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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acemetacin
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Accession:CHEBI:31162 term browser browse the term
Definition:A carboxylic ester that is the carboxymethyl ester of indometacin. A non-steroidal anti-inflammatory drug, it is used in the treatment of rheumatoid arthritis, osteoarthritis, and low back pain, as well as for postoperative pain and inflammation. Its activity is due to both acemetacin and its major metabolite, indometacin.
Synonyms:exact_synonym: {2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}acetic acid
 related_synonym: Acemix;   Emflex;   Formula=C21H18ClNO6;   InChI=1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25);   InChIKey=FSQKKOOTNAMONP-UHFFFAOYSA-N;   K-708;   Rantudil;   SMILES=COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)OCC(O)=O)c2c1;   Solart;   TV-1322;   TVX 3322;   acemetacina;   acemetacine;   acemetacinum;   indometacin carboxymethyl ester;   indometacin glycolic ester;   indomethacin carboxymethyl ester;   indomethacin glycolic ester
 xref: CAS:53164-05-9;   Drug_Central:47;   KEGG:D01582;   LINCS:LSM-5753
 xref_mesh: MESH:C026784
 xref: Patent:DE2234651;   Patent:US3910952;   Reaxys:501672;   Wikipedia:Acemetacin


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acemetacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glo1 glyoxalase 1 decreases activity ISO acemetacin results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        xenobiotic 18452
          indometacin 3184
            acemetacin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                N-acylindole 3184
                                                  indometacin 3184
                                                    acemetacin 1
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