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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:biperiden
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Accession:CHEBI:3112 term browser browse the term
Definition:A member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.
Synonyms:related_synonym: 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol;   Formula=C21H29NO;   InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;   InChIKey=YSXKPIUOCJLQIE-UHFFFAOYSA-N;   SMILES=OC(CCN1CCCCC1)(C1CC2CC1C=C2)c1ccccc1;   alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropanol;   alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol;   biperidene;   biperideno;   biperidenum
 alt_id: CHEBI:251063
 xref: Beilstein:290038;   CAS:514-65-8;   DrugBank:DB00810;   Drug_Central:374;   KEGG:C07941;   KEGG:D00779;   LINCS:LSM-1235
 xref_mesh: MESH:D001712
 xref: PMID:10877003;   PMID:12873507;   PMID:25160769;   PMID:25466702;   PMID:2579237;   PMID:26479221;   PMID:28216067;   Patent:US2789110;   Wikipedia:Biperiden


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biperiden term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Biperiden results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
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G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Biperiden binds to and results in decreased activity of CHRM1 protein CTD PMID:21336581 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            antidyskinesia agent 1133
              biperiden 2
                biperiden hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            inorganic hydride 17433
                              pnictogen hydride 17405
                                nitrogen hydride 17247
                                  azane 16964
                                    ammonia 16963
                                      organic amino compound 16962
                                        tertiary amino compound 8638
                                          biperiden 2
                                            biperiden hydrochloride 0
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