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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aceclofenac
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Accession:CHEBI:31159 term browser browse the term
Definition:A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Synonyms:exact_synonym: (2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetoxy)acetic acid
 related_synonym: 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;   2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid;   Cincofen;   Clanza;   Formula=C16H13Cl2NO4;   Hifenac;   InChI=1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21);   InChIKey=MNIPYSSQXLZQLJ-UHFFFAOYSA-N;   PR-82/3;   SMILES=OC(=O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl;   aceclofenaco;   aceclofenacum;   glycolic acid [o-(2,6-dichloroanilino)phenyl]acetate ester
 xref: CAS:89796-99-6;   Drug_Central:43;   KEGG:D01545;   LINCS:LSM-5762
 xref_mesh: MESH:C056498
 xref: PMID:11511027;   PMID:22807412;   PMID:23261744;   PMID:23944964;   Patent:ES8404783;   Patent:US4548952;   Reaxys:4884476;   Wikipedia:Aceclofenac


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aceclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 increases response to substance ISO ADAM17 results in increased susceptibility to aceclofenac CTD PMID:12147693 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO aceclofenac results in increased expression of GDF15 protein
aceclofenac results in increased expression of GDF15 mRNA		 CTD PMID:15555568 PMID:18076062 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Sell selectin L decreases expression ISO aceclofenac results in decreased expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein CTD PMID:17328244 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        xenobiotic 18547
          diclofenac 1007
            aceclofenac 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic group 18752
                              organic divalent group 18771
                                organodiyl group 18737
                                  carbonyl group 18704
                                    carbonyl compound 18738
                                      carboxylic acid 18409
                                        monocarboxylic acid 17702
                                          acetic acid 10885
                                            phenylacetic acid 1166
                                              diclofenac 1007
                                                aceclofenac 4
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