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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aceclofenac
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Accession:CHEBI:31159 term browser browse the term
Definition:A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Synonyms:exact_synonym: (2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetoxy)acetic acid
 related_synonym: 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;   2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid;   Cincofen;   Clanza;   Formula=C16H13Cl2NO4;   Hifenac;   InChI=1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21);   InChIKey=MNIPYSSQXLZQLJ-UHFFFAOYSA-N;   PR-82/3;   SMILES=OC(=O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl;   aceclofenaco;   aceclofenacum;   glycolic acid [o-(2,6-dichloroanilino)phenyl]acetate ester
 xref: CAS:89796-99-6;   Drug_Central:43;   KEGG:D01545;   LINCS:LSM-5762
 xref_mesh: MESH:C056498
 xref: PMID:11511027;   PMID:22807412;   PMID:23261744;   PMID:23944964;   Patent:ES8404783;   Patent:US4548952;   Reaxys:4884476;   Wikipedia:Aceclofenac


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aceclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to aceclofenac CTD PMID:12147693 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO aceclofenac results in increased expression of GDF15 protein
aceclofenac results in increased expression of GDF15 mRNA 		CTD PMID:15555568 PMID:18076062 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Sell selectin L decreases expression ISO aceclofenac results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein CTD PMID:17328244 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        xenobiotic 19528
          diclofenac 1219
            aceclofenac 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      monocarboxylic acid 18309
                                        acetic acid 11175
                                          phenylacetic acid 1372
                                            diclofenac 1219
                                              aceclofenac 4
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