CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: aceclofenac
Accession: CHEBI:31159
browse the term
Definition: A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Synonyms: exact_synonym: (2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetoxy)acetic acid
related_synonym: 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester; 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid; Cincofen; Clanza; Formula=C16H13Cl2NO4; Hifenac; InChI=1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21); InChIKey=MNIPYSSQXLZQLJ-UHFFFAOYSA-N; PR-82/3; SMILES=OC(=O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl; aceclofenaco; aceclofenacum; glycolic acid [o-(2,6-dichloroanilino)phenyl]acetate ester
xref: CAS:89796-99-6; Drug_Central:43; KEGG:D01545; LINCS:LSM-5762
xref_mesh: MESH:C056498
xref: PMID:11511027; PMID:22807412; PMID:23261744; PMID:23944964; Patent:ES8404783; Patent:US4548952; Reaxys:4884476; Wikipedia:Aceclofenac
G
Adam17
ADAM metallopeptidase domain 17
increases response to substance
ISO
ADAM17 results in increased susceptibility to aceclofenac
CTD
PMID:12147693
NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344
G
Gdf15
growth differentiation factor 15
increases expression
ISO
aceclofenac results in increased expression of GDF15 protein aceclofenac results in increased expression of GDF15 mRNA
CTD
PMID:15555568 PMID:18076062
NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022
G
Sell
selectin L
decreases expression
ISO
aceclofenac results in decreased expression of SELL protein
CTD
PMID:12147693
NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600
G
Tnf
tumor necrosis factor
multiple interactions
ISO
[aceclofenac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein
CTD
PMID:17328244
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all