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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acemetacin
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Accession:CHEBI:31162 term browser browse the term
Definition:A carboxylic ester that is the carboxymethyl ester of indometacin. A non-steroidal anti-inflammatory drug, it is used in the treatment of rheumatoid arthritis, osteoarthritis, and low back pain, as well as for postoperative pain and inflammation. Its activity is due to both acemetacin and its major metabolite, indometacin.
Synonyms:exact_synonym: {2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}acetic acid
 related_synonym: Acemix;   Emflex;   Formula=C21H18ClNO6;   InChI=1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25);   InChIKey=FSQKKOOTNAMONP-UHFFFAOYSA-N;   K-708;   Rantudil;   SMILES=COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)OCC(O)=O)c2c1;   Solart;   TV-1322;   TVX 3322;   acemetacina;   acemetacine;   acemetacinum;   indometacin carboxymethyl ester;   indometacin glycolic ester;   indomethacin carboxymethyl ester;   indomethacin glycolic ester
 xref: CAS:53164-05-9;   Drug_Central:47;   KEGG:D01582;   LINCS:LSM-5753
 xref_mesh: MESH:C026784
 xref: Patent:DE2234651;   Patent:US3910952;   Reaxys:501672;   Wikipedia:Acemetacin



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acemetacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glo1 glyoxalase 1 decreases activity ISO acemetacin results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        xenobiotic 18664
          indometacin 3193
            acemetacin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            carbamoyl group 17546
                                              carboxamide 17546
                                                N-acylindole 3193
                                                  indometacin 3193
                                                    acemetacin 1
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