browse the term
Definition:A carboxylic ester that is the carboxymethyl ester of indometacin. A non-steroidal anti-inflammatory drug, it is used in the treatment of rheumatoid arthritis, osteoarthritis, and low back pain, as well as for postoperative pain and inflammation. Its activity is due to both acemetacin and its major metabolite, indometacin.
Synonyms:exact_synonym: {2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}acetic acid
 related_synonym: Acemix;   Emflex;   Formula=C21H18ClNO6;   InChI=1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25);   InChIKey=FSQKKOOTNAMONP-UHFFFAOYSA-N;   K-708;   Rantudil;   SMILES=COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)OCC(O)=O)c2c1;   Solart;   TV-1322;   TVX 3322;   acemetacina;   acemetacine;   acemetacinum;   indometacin carboxymethyl ester;   indometacin glycolic ester;   indomethacin carboxymethyl ester;   indomethacin glycolic ester
 xref: CAS:53164-05-9;   Drug_Central:47;   KEGG:D01582;   LINCS:LSM-5753
 xref_mesh: MESH:C026784
 xref: Patent:DE2234651;   Patent:US3910952;   Reaxys:501672;   Wikipedia:Acemetacin


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acemetacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glo1 glyoxalase 1 decreases activity ISO acemetacin results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      biological role 19873
        xenobiotic 18765
          indometacin 3441
            acemetacin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    p-block element atom 19845
                      carbon group element atom 19792
                        carbon atom 19787
                          organic molecular entity 19787
                            organic group 18957
                              organic divalent group 18938
                                organodiyl group 18938
                                  carbonyl group 18890
                                    carbonyl compound 18890
                                      carboxylic acid 18611
                                        carboacyl group 17702
                                          univalent carboacyl group 17702
                                            carbamoyl group 17547
                                              carboxamide 17547
                                                N-acylindole 3441
                                                  indometacin 3441
                                                    acemetacin 1
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